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Goodbye, Dolly

goombah99 writes "Dolly, the famous cloned sheep has been put to death after being diagnosed with a progressive lung disease, according to many reports. This follows on earlier reports that she was prematurely aging, including developing arthritis. While one should be cautious about drawing conclusions from a single data point, its interesting to speculate." Here is a link to her birthplace courtesy of Captain Large Face

365 comments

  1. GoodBye Dolly... by tealover · · Score: 5, Funny

    Hello Lamb Chops !!!

    This is the best thing about cloning. An endless supply of lamb chops !!!

    --
    -- You see, there would be these conclusions that you could jump to
    1. Re:GoodBye Dolly... by Anonymous Coward · · Score: 0

      Has puppet cloning really progressed so far?

    2. Re:GoodBye Dolly... by redgopher · · Score: 5, Funny

      Indeed... an endless supply of lambchops would be nice, but I wonder if it will all just taste the same? ;)

      --
      Insert clever one liner here.
    3. Re:GoodBye Dolly... by Slightly+Askew · · Score: 3, Informative

      I believe that would be mutton. Lamb chops are less than 18 months old. Dolly's chops would be, uh, less than desirable at her age.

      --
      Public use of any portable music system is a virtually guaranteed indicator of sociopathic tendencies. -- Zoso
    4. Re:GoodBye Dolly... by Exiler · · Score: 1

      But what we need is another pupeteer, not another dressed up sock.

      --
      Banaaaana!
    5. Re:GoodBye Dolly... by Cruciform · · Score: 4, Funny

      Dolly was a double ewe,
      An ex ewe, since she's dead,
      She'd aged somewhat imperfectly,
      But still tastes great with bread.

    6. Re:GoodBye Dolly... by macdaddy357 · · Score: 1

      It's a baaaaaaad day for fans of Dolly, and for cloning advocates. Goodbye, Dolly. We will miss ewe.

      --
      How ya like dat?
    7. Re:GoodBye Dolly... by dacarr · · Score: 2, Funny

      Of course. After all, everything tastes more or less like chicken.

      --
      This sig no verb.
    8. Re:GoodBye Dolly... by Xaoswolf · · Score: 1

      what about eve chops. I hear that mental illness adds a special spicyness to the meat.

    9. Re:GoodBye Dolly... by AndroidCat · · Score: 2, Funny
      Little Bo Peep has lost her sheep,
      And thinks they may be roaming.
      They haven't fled,
      They just dropped dead,
      From imperfections in cloming.

      What? It rhymes .. sort of..

      --
      One line blog. I hear that they're called Twitters now.
    10. Re:GoodBye Dolly... by Jace+of+Fuse! · · Score: 1

      Scientists cloned a little lamb,
      and Dolly was her name.
      She was looked on by the media,
      and give world wide fame.
      And though she was a carbon copy,
      she was different just the same.
      So now she's just a rotting corpse,
      and poor cloning was to blame.

      --

      "Everything you know is wrong. (And stupid.)"

      Moderation Totals: Wrong=2, Stupid=3, Total=5.
    11. Re:GoodBye Dolly... by Chocolate+Teapot · · Score: 1

      Dolly was a little lamb,
      She looked just like her mother,
      But now she's smothered with mint sauce,
      Oh well. They'll make another.

      --
      Modest doubt is called the beacon of the wise. - William Shakespeare
    12. Re:GoodBye Dolly... by caluml · · Score: 2, Funny

      Or is it that chicken tastes like everything else?

      Who came first, the taste of chicken, or the taste of other things that happen to taste like chicken?

    13. Re:GoodBye Dolly... by Anonymous Coward · · Score: 0

      Hmm...an Android Cat...dreaming of...hmm.

    14. Re:GoodBye Dolly... by Old+Uncle+Bill · · Score: 1

      Maybe the machines didn't know what chicken tastes like...

      --
      Yes, I am an agent of Satan, but my duties are largely ceremonial.
    15. Re:GoodBye Dolly... by dacarr · · Score: 1

      Two words, sir: Tasty Wheat.

      --
      This sig no verb.
    16. Re:GoodBye Dolly... by Anonymous Coward · · Score: 0

      Electric mice?

    17. Re:GoodBye Dolly... by Anonymous Coward · · Score: 0

      A friend on a mailing list responded to this news as follows:

      "That's a relief. I thought she had just stopped returning my calls."

  2. Oh boy... by Exiler · · Score: 1, Insightful

    Anti-cloning zealots are going to have a ball with this. They're going to say there will be a pattern in euthanasia of clones.

    --
    Banaaaana!
    1. Re:Oh boy... by Anonymous Coward · · Score: 0

      yep, they will -- I mean we will. Hey, no one wants to install x.0 software, right? Why, then, would we want to create x.0 creatures? especially people. Cloning is just not what you see in sci-fi TV.

    2. Re:Oh boy... by Bastian · · Score: 1

      Unless those anti-cloning zealots are also militant vegans, I'm going to laugh heartily when they start with damning speeches about the euthanasia of sheep.

    3. Re:Oh boy... by GreyPoopon · · Score: 5, Insightful
      Anti-cloning zealots are going to have a ball with this.

      Yes, but if the rumors of premature aging are true, they may actually have some science to base their argument on. You see there's this very important substance called telomeres attached to the end of chromosomes. As cells divide, the telomere caps become shorter, and eventually the cells stop dividing and either malfunction or die. It stands to reason that, if you start off with an adult cell, you already have shortened telomeres and will therefore have a reduced lifespan. [Any biology experts should feel free to correct me.]

      Rather than terminate Dolly, I'd rather they have experimented with telomerase to see if they could rejuvinate her. Although, I guess that's a little on the unethical and cruel side.

      --

      GreyPoopon
      --
      Why is it I can write insightful comments but can't come up with a clever signature?

    4. Re:Oh boy... by Anonymous Coward · · Score: 0

      they have a problem with the care of animals and treatment for producing food.

      Putting a sheep that probably had one of hte best living conditions in the world that was going to suffer would probably not qualify as cruelty to animals ;)

      but then again, these people are not always the most logical (lawsuit for mcdonalds beef fat used in french fries, when they never claimed that they were vegan safe)

    5. Re:Oh boy... by Anonymous Coward · · Score: 2, Funny

      President George Bush is visiting an elementary school and enters one of the classes. They are in the middle of a discussion related to words and their meanings. The teacher asks the President if he would like to lead the class in the discussion of the word, "tragedy." So the illustrious leader asks the class for an example of a "tragedy." One little boy stands up and offers, "If my best friend, who lives next door, is playing in the street and a car comes along and runs him over, that would be a tragedy." "No," says Bush, "that would be an ACCIDENT." A little girl raises her hand: "If a school bus carrying 50 children drove off a cliff, killing everyone involved, that would be a tragedy." "I'm afraid not," explains Mr. President. "That's what we would call a GREAT LOSS." The room goes silent. No other children volunteer. President Bush searches the room. "Isn't there someone here who can give me an example of a tragedy?" Finally, way in the back of the room, a small boy raises his hand. In a quiet voice he says, "If Air Force One, carrying Mr.Bush and Mrs.Bush, were struck by a missile and blown up to smithereens, by a terrorist like Osam bin Laden, that would be a tragedy." "Fantastic," exclaims Bush, "that's right. And can you tell me WHY that would be a TRAGEDY?" "Well," says the boy, "because it wouldn't be an accident, and it certainly wouldn't be a great loss."

