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the_newsbeagle writes: Neuroscientist Ted Berger has achieved some remarkable feats in his work on an implanted brain prosthetic to boost memory. Working with rats, he recorded the electrical signals associated with a specific memory from one animal's brain, then inserted that signal -- and thus the memory -- into another animal's brain. Working with monkeys, the implanted device enhanced the animals' recall in difficult memory tasks.

Still, it's startling to learn that a startup is ready to commercialize Berger's work, and is trying to build a memory prosthetic for humans suffering from Alzheimer's, brain injuries, and stroke. The new company, named Kernel, will fund human trials and develop electrodes that can record from and stimulate more brain cells. "An implanted memory prosthetic would have electrodes to record signals during learning, a microprocessor to do the computations, and electrodes that stimulate neurons to encode the information as a memory," writes Eliza Strickland via IEEE Spectrum.

the_newsbeagle writes: Neuroscientist Ted Berger has achieved some remarkable feats in his work on an implanted brain prosthetic to boost memory. Working with rats, he recorded the electrical signals associated with a specific memory from one animal's brain, then inserted that signal -- and thus the memory -- into another animal's brain. Working with monkeys, the implanted device enhanced the animals' recall in difficult memory tasks.

Still, it's startling to learn that a startup is ready to commercialize Berger's work, and is trying to build a memory prosthetic for humans suffering from Alzheimer's, brain injuries, and stroke. The new company, named Kernel, will fund human trials and develop electrodes that can record from and stimulate more brain cells. "An implanted memory prosthetic would have electrodes to record signals during learning, a microprocessor to do the computations, and electrodes that stimulate neurons to encode the information as a memory," writes Eliza Strickland via IEEE Spectrum.

An anonymous reader quotes a report from Business Insider: A new study out Tuesday in the journal Environmental Science and Technology Letters looked at a national database that monitors chemical levels in drinking water and found that 6 million people were being exposed to levels of a certain chemical that exceed what the Environmental Protection Agency considers healthy. The chemicals, known as poly- and perfluoroalkyl substances, or PFASs, are synthetic and resistant to water and oil, which is why they're used in things like pizza boxes and firefighting foam. They're built to withstand the environment. But PFASs also accumulate in people and animals and have been observationally linked to an increased risk of health problems including cancer. And they can't be easily avoided, like with a water filter, for example. You can view the chart to see the tested areas of the U.S. where PFASs exceed 70 ng/L, which is what's considered a healthy lifetime exposure.

HughPickens.com writes: Discovery News reports that dirty laundry smells bad because of certain chemicals called volatile organic compounds, which can't always be washed out on an eco-friendly 20C cycle. Researchers identified six volatile organic compounds (VOCs) on dirty t-shirts and socks. "The need to conserve the environment by reducing the wash temperature and the use of biodegradable washing products have grown in importance in the new millennium, making this type of research more high profile," says Professor John Dean. The researchers gave 6 men and two women a new pair of socks. They asked the volunteers to wash their feet with tap water and dry them before wearing the socks for at least 10 hours in a specified type of shoe. They then put each sock into a separate sample bag and stored them in the dark overnight. The researchers graded each sock and t-shirt on a scale of 0 (no malodor) to 10 (malodorous) by smelling them. To determine the chemicals present, samples were taken from each one. Items were then washed on a cold cycle using unscented detergent, and resampled before they were dried, at which point researchers took one final series of specimens. Following a method called static headspace-multi-capillary column-gas chromatography-ion mobility spectrometry (SHS-MCC-GC-IMS), six main VOCs were identified as the main culprits behind smelly clothing. Each one left its own scented signature. Butyric acid, for example, produced a rancid butter-like odor, while 2-heptanone created a banana-like fruity smell. "The work is fascinating as it links an everyday event -- the washing of clothes -- with cutting-edge research," says Dean. "In this particular research project we applied a new and innovative analytical technique for the detection of volatile compounds found in laundry items. We hope this provides a way of analyzing the effectiveness of different washing techniques."

iONiUM quotes a report from Futurism: Research conducted by a team from the National Institutes of Health reported a new vulnerable site on HIV for vaccines to target. It is based on an antibody from the blood of an HIV-infected patient that binds with the virus and also prevents it from infecting a cell. A recent press release reports that a team of scientists led by the National Institutes of Health (NIH) has discovered a new "weak spot" in HIV that vaccines can target. The area, called the fusion peptide, is a simple structure of eight amino acids that helps the virus fuse with a cell. According to the study, the team used a particularly powerful antibody, called VRC34.01, taken from the blood of an unnamed HIV-positive patient that caught the weak spot in the virus. It's not only capable of binding with the virus through the fusion peptide but also preventing it from infecting an entire cell.

iONiUM quotes a report from Futurism: Research conducted by a team from the National Institutes of Health reported a new vulnerable site on HIV for vaccines to target. It is based on an antibody from the blood of an HIV-infected patient that binds with the virus and also prevents it from infecting a cell. A recent press release reports that a team of scientists led by the National Institutes of Health (NIH) has discovered a new "weak spot" in HIV that vaccines can target. The area, called the fusion peptide, is a simple structure of eight amino acids that helps the virus fuse with a cell. According to the study, the team used a particularly powerful antibody, called VRC34.01, taken from the blood of an unnamed HIV-positive patient that caught the weak spot in the virus. It's not only capable of binding with the virus through the fusion peptide but also preventing it from infecting an entire cell.

An anonymous reader writes: People who are paralyzed from a spinal cord injury still generate movement commands in their brains, but those commands can't travel down their spinal cords and peripheral nerves to reach their muscles. So biomedical engineers came up with a "neural bypass" to route brain signals around the roadblock. The system has just been demonstrated by a human patient for the first time. The patient has a brain implant to record signals from his motor cortex which are sent to a computer, where a decoder algorithm figures out which signals correspond to which specific imagined movements. It then sends a command to a sleeve of electrodes the patient wears on his forearm, which stimulates his muscles in precise patterns to produce the desired hand movement. The patient has already poured from a bottle, stirred with a swizzle stick, swiped a credit card, and played Guitar Hero.

mdsolar quotes a report from TIME: Air pollution leads to 16,000 premature births in the United States each year, leading to billions of dollars in economic costs, according to new research. Researchers behind the study, published in the journal Environmental Health Perspectives, found that preterm births associated with particulate matter -- a type of pollutant -- led to more than $4 billion in economic costs in 2010 due to medical care and lost productivity that results from disability. And, like many other public health issues, affected populations tend to be concentrated in low-income areas home to large numbers of minorities. "This is another piece of the evidentiary pie about why we should really be doing something about air pollution," says Tracey Woodruff, a professor who studies reproductive health and the environment at the University of California, San Francisco. "When you reduce air pollution you get lots of different health benefits." Countless studies have shown the effect of air pollution on cardiovascular and respiratory health -- killing millions each year. Air pollution leads to inflammation in blood vessels and contributes to lung cancer, asthma and a slew of other disorders. The effect on pregnancy may in some ways be an extension of those effects as air pollution disrupts the way a pregnant woman delivers oxygen to the fetus. Air pollution may also disrupt the endocrine system, keeping women from producing a protein needed to regulate pregnancy, researchers say.

