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Stem Cell Injections Pioneering Step Forward?
sanspeak writes "Indian Doctors at All India Institute of Medical Sciences have performed a radical new operation of sorts by pioneering the method of stem cell injections. Ishika Gupta, a seven month old girl child who was suffering from cardiac myopathy, was treated by injecting stem cells into her heart from bone in her own leg. AIIMS has marked a global first in pioneering stem cell medicine by the "injection method''." From the article: "There will now be a national stem cell centre at AIIMS which will coordinate the research and its applications. The statistics speak for themselves. After six months, 56% of the affected (dead muscle) area injected with these cells had shown improvement." Additional details on this therapy available from the Fort Wayne News-Sentinel and Medical News Today.
I hear that the world is moving towards stem cell what?
The attractive thing about these results to many is that is identifies a built in population of stem cells in adult individuals that could be harvested for some applications which gets around certain issues related to the Bush administrations religiously imposed dogma on science and progress.
The problem with this approach is that often, they really do not know what cells they are injecting. Sure they are harvesting cells from the bone marrow which do contain some stem cell populations. But here is the deal: These cells are already partially differentiated. They are not totipotent. Certainly there will be some applications where you can take partially differentiated cells and inject them into some systems that will show positive results, such as the cardiac improvements observed in these studies. However, this will not be generalizeable to other disorders such as vision loss or other degenerative diseases.
Visit Jonesblog and say hello.
My wife is pregnant right now and we are going to have to make the choice if we want the 'stem cells' harvested from the cord after birth. I realize that there are costs involved, but is it worth it? Gut feeling says that if I don't I could regret it later. Any thoughts?
It could be worse, it could be Monday.
the only country to not get the benefits of these advancements will be the US. it's great when the leader of the nation is a total f-ing moron.
And yet federal money can't go to stem cell research? I'd rather my tax money go to that than a stupid war....
This is why there should be no ban on stem cell research. Peoples own personal beliefs getting in the way of science. But such evidence should persuade lawmakers (sorry to those not in the US) to promote MORE research, instead of cutting back on the types of research that can be done...
I haven't lost my mind. It's backed up on disk somewhere.
injected stem cells tend to transmongrify into tumors.
this tech is not ready for hospitals.
Directly on-topic? Well, no, but I guarantee there will be several positively moderated messages in this thread that don't get it right.
- This article isn't talking about embryonic stem cells, so any references to the Bush administration embryonic stem cell policy are utterly irrelevant
But for those who still don't get it:
- There isn't a "ban" on any kind of stem cell research in the US. There is a restriction on federal funding for embryonic stem cell research - entities are still free to perform embryonic stem cell research (see California's recent US$3 billion bond initiative to support such research in the state)
- The Bush administration is the first administration to allow any federal funding at all for embryonic stem cell research. Granted, this is partly due to timing, but it's still a point of information.
- When is an embryo "life"? At some arbitrary time? When it's in a woman's womb? When it's "wanted" by someone as the product of actions to create a child? When and how does it become life? What's the magic cutoff? When and why is it ok to destroy it? When it can exist on its own? What does "exist on its own" mean? I'm not saying any of these things necessarily should preclude embryonic stem cell research, and indeed, federal funding for it. But doesn't it seem that those ethical questions should be addressed or at least considered? It may well be that society collectively decides that the benefit outweighs ethical concerns. But bear in mind, too, that farming more developed human life for research would no doubt yield untold answers to questions that might hold great benefit. Does that mean we should do it? If not, why is that any different? Scientifically, it would seem clear that it's a life the second the embryo comes into being...
(Note: No, I am not anti-abortion, but do think we should acknowledge that abortion isn't just a "woman's choice" or a "medical decision" (unless it is a decision in relation to the safety of the mother). It is, essentially, the state sanctioned ability to end a life when it is not wanted by the mother. Let's at least acknowledge what we're doing instead of hiding it under the blinders of "choice" or "scientific progress".)
Proof that alot of good can come of stem cell research aside from EMBRYONIC stem cells.
Adult stem cells show even more potential despite the media bias that would lend you to believe the oposite.
And yet federal money can't go to stem cell research?
And yet again someone missinformed. Bush DID NOT BAN Federal Funding of Stem Cell Research. He banned Federal Funding going to Embryonic Stem Cell Research on new lines. This research used Adult Stem Cells. Something that Federal money can go to.
Fly me to the moon Let me sing among those stars Let me see what spring is like On jupiter and mars
What was wrong with "seven month old girl" or "seven month old child?" Sheesh.
- This article isn't talking about embryonic stem cells, so any references to the Bush administration embryonic stem cell policy are utterly irrelevant
But for those who still don't get it:
- There isn't a "ban" on any kind of stem cell research in the US. There is a restriction on federal funding for embryonic stem cell research - entities are still free to perform embryonic stem cell research (see California's recent US$3 billion bond initiative to support such research in the state)
- The Bush administration is the first administration to allow any federal funding at all for embryonic stem cell research. Granted, this is partly due to timing, but it's still a point of information.
- When is an embryo "life"? At some arbitrary time? When it's in a woman's womb? When it's "wanted" by someone as the product of actions to create a child? When and how does it become life? What's the magic cutoff? When and why is it ok to destroy it? When it can exist on its own? What does "exist on its own" mean? I'm not saying any of these things necessarily should preclude embryonic stem cell research, and indeed, federal funding for it. But doesn't it seem that those ethical questions should be addressed or at least considered? It may well be that society collectively decides that the benefit outweighs ethical concerns. But bear in mind, too, that farming more developed human life for research would no doubt yield untold answers to questions that might hold great benefit. Does that mean we should do it? If not, why is that any different? Scientifically, it would seem clear that it's a life the second the embryo comes into being...