    6. Re:Oh boy... by Moridineas · · Score: 1

      Unlike the pro-cloning zealots who would rather play with cloning regardless of the consquences to the cloned?

      The truth of the matter is we don't KNOW all the consequences of cloning. There's no reason you have to take such a politicized stand until we do know a bit more.

    7. Re:Oh boy... by macdaddy357 · · Score: 1

      Of course clones age prematurely, didn't you see Attack of the Clones? They are fully grown in ten years instead of 21.

      --
      How ya like dat?
    8. Re:Oh boy... by Milo+Fungus · · Score: 4, Informative

      Your telomere explanation was pretty good, except that telomeres aren't just any substance. They're DNA. The end of a chromosome has short repeating sequences of a few base pairs (ex: AATTAATT, etc.) which are not all replicated when a cell duplicates its genome and divides. This presumably acts as a molecular "clock" for the organism to keep track of its "age," but this is pretty controversial and unsubstantiated.

      Click here to read more about telomeres. (Why don't more people link to Wiki?)

      Even if this telomere function were well-established, it doesn't entirely explain the aging process. It seems that part of the process is due to oxidative damage caused by radical reactions in the mitochondria. But similar reactions happen in chloroplasts and some plants live for millenia!

      The exciting thing about biology is that you reach the frontiers of knowledge in the field during your first year of introductory undergraduate coursework. In math you reach the frontiers maybe by your fourth year or in grad school. For physics and chemistry, somewhere in between. Biology is full of unexplained phenomena. If you want to make a great fundamental discovery in one of the hard sciences, then become a biologist. So much is unknown!

    9. Re:Oh boy... by Anonymous Coward · · Score: 3, Funny

      If you want to make a great fundamental discovery in one of the hard sciences, then become a biologist. So much is unknown!

      There are more chicks too.

    10. Re:Oh boy... by God!+Awful+2 · · Score: 1

      Organisms don't have a "clock" to keep track of their age. That's ridiculous. What happens is that natural selection finds a solution that is good enough, not necessarily the optimal solution. After the telomeres reach a certain length, there is simply not enough selective power to make them any longer.

      -a

    11. Re:Oh boy... by AeternitasXIII · · Score: 4, Interesting

      There is good reason those zealots will have a ball with this. Shortly after Dolly was born lots of individuals familiar with the science had already predicted she'd suffer from advanced and premature aging. This has been the primary reason why the scientific community has wanted to forestall human cloning, since even when we get the successful clones they'll have decades hacked off their lives and be prone to numerous diseases seen primarily in geriatrics.

      I fully support the use of cloning, both human and animal for whatever reasons, but only when we can first correct this very severe problem that exists in the process. The zealots, however, will use this legitimate ammo to get laws passed in a few years that will take decades, if not longer, to overturn. Thats why I oppose any mandatory bans on cloning research.

    12. Re:Oh boy... by GreyPoopon · · Score: 1
      Your telomere explanation was pretty good, except that telomeres aren't just any substance. They're DNA.

      Thanks! Yeah, I knew that telomeres were the end pairs found in DNA. I just kept it at a higher level. :-)

      If you want to make a great fundamental discovery in one of the hard sciences, then become a biologist

      Unfortunately, I'm already halfway through to retirement. However, I've always really enjoyed biology and biochemistry, so if you can find for me a job that pays six figures while letting me pursue a graduate-level education in biology and biochemistry, I'd strongly consider changing my career. :-)

      Of course, I haven't seen any flying pigs yet either, but what with genetic manipulation, you never know.

      --

      GreyPoopon
      --
      Why is it I can write insightful comments but can't come up with a clever signature?

    13. Re:Oh boy... by raretek · · Score: 1

      "Anti-cloning zealots are going to have a ball with this"

      I'm not a zealot either way on the issue, but I know this, had America listened to the Anti-Nuke zealots back in the 50's and not experimented in the atmosphere with nuclear weapons without fully understanding what they were doing, 15,000 people would not have died from the fallout, and some hundreds of thousands, perhaps even millions, would not have had the vast increase in disease that occured as a result.

      It is a headstrong fool that rushes forward without carefully considering all sides and perspectives of an issue. Logic would dictate that research should be conducted to find out if this is going to be a problem for clones in general, before anyone begins to attack others for their viewpoints.

      I mean seriously, with the evidence available, your finding fault with "anti-cloning zealots" is itself, dogmatic zealotry, because you sure as hell don't know if they're wrong.

      If you do, then by all means, shine your light that we may all share your insight.

      --
      Show me an effect without cause and then I'll believe in chaos.
    14. Re:Oh boy... by joshsisk · · Score: 1

      (lawsuit for mcdonalds beef fat used in french fries, when they never claimed that they were vegan safe)

      As I recall, the lawsuit happened after McDonalds announced they were switching to beef-free cooking oil, then still kept some beef in them... Which _is_ pretty annoying for Hindus and other people who can't eat beef on certain days (or at all) for religious reasons.

    15. Re:Oh boy... by lenski · · Score: 1
      I'll have to agree WRT human cloning. It is truly irresponsible to inflict artifically-generated risks on a person with the perfectly ordinary goals and aspirations of a human being.

      Cats, cattle and sheep are one thing... Human children are another entirely.

      Disclaimer: I would be hesitant even to clone animals until I feel that we have some confidence in the process, as I believe that humans have a responsibility to consider the effects of their actions. Particularly when the subject of the experiment doesn't have any say in it.

    16. Re:Oh boy... by Anonymous Coward · · Score: 4, Informative

      Telomeres are repeating sequences of non-protein-coding DNA at the end of a chromosome. Due to an inefficiency involoved in the replication of chromosomes, they become shorter and shorter with each cell division. Eventually, the telomere is depleted and parts of actual genes begin to be cut off. This explains death by old age.

      An interesting side note is that cancer cells do not undergo the shortening of telemeres unlike normal cells. As opposed to normal cells which have a finite lifetime, cancer cells are functionally immortal.

      A little off topic, but still somewhat interesting.

    17. Re:Oh boy... by drdrs · · Score: 2, Informative
      Yes, but if the rumors of premature aging are true, they may actually have some science to base their argument on. You see there's this very important substance called telomeres attached to the end of chromosomes. As cells divide, the telomere caps become shorter, and eventually the cells stop dividing and either malfunction or die. It stands to reason that, if you start off with an adult cell, you already have shortened telomeres and will therefore have a reduced lifespan. [Any biology experts should feel free to correct me.] Rather than terminate Dolly, I'd rather they have experimented with telomerase to see if they could rejuvinate her. Although, I guess that's a little on the unethical and cruel side.
      This is almost right but I just can't let it go without comment.