eggboard writes: While blue light emitted by monitors and mobile displays has been widely cited as a cause in disrupting people's circadian rhythm, the evidence is thin: a narrow range of blue spectra might not be the problem (it may be a more complicated interaction), brightness may be more important, and Night Shift's (and f.lux's) effects are probably too negligible anyway. Apple's Night Shift feature lets you adjust the color temperature of your display to the warmer end of the spectrum. Apple notes, "Many studies have shown that exposure to bright blue light in the evening can affect your circadian rhythms and make it harder to fall asleep."

HughPickens.com writes: Christopher Ingraham writes in the Washington Post that a new study finds that when smart people spend more time with their friends, it makes them less happy. "The findings in here suggest (and it is no surprise) that those with more intelligence and the capacity to use it ... are less likely to spend so much time socializing because they are focused on some other longer term objective," says Carol Graham, a Brookings Institution researcher who studies the economics of happiness. According to Graham you should think of the really smart people you know. They may include a doctor trying to cure cancer or a writer working on the great American novel or a human rights lawyer working to protect the most vulnerable people in society. To the extent that frequent social interaction detracts from the pursuit of these goals, it may negatively affect their overall satisfaction with life. (More, below.) Hugh Pickens continues: Kanazawa and Li's theory of happiness starts with the premise that the human brain evolved to meet the demands of our ancestral environment on the African savanna, where the population density was akin to what you'd find today in, say, rural Alaska (less than one person per square kilometer). Take a brain evolved for that environment, plop it into today's Manhattan (population density: 27,685 people per square kilometer), and you can see how you'd get some evolutionary friction. "Our ancestors lived as hunter–gatherers in small bands of about 150 individuals," Kanazawa and Li explain. "In such settings, having frequent contact with lifelong friends and allies was likely necessary for survival and reproduction for both sexes." If you're smarter and more able to adapt to things, you may have an easier time reconciling your evolutionary predispositions with the modern world. Accordingly smarter people may be better-equipped to jettison that whole hunter-gatherer social network — especially if they're pursuing some loftier ambition. "Whatever the explanation might prove to be, this obviously doesn't mean smart people don't like having friends," says Emma Cueto. "But it does probably mean that they don't enjoy having too many — after all, keeping track of lots of people does usually involve, you know, talking to them. So if you're naturally more of a loner, congratulations! It might be a sign of intelligence."

Science_afficionado writes to note that the FDA "has approved a powered lower-limb exoskeleton created by a team of Vanderbilt engineers and commercialized by the Parker Hannifin Corporation for both clinical and personal use in the United States." Indego, which allows people paralyzed below the waist to stand up and walk, is the result of an intensive, 10-year effort. The initial development was funded by a grant from the National Institute of Child Health and Human Development. The device acts like an external skeleton as it straps in tightly around the torso. Rigid supports are strapped to the legs and extend from the hip to the knee and from the knee to the foot. The hip and knee joints are driven by computer-controlled electric motors powered by advanced batteries. The device operates a lot like a Segway with legs and the minimalist design allows users to take it on and off while sitting in a wheelchair. Indego's clearance came after completion of the largest exoskeleton clinical trial conducted in the United States. It has been available in Europe since November, when it received the CE Mark, the European Union's equivalent of FDA approval. The initial price is $80,000.

New submitter Alypius writes: Dr Tom Insel, the head of the NIH, will be joining Google Life Sciences to research how wearable technology, already used for monitoring physical activity and sleep, can be expanded to cover mental health issues such as depression. Dr. Insel will also be researching how to integrate tech to monitor other aspects of day-to-day living such as calorie and alcohol consumption.

HughPickens.com writes: Jeff Guo reports at the Washington Post that development of qinghaosu — or artemisinin — is one of modern China's proudest accomplishments winning a Noble Prize in Medicine this year for Tu Youyou, but it's also a story about Communism, Chairman Mao, and China's return to the world economy. On May 23, 1967, Chinese scientists commenced Project 523, a secret effort that enlisted hundreds of researchers to discover a new malaria drug during the Vietnam War. Although in a better warfare position, the People's Army of Vietnam (North Vietnamese Army) and its allies in the South, Viet Cong, suffered increasing mortality because of malaria epidemics. The project began at the height of Mao Zedong's Cultural Revolution, a brutal time during which academics and intellectuals were murdered, imprisoned, or sent to "reeducation camps" in mass purges.

For doctors and chemists. Project 523 was a lifeline, according to Professor Zhou Yiqing. "By the time Project 523 had got under way, the Cultural Revolution had started and the research provided shelter for scientists facing political persecution." Tu's husband had been banished to the countryside when she was asked to get involved in Project 523. Tu's research project sought to find modern logic in ancient ways, much as the French researchers identified quinine from the bark of the cinchona tree. According to Tu, she and her team screened over 2,000 different Chinese herbs described in old texts, of which about 200 were good enough to test in mice. That's when they hit upon a plant called Artemisia annua: annual wormwood, or qinghao in Chinese. At the time, all of this work remained a Chinese military secret; some of the results were published in Chinese-language journals, but it would be well after the death of Mao Zedong until China would reveal that it had discovered a surprisingly potent new weapon against malaria.

According to Guo the lion's share of the credit rightly goes to Tu and the countless other Chinese scientists who worked on Project 523. But Oxford anthropologist Elisabeth Hsu suggests that the political climate at the time also deserves recognition. Qinghaosu might never have been discovered had it not been for Maoist China's nationalist infatuation with Chinese folk medicine. "It was thus a feature specific to institutions of the People's Republic of China that scientists, who themselves had learnt ways of appreciating traditional knowledge, worked side by side with historians of traditional medicine, who had textual learning," Hsu argues. "This was crucial for the 'discovery' of qinghao."

schwit1 writes with this story at the Atlantic that profiles Ian Lipkin and his new method for quickly detecting all known human viruses in a sample: Ian Lipkin, a virus hunter from Columbia University, recently received a blood sample from colleagues at the National Institutes of Health. They came from a man who had received a bone-marrow transplant and had fallen mysteriously ill, with evidence of severely inflamed blood vessels. In analyzing a similar case a few years back, Lipkin had discovered a new polyomavirus, part of a family that can cause disease in people with compromised immune systems. Perhaps this new case would yield another new virus. It didn't. Instead, when Lipkin's team ran the sample through a system that they had devised to detect human viruses, they found that the man was infected with dengue virus. In hindsight, that made sense-he had recently returned from Vietnam, where dengue is prevalent. But the thing is: The team wasn't looking for dengue virus.