(Note: No, I am not anti-abortion, but do think we should acknowledge that abortion isn't just a "woman's choice" or a "medical decision" (unless it is a decision in relation to the safety of the mother). It is, essentially, the state sanctioned ability to end a life when it is not wanted by the mother. Let's at least acknowledge what we're doing instead of hiding it under the blinders of "choice" or "scientific progress".)
Although the U.S. article identified the applicability of stem cells harvested from (adult) bone marrow and other sources, the Indian article discusses the successes achieved from utilizing umbilical cord stem cells...
mmm... yeah... You see, we're putting the cover sheets on all TPS reports now before they go out...
Directly on-topic? Well, no, but I guarantee there will be several positively moderated messages in this thread that don't get it right.
- This article isn't talking about embryonic stem cells, so any references to the Bush administration embryonic stem cell policy are utterly irrelevant
But for those who still don't get it:
- There isn't a "ban" on any kind of stem cell research in the US. There is a restriction on federal funding for embryonic stem cell research - entities are still free to perform embryonic stem cell research (see California's recent US$3 billion bond initiative to support such research in the state)
- The Bush administration is the first administration to allow any federal funding at all for embryonic stem cell research. Granted, this is partly due to timing, but it's still a point of information.
- When is an embryo "life"? At some arbitrary time? When it's in a woman's womb? When it's "wanted" by someone as the product of actions to create a child? When and how does it become life? What's the magic cutoff? When and why is it ok to destroy it? When it can exist on its own? What does "exist on its own" mean? I'm not saying any of these things necessarily should preclude embryonic stem cell research, and indeed, federal funding for it. But doesn't it seem that those ethical questions should be addressed or at least considered? It may well be that society collectively decides that the benefit outweighs ethical concerns. But bear in mind, too, that farming more developed human life for research would no doubt yield untold answers to questions that might hold great benefit. Does that mean we should do it? If not, why is that any different? Scientifically, it would seem clear that it's a life the second the embryo comes into being...
(Note: No, I am not anti-abortion, but do think we should acknowledge that abortion isn't just a "woman's choice" or a "medical decision" (unless it is a decision in relation to the safety of the mother). It is, essentially, the state sanctioned ability to end a life when it is not wanted by the mother. Let's at least acknowledge what we're doing instead of hiding it under the blinders of "choice" or "scientific progress".)
Bush banned Federal Funding of Embryonic Stem Cell research on new lines only. If you get private funding, you can do research on new embryoninc lines. Or, you can use Federal Funding on the old lines or Adult Stem Cells. This new technique used Adult Stem Cells. They can get federal funding for this.
There is no outright ban. It is a myth.
Fly me to the moon Let me sing among those stars Let me see what spring is like On jupiter and mars
This reminds me of Smallville, where one guy would get bitten by a bug who ate meteor rock, and the guy would develop bug powers. Another guy would fall on a hot meteor rock, and would develop heat powers. I can't wait for the stem cell meteor rock episode.
While our country (USA) moves backward the rest of the world moves forward. Thanks for nothing evangelicals! Take us back to some ideal "Christian" society that never truely existed in this country in the first place!
Do really dense people warp space more than others?
- This article isn't talking about embryonic stem cells, so any references to the Bush administration embryonic stem cell policy are utterly irrelevant
But for those who still don't get it:
- There isn't a "ban" on any kind of stem cell research in the US. There is a restriction on federal funding for embryonic stem cell research - entities are still free to perform embryonic stem cell research (see California's recent US$3 billion bond initiative to support such research in the state)
- The Bush administration is the first administration to allow any federal funding at all for embryonic stem cell research. Granted, this is partly due to timing, but it's still a point of information.
- When is an embryo "life"? At some arbitrary time? When it's in a woman's womb? When it's "wanted" by someone as the product of actions to create a child? When and how does it become life? What's the magic cutoff? When and why is it ok to destroy it? When it can exist on its own? What does "exist on its own" mean? I'm not saying any of these things necessarily should preclude embryonic stem cell research, and indeed, federal funding for it. But doesn't it seem that those ethical questions should be addressed or at least considered? It may well be that society collectively decides that the benefit outweighs ethical concerns. But bear in mind, too, that farming more developed human life for research would no doubt yield untold answers to questions that might hold great benefit. Does that mean we should do it? If not, why is that any different? Scientifically, it would seem clear that it's a life the second the embryo comes into being...
You ignorant dumbass.
And I doubt the 8 million plus Iraqis who actually got to vote in a real election agree with your assessment of the Iraqi war.
Nor do the protestors for democracy now showing up in Egypt, Iran, and Syria.
Or maybe you think Arabs don't deserve freedom and democracy?
The sec-fundies are gonna have a field day with this one...
It doesn't have to be true, it just has to be read.
BTW, this would be perfectly legal here in the US.Free Mac Mini Yeah, it's
The Indian research is using adult and umbilical stem cells. Funding of neither is restricted in the US. And embryonic stem cell research is unrestricted, but federal funding is not available for research on new lines that would destroy embryos (though any organization is free to perform such research without federal funding).
And, since you seem to have all the answers, I suppose you can tell us with certainty exactly when and why an embryo is life, and therefore when it's ok to destroy it?