      Telomeres are not so much a substance as a sequence of base pairs located at the ends of chromosomes. They're important because the enzymes used to copy these chromosomes during cell divison can't quite go all the way to the end. In theory this means that there must be a maximum number of replications a cell can go thorugh before you start to loose important information off the end of the DNA molecule.

      Some people have speculated that this may be an important cause of aging but I've never seen completely convincing research to support this. Cells do have enzymes called telomerases which can reconstitute these terminal sequences but they do shorten with each generation of cells. The whole effect is complicated.

      As to using telemerase to treat Dolly - whatever the effect of telemeres is on aging, Dolly died of a "lung infection" so I don't think her chromosomes were directly to blame.

      David
      --
      Please, for the love of God, stay off the dunes.
    18. Re:Oh boy... by GreyPoopon · · Score: 1
      Dolly died of a "lung infection" so I don't think her chromosomes were directly to blame.

      I get your drift, but you must admit that as the body ages, it's ability to prevent and fight disease diminishes rapidly. Many elderly humans don't die just because their body stops working. They frequently die of something like pneumonia or some other disease because their body was unable to fight it. But you're right -- if they had put Dolly into a sterile bubble, this might not have happened.

      --

      GreyPoopon
      --
      Why is it I can write insightful comments but can't come up with a clever signature?

    19. Re:Oh boy... by Anonymous Coward · · Score: 0

      Mita this, meta that. You sound like a bad movie!

    20. Re:Oh boy... by DunbarTheInept · · Score: 1

      Natural selection doesn't optimize for long life. It optimizes for making babies. The long-lived old couple that is no longer breeding is actualy detrimental to evolution, as they are using up resources that could have been used by breeders. Horrible as it may sound, us dying after getting old is not a mistake of evolution, it's an actual goal of it.

      --

      Don't label something "offtopic" unless you know the topic well enough to tell what's on topic.

    21. Re:Oh boy... by nursedave · · Score: 1
      I'm not a zealot either way on the issue, but I know this, had America listened to the Anti-Nuke zealots back in the 50's and not
      I'm sure you meant to say, America and the USSR, right? We can share this particular blame.
      --

      The Democratic Party: We've been pussies since 1968!

    22. Re:Oh boy... by m1a1 · · Score: 2, Informative

      It is my understanding (which doesn't mean too much) that telomeres weren't so much a clock as a failsafe. When chromosomes replicate a little genetic information tends to be lost during this dividing process. Telomeres are "spare" genetic material at the ends of the chromosome, so they get cut off first. When the chromosomes in a certain cell have no telomere left, the cell cannot successfully divide.

    23. Re:Oh boy... by liverkill · · Score: 3, Informative
      Just a little point on cellular aging; i believe that the main link between 'aging' and telomeres in mamals is due to the link between the progressive shortening of telomeres and cell senesance.

      The telomeric shortening results in the 'Hayflic Limit' where mamalian cells in culture are observed to divide 50-80 times before killing themselfs, telomeric shortening is linked to this process, prehaps providing some sort of timer as to when to kill off the cell in order to prevent conditions such as cancer.

      While the telomere exists as a protection against genetic instability arising from CRISIS, I think that ascribing it a role in 'aging' is a bit of a jump. I am much more comfortable with the idea that Telomeres act to help prevent genetic instability due to the problems associated with replication of linear chromasones. While the Telomere acts as a 'molecualr clock' of sorts, it is only really concerned with the cells DNA, aging in other ways (such as progressive modifications in collagen with increased age) is nothing to do with Teleomers.

      As to the point on the aging process itself, i would argue that it is entirely independent of telomeric shortening, and that change in telomeric length is *just* a timer indicating the age of the cell/number of divisions to reach its current condition. The aging process is due to a large number of ancillary effects which have no relationship to the telomeres.

      And yes, biology (or in this case, not to nitpick, genetics) is one of the places where you find yourself with the cutting edge stuff very early on. Makes for really interesting study, if a bit annoying that no text book you can buy is up to date enough.

    24. Re:Oh boy... by caluml · · Score: 1

      lots of individuals familiar with the science had already predicted she'd suffer from advanced and premature aging

      I heard this and I wondered about it.
      Do they treat the embryoes or whatever? Otherwise I can't see how it's different to a normal birth. Why should the result age more rapidly?

    25. Re:Oh boy... by caluml · · Score: 1

      Dave, I can get 5 out of the 6 words in your sig - B soviyetski Rossee, yob tvoya mat!

      I feel sure I know the 6th.

      So go on - In Soviet Russia, what happens to my mother? :)

    26. Re:Oh boy... by Anonymous Coward · · Score: 0

      With a name like euthanasia, how bad can it be?

      (can I have some friendly fire, please?)

    27. Re:Oh boy... by Anonymous Coward · · Score: 0

      Well, Greek vegetarians can eat lamb. So I guess if they're Greek it's also ok.

    28. Re:Oh boy... by Forgotten · · Score: 1

      Or, become a psychologist, and reach the frontiers of knowledge in your field as the psych 100 syllabus is handed out. ;)

    29. Re:Oh boy... by Forgotten · · Score: 1

      It's not quite so cruel as that, since older animals serve a support role and lend the value of experience. This is particularly true for humans, and it's probably why we live so long (for a mammal our size). Human (and prehuman) society and culture is very much a contributing factor in the evolution of the human organism - you really can't separate the one from the other. Heck, you can say the same to a different degree of chimpanzees, or wolves. Life is a continuous thread; generations don't war against each other.

    30. Re:Oh boy... by Comen · · Score: 0

      If you want to make a great fundamental discovery in one of the hard sciences, then become a biologist. So much is unknown!

      I just saw a short mention of Dolly on the news.
      They mentioned that they might be able to tell from some testing if the reason the animal had problems was cause she was a clone.
      Isn't it possible that even though we are smart enough to play with making these clones, we still don't have the technology to understand it, or tell if the animals problems were do to cloning or just a coincidence?
      Just curious about that I guess.

    31. Re:Oh boy... by Anonymous Coward · · Score: 0

      You must work for Microsoft. Who else uses the freakin word "zealots"

    32. Re:Oh boy... by Forgotten · · Score: 1

      Actually "lung infection" (or more generally pulmonary edema) would be the immediate cause of death for a lot of people in hospitals, whether they died of old age, cancer, AIDS and/or another disease, or even acute trauma. It's just one of those signs of systemic failure. I suspect a more detailed analysis of what would have killed Dolly will become available. I'd be surprised if her high effective cellular "age" (for a sheep) wasn't a part of it, but then I guess I'd also be surprised if the explanation was clear.