"It wasn't what we anticipated, but we didn't have to make a priori decisions about what we planned to find," Lipkin says. "When people analyze samples from people who are ill, they have some idea in mind. This is probably an enterovirus, or maybe it's a herpesvirues. They then do a specific assay for that particular agent. They don't usually have the capacity to look broadly." The new system, known as VirCapSeq-VERT, barrels past this limitation. Lipkin, together with fellow Columbia professors Thomas Briese and Amit Kapoor, designed it to detect all known human viruses, quickly, efficiently, and sensitively. By searching for thousands, perhaps millions, of viruses at once, it should take a lot of the (educated) guesswork out of viral diagnosis.

HughPickens.com writes: If you walk along South Beach in Miami right now, you will notice something strange, even by Florida standards: Dotting the sandscapes are sky-blue boxes that supply free sunscreen. In a novel experiment this year, the City of Miami Beach has put 50 free sunscreen dispensers in public spaces, and those dispensers are full of radiation-mitigating goo, free to any and all passersby. BBC reports that one in five people living in Florida will eventually suffer from skin cancer but the new campaign hopes that increasing people's awareness will lead to a change in behavior. "[The sunscreen dispensers'] visibility — even without additional messaging — could be a good cue to action," says Dr Richard De Visser, a psychologist who has researched health campaigns.

The sunscreen is the type that is effective at preventing cancer and premature skin aging: Broad-spectrum, water resistant, and SPF 30. You can buy a product that is labeled as higher than SPF 30, but it's almost always a waste, and potentially harmful. Above SPF 30, the difference is essentially meaningless. SPF 15 filters out about 93 percent of UV-B rays, SPF 30 filters out 97 percent, SPF 50 filters out 98 percent, and SPF 100 might get you to 99. The problem, though, is the psychology of the larger number. "We put on the "more powerful" sunscreens and then suddenly think we're Batman or some other superhero who can stay out in the sun indefinitely." says James Hamblin. "But no sunscreen is meant to facilitate prolonged exposure of bare skin to direct sunlight." Dr. Jose Lutzky, head of the melanoma program out Mount Sinai, says Florida is second behind California in incidence of melanoma but the trend is going in the wrong direction. "Unfortunately, our numbers are growing. That is really something we do not want to be first in."

Last week you had a chance to ask Dr. Tarek Loubani about his 3D-printable, 30-cent stethoscope project, and other open source, ultra-low cost medical equipment. Below you'll find his answers to your questions. What about patents?
by ciaran2014

Most activities that can be performed commercially but which can also be performed non-commercially are either exempt from patents or never get prosecuted. Fixing other people's bicycles, writing a book, and performing music come to mind. (Software development is a grey area.) But 3D printing is taking an activity where efficient production on any reasonable scale was pretty much the exclusive domain of businesses, and making it accessible to DIY-ers and people who would do it while doing their job or performing some task at home, without any direct commercial aspect. Any idea what stage the debate is at regarding patent restrictions on printing or distributing designs for things more complicated or more modern than stethoscopes?

Tarek: This project does not aim to innovate as such. We aim to drop the bottom out of the costs on devices whose patents have long since expired. We might be trolled, harassed and sued into oblivion, but not because we are in violation of any patents. Indeed, the patents that cover the stethoscope we made are long expired US3168160, filed in 1962; US3108652, filed in 1960; US3515239, filed in 1968. The patents that cover a few small innovations in the Littmann Cardiology III expire in just a couple of years US5945640, but fundamentally the tech is ancient.

It's the same for pulse oximetry. Same for electrocardiograms.

Regarding your overarching question, brilliant minds like Geist, Doctorow, Stallman, etc. might be better positioned to answer. My hope, of course, is that the copyright bargain turns in favour of users and citizens sooner rather than later.



Was your stethoscope 3D printed in Gaza?
by mrops

It seems there are a lot of restrictions on what can be imported into gaza as there is a risk technologies might fall into terrorist hands and used for nefarious purpose. Under this, is it really possible to import a 3D printer into gaza for such tasks?

Tarek: There are already 3D printers in Gaza. Those who have made Prusa i3 printers know that it's trivial to make one from salvaged parts taken from old inkjet and laser printers. These printers will be used in the production of prosthetics and medical devices.

Those who support the blockade or oppose the rights of patients in Gaza to access health care might contend that 3D printers could be used to make weaponry. This is a ridiculous claim: Gaza has hundreds of CNC routers, and most of the weaponry currently in the hands of the Palestinian resistance was either captured from Fatah forces during an “attempted coup” (David Wurmser's words) in 2007 or smuggled, mostly via tunnels under the Egyptian border. The armed resistance groups in Gaza are not waiting for us to bring in 3D printers. If they wanted them, they'd have brought them in with the last batch of rockets.



Are medical devices restricted?
by Anonymous Coward

I see lots of stuff blamed on the import restrictions, but are medical devices actually blockaded, or are they stopped because they're used as a cover to smuggle in other things?

Tarek: According to Gisha, an Israeli NGO, the blockade is “not in order to protect against security threats ... but rather as part of a policy to apply 'pressure' or 'sanctions' on the Hamas regime.” Your question assumes that the blockade is security instead of sanction, which is not the case. Even so, there has never been smuggling of illicit items into Gaza under the cover of medical supplies.

Israel does not declare the list of banned items, but claims that medicines are not banned (see this partial list of banned items, but MSF and others report chronic severe shortages of medical supplies. The World Health Organization reported in 2011 that “shortages of the 190 medical disposable items include some basic and very critical items such as: syringes, Central Venous Pressure devices, ECG and CTG paper, X-Ray film, gauze, disposables used in laparoscopies, and filtration cartridges used in haemodialysis for patients with kidney failure.”

Frankly, I have never cared about why. In Gaza, it's blockade. In Democratic Republic of Congo it's war. In Rwanda, it's poverty. The end result is the same: The denial of health care to the world's most vulnerable people. Everyone deserves health care. This project is about ensuring that doctors and patients in Gaza and elsewhere can alleviate their own suffering without waiting for international law and public goodwill to catch up with illegal occupations, collective punishments and colonial legacies.



3D Printing, catalyst for Intermediate Technology?
by Anonymous Coward

Your 30-cent stethoscope seems to be an excellent example of "Intermediate Technology" (or “Appropriate Technology“) as popularized by Dr Hans Schumacher in his influential book, Small is Beautiful. Do you think that 3D printing will become increasingly important in the third world with regards to improving basic medicine, agriculture etc?