I await your reply.
I did a stem cell donation for my brother last week. It cost about $6000 and involved hooking up veins in both arms to a continuous centrifuge that pumped blood out of one arm, centrifuged it to remove the stem cells, and then injected the plasma and red cells back into the other arm. I had to get injections of Neupogen for four days prior to what the docs called the "harvest".
I didn't have to have long needles stuck into my bone marrow. The worst part was not being able to move my arms for 5 1/2 hours for any reason because of the needles in veins in my elbows.
They got 3 times as much material as they need and I am trying to arrange to have the rest stockpiled in case I need them at some later date. They needed 8 million cells per kilo of body weight for a cross donation, but only 4 million for self-donation.
I can't let this one go.
(1) The Bush Administration does not have a "religiously imposed dogma on science and progress". There is a significant segment of the American population that is concerned about scientists initiating the process of conception for the sole purpose of ripping apart the component stem cells while receiving federal funding to do so. Corporations and universities are welcome to continue studying embryonic stem cells, just not while using federal research grants.
(2) Unlike the aformentioned Embryonic Stem Cells, this process is another form of Adult Stem Cell research, which is using the patient's own stem cells to culture and augment existing organs. There has never been any political problems with this branch of stem cell research, and the Bush Administration has advanced this research alternative several times as the preferred path.
(3) Bone Marrow has long been known to be a source of red blood cells as well as muscle stem cells. If they are partially differentiated as marrow cells, they are still in the same family as cardiovascular muscles, and thus are a prime candidate for this type of injection research. It would be like taking neurons from the brain and injecting them into the spinal column, to see if the cells can merge and augment the spinal tissues.
Part of the problem of degenerative diseases is that there is a genetic problem with the adult, so transplanting cells with the same genetic makeup within the same adult will not magically create a missing protein... that is where we need to initiate aditional research with inter-adult stem cell research, and proceed from there.
Remember the 1990s hype that 'Gene Therapy' was going to solve all of our medical problems.
When it's born. Why then? That's when humans have decided that new humans will be welcomed into the world. It's a tradition that's thousands of years old and will endure for sometime.
Even the celebrations that come before the birth of a child, are celebrations of the opportunity and in anticipation of the great change the parents will face. Despite the ability, for some time now, to narrow down conception fairly precisely, the day that everyone celebrates their induction into the human club is their birthday, and no other.
The embryos Bush is banning, don't even have the possibility of becoming a human without the skilled intervention of medical professional. Even were they in a womb, their greatest hurdles behind them, the odds that they would eventually grow into fully realized humans is far from certain, and even unlikely. He doesn't hate abortion, to do so would be to hate human reproduction, which frequently decides some babies aren't worth keeping. He hates other people taking control of their own lives. He hates the freedom that God gave to everyone. That's the real face of Evangelicals.
I just want to make sure we're clear.
That also means that a baby grown outside of the womb has no protections.
That also means we can farm developed fetuses for destructive research that might yield great benefit. You could even go further and grow them beyond any arbitrary period (e.g., 9 months for example). Since they've never been "born", and have never been wanted by a parent, it's not a "life" by your definition. And if such research could hold untold answers to questions and benefit for mankind, why should we not do it?
I just want to make sure you're being logically consistent here.
As a born and raised native of Fort Wayne, it's nice to see them slashdotted. ...kinda
Especially after they were ranked at the Very Bottom of Men's Health magazine's list of city intelligence in the US.
Even though I moved out as soon as I was able (to Columbus, OH [19], NYC [32], and currently Miami [94]), the place isn't so bad. There are even a few people there smart enough to read to everyone else. It's nice, storytime is. I especially liked the milk and cookies.
Futurama was (almost) Right!
Please list for us the therapies under development that use embryonic stem cells.
Clear, Dark Skies
Preface: Your point to the grandparent poster about these being adult stem cells, and Bush comments not having any bearing on this conversation are correct. I'm not trying to argue against them. Having said that, here's why many of us don't see his decision as "Wisdom". There goes my karma. *sigh*
Someone has their (rare typed) blood stored for a surgical procedure. There is less bleeding than predicted. Would it be morally wrong for the excess blood (with the patient's permission) to be moved to the local blood bank, for other people with the rare blood type, instead of disposed of as medical waste? Many of the fetuses that would be used in this situation come from fertility clinics whose patients have moved on, and have no more use for the embryos. Those of us who do NOT believe that life begins at conception, but rather later in gestation, see the fetuses as portions of the woman's body, more like blood cells than individuals. And they are cells that are to be destroyed anyway. Denying Federal funds to scientists whose research uses these cells is a problem for us.
You may disagree with me, and that's fine. But hopefully you'll have a better idea where we're coming from.
Somebody actually noticed that non-embryonic stem cells are being used to treat diseases today. Kind of ironic that while adult stem cell therapies are being tested in clinical trials, the Bush administration is taking heat because they didn't fund ethically suspect embryonic stem cell research - research which has yet to produce even a single cure.
The society for a thought-free internet welcomes you.
The NIH even publishes guidelines on how to keep your embryonic stem cell research from impacting your other funding.
Clear, Dark Skies
its not that pionering...
o rter/0,19125, VGC0-2703-4724-3,00.html
Here stem cells injection are being use in juvenile diabetes, lupus (resulted in complete disappear in some patientes, but may not be considered a cure) and multiple sclerosis, heart and cerebral vascular accidents.