    33. Re:Oh boy... by AeternitasXIII · · Score: 1

      The DNA they use from the parent to seed the host egg are taken straight from mature cells. The egg itself is simply a normal egg from the species (I believe some work in using eggs from other species is being done as well) that has had all its genetic material removed. The defects in the parent DNA from mutations and from the natural aging process (primarily telomere loss), are carried along with the expected genes. In effect the new embryo is given a legacy code base rife with bugs and a timing mechanism set to that of the age of the parent. Its not that the cloned offspring age faster, its that they simply start their aging well ahead of where they should be.

      The theory behind this is pretty well developed, since a large number of asexual creatures essentially clone themselves to reproduce in nature. They don't have the issues with the telomeres that cloning in complex animals has, but they are known to have a higher overall rate of mutations transmitted to offspring. It would have been far more unsettling to current theory if Dolly had been born healthy and lived out full life cycle of a normal sheep.

    34. Re:Oh boy... by Anonymous Coward · · Score: 0
      If you want to make a great fundamental discovery in one of the hard sciences, then become a biologist.


      Hard sciences? Do you mean hard as in difficult? I always thought of "hard science" as being science that had certain characteristics:
      - repeatability: do the same experiment and get the same results within the measuring capabilities of the apparatus
      - predictability: given a theory, it's possible to predict the outcome with reasonable precision

      Biology may be better than "social sciences," but biology doesn't seem to have the characteristics that hard sciences do...

    35. Re:Oh boy... by nursedave · · Score: 1

      Yob... yebat... Damn, where is that Rooskey dictionary when I need it? ;)

      --

      The Democratic Party: We've been pussies since 1968!

    36. Re:Oh boy... by the+gnat · · Score: 1

      but only when we can first correct this very severe problem that exists in the process.

      Okay, I oppose reproductive cloning for other reasons too, but let's start here. How exactly can scientists determine that they've fixed the problem without actually cloning and raising a human, perhaps with disasterous results? It would suck to spend the first 18 years of your life as a medical experiment.

    37. Re:Oh boy... by Anonymous Coward · · Score: 0

      There are more chicks too.

      And sheep.

    38. Re:Oh boy... by JebusIsLord · · Score: 1

      AFAIK "Hard Sciences" is just another way of saying "Natural Sciences", the study of natural phenomena. This is in contrast of course to the social sciences which study human behaviour.

      The characteristics you listed above are inherent in ALL sciences, though they probably are easiest to follow in Physics and hardest to follow in the social disciplens.

      --
      Jeremy
    39. Re:Oh boy... by DaemonGem · · Score: 0

      Umm, pardon me, but cloning is not going to kill millions or hundreds of thousands or even 15,000. Comparing Nuclear research and cloning with respect to death tolls is like comparing a mosquito bite (not west nile mind) to a bear ripping your arm off. Hardly proportional. -Dae

      --
      "Alle reden vom wetter. Wir nicht." - SDS Sozialistischer Deutscher Studentenbund.
      j00 4r3 3n73r1ng l337 w0r1d.
    40. Re:Oh boy... by God!+Awful+2 · · Score: 1


      Natural selection doesn't optimize for long life. It optimizes for making babies. The long-lived old couple that is no longer breeding is actualy detrimental to evolution, as they are using up resources that could have been used by breeders. Horrible as it may sound, us dying after getting old is not a mistake of evolution, it's an actual goal of it.

      You're misunderstanding natural selection. Us dying after getting old is not a specific goal of evolution, it's just that letting us get old is a non-goal.

      That old adage about the prey "needing" the predators in order to cull the herd of the sick and weak is just BS.

      -a

    41. Re:Oh boy... by Znork · · Score: 1

      Actually, according to some theories, the evolutionary pressure would keep them at a certain length. The existence of telomers (or, rather, the cell divisions reducing them) stops mutated cells from runaway divisions for example. There are indications that cancer cells replenish their telomers with certain enzymes (as do stem cells and reproductive cells). A longer telomer, or replenishing telomer, and you might get several orders of magnitude more cancers instead as cells would now only require a mutation for rapid division to create a cancer since no cell strains would have a natural 'stop'.

      Of course, if you're going around cloning things then it might be a good idea to re-set the telomer on the clone cell.

    42. Re:Oh boy... by Carnivorous+Carrot · · Score: 1

      So they're going to sue McDonald's for spiritual degredation, karma loss, or getting thrown into Hell?

      Why not sue the dopey, ignorant, savage Gods instead?

      --
      "Has [being a kidnapped teenage girl, raped repeatedly for months] changed you?" - Katie Couric to Elizabeth Smart
    43. Re:Oh boy... by Carnivorous+Carrot · · Score: 1
      Anti-cloning zealots are going to have a ball with this.


      Actually, balls had nothing to do with it. It was test tubes.
      --
      "Has [being a kidnapped teenage girl, raped repeatedly for months] changed you?" - Katie Couric to Elizabeth Smart
    44. Re:Oh boy... by Carnivorous+Carrot · · Score: 1

      Indeed, the organism that bred successfully into their 70's (or 170's or 2525's) would be highly successful in an evolutionary sense.

      These are two fighting forces in the dynamic gradient descent of evolution. The benefit of rapidity of successive generations in adapting to changes (both static and dynamic environment i.e. adaptation of your predators or your prey) fights against the evolutionary "wins" of continued reproduction of an individual decade after decade.

      Indeed, the past 20 years have seen a skyrocketting in women having babies (or trying) in their late 30's and even thru their 40's. Some succeed, many fail. Those who succeed pass on their "late baby capacity" to future generations.

      A dozen generations later, I have no doubt you'll see a capacity for women in their 50's to reproduce without drugs.

      --
      "Has [being a kidnapped teenage girl, raped repeatedly for months] changed you?" - Katie Couric to Elizabeth Smart
    45. Re:Oh boy... by Tablizer · · Score: 1

      they become shorter and shorter with each cell division. Eventually, the telomere is depleted and parts of actual genes begin to be cut off. This explains death by old age.

      while (telomere--) {live();}

      You know, this telomere shortening thing might explain why movie sequels suck more than the original :-)

    46. Re:Oh boy... by God!+Awful+2 · · Score: 1


      Indeed, the organism that bred successfully into their 70's (or 170's or 2525's) would be highly successful in an evolutionary sense.

      Not necessarily. An organism like that would eventually have hundreds of grandchildren and great-grandchildren, meaning that its own individual contribution to the breeding process would become insignificant.

      -a

    47. Re:Oh boy... by God!+Awful+2 · · Score: 1


      Actually, according to some theories, the evolutionary pressure would keep them at a certain length. The existence of telomers (or, rather, the cell divisions reducing them) stops mutated cells from runaway divisions for example.

      I had thought about this, but didn't give it much credance since I didn't know the bit about cancer cells replenishing the telomeres.

      Of course, if you're going around cloning things then it might be a good idea to re-set the telomer on the clone cell.