Tarek: I see my 3D printer as a portable factory. It can't do all the same things at the same scales, but it is possible for people in very poor places to create high precision plastic parts that were previously impossible. Because these parts are created from digital models, it also allows collaboration via open source models, as we see on various model repositories. Open source models and repositories are where I think exponential achievements are happening today.

3D printing then becomes one of the ingredients in the empowering of disenfranchised people to take control and come up with indigenous solutions to problems.



Local making of tools
by fortunatus

While reviewing the online repository for the stethoscope design, I saw that mainly it's the sound gathering part that is 3D printed. The rest is - reasonably - made out of regular stuff. So then, with some regular stuff, can't local people figure out how to make stethoscopes? They really can't figure out that one sound gathering piece? It takes a doctor/hacker to come from some land far away bearing the URL to a 3D printable part to solve the problem?

Tarek: You're right - there is nothing special here, and I embrace my mediocrity as a doctor and geek. Somebody just had to do a bit of work and spend a bit of money. I don't consider myself to be from some “land far away”: I am Palestinian and lived as a stateless refugee the first 13 years of my life in Kuwait where I was born, and then in Canada. However, I now have the luxury of a Canadian passport, a first-world academic post at the Division of Emergency Medicine in London, Canada, and the ability to connect two disparate worlds.

When I saw the problem while trying to treat wounded patients in the 2012 war in Gaza, I didn't ask myself “why not somebody else?” I asked: “why not me?”



non alergenic materials for printing
by McLae

With all the allergies to various materials, such as nickel and latex, what materials can be 3d-printed that are medically inert? Surgical instruments are stainless steel, implants are titanium, how do you print these? It seems another whole line of questions to find proper materials that can be printed.

Tarek: A few plastics come to mind. ABS is FDA approved, as is Nylon 680 and some PETT. For now, underserviced populations will not be able to receive 3D printed metals – it's too costly and out of scope. However, there can be some creativity. 3D4MD, a group in Toronto, Canada has successfully developed and published on 3D printed surgical instruments made from ABS. Because their models are not published online and I believe are not open source, we have started our own surgical tools project, which will have tremendous impact when completed.

Your answer, then, has two parts. The first is that we should aim at the low-hanging fruit of medicine. Off-patent, ubiquitous devices like stethoscopes, pulse oximeters, electrocardiograms, and hemodialysis are good examples.

The second part is that we in the global south accept that some people will die because of the lack of proper supplies. Given latex gloves or no gloves at all, the choice is obvious. This is not academic: physicians and policymakers have been forced to make this decision in Gaza at the Shifa hospital's emergency department, where most of our gloves are latex.

We're talking about basics like gloves and gauze. Nobody here is talking about custom-printed titanium implants.



Challenges
by Anonymous Coward

What do you see as the main challenges in getting your devices to the regions that need them?

Tarek: I guess the main challenge by far is buy-in. Once a ministry of health or hospital buys into the idea, then the technical parts are trivial and inexpensive.



What else is out there?
by ciaran2014

I've read there are other 3D-printed stethoscopes. Is yours (the Gila 3D stethoscope) attracting attention because it's better, or cheaper, or because it's actually getting used? Or is the Gila 3D stethoscope getting attention not for what it is but for it being an example from a domain where 3D seems set to bring radical change?

Tarek: I know of a few other stethoscopes. In that sense, what we're doing is not unique technically. Our innovation is taking the technology and mixing it with the politics of Free hardware and enfranchisement and the science of verification and validation. Then, as you noted, we put it to use in the real world.

Our stethoscope is as good or better than a Littmann Cardiology III. I can prove it. You can build it today, all of the models are available to modify, and soon it will be Health Canada approved as a Class I device. A peer-reviewed publication is hopefully forthcoming.

The attention is indeed because of the idea and the promise, not the stethoscope. However, the stethoscope has created a model and a high standard that we and other groups must meet when working on future projects of this kind.

An anonymous reader writes: By using custom tracking software to monitor the output from a digital pen, MIT researchers say they have found a way to better predict the onset of brain conditions like Alzheimer's and Parkinson's. according to MIT: "For several decades, doctors have screened for conditions including Parkinson's and Alzheimer's with the CDT, which asks subjects to draw an analog clock-face showing a specified time, and to copy a pre-drawn clock. But the test has limitations, because its benchmarks rely on doctors' subjective judgments, such as determining whether a clock circle has 'only minor distortion.' CSAIL researchers were particularly struck by the fact that CDT analysis was typically based on the person's final drawing rather than on the process as a whole. Enter the Anoto Live Pen, a digitizing ballpoint pen that measures its position on the paper upwards of 80 times a second, using a camera built into the pen. The pen provides data that are far more precise than can be measured on an ordinary drawing, and captures timing information that allows the system to analyze each and every one of a subject's movements and hesitations."

schwit1 writes: A new technique called transcutaneous stimulation has allowed five men with complete motor paralysis regain the ability to move their legs voluntarily and produce step-like movements. The treatment requires no surgery and adds to prior work to help paralyzed people gain voluntary movement through electrical stimulation (one completed in 2011, the other in 2014). Gizmag reports: "The new treatment uses a technique called transcutaneous electrical nerve stimulation, which involves strategically placing electrodes on the skin of the lower back. While receiving stimulation, the men's legs were supported by braces that hung from the ceiling. At first their legs only moved involuntarily, if at all. But they soon found they could voluntarily extend the distance their legs moved during stimulation. They doubled their range of voluntary motion after four treatment sessions."

derekmead writes: While the media might focus on prosthetics, the technology and techniques involved in limb salvage have advanced tremendously, too, spurred in large part by America's recent military conflicts. Now, when a soldier or civilian faces a brutal limb injury, they have choices—save the limb, or amputate. Be a limb salvage patient, or an amputee. Reconstruct the limb you were born with, out of the pieces you have left over, or lose that limb altogether. And that choice is, increasingly, a really difficult one.

chicksdaddy writes: Lots of studies have shown that assertiveness works in the professional sphere as well as the personal one. It turns out to work pretty well in the cyber criminal sphere, also. Websense Labs has posted a blog warning of a new round of spear phishing attacks that rely on e-mail messages posing as urgent communications from senior officers to lower level employees. The messages demand that the employees wire funds to a destination account provided in the message.

According to Websense, these attacks are low tech. The fraudsters register "typo squatting" domains that look like the target company's domain, but are subtly different. They then set up e-mails at the typo squatted domain designed to mirror legitimate executive email accounts. Like many phishing scams, these attacks rely on the similarities of the domains and often extensive knowledge of key players within the company, creating e-mails that are highly convincing to recipients.