There is a tv program transcription from 2005-01-14 here, in portuguese:
http://redeglobo6.globo.com/Globorep
On a minor note, Will this treatment be affordable?
Just like the "cure" for AIDS I foresee that this treatment will only be available to the rich.
Call me crazy, but before this becomes a generally used treatment it has to be affordable for all.
I doubt anyone on MEDICAID will have stemcell therapy as an option.
perpetually dwelling in the -1 pits
Somehow, the issue of abortion has changed from the actual basis of the Supreme Court decision into something else entirely. The reasoning behind the decision in Roe v. Wade is that what happens between a Doctor and a patient is and ought to be a private matter.
Now, one could very easily argue that the Constitution of the United States does not guarantee one's privacy and I can agree that there is no privacy right enshrined in the Constitution or any of the Amendments, including the Bill of Rights. Certainly what the Supreme Court did in Roe v. Wade was to "make law" or legislate from the bench and this single decision is the reason why the right drones on in their rhetoric about "activist judges" and "strict interpretation" though I challenge anyone to find either in the decision handed down in 2000 in the case of Bush v Gore.
Both the left and the right are talking about things like the "sanctity of life" and "a woman's right to choose," when niether was considered by the Supreme Court in their decision and these issues were not discussed in the opinion and the dissenting opinion.
The use of stem cells, either adult or embryonic is blue sky science presently and the cures that may be effected are still theory. I wonder whether or not the child so treated will eventually develop a tumor at the site of the "treatment." Frankly, I would treat this patient as a potential cancer patient, not claiming any cure until five years (the standard for non reoccurance of cancer) after treatment.
Gods don't kill people, people with gods kill people.
if women laid eggs and then walked away from them, never to return, then the anti-abortion crowd would be 100% ethical and moral in their stance
however, mother nature has designed us mammals so that for a moment in time, 2 lives are interconnected biologically, and then, 2 lives are socially connected for years
what this means is that you can not consider either the rights of the fetus or the rights of the mother in a vacuum and consider yourself to be moral or ethical
therefore, to fall 100% on the side of fetal rights is to basically consider a woman to be nothing but a breeding pod chamber
and to fall 100% on the side of maternal rights is tantamount to considering infanticide reasonable
but, of course, exactly where you draw the line, exactly when you draw the line: 3 months old fetus... 3 day old fetus... whatever, that becomes the critical question
and the problem is that no outside panel of people, no matter how reasonable or passionate about the issue, can decide the issue to satisfaciton on each individual case
there is, however, one person who can make such a passionate, reasonable decision: the mother
it seems that the anti-abortion crowd thinks women are all out having one night stands at raves and then aborting a month later and going to another rave to have one night stands the same night
as if women don't have any feelings about the fetus?! why do anti-abortionists have such a dim view of women?
so let the mother decide, and the mother ALONE decide, and all of us hyperconcerned but UNINVOLVED third party members should learn to BUTT OUT
this is the ONLY moral and ethical stand you can take on abortion: the mom decides, no one else can possibly have a say
is it superior to force a woman to have a child she does not love with no father there to support it?
are we only in the business of punishing women for acts of sex outside of marriage? what about the man's responsibilty?
the more you examine the issue, the more you realize anti-abortion stances are simply anti-women
let the mother decide, it's her body, and you cannot assume she doesn't care about the fetus, unless you have some sort of psychological problem with women
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
There is no ban on stem cell research or even funding stem cell research - there is a ban on funding /embryonic/ stem cell research which has nothing to do with the original article - which people have pointed out over and over again.
The value of adult stem cells has been shown over and over again. The value of embryonic stem cells has never been shown and, in fact, embryonic stem cells cause all sorts of havoc when injected into another individual. Havoc like sudden cancers caused by the embryonic cells not adapting well to life in a grown host.
Clear, Dark Skies
A news googling reveals pending bills that would create a ban in Missouri. Other states might try similar measures.
There was a case in Royal Oak MI where a 16 year old with severe heart damage was treated with stem cells from his bone marrow. This was almost 2 years ago and seems to have been a complete success, but you never read about it. It saved the kid from needing a heart transplant.
m ai n542962.shtml
http://www.cbsnews.com/stories/2003/03/06/tech/
or google for royal oak heart stem cell
If the only thing of value is that more lives were saved than lost, then the same argument can be applied to therapies derived from embryonic stem cells.
If more lives are saved than lost, what do you care if a few embryos were harvested for this treatment.
Clear, Dark Skies
Thanks for that link. Very, very well put together.
-Daniel
It could be worse, it could be Monday.
As a quick google would have told you.
Clear, Dark Skies
If the only thing of value is that more lives were saved than lost, then the same argument can be applied to therapies derived from embryonic stem cells.
Um, yes, that's kind of the converse of the point I was making.
I don't have any problems with my own logical consistency, here, as I support both, for the reasons you (and I) stated.
If more lives are saved than lost, what do you care if a few embryos were harvested for this treatment.
I don't. Did I ever say I was opposed to embryonic stem cell research or federal funding for it? No? Ok then.
It's too bad that the majority of the replies to this article on novel Indian research revolve about Bush embryonic stem cell policy, which is completely and utterly unrelated to the Indian research, which is using adult and umbilical stem cells, neither of which are restricted in any way in the US.
I need some stem cells so I can inject them into my cock! YES. New type of penis enlargement!
And here people want to talk politics OVER Technology? Stem cell research is the first glimpse we humans have at a significantly longer life .. with more importantly .. the opportunity at a better quality of life.