      If we have the technology to do that, then it should be pretty easy to verify the above theory on cloned rats, etc.

    48. Re:Oh boy... by joshsisk · · Score: 1

      Uh, no... They are suing because McDonalds said they were switching to vegetable oil. Then it turned out they lied. At the very least it's false advertising, and there are probably other laws about lying about whats in food, I'd imagine.

      It would have been a non-issue had they not publically stated they were switching to vegetable oil, then not done so.

    49. Re:Oh boy... by ckaminski · · Score: 1

      And now thanks to all those damn hippy vegans, McDonalds fries now suck. First BK, then Mcy-D's... Guess I'll just have to resort to cooking my own fries in my deep-fat fryolator. The trouble I go through for a good-tasting fry... 3rd degree burns, here I come...

      Yes, the above was mostly sarcasm. I don't hate vegans, although I do taunt them with meat every chance I get. ;-)

      -Chris

    50. Re:Oh boy... by AeternitasXIII · · Score: 1

      The same way we test many medical experiments intended for future human use: animal testing. The mechanisms that control aging are, as far as we know, identical in underlying structure in insects and mammals. The difficulty in translating the results of one to the other is insuring that a treatment for insects can actually be applied systemically to the vastly more complex mammalian body. If you're cloning, you can give yourself a very very high certainty that any systemic treatment has worked across the entire organism simply by applying the treatment to the initial fertilized egg. Any treatment is likely going to involve introduction of genome changes either by retrovirus or even direct application, and as the egg goes into its development cycle it should pass all genome changes down to its produced cells.

      Until we reach the point that we have a treatment, we'll continue to experiment on lower order complexity lifeforms and periodically test our methods on animals like sheep or cattle. This leads to the economic side of things, where a successful treatment for cloned livestock will be approved fairly quickly by the FDA, leading to a revenue stream that can support the end run to applying the treatment on humans.

    51. Re:Oh boy... by DunbarTheInept · · Score: 1

      But an old person is only useful to survival of the "breeders" so long as that old person's role is one that cannot be done by a younger person. In societies where culture has been slow moving for a long time, people grow older (because the wisdom of old people is very useful to the offspring.) In societies where things changed rapidly, the wisom of old people isn't as useful to the next generation, and as such evolution doesn't have the incentive to make them last.

      The good news, though, is that we've reached a point where biological evolotion is so slow compared to technology and science learning, that it doesn't matter much anymore that evolution doesn't "want" us to grow old. Evolution doesn't have time to react to the changes we impose on our world now.

      --

      Don't label something "offtopic" unless you know the topic well enough to tell what's on topic.

    52. Re:Oh boy... by raretek · · Score: 1

      "I'm sure you meant to say, America and the USSR, right? We can share this particular blame."

      You are right, the USSR definetly did such things too. I didn't mention it because I am one of those US centric Americans. :)

      I want to point out that my point wasn't about blaming America... I was using a mistake that America made to demonstrate the need for well reasoned level headedness when developing new technologies.

      Besides, when the commies do something stupid, that's just stupid old communism. When the US does something stupid, its just a grave error in judgement made out of the deepest sense of patriotic conviction that originates in the subcochle area... I think...

      --
      Show me an effect without cause and then I'll believe in chaos.
  3. Okie, I'll speculate.. by Anonvmous+Coward · · Score: 4, Funny

    "While one should be cautious about drawing conclusions from a single data point, its interesting to speculate."

    It's obviously a sign from above...

    1. Re:Okie, I'll speculate.. by Anonymous Coward · · Score: 0

      "While one should be cautious about drawing conclusions from a single data point, its interesting to speculate."

      Which is why Slashdot will run the same story tomorrow as well :)

    2. Re:Okie, I'll speculate.. by Kaz+Riprock · · Score: 1

      No, it was probably a shovel or a hammer from above...maybe they just drugged here instead.

      --
      Mordor...a magical, mythical land where women are more rare than dragons--but where every man would rather find a dragon
  4. Nothing sadder by Cipster · · Score: 5, Funny

    There is nothing sadder for a parent than having to burry their clone....
    Somehow that just did not sound right.

    1. Re:Nothing sadder by Anonymous Coward · · Score: 0

      That's probably because you don't have a fucking clue how to speak English. Burry? What do pricks have anything to do with a cloned sheep, other than the one that just tried to make a cheap joke out of it?

    2. Re:Nothing sadder by Anonymous Coward · · Score: 0
      What do pricks have anything to do with a cloned sheep

      You should talk, Mr. fucking grammar king.

    3. Re:Nothing sadder by Anonymous Coward · · Score: 0

      Congratulations! Your e-peins has grown by a full 2 inches by pointing out a spelling mistake on Slashdot.

    4. Re:Nothing sadder by Anonymous Coward · · Score: 0

      to bad it shrank again by about 5, cause his gramar sucks

    5. Re:Nothing sadder by Anonymous Coward · · Score: 0

      That would be "too", not "to", and either "'cause" or "because" in place of "cause".

    6. Re:Nothing sadder by Anonymous Coward · · Score: 0

      grammar

      Fool

    7. Re:Nothing sadder by y0bhgu0d · · Score: 1, Informative

      i know your post was meant to be funny, but iirc, dolly lived somewhere near twice as long as the sheep she was cloned from. shortly after dolly was born, the clonee died from a weird disease.

  5. Random speculation by grahams · · Score: 1

    While one should be cautious about drawing conclusions from a single data point, its interesting to speculate. Isn't that what Slashdot is all about?

    1. Re:Random speculation by Anonvmous+Coward · · Score: 1

      " Isn't that what Slashdot is all about?"

      Depends. Are we talking about Microsoft's involvement in it?

    2. Re:Random speculation by gmuslera · · Score: 1

      You can always put this in this light:

      "If Dolly was a object oriented desktop, and Microsoft cloned it..."

      and be ready to 700+ replies

    3. Re:Random speculation by Big+Mark · · Score: 1

      No, we're talking about the GPLd Beowulf-clustered non-platform-dependant future of cloning!

      Soon, with every boxed copy of SuSE you'll receive a voucher entitling you to own exactly 1 (one) clone, which does not have to be of yourself, SuSE's customers in the past have been favourites of, among other personalites, Natalie Portman, CowboyNeal and the Goatse Man!

      -Mark

    4. Re:Random speculation by Anonymous+DWord · · Score: 1

      If Dolly was a object oriented desktop, and Microsoft cloned it...

      ...It'd get rooted faster than a nekkid sheep in Scotland.

      *rimshot*

      --
      "If he thinks he can hide and run from the United States and our allies, he's sorely mistaken." Bush on bin Laden
  6. First clone by fudgefactor7 · · Score: 2, Interesting

    Ya know, it was a good run for the first complex clone (mammal). I bet eventually they get the kinks worked out and cloned everything will be available. But for now, it's like the old addage: "in order to make an omlette, you have to break a few eggs."