The key element of their attack is – simply – "obeisance," Websense notes. "When the CEO or CFO tells you to do something, you do it." The messages were brief and urgent, included (phony) threads involving other company executives and demanded updates on the progress of the transfer, making the request seem more authentic. Rather than ask the executive for clarification (or scrutinize the FROM line), the employees found it easier to just wire the money to the specified account, Websense reports.

Websense notes the similarities between the technique used in the latest phishing attack and the grain trading firm Scoular in June, 2014. That company was tricked into wiring some $17 million to a bank in China, with employees believing they were acting on the wishes of executives who had communicated through e-mail.

sciencehabit writes: Where did the thief go? You might get a more accurate answer if you ask the question in German. How did she get away? Now you might want to switch to English. Speakers of the two languages put different emphasis on actions and their consequences, influencing the way they think about the world, according to a new study (abstract). The work also finds that bilinguals may get the best of both worldviews, as their thinking can be more flexible.

schwit1 writes Compared to other recreational drugs — including alcohol — marijuana may be even safer than previously thought. And researchers may be systematically underestimating risks associated with alcohol use. They found that at the level of individual use, alcohol was the deadliest substance (abstract), followed by heroin and cocaine.

An anonymous reader sends this excerpt from Quanta Magazine: The physicist Freeman Dyson and the computer scientist William Press, both highly accomplished in their fields, have found a new solution to a famous, decades-old game theory scenario called the prisoner's dilemma, in which players must decide whether to cheat or cooperate with a partner. The prisoner's dilemma has long been used to help explain how cooperation might endure in nature. After all, natural selection is ruled by the survival of the fittest, so one might expect that selfish strategies benefiting the individual would be most likely to persist. But careful study of the prisoner's dilemma revealed that organisms could act entirely in their own self-interest and still create a cooperative community.

Press and Dyson's new solution to the problem, however, threw that rosy perspective into question (abstract). It suggested the best strategies were selfish ones that led to extortion, not cooperation.

[Theoretical biologist Joshua] Plotkin found the duo's math remarkable in its elegance. But the outcome troubled him. Nature includes numerous examples of cooperative behavior. For example, vampire bats donate some of their blood meal to community members that fail to find prey. Some species of birds and social insects routinely help raise another's brood. Even bacteria can cooperate, sticking to each other so that some may survive poison. If extortion reigns, what drives these and other acts of selflessness?"

vortex2.71 (802986) writes I imagine that enough of us on Slashdot are on the Autism Spectrum or were once diagnosed as having Aspergers that this might be the right venue for this question. My son is on the spectrum, but is in a mainstream classroom at a private school. We have spent thousands of dollars on a bunch of different social skills groups, speech communication therapy, occupational therapy, and physical therapy. We've found that the specific skills and intuition that the therapists possess is much more important than their credentials and are frequently disappointed by the overwhelming mediocrity of special education teachers, speech therapists, and OT/PT therapists. We are at the point where we wonder if our time is better spent with playdates with peers that are facilitated by us than continuing with the groups. I'm curious if there are adult Slashdoters who are on the spectrum who participated in these therapies as children who can weigh in on this? What was your experience with social skills groups and social communication therapy? Did they help?

HughPickens.com writes The human genome is astonishingly complex and dynamic, with genes constantly turning on or off, depending on what biochemical signals they receive from the body. Scientists have known that certain genes become active or quieter as a result of exercise but they hadn't understood how those genes knew how to respond to exercise. Now the NYT reports that scientists at the Karolinska Institute in Stockholm have completed a study where they recruited 23 young and healthy men and women, brought them to the lab for a series of physical performance and medical tests, including a muscle biopsy, and then asked them to exercise half of their lower bodies for three months. The volunteers pedaled one-legged at a moderate pace for 45 minutes, four times per week for three months. Then the scientists repeated the muscle biopsies and other tests with each volunteer. Not surprisingly, the volunteers' exercised leg was more powerful now than the other, showing that the exercise had resulted in physical improvements. But there were also changes within the exercised muscle cells' DNA. Using technology that analyses 480,000 positions throughout the genome, they could see that new methylation patterns had taken place in 7,000 genes (an individual has 20–25,000 genes).

In a process known as DNA methylation, clusters of atoms, called methyl groups, attach to the outside of a gene like microscopic mollusks and make the gene more or less able to receive and respond to biochemical signals from the body. In the exercised portions of the bodies, many of the methylation changes were on portions of the genome known as enhancers that can amplify the expression of proteins by genes. And gene expression was noticeably increased or changed in thousands of the muscle-cell genes that the researchers studied. Most of the genes in question are known to play a role in energy metabolism, insulin response and inflammation within muscles. In other words, they affect how healthy and fit our muscles — and bodies — become. Many mysteries still remain but the message of the study is unambiguous. "Through endurance training — a lifestyle change that is easily available for most people and doesn't cost much money," says Sara Lindholm, "we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles that ultimately improve our quality of life."

cold fjord writes: Phys.org reports, "The life sciences have come under fire recently with a study published in PLOS ONE that investigated the level of sexual harassment and sexual assault of trainees in academic fieldwork environments. The study found 71% of women and 41% of men respondents experienced sexual harassment, while 26% of women and 6% of men reported experiencing sexual assault. The research team also found that within the hierarchy of academic field sites surveyed, the majority of incidents were perpetrated by peers and supervisors. The New York Times notes, "Most of these women encountered this abuse very early in their careers, as trainees. The travel inherent to scientific fieldwork increases vulnerability as one struggles to work within unfamiliar and unpredictable conditions."

An anonymous reader writes: Caffeine is a staple of most workplaces — it's rare to find an office without a coffee pot or a fridge full of soda. It's necessary (or at least feels like it's necessary) because many workers have a hard time staying awake while sitting at a desk for hours at a time, and the alternative — naps — aren't usually allowed. But new research shows it might be more efficient for employers to encourage brief "coffee naps," which are more effective at returning people to an alert state than either caffeine or naps alone. A "coffee nap" is when you drink a cup of coffee, and then take a sub-20-minute nap immediately afterward. This works because caffeine takes about 20 minutes to get into your bloodstream, and a 20-minute nap clears adenosine from your brain without putting you into deeper stages of sleep. In multiple studies, tired participants who took coffee naps made fewer mistakes in a driving simulator after they awoke than the people who drank coffee without a nap or slept without ingesting caffeine.