Having had family members with significantly reduced quality of life as a result of macular degeneration and loss of hearing .. its not simply a matter of living longer. We will live longer, but what good is it if we can't read, see our monitors, and even listen to a good ol mp3 along the way.
Quit with the politics .. and focus on the science folks. Sure, its tough I know .. but lets let the research pan out.
Jason Key
Stem Cell Research Geek
http://www.stemnews.com
Today's Stem Cell Research
Nobody died to give the stem cells.
Technically, it's true--technically, states were free to set the drinking age to whatever they saw fit, and technically, research labs are free to conduct embryonic stem cell research on new cell lines.
[...]
There exist only a bare handful of labs who can afford to lose government funding. When the government says "Do this or you'll lose your federal funding", a PI can either do what the government says or close up shop--which means losing years of research, losing his livelihood, and firing a group of highly trained, carefully sought-after and brilliant scientists.
I'm sorry, but you're completely and utterly wrong.
Research institutions with federal funding are already easily working around the federal funding restrictions.
For example, the University of Wisconsin - currently the number one recipient of federal research grant money in general, and recipient of the greatest number of R01 NIH grants - launched the Wisconsin Institute for Discovery, a private research institute, in part to work around these restrictions. The institute can pursue embryonic stem cell research without affecting federal funding at the University of Wisconsin in any way. The NIH even has guidelines and recommendations about how institutions can work around federal funding guidelines for embryonic stem cell research, so as not to jeopardize other funding. California is doing the same sort of thing.
"Acknowledge the reality of the situation," indeed.
Let them do the embrionic research elsewhere than the US. If my tax dollars can't go toward a religious cause I support, then I don't want them going to another religious cause that I don't support, namely, one that says embryos are not life.
(This is not a reply to the parent post)
Don't take life so seriously. No one makes it out alive.
If more lives are saved than lost, what do you care if a few embryos were harvested for this treatment.
I don't. Did I ever say I was opposed to embryonic stem cell research or federal funding for it? No? Ok then.
Damn. I am amazed at how stupid the people are around here. So, the experiments on Jews in concentration camps are justified as long as more people benefit than suffered.
See my journal for slashdot ID's by year. Mine created in 2005. http://slashdot.org/journal/289875/slashdot-ids-by-year
A complete change of life.
They now can line up to get their mojo injected.
Yeah baby. Yeah!
First of all, I understand that purely by my original post you have no reason to think I may know a thing or three about this issue. But assumptions are dangerous.
I worked as a researcher for many years. I firmly believe the current policy, which is driven by politics and not sound scientific reasons, is bad for all forms of stem cell research in this country.
1)The policy currently bans Federal money from being used for creating or using embryos for stem cell research. Even though there are plenty of extra embryos that will be destroyed in fertilization clinics all over the country, we can't use them. These are embryos that will never get the chance to become a full human life. The cell lines that do exist are effectively unusable and no new ones can be created by people doing basic research. This means the researchers in academic institutions across the country cannot apply for grant money to do this type of research. There will be some very smart people driven away from doing any stem cell research because they don't have the freedom to conduct the experiments necessary.
2)Allowing other funding of the research (such as California or private) will keep critical data out of the hands of basic researchers. Private investment will not allow "trade secrets" to be published in a peer-reviewed manner. This is not a method of doing science that I put much trust in. Go research Celgene and Thalidomide. Go look at the "research" done by tobacco funding. I can't wait for the future day when the same people currently saying "not my tax dollars" will complain that the cell procedure they or their kid needs is too expensive. They'll be complete hypocrites that will be more than happy to have a procedure done that came from this research but not want to pay to have funded it in the first place.
3)Did you ever stop to think that maybe we can only learn certain things from embryonic stem cells? They could have the 'rosetta stone' of how to make use of all other stem cells. Yet, because of the funding ban some other country will get this prize. I know the article wasn't about embryonic cells. The point is, unless we do basic research on all possible forms we aren't doing it right and in the long run we'll lose because of it.
Do really dense people warp space more than others?
> Damn. I am amazed at how stupid the people are around here. So, the experiments
> on Jews in concentration camps are justified as long as more people benefit
> than suffered.
It's not stupid to raise the question - it's a perfectly valid ethical question, as is the question of whether it's satisfactory to torture the children of, say, terrorist suspects if doing so raises the possibility of saving very many more lifes.
Why is the left so dead set on using embryonic stem cells? Do they like the idea of slaughtering unborn humans to do research? They call us (christians, conservatives, red staters...choose your term)dogmatic in not allowing it, but they are wildly advocating something that hasn't produced a single treatment. THAT is dogmatic.
Why not push for research using non-embryonic stem cells? It's safe, not controversial, and has had quite a bit of success so far.
I don't get it.
Don't take life so seriously. No one makes it out alive.
Why does the state get to choose if you can have an abortion? Why does the state ever have any power over what I do with my body? Hint: they make laws, but they really don't.
Blar.
"Indian Doctors at All India Institute of Medical Sciences have performed a radical new operation of sorts by pioneering the method of stem cell injections...There will now be a national stem cell centre at AIIMS which will coordinate the research and its applications..."
So, despite the assurances of U.S. politicos, once again the U.S. is NOT the world leader in science and technology. Another country leads (gasp! A THIRD-WORLD country!), and the U.S. has a flat tire.