    1. Re:First clone by interiot · · Score: 4, Informative

      The main suspected "kink" are the telomeres, and if we do discover it's a kink, it may be a difficult one to work around. Here's a good article on telomeres and telomerase.

    2. Re:First clone by spiro_killglance · · Score: 4, Insightful

      Its more important than that, that fact clones aren't medically identical or as fit as the
      orignal, tells us, that there is something we
      don't know about genetics. Whatever it is, it
      can cause premature aging and auto-immune disease,
      that may well mean, that whatever we learn about
      why clone are unfit, can produce cure for auto-immune diseases and maybe slow down aging.

      Perphap the key to clones failure is methylization, the genes in cells can be selectly
      switched on and off by attacting methyl group
      to potions of the DNA, how this works, is controlled, and how/if its passed on, is very
      important unknown of cell biology. In the same
      way over half the DNA is a cell, is made up of
      intron sequence that don't code for proteins or gene, however intron a preversed across millions
      of years of evolution, human share many of the
      same introns as mice. That means introns have to
      be doing something important, but unknown. We've
      much yet to learn about cellular biology and cloning as much to teach us.

    3. Re:First clone by Gortbusters.org · · Score: 1

      Very insightful.. what if there's something missing that we can't reproduce (like a soul). Like the whole debate of when a baby is born, is there any religious implications (maybe the birth process includes getting a "soul" and we can't clone that). Just thinking out loud on the greater scheme of things...

      --
      --------
      Free your mind.
    4. Re:First clone by cheeseSource · · Score: 1

      Sorry man no such thing as a soul. It is as it was and as it always will be: we are all just a bag of bones. To stay on topic I'd like to point out that Dolly was a good beginning. It's like programming you can't just pick up a language and go write an OS and expect it to be error/bug free on the first couple of runs. It takes time. It's worth the time too. The only part that's really sad and tormenting is that it will cost animal and probably eventually human lives in the process.

      --
      (Sponsored by cheeseSource for President 2012)
    5. Re:First clone by joshsisk · · Score: 1

      So what you're saying is that you think sheep have souls?

    6. Re:First clone by drinkypoo · · Score: 1

      And in order to make a M.L.T, you have to kill a sheep. And cut up or or two tomatoes and a head of lettuce.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    7. Re:First clone by the+gnat · · Score: 1

      But for now, it's like the old addage: "in order to make an omlette, you have to break a few eggs."

      Ouch. This is exactly why I, as an atheist molecular biologist, remain 100% opposed to human reproductive cloning. More than two thousand years of medical ethics is solidly against medical experimentation on unsuspecting human subjects.

    8. Re:First clone by Anonymous Coward · · Score: 0

      ...shouldn't that be "to make a sheep you need to recombine a few ova"?

    9. Re:First clone by coopaq · · Score: 1
      Ahhhh /.

      The place everyone goes and has to look up things
      like telomeres, but can give you intricate details on
      midichlorians.

      -J

    10. Re:First clone by Gortbusters.org · · Score: 1

      I'm not excluding the possibility. I think the native americans were more on the money when they realized that we're all organisms tied into one great ecosystem (or even Great Spirit). Just because the Bible implies that only humans has souls does not make that so. I think Buddhists have a concept of souls in non-humans as well.

      --
      --------
      Free your mind.
    11. Re:First clone by joshsisk · · Score: 1

      First of all, I don't believe in the bible. Secondly, I don't think sheep or people have souls.

      But if something has to have a soul to have life, I'd say Dolly had a soul since she was definitely alive... Even if she had medical problems.

  7. Fiery the Angels fell by Twirlip+of+the+Mists · · Score: 4, Funny

    This follows on earlier reports that she was prematurely aging, including developing arthritis.

    The light that burns twice as bright burns half as long. And you have burned so very, very brightly, Roy-- um, I mean Dolly.

    --

    I write in my journal
    1. Re:Fiery the Angels fell by Picass0 · · Score: 2, Insightful

      Dolly: I... want... more... life, fucker!

    2. Re:Fiery the Angels fell by Gojira+Shipi-Taro · · Score: 2, Funny

      Hmm, she really was an "Electric" Sheep, now wasn't she?

      --
      "Oh my God. This is terrible. This is the end of my Presidency. I'm fucked."; ~ Donald J. Trump
    3. Re:Fiery the Angels fell by Twirlip+of+the+Mists · · Score: 1

      Bastard! Your comment was even funnier than mine, though I doubt as many people will get it.

      Touche.

      --

      I write in my journal
    4. Re:Fiery the Angels fell by unspecified+poltroon · · Score: 1
    5. Re:Fiery the Angels fell by circletimessquare · · Score: 1

      if only you could have seen the things i've seen with your eyes BAAAAAAH ;-P

      --
      intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
    6. Re:Fiery the Angels fell by EvilTwinSkippy · · Score: 1

      I've done some... bahahad things.

      --
      "Learning is not compulsory... neither is survival."
      --Dr.W.Edwards Deming
    7. Re:Fiery the Angels fell by Anonymous Coward · · Score: 0

      It's the image of those two hooves pressing into his eyes that really stays with you...BAAAAAHHHH!

  8. No more cloned sheep... by jstrain · · Score: 1

    All your clones sheep are belong to us?

  9. Method of Cloing... Inefficient? by LordYUK · · Score: 1

    One of the scientists stated that the cloning process used to make Dolly might have been inefficient, and that sheep usually live 10-12 years.

    I hope that the people opposed to cloing dont take her untimely death as a reason to stop further research into this field.

    I for one cannot wait to see spaarti cylinders everywhere. (That was a Star Wars joke, FYI...)

    --
    This is my sig. Its pathetic.
  10. Re:I never.... by Anonymous Coward · · Score: 0

    Worst rhyme, ever.

  11. Reported as saying... by CommieLib · · Score: 5, Funny

    "We had to put her to sleep," they said sheepishly. "She was in shear agony. There was mutton we could do about it."

    --
    If your bitterest enemies are people who hack the heads off civilians, then I would say you're doing something right.
    1. Re:Reported as saying... by Anonymous Coward · · Score: 1, Funny

      Ewe can't pull the wool over my eyes. Those puns are horrible!!!!

    2. Re:Reported as saying... by Orne · · Score: 1

      You're telling me, they were really baaaad.

    3. Re:Reported as saying... by nathanh · · Score: 1

      Though ewethenasia is illegal so Dolly had to commit seweicide.

    4. Re:Reported as saying... by Anonymous Coward · · Score: 0

      I wish I could have fucked Dolly before she died. Did you know that lamb pussy is the most similar to human pussy of all the animals? Only it is better -- tighter and firmer (most human women are lazy and soft, from head to puss). It would have been a great honor to shoot a load of semen into Dolly's little pussy hole. Yes sir.

  12. At least by dubiousmike · · Score: 1, Funny

    I'll have my inflatable sheep to remember her by...

  13. Goodbye Dolly.. by grub · · Score: 1


    ..Hello mint jelly!