An anonymous reader writes: Caffeine is a staple of most workplaces — it's rare to find an office without a coffee pot or a fridge full of soda. It's necessary (or at least feels like it's necessary) because many workers have a hard time staying awake while sitting at a desk for hours at a time, and the alternative — naps — aren't usually allowed. But new research shows it might be more efficient for employers to encourage brief "coffee naps," which are more effective at returning people to an alert state than either caffeine or naps alone. A "coffee nap" is when you drink a cup of coffee, and then take a sub-20-minute nap immediately afterward. This works because caffeine takes about 20 minutes to get into your bloodstream, and a 20-minute nap clears adenosine from your brain without putting you into deeper stages of sleep. In multiple studies, tired participants who took coffee naps made fewer mistakes in a driving simulator after they awoke than the people who drank coffee without a nap or slept without ingesting caffeine.

sciencehabit (1205606) writes "Pregnant women who smoke don't just harm the health of their baby—they may actually impair their child's DNA, according to new research. A genetic analysis shows that the children of mothers who smoke harbor far more chemical modifications of their genome — known as epigenetic changes — than kids of non-smoking mothers. Many of these are on genes tied to addiction and fetal development. The finding may explain why the children of smokers continue to suffer health complications later in life.

An anonymous reader writes: The Mississippi child, who was born with HIV passed from her mother, received HIV treatment for 18 months after her birth. In the course of over two years after the treatment, her blood indicated no trace of the virus or of HIV-specific antibodies, leading many to hope that she may have been cured completely. Earlier this month, however, the virus was detected again. Nearly 4 years old, the child is once more being given HIV treatment, and scientists are trying to figure out how she could have gone so long before relapsing.

First time accepted submitter LordFlower (606949) writes "In a study, published today in Neuropsycopharmacology, exposure to general anesthesia in both human and rat infants was associated with long-term episodic memory deficits. Children aged 6 to 11 years exposed to general anesthesia during infancy had poorer episodic memory than age/gender matched controls. This deficit was replicated in rats using an analogous paradigm with full experimental control of pre-existing conditions could be exercised, suggesting a causal relation rather than correlational one. Prior research in rats suggests a mechanism of disrupted developmental synaptogenesis and apoptosis.

While a growing literature has demonstrated the presence of memory deficits and neurodegeneration in rats after general anesthesia exposure in infancy, this is the first to demonstrate a long-term deficit after exposure during human infancy. Given that each year 1.5 million infants undergo a surgery requiring general anesthesia, these findings are particularly alarming."

Daniel_Stuckey (2647775) writes "Pot and video games have long been bound together in hazy, wedded bliss—as well as in compulsion and codependency. Many a World of Warcraft binger has been found in the darkest hours of the night with clouds of sweet, milk-white smoke curling around him, a bong next to the keyboard. But the way these lovers, games and weed, commingle has only rarely been studied, and when done so, usually exclusively in the context of substance abuse and how it relates to what is known as PVP: 'problem video game playing.'" Motherboard takes a different look.

the_newsbeagle writes "When surgeons set out to repair holes in the walls of the heart's chambers or in blood vessels, they often do invasive open-heart surgery and use sutures, staples, and glue to keep a patch in place. But the sutures and staples are a rough fix, and many of the glues on the market today don't work well on wet tissue that's continually flexed by the heart's contractions and the movement of pumping blood. Today biomaterial researchers announced a new light-activated glue that could make surgery less invasive, quicker, and easier. The adhesive was inspired by slugs' and sandcastle worms' sticky secretions, which work underwater, and it can be applied with slender tools during minimally invasive surgery. A flash of UV light then sets the glue, which bends and flexes with the tissue."

Hugh Pickens DOT Com writes "Suzanne Koven, a primary-care doctor at Massachusetts General Hospital in Boston, writes in the New Yorker that the FDA has currently approved four drugs that will help patients lose weight but few primary-care physicians will prescribe them. Qsymia and Belviq work by suppressing appetite and by increasing metabolism, and by other mechanisms that are not yet fully understood. 'But I've never prescribed diet drugs, and few doctors in my primary-care practice have, either,' writes Koven and the problem is that, while specialists who study obesity view it as a chronic but treatable disease, primary-care physicians are not fully convinced that they should be treating obesity at all. The inauspicious history of diet drugs no doubt contributes to doctors' reluctance to prescribe them. In the nineteen-forties, when doctors began prescribing amphetamines for weight loss, rates of addiction soared. But in addition, George Bray thinks that socioeconomic factors play into physicians' lack of enthusiasm for treating obesity because obesity is, disproportionately, a disease of poverty. Because of this association, many erroneously see obesity as more of a social condition than a medical one, a condition that simply requires people to try harder. Louis Aronne likens the current attitude toward obesity to the prevailing attitude toward mental illness years ago and remembers, during his medical training, seeing psychotic patients warehoused and sedated, treated as less than human. 'What the hell was I thinking when I didn't do anything to help them? How wrong could I have been?' Specialists are now developing programs to aid primary-care physicians in treating obesity more aggressively and effectively but first primary-care physicians will have to want to treat it. 'Whether you call it a disease or not is not so germane,' says Lee M. Kaplan. 'The root problem is that whatever you call it, nobody's taking it seriously enough.'"

First time accepted submitter neapolitan writes "PBS has a report on the difficulties of tracking the complications arising from surgical robotic systems, particularly the Da Vinci robotic surgery apparatus. The original study (paywall) notes that there is a large lag in filing reports, and some are not reported at all. It is difficult to assess the continued outcomes and safety without accurate reporting data."

Hugh Pickens DOT Com writes "Michael Hiltzik writes in the LA Times that you'd think the one place you can depend on for verifiable facts is science but a few years ago, scientists at Amgen set out to double-check the results of 53 landmark papers in their fields of cancer research and blood biology and found only six could be proved valid. 'The thing that should scare people is that so many of these important published studies turn out to be wrong when they're investigated further,' says Michael Eisen who adds that the drive to land a paper in a top journal encourages researchers to hype their results, especially in the life sciences. Peer review, in which a paper is checked out by eminent scientists before publication, isn't a safeguard because the unpaid reviewers seldom have the time or inclination to examine a study enough to unearth errors or flaws. 'The journals want the papers that make the sexiest claims,' Eisen says. 'And scientists believe that the way you succeed is having splashy papers in Science or Nature — it's not bad for them if a paper turns out to be wrong, if it's gotten a lot of attention.' That's why the National Institutes of Health has launched a project to remake its researchers' approach to publication. Its new PubMed Commons system allows qualified scientists to post ongoing comments about published papers. The goal is to wean scientists from the idea that a cursory, one-time peer review is enough to validate a research study, and substitute a process of continuing scrutiny, so that poor research can be identified quickly and good research can be picked out of the crowd and find a wider audience. 'The demand for sexy results, combined with indifferent follow-up, means that billions of dollars in worldwide resources devoted to finding and developing remedies for the diseases that afflict us all is being thrown down a rathole,' says Hiltzik. 'NIH and the rest of the scientific community are just now waking up to the realization that science has lost its way, and it may take years to get back on the right path.'"