Standard U.S. knee-jerks:
"Stem-cell" == "abortion"
"nuclear" == "bomb"
"food" == "McDonald's"
"Britney Spears" == "music"
"language" == "English"
"Don't blame the log for the fire." --Andrew Ratshin
Annihilating the human race today would prevent a lot of net deaths in the future.
The "net preservation" argument was used by the Nazis to argue that a great war in Europe was necessary for a lasting peace.
The "net preservation" argument in this case is also a red herring, because the justification for the Iraq invasion had nothing at all to do with preserving Iraqi life. The proof of this is right here.
This is getting ridiculous with all the posts trying to use this to justify the effective ban on embryonic stem cell research. IF you belIeve that this research is immoral that's fine - I do understand your opinion and I have no problem with it though I disagree.
BUT stop claiming that the denial of federal funds doesn't make embryonic stem cell research in the US very difficult. Stop claiming that there is no merit to embryonic stem cell research - that is just patently untrue (yes I am a scientist and I have worked with EC but not ES cells). Look up Parkinson's and Diabetes and get a developmental biologist to explain to you why embryonic stem cell research provides hope for a cure to these diseases. Or read NIH's own summary on stem cell research
http://stemcells.nih.gov/info/basics/basics1.asp
Like I said if you have strong opinions that embryonic cell research is immoral - stand up for yourself and just say so. I respect that much more than trying to trick other people into accepting your agenda with naked FUD.
The concept of injecting bone marow derived cells into the heart is not new. It was featured a couple of years ago in a PBS special on stem cells and described as an experimental therapy being tested in Germany to help adult heart attack victims recover heart muscle function. It had impressive results. The specific application of injecting into the heart of a child born with a heart malformation is new but it is really a logical extension of previous work. Please don't let the hype about anyone's little corner of the stem cell field deny the real innovators their due.
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model.
Twenty-five rats received ES cell injections, and 13 rats received sham surgery by injection of vehicle (medium). Six rats showed no graft survival and five rats died before completed behavioral assessment and were found to have teratoma-like tumors at postmortem analysis.
Maybe because we'll need thousands of dead embryos to treat a few people?
Gamingmuseum.com: Give your 3D accelerator a rest.
On the contrary, it's all coming back to that central question of when life begins, how much we value it, and whether, if we believe a being to be human, it's ethical to kill them to aid others. Yes, stem cells aren't directly related to abortion, but they have the same root ethical quandry.
Although, interestingly enough, when the partial birth abortion (breech birth followed by a pair of scissors and a vacuum to the back of the skull before the baby can get its head out), the media did associate it with stem cells, as the idea of using fetal stem cells to curze Alzheimer's (or was it Parkinsons's?) by direct injections to the brain was in vogue. I suspect somewhere along the line, people got confused about what stem cells were and assumed that the vacuumed neural matter of the baby was equivalent.
Incidentally, last I'd seen about the Alzheimers/Parkinsons cure, experiments had shown that the results seemed largely a combination of a placebo effect along with that any needles injected directly into the brain did something to stimulate the nerve cells to improve.
This sig has absolutely no significance and serves only to take up screen space and waste the time of the reader.
*Now with 10% more stem cells!*
No one else thinks this is scary? This is foundation upon which some of the most horrifying events of our time we built.
Social Darwinism: If more lives are saved then lost, everything is ok. So if we just round up people how have undesirable traits, genetic faults, dreadful diseases, etc and kill them, the society as a whole benefits, so it's ok. We did evil, but it was a net good, so we're good people...
Naturally, we should take into account the benefits versus the costs, but "the ends justify the means" is a scary statement...
Think of it this way: So Saddam Hussein is a leader that should be taken out of power for the good of his people. Let's pretend that the UN actually stood a chance of taking him out of power through political means (without war.) (I really don' think they did, but let's pretend.)
Then the idea of going to war would clearly be wrong. (it may or may not be wrong as is, but that's a different story.)
So we have ways of obtaining stem cells without harming any children, so the idea of harming children to obtain stem cells should clearly be wrong.
Nothing is ever clearly anything, but I thought I'd put it out there......
You are attempting to merge two entirely separate conceptions of the world that can not be combined. One is that of sacrifice for improvements in the capital goods, to use a term from economics to allow for less writing, of the species by maintaining general freedom from genetic disease, and the pursuit of all methods of plausible and undeniable potential for accomplishing that goal. The other is that of the poorly contrived general "life is good" position that, rather than accomplishing a great benefit, has massively increased the unsuitability of the species by not allowing for systematic regulations despite the accomplished elimination of most "natural"-and thus strangely acceptable to that second position, means of reducing those faults.
Yup, above me posters, he's talking white blood cells.
:)
...)
Note Neupogen was withdrawn from the market.
Perhaps becuase it does affect the brain
(from various cut's 'n' pastes from the internet
Pharmacologic Effects of NEUPOGEN®
In phase 1 studies involving 96 patients with various nonmyeloid malignancies NEUPOGEN® administration resulted in a dose-dependent increase in circulating neutrophil counts over the dose range of 1 to 70 mcg/kg/day.9-11 This increase in neutrophil counts was observed whether NEUPOGEN® was administered IV (1 to 70 mcg/kg twice daily)9 SC (1 to 3 mcg/kg once daily)11 or by continuous SC infusion (3 to 11 mcg/kg/day).10 With discontinuation of NEUPOGEN® therapy neutrophil counts returned to baseline in most cases within 4 days. Isolated neutrophils displayed normal phagocytic (measured by zymosan-stimulated chemoluminescence) and chemotactic (measured by migration under agarose using N-formyl-methionyl-leucyl-phenylalanine [fMLP] as the chemotaxin) activity in vitro.