    --
    Trolling is a art,
  14. um... by stinky+wizzleteats · · Score: 1

    While one should be cautious about drawing conclusions...

    It's a little late to be cautious.

  15. Cloning still in version 0.X by TopShelf · · Score: 1
    While one should be cautious about drawing conclusions from a single data point, its interesting to speculate.

    Recall, however, that the success rate to at least produce Dolly was only around 1 in 200. This is still an early-stage technology, and there will be many more obstacles along the way. That, in my mind, is the major justification for a ban on human cloning at this time...

    --
    Stop by my site where I write about ERP systems & more
  16. Baaaaad news by sboyko · · Score: 2, Funny

    It wasn't cloning that got her lungs - it was secondary cigarette smoke from the black sheep of the family.

    --
    SCO, Microsoft, P2P, what's your hot button?
    1. Re: Baaaaad news by ibbie · · Score: 1

      oh that's fine. i like my lamb a bit on the seared side, anyways.

      --
      The wise follow a damned path, for to know is to be forsaken.
    2. Re:Baaaaad news by Anonymous Coward · · Score: 0

      You're such a Baaaaastard. :)

    3. Re:Baaaaad news by Anonymous Coward · · Score: 1, Funny

      oh sure, always blaming the black sheep.
      this is another example of the white sheep trying to keep the black sheep down.

  17. Chops, no... by Anonymous Coward · · Score: 1, Funny

    but boy, that ass...

    Now that's desirable!

    1. Re:Chops, no... by Big+Mark · · Score: 2, Funny

      Only in more, er, "rural" parts of the UK... which Scotland counts as!

      Everyone, lock up your sheep, they've become sensitized to the sound of a fly unzipping so sales of velcro-fastened trousers have skyrocketed!

      -Mark

    2. Re:Chops, no... by EricV314a · · Score: 3, Funny

      In the upper midwest they are referred to as "Montana Blondes"

    3. Re:Chops, no... by Anonymous+DWord · · Score: 5, Funny

      Ahh, Scotland - where the men are men, and the sheep are nervous.

      --
      "If he thinks he can hide and run from the United States and our allies, he's sorely mistaken." Bush on bin Laden
    4. Re:Chops, no... by Verteiron · · Score: 1

      Velcro, hell. Why do you think Scotsmen wear kilts?

      --
      End of lesson. You may press the button.
    5. Re:Chops, no... by Spunk · · Score: 1

      Um, don't boys wear skirts in France? I mean Scotland.

    6. Re:Chops, no... by zeno_2 · · Score: 1

      I thought that was Montana

    7. Re:Chops, no... by fatboyslack · · Score: 1

      A couple of jokes... ? Not too off topic. What do you call three sheep tied to a pole in New Zealand/Scotland/Spain/(insert sheep loving country here)? A Leisure Centre. A ventriloquist (sp?) is on holiday in New Zealand, and walks onto a farm. He sees the farmer and they start having a chat. The ventriloquist decides to tell the farmer that he can make animals talk. The farmer looks at the ventriloquist skeptically. The ventriloquist then says, see that horse? I'll make hime talk to you. "How are you?" The horse replies "Good, my owner treats me well, always feeds me and keeps me sheltered." The farmer is astonished. Then the ventriloquist asks the dog, who replies "I always have food, and lots of work to do" The farmer is now dumb struck. Then the ventriloquist asks the Sheep "How are you?" But before the sheep replies the farmer recovers from his shock, and looking a little panicky yells "The sheeps a bloody liar!"

      --
      Everyone thinks of changing the world, but no one thinks of changing himself. -- Leo Tolstoy
    8. Re:Chops, no... by Anonymous Coward · · Score: 0

      Why do new zealanders screw their sheep at the edge of a cliff?

      Because the sheep pushes back harder.

    9. Re:Chops, no... by steelframe · · Score: 1

      Q. Why did the Scots start wearing kilts?
      A. Because sheep can hear a zipper a mile away.

    10. Re:Chops, no... by Carnivorous+Carrot · · Score: 1

      > I thought that was Montana

      Montana, Scottland, Australia, I've heard 'em all. Throughout all cultures, men are universally given to taken an opportunity if they're sure no one will find out.

      --
      "Has [being a kidnapped teenage girl, raped repeatedly for months] changed you?" - Katie Couric to Elizabeth Smart
  18. Poor Dolly... by Anonymous Coward · · Score: 0

    Poor Dolly. It was such a lovely sheep... :(
    Sheep are great animals. People think they are not very intelligent, but they are, and in fact, they are extremely innocent and have a good heart. Sheep are my favorite animals.

    I am thinking of creating a new kind of application distribution, called "sheepware". Each person who would like to keep using a sheepware application, will have to skip a pre-defined number of lamb meals. For example, if a sheepware application costs 3 Lambs, people will have to leave aside 3 meals of lamb chops and only eat the vegetables. :D

    Eugenia

  19. Etiology still pending by Doctor+Beavis · · Score: 5, Informative

    Although the shortening of her telomeres is well-publicized, it very well may have had nothing to do with the death. A somewhat more detailed story can be found here [Reuters].

    1. Re:Etiology still pending by jj_johny · · Score: 2, Interesting

      But the problem is that they have no idea what really did her in and what they did wrong. I really love the nuts that thinks the first time they try to clone a human it will work perfectly. Ha. About as likely as ... fill the blank... But seriously, it was a stroke of genious to think that when we can't figure out how protiens fold and what most of the junk inside cells do, that we could move some DNA around in a rather clumsy way and voila have a perfect clone. Next thing they are going to start talking about error free coding... yada yada yada. Dolly is dead and we don't have a clue and won't for a long long time. And when we do successful cloning we won't have a clue about what we did right, what we did wrong or what the difference is between the two.

    2. Re:Etiology still pending by EvilTwinSkippy · · Score: 1
      I just keep thinking about the time I tried to DD an NT partion onto another (identical) computer. It booted up fine, but it seemed to have more cruft than the donor machine. The machine would lock up with Graphics drivers related hangs, the networking would sometimes screw up. The original would behave just fine.

      None of it made sense, unless you believe in the theory of cruft.

      Maybe when you clone something, you clone all of the cruft from the original, and then add some? I dunno, my US0.02

      --
      "Learning is not compulsory... neither is survival."
      --Dr.W.Edwards Deming
  20. Happy Valentine's Day, Nigs!! by Anonymous Coward · · Score: 0

    Death By A Thousand CLITs up in da hizzle, nizzle -- fuck all y'all hataz

    I've been through two marriages in the past. My first wife died at an early age of 29 from a massive heart attack and my second marriage was a nightmare from hell, that I'm now free of. When I met Jeanie, I knew I had to take it slow and easy.

    Jeanie was a very nice lady in her early 40's. I myself was a few years older. Jeanie had two lovely girls. I had no children. I grew to love Jeanie and her girls and a few years later we were married.