New submitter smegfault writes "In a new trial, PubMed Commons has been released. Until now, post-peer-publication results were restricted to letters to the editor of scientific journals; and even then some journals don't accept letters to the editor. With PubMed Commons, scientific peers can comment on PubMed-indexed articles without the interference of journal editors and peer reviewers. At the moment, eligible for participating are: 'Recipients of NIH (US) or Wellcome Trust (UK) grants can go to the NCBI website and register. You need a MyNCBI account, but they are available to the general public. If you are not a NIH or Wellcome Trust grant recipient, you are still eligible to participate if you are listed as an author on any publication listed in PubMed, even a letter to the editor. But you will need to be invited by somebody already signed up for participation in PubMed Commons. So, if you have a qualifying publication, you can simply get a colleague with the grant to sign up and then invite you.' However, reports are in that anyone with a PubMed / NCBI account can sign up on the PubMed home page."

the_newsbeagle writes "About four million people around the world have pacemakers implanted in their bodies, and those devices all got there the same way: surgeons sliced open their patients' shoulders and inserted the pulse-generating devices in the flesh near the heart, then attached tiny wires to the heart muscle. ... A device that just received approval in the EU seems to solve those problems. This tiny pacemaker is the first that doesn't require wires to bring the electrical signal to the heart muscle, because it's implanted inside the heart itself, and is hooked onto the inner wall of one of the heart's chambers. This is possible because the cylindrical device can be inserted and attached using a steerable catheter that's snaked up through the femoral artery."

An anonymous reader writes "A research team at the National Heart, Lung, and Blood Institute has been experimenting with changing mouse genes and seeing how it impacts their life. In a surprising discovery, when targeting just one gene change it was found they could extend the life of a mouse by 20 percent. The gene the researchers focused on is called mTOR and is associated with metabolism. By lowering its expression (to about 25 percent of what is normal) in a batch of mice they did indeed live longer (abstract). They also displayed better memory, balance, muscle strength, and posture as they aged. However, the health of their bones deteriorated more quickly and their immune system was weakened, suggesting that extra time alive wouldn’t really be worth it in terms of overall health. Lead researcher Toren Finkel said, 'While the high extension in lifespan is noteworthy, this study reinforces an important facet of aging; it is not uniform. Rather, similar to circadian rhythms, an animal might have several organ-specific aging clocks that generally work together to govern the aging of the whole organism.'"

An anonymous reader writes "An NJIT research professor known for his cutting-edge work with carbon nanotubes is overseeing the manufacture of a prototype lab-on-a-chip that would someday enable a physician to detect disease or virus from just one drop of liquid, including blood. 'Scalable nano-bioprobes with sub-cellular resolution for cell detection,' (Elsevier, Vol. 45), which will publish on July 15, 2013 but is available now online, describes how NJIT research professors Reginald Farrow and Alokik Kanwal, his former postdoctoral fellow, and their team have created a carbon nanotube-based device to noninvasively and quickly detect mobile single cells with the potential to maintain a high degree of spatial resolution."

eldavojohn writes "PBS's NewsHour interviewed Geoffrey Donovan on his recent research published in the American Journal of Preventative Medicine that noted a correlation between trees (at least the 22 North American ash varieties) and human health: 'Well my basic hypothesis was that trees improve people's health. And if that's true, then killing 100 million of them in 10 years should have an effect. So if we take away these 100 million trees, does the health of humans suffer? We found that it does.' The basis of this research is Agrilus planipennis, the emerald ash borer, has systematically destroyed 100 million trees in the eastern half of the United States since 2002. After accounting for all variables, the research found that an additional 15,000 people died from cardiovascular disease and 6,000 more from lower respiratory disease in the 15 states infected with the bug, compared with uninfected areas of the country. While the exact cause and effect remains unknown, this research appears to be reinforcing data for people who regularly enjoy forest bathing as well as providing evidence that the natural environment provides major public health benefits."

New submitter Big Nemo '60 writes with news that the National Institute of Mental Health is seeking to modernize the diagnosis of mental illness through the use of neuroscience, genetics, etc. From the article: "The world's biggest mental health research institute is abandoning the new version of psychiatry's 'bible' — the Diagnostic and Statistical Manual of Mental Disorders — questioning its validity and stating that 'patients with mental disorders deserve better.' This bombshell comes just weeks before the publication of the fifth revision of the manual, called DSM-5." More importantly, they are going to be shifting funding to research projects that seek to define new categories of mental illness using modern medical science, ignoring the current DSM categorizations: "The strength of each of the editions of DSM has been 'reliability' .. The weakness is its lack of validity. Unlike our definitions of ischemic heart disease, lymphoma, or AIDS, the DSM diagnoses are based on a consensus about clusters of clinical symptoms, not any objective laboratory measure. In the rest of medicine, this would be equivalent to creating diagnostic systems based on the nature of chest pain or the quality of fever. ... NIMH has launched the Research Domain Criteria (RDoC) project to transform diagnosis by incorporating genetics, imaging, cognitive science, and other levels of information to lay the foundation for a new classification system. ... It became immediately clear that we cannot design a system based on biomarkers or cognitive performance because we lack the data. In this sense, RDoC is a framework for collecting the data needed for a new nosology. But it is critical to realize that we cannot succeed if we use DSM categories as the 'gold standard.' ... Imagine deciding that EKGs were not useful because many patients with chest pain did not have EKG changes. That is what we have been doing for decades when we reject a biomarker because it does not detect a DSM category. We need to begin collecting the genetic, imaging, physiologic, and cognitive data to see how all the data — not just the symptoms — cluster and how these clusters relate to treatment response."