A neutrophil cell, especially an abundant type of granular white blood cell that is highly destructive of microorganisms.
I've got no problem harvesting stem cells from umbilical cord blood, or existing body parts for one's self....I can even accept harvesting them from embryos at fertility clinics that are going to be destroyed, though I still have some qualms with it. But I'm deeply disturbed by the idea that we should create embryos for the purpose of harvesting stem cells. I know about 90 percent of you are going to rush in and attack this, but it smacks of creating human life for the sole purpose of destroying it so that other human life can benefit. It's a little too close to cloning ourselves for the purpose of of having an endless supply of organs and tissues. Yes, again, so many of you will go "but think of the crippled/diseased children that could benefit!". Yes, I'm a horrible evil man for not thinking of the children. I guess I'm also evil for thinking that it's a bad idea for the human race to cannibalize itself (no, blood donations and organ donations don't count...blood is renewable, for lack of a better word, and organs come from those that are deceased). I guess what it comes down to is your definition of human life, and what it's worth (especially innocent human life). In that regard, some divides shouldn't be crossed.
Life is hard, and the world is cruel
Jews, Slavs, Romani, Homosexuals, and many others.
what kind of world do we live in where Superman can't walk? huh? what kind of world do- oh my, okay, never mind, my bad
LMFAO!!!
The Leg bone's connected to the ... Heart bone.
Well, insofar as primarily Jews and Gypsies, and similar groups were the primary experimental subjects, there was not adequate control group except in the United States with its experiments on the mentally ill and retarded, and on the descendants of slaves. Combined, yes-these efforts did massively improve general medical knowledge in the western world. Perhaps you do not relise the truly immense difference in medical care in 1865, for example, when US Civil war veterans were primarily treated by amputation, and the treatments of the second world war veterans in 1946 and during it beforehand-not to mention the vast improvement in life expectancy of veterans after the US Vietnamese, Laotian, and Cambodian campaigns ended in 1975 and during it beforehand (but that is less important as other advances had more significant impacts). This gives a conceptual gauge for the improvements gained by all of those programs, and yes they are justified by them.
I remember reading in the news a while back about a group of south korean doctors who did this. They restored her ability to walk after being paralyzed for a decade by injecting stem cells into her spinal cord. Can anybody confirm this?
With Adult stem cells, you can use your own cells, guaranteeing that they won't be rejected or causing other weird problems because of differing genetics.
With Embryonic stem cells, you end up with little bits of someone else in you, leading to unpredictable behaviour from the interactions between your genetics and theirs.
There may be some very specialized cases where embryonic stem cells can be used and adult stem cells can't, but it will always be safer to use the adult stem cells.
I realize by putting expert into this topic I probably have started a giant flaming ball rolling but ohhh well. To clarify I am a 4th yr Ph.D student who has spent most of my college and grad school career studying neurodegenerative diseases and stem cells. In posting I am not advocating any particular position, merely trying to give to the community at large the current state of stem cell research as seen from one actually doing it. Adult stem cells have shown good potential in treating different conditions arising in tissues from which they are derived (ie stem cells from the brain used to treat brain degeneration, stem cells from the liver treating liver disease). Adult stem cells show little to no evidence of tumor formation and some types can be cultured and expanded for use, though not all (bone marrow stem cells cannot be expanded which is why you have to collect and freeze so many) The ability to turn one type of adult stem cell into a cell from another part of the body is VERY controversial, though many people believe that there are certain conditions that can push adult stem cells into other types, but the functional ability of these cells is still under vigorous experimentation. ES cells on the other hand have a well established history of being able to transform into almost all of the tissue and cell types in the body. Most of these experiments have noted that tumor formation, in the form of teratocarcinomas, is a common occurence, especially in trying to use ES cells to repair brain damage from Parkinson's disease or to replace pancreatic islet cells in diabetes. Bush's stance on no federal funding to derive new ES cell lines, regardless of morality, is hindering the effort. A recent report has stated that current human ES cell lines are likely contaminated with a mouse protein that can cause an immune reaction in human patients. Even with all that being said there is great potential for ES cells and having worked with mouse ES cells I can tell you that they are opeing some exciting doors for being able to repair dmaged brain circuits. I will end on the note that mouse ES cells and human ES cells behave very differently so that those who think we can do all of our work with animal cells and then jump directly to humans are sadly mistaken Also there seems to be a mental association with abortion and ES cell derivation. Most private comapnies deriving ES cell lines are taking previously donated eggs and sperm to fertilize the egg and then witin a few days stopping the cell division to harvest the ES cell. Outside of a human body these blastocyts could not generate a viable human. For one ES cells do not generate the extraembryonic tissue needed for placenta formation. Withou this the blastocyst would lack nutrient and die as they became more developed. As far as I know there is no work being done on any sort of abortion derived material. I am more than willing to provide any other information or references to anything related to the above or any other stem cell or neuroscience related topics...my way of giving back to a community that has brought me so much knowledge and debate.
At the same time people stop spreading the FUD that this article proves the funding ban is preventing valuable research.
Clear, Dark Skies
Irrelevent. The Supreme Court decided that Dred Scott was still a slave, and that the law limiting slavery in new states was unconstitutional. Does that mean that we had no business addressing the morality of the institution of slavery?
...of course not. In the same way, a discussion of the morality of abortion is highly appropriate in the wake of Roe v Wade...