New submitter Big Nemo '60 writes with news that the National Institute of Mental Health is seeking to modernize the diagnosis of mental illness through the use of neuroscience, genetics, etc. From the article: "The world's biggest mental health research institute is abandoning the new version of psychiatry's 'bible' — the Diagnostic and Statistical Manual of Mental Disorders — questioning its validity and stating that 'patients with mental disorders deserve better.' This bombshell comes just weeks before the publication of the fifth revision of the manual, called DSM-5." More importantly, they are going to be shifting funding to research projects that seek to define new categories of mental illness using modern medical science, ignoring the current DSM categorizations: "The strength of each of the editions of DSM has been 'reliability' .. The weakness is its lack of validity. Unlike our definitions of ischemic heart disease, lymphoma, or AIDS, the DSM diagnoses are based on a consensus about clusters of clinical symptoms, not any objective laboratory measure. In the rest of medicine, this would be equivalent to creating diagnostic systems based on the nature of chest pain or the quality of fever. ... NIMH has launched the Research Domain Criteria (RDoC) project to transform diagnosis by incorporating genetics, imaging, cognitive science, and other levels of information to lay the foundation for a new classification system. ... It became immediately clear that we cannot design a system based on biomarkers or cognitive performance because we lack the data. In this sense, RDoC is a framework for collecting the data needed for a new nosology. But it is critical to realize that we cannot succeed if we use DSM categories as the 'gold standard.' ... Imagine deciding that EKGs were not useful because many patients with chest pain did not have EKG changes. That is what we have been doing for decades when we reject a biomarker because it does not detect a DSM category. We need to begin collecting the genetic, imaging, physiologic, and cognitive data to see how all the data — not just the symptoms — cluster and how these clusters relate to treatment response."

Guppy writes "Does Tylenol reduce existential distress? Acetaminophen (Paracetamol) has been used to relieve mild-to-moderate physical pain for over a century, yet its actual mechanism of action continues to be debated; modern research has demonstrated an intriguing connection with the body's endocannabinoid system, raising the question of whether it may also have subtle psychological effects as well. A recent paper claims Acetaminophen can alter our response to existential challenge; previous findings have suggested that it may blunt the pain of social rejection as well."

Dr. Tom writes "The U.S. has deployed more than 11,000 military drones, up from fewer than 200 in 2002. They carry out a wide variety of missions while saving money and American lives. Within a generation they could replace most manned military aircraft, says John Pike, a defense expert at the think tank GlobalSecurity.org. Pike suspects that the F-35 Lightning II, now under development by Lockheed Martin, might be 'the last fighter with an ejector seat, and might get converted into a drone itself.' The weakest link is the pilot. A jet could pull 15 Gs, out-turning any conventional aircraft, except it would kill the pilot. Is it time to stop spending billions on obsolete aircraft?"

theodp writes "A paper by Wharton's Jonathan Klick and Joshua Wright suggested that San Francisco's eco-friendly ban on plastic bags might actually be killing people. Klick and Wright found that food-borne illnesses in San Francisco increased 46% after the bag ban went into effect in 2007, with no such uptick in neighboring counties. Most likely, the authors concluded, this was due to the fact that people were putting their food into dirty reusable bags and not washing them afterward. But Tomas Aragon, an epidemiologist at UC Berkeley and health officer for the city of San Francisco, begs to differ, arguing that in order to establish a link between the bag ban and illnesses, the authors would have to show that the same people who are using reusable bags are also the ones getting sick. Aragon offers an alternative hypothesis for the recent rise in deaths related to intestinal infections, noting that a large portion of the cases in San Francisco involve C. difficile enterocolitis, a disease that's often coded as food-borne illness in hospitals which has become more common in lots of places since 2005, all around the U.S., Canada, and Europe (for yet-unexplained reasons). 'The increase in San Francisco,' he suggests, 'probably reflects this international increase.'"

hypnosec writes "Korean scientists have developed a 'fluid-like' polymer electrolyte used in lithium-ion batteries that would pave way for flexible batteries and flexible smartphones. The discovery was made by a joint team of researchers that was led by Professor Lee Sang-young of Ulsan National Institute of Science and Technology. The new electrolyte, though flexible, is made of solid materials hence making the batteries more stable than the lithium-ion batteries used today." Paper, but full text is paywalled.

Hugh Pickens writes writes "Farhad Manjoo writes that there are a number of technologies that gunmakers could add to their products that might prevent hundreds or thousands of deaths per year. One area of active research is known as the 'smart gun' — a trigger-identification system that prevents a gun from being fired by anyone other than its authorized user. Researchers at New Jersey Institute of Technology created a working prototype of a gun that determines whether or not to fire based on a user's 'grip pattern.' Gunmakers have been slow to add other safety technologies as well, including indicators that show whether a gun is loaded, and 'magazine safeties' that prevent weapons from being fired when their ammunition magazine is removed (PDF). That could save 400 lives a year. So why aren't gunmakers making safer guns? Because guns are exempt from most of the consumer safety laws that have improved the rest of American life. The Consumer Product Safety Commission, charged with looking over thousands of different kinds of products, is explicitly prohibited from regulating firearms. In 2005, Congress passed and President George W. Bush signed the Protection of Lawful Commerce in Arms Act, which immunizes gun makers against lawsuits resulting from 'misuse' of the products. If they can't be sued and can't be regulated, gunmakers have no incentive to make smarter guns." Note that gun safety features (not universally loved) like loaded-chamber indicators, grip safeties, and magazine disconnects are constantly evolving and have been available in some form and in various combinations for many decades, so gun makers seem to have some incentive to produce and improve them, and that the PLCAA does not prevent consumer safety lawsuits, but does shield gun makers from suits based on criminal conduct by gun buyers (though imperfectly).

Hugh Pickens writes writes "Farhad Manjoo writes that there are a number of technologies that gunmakers could add to their products that might prevent hundreds or thousands of deaths per year. One area of active research is known as the 'smart gun' — a trigger-identification system that prevents a gun from being fired by anyone other than its authorized user. Researchers at New Jersey Institute of Technology created a working prototype of a gun that determines whether or not to fire based on a user's 'grip pattern.' Gunmakers have been slow to add other safety technologies as well, including indicators that show whether a gun is loaded, and 'magazine safeties' that prevent weapons from being fired when their ammunition magazine is removed (PDF). That could save 400 lives a year. So why aren't gunmakers making safer guns? Because guns are exempt from most of the consumer safety laws that have improved the rest of American life. The Consumer Product Safety Commission, charged with looking over thousands of different kinds of products, is explicitly prohibited from regulating firearms. In 2005, Congress passed and President George W. Bush signed the Protection of Lawful Commerce in Arms Act, which immunizes gun makers against lawsuits resulting from 'misuse' of the products. If they can't be sued and can't be regulated, gunmakers have no incentive to make smarter guns." Note that gun safety features (not universally loved) like loaded-chamber indicators, grip safeties, and magazine disconnects are constantly evolving and have been available in some form and in various combinations for many decades, so gun makers seem to have some incentive to produce and improve them, and that the PLCAA does not prevent consumer safety lawsuits, but does shield gun makers from suits based on criminal conduct by gun buyers (though imperfectly).

An anonymous reader writes "A new experimental flu vaccine made out of messenger RNA that may work for life is now being developed. German researchers said on Sunday that the vaccine, made of the genetic material that controls the production of proteins, protected animals against influenza and, unlike traditional vaccines, it may work for life and can potentially be manufactured quickly enough to stop a pandemic (abstract)."