(In fact, it's directly applicable here, too, in the stem-cell research debate: it's the question of the "right to life".)
mmm... yeah... You see, we're putting the cover sheets on all TPS reports now before they go out...
No kidding? Perhaps because human samples come from cell lines which are basicly cancer in a petri dish and the mouse cells are coming from healthy embryos?
Really? Whodda thunk it.
"Ishika Gupta, a seven month old girl child "
As opposed to CmdrTaco, who is a thirty-something man-child?
I kid, I kid.
"I would say that 99 per cent of what my father has written about his own life is false." - L. Ron Hubbard Jr.
So?, a lot of them come from IVF clinics that are going to destroy them anyway, so instead of just wasting them, why not use them to help save a life?
Good point and I agree with you; there is an inherent morality issue. But I think that the morality issue of privacy ought to be considered as well. And that is what I was trying to point out.
In the infamous Dred Scott case, the Supreme Court did affirm that property does transcend State boundaries, which allows you to keep your car if you move from, say Kansas to Missouri, without needing to renew the purchase contract for the car in Missouri. It essentially affirms the full faith and credit provision in the Constitution.
The application had horrible potential until the passage of the 13th amendment, whereupon the affirmation of interstate ownership has a very positive usefulness today. Personally I would not like to see either federal (or State) law or constitutional law take away my right to privacy. And since that right is enshrined in Roe v Wade any threat to that bothers me.
Gods don't kill people, people with gods kill people.
only completely ignorant people would object stem cell research. Unfortunally, some of them are presidents...
1's and 0's should be free.
Nucular == of or pertaining to nucules. "Nucule" (NEW-kyool) is either a small nut or the diminutive of "nuke", so a nucule must be a small nuke, probably a tactical nuke.
This is an interesting anecdote, but bears little or no merit as science. Having a single individual treated, then reporting that 57% of the cells showed improvement is non-informative. How do we know that 57% of the cells would not have improved in the absence of the treatment?
To merit a scientific breakthrough, this needs to be properly designed and researched. You would need to have a sample of individuals that are treated, and another sample of individuals that serve as controls. They would all need to be similarly afflicted with the defect, of similar age, ethnicity, nutritional status, etc. After measuring progress and properly analyzing the data from a well-designed study, perhaps it will be found that this form of treatment is viable.
Until then, this is mere conjecture... Wishful thinking, perhaps. I hope that the report is valid, but would not put any credence in such a one-off claim as this.
Now, back to the polemics...
I think I see your point but you make several tacit assumptions which I don't believe are true.
One is that there is enough available capital out there to take the place of the missing funding. The major source of funding for basic research is the federal government. Corporate funding is pretty much non-existent for this type of risky research which leaves us with other levels of government, foreign govenments, and some charitable foundations to make up the shortfall. Unless the states come through in a big way - I don't think that there is enough capital out there.
Secondly, demand is not going to be constant - but is very soft. It is always a risky proposition for scientists to get proposals funded in the best circumstances. Loss of funding means the end of a research career so the stakes are very high. By making it harder to find funding for EC research many scientists (while stubborn also have VISA bills) will alter their proposals to adult stem cells research even when that is the less likely to succeed.
So I believe the net effect of the Bush policy will be to drive remaining embryonic research overseas, or to the states that specifically set aside money for it (the accounting thing you were talking about) and encourage scientifically inferior research elsewhere.
[That is false.] As a quick google would have told you.
[re: as far as I know, such research cannot be done in ANY FACILITY THAT RECEIVES FEDERAL FUNDING at all whatsoever.]
I googled your reference. I found these salient points:
IANAL. I did serve as a minor bureaucrat in a US Federal health care institution for 9 years and I've had to deal with this kind of language before. This is how the above translates into normal speech:
An institution recieving Federal funds that wants to conduct research that is outside of Bush's proscriptions would have to assure that all costs for the corner of the laboratory that was dedicated to this purpose were not paid for by federal funds. This includes everything from HVAC, phone service, janitorial supplies, and a portion of the janitor's wages. This also extends to administrative items, such as a portion of secretary wages, a portion of the service contract on computer maintenance and so on. How hard-nosed these rules would actually be would depend on agency law, not legislative law, and could therefore be dictated by the White House to any desired level of micromanagement.
The necessary changes in bookkeeping practices had an immediate effect of preventing any institution from doing proscribed stem cell research. The OP was correct in what he said, at the time when these regulations went into effect. Now some institutions have apparently set up mechanisms that they think will meet these new regulations-- but most institutions are not in a position to do this.
Changing bookkeeping systems to meet these requirements is a very costly process, with no productive benefit resulting from the change. And because this is an area mediated by brand-new agency regulations (which have the same force as federal legislative law), there are no precedents that can be used as guidance, or as shield. The enforcing agencies are currently in a position where they can make up the rules as they go along.
The phrase "lip service" comes to mind when I look at how Bush's administration has phrased these laws. On the surface, this issue appears to be a laudable attempt to ease moral concerns about government involvement in embryonic research while still seeming to allow such research to continue. But in practice it screws any attempt by anyone except some private corporations from doing anything in this field.
And perhaps that will prove to be the most significant part of all this-- that the large pharmaceutical houses with their $billions are now effectively the only ones who can explore th
I haven't worked for the feds for ~20 years now, so I'm not used to thinking in terms of how difficult it can be to implement regulations. I saw those statements and simply thought in terms of "keep your budget lines straight" without thinking about infrastructure and so on.
Clear, Dark Skies