    When I met Jeanie, one of her girls was a senior in high school. Anna was six months from graduation. She was good a good looking, bright student, but very spoiled. We got along fine and a few years after Jeanie and I were wed, Anna started calling me Dad.

    Jeanie's other daughter was living with her Dad some 1200 miles away. I didn't get to meet her till a few weeks before the wedding. When I met Dawn, I knew she was the free spirit of the family. Dawn was 4 years older then Anna, more mature and for sure, sexier. I'll have to be honest and admit that she did catch my eye and stirred reactions in my loins. She was a flirter and over time she did cause me to jack off thinking of her, many times.

    When Anna graduated from High school, Dawn moved back home that summer. Her and Anna were going to go to college in the fall. The school was a few hundred miles away and they would room together. It was during that summer that my lust for Dawn sprouted.

    I have a job that gives me the summers off. Jeanie worked days and so did Anna. Dawn was a bartender, so it meant she was home during the days with me. I didn't know if Dawn was actually showing off for me, or if that was who she was and how she acted. I was naive, so I decided it was for my benefit. She did dress more provocative when we were alone, then when others were around. Dawn was a beautiful girl. Her long curly reddish hair would swirl around her shoulders and shine in the light. The color of her hair also brought out her green eyes. Eyes that could rule me. Her lips were full and I fantasized many times about having them wrapped around my aching cock. Dawn was about 5'6" and I would guess under weight for her height. Her long legs, hips and breasts combined to makeup a very sexy body. I know I was married to her Mom, but this vixen was turning me on and I was wasting good cum into a Kleenex. It was a long... hot... exciting... summer.

    Fall came and we moved the girls into there dorm room. Anna and Dawn were grateful for my help. Both girls hugged me, but Dawn's hug was more. It was done when Jeanie and Anna had left the dorm room and was very seductive. She hugged and squeezed me like she was saying goodbye to a lover. Her warm, sexy body made my cock grow hard instantly as she pressed against me. She gave me a kiss on the cheek and a very wicked smile as she backed up and said, "Thanks Daddy!"

    Over the 4 years they were away at school, the flirting grew and became more intense. I, as Dawn's Stepdad, should of put a stop to it, but I couldn't, or wouldn't. I enjoyed it and even encouraged it. I was excited that a beautiful, young, sexy girl would find me attractive enough to want to flirt with me and perhaps want more?

    Dawn had no serious relationships during her college years. I assumed it was because she worked and studied hard. She was a smart girl and carried an "A" average. Dawn planned to pursue her education by going after her Masters Degree.

    Anna had a boyfriend and planned to move with him to Lansing, MI. Jeanie and I helped her move in June, soon after graduation. Dawn stayed in the apartment they had shared until Aug. , when she put her stuff in storage and went to find a place to stay in the new town her school was in. She found a nice 1 bedroom apartment. Dawn then came home and we made plans to move her. We rented a Ryder truck, got a ride to her stored stuff, then proceeded to load up.

    When we were finished and before we ate and left town, Dawn wanted to shower at her friends house. She said, "please Daddy, I feel so sweaty. "

    What could I do. I'd do anything for her.

    I took a short walk while I waited and when I returned Dawn was just coming out of her friends place. She looked like she was going to a party. All made up and dressed to kill. I couldn't figure out what was going on and I also didn't care. My cock was growing and by the time I got to her, it was at full hardness.

    "I can see your happy to see me Daddy! I hope the wait wasn't to long for you?" Dawn added.

    I tried to stop my eyes from ogling her body, but I couldn't. She was wearing a black silk blouse, knee length skirt with nylon stockings. Her lips were a soft shade of red and she smelled fantastic. I had never seen this side of my stepdaughter before. Oh don't get me wrong. I've seen her dressed up before and looking nice, but today she was more then that. She had this mature sexiness about her. Let's face it, she was downright gorgeous. It was going to be a long ride home, or was it?

    "No Honey, it wasn't, but why are you all dressed up?" I asked.

    "We are going to stop to eat and I wanted to look nice for you Daddy. Are you upset?" she asked.

    "Oh no Honey, I'm not upset. You look beautiful, but now I feel grubby. " I answered.

    "You look great to me Daddy, but if you want to freshen up, you can use my friends washroom. "

    "That would be a great idea Sweetie. I do smell. "

    I went in and took a quick shower. I had a clean shirt, but that was it. I left my underwear off as I slipped my pants back on. I felt better, but my cock was still slightly hard and aching. It was time to go.

    I got into the truck as Dawn said goodbye to her friend. I kept my eyes on my stepdaughter. I couldn't help myself. As Dawn was getting into the truck, her skirt hiked up showing me more of herself. I could see where her stockings ended and the red straps of what I assumed was a garter, holding them up. Her blouse also seemed to have a few more buttons undone then before. That allowed me to see that her bra was also red. I had found out earlier that Dawn loved to wear sexy lingerie. That's because, I've used her soiled panties many times to jack off.

    "All set Daddy, lets go. I'm starving!"

    "Me too Honey, " I said.

    To myself I was thinking, Me too Honey, but for you, not food.

    As we got out of the truck at the supper club, Dawn held my hand as we walked in. Feeling no resistance, she said to me, "I love you Daddy!"

    "I love you too, Honey!"

    The club wasn't very busy and we got a somewhat secluded booth. I was driving, so it was coffee for me. Dawn had a wine. Again I marveled at how beautiful she was, especially in the glow of candle light. We ordered, then Dawn said, "I have something to tell you Daddy and I don't want you to butt in till I'm done. "

    "Since I've met you Daddy, you have been more of a Father to me and Anna, then our real Dad. You are more caring, more loving and helpful. You don't criticize our decisions, instead you support them, right or wrong. You never judge us and only love us for whom we are. For what I'm going to say next, I'll need all these things from you, Daddy. " She paused then continued, "I want you to make love to me tonight, Daddy. I've wanted you for a long time now. I love you. "

    "I love you too Honey, but it would not be right. I know it wouldn't be incest, but what about your Mother? Could we handle this?"

    "I know it would be hard Daddy, but I want you so bad, that I'm ready to deal with it. I know you want me. I've seen the bulges in your pants and I've seen the cum stains in my panties. You can't deny it?"

    "No honey, I can't, I do want you, but flirting and fantasizing are one thing. To act on those feelings are another. "

    Our food came then. We continued to talk as we ate. After we were finished, Dawn laid her cards on the table.

    "You know where the Clear Lake roadside park is don't you. "

    "Yes, I know. "

    As she continued, her toes started to rub my aching cock. "We could pull off there and act like we were tired and getting some rest. It's hardly used anyways. It'll be up to you Daddy. If you want me, just pull in and all I have is yours for the taking. If you pass it by, I'll try to never put you in this position again. You'll have about 45 min. till we get there to decide. Agreed?"

    "Agreed, but you better stop rubbing my cock or I'm going to cum in my pants. "

    "I wouldn't want to waste it there Daddy. After I found out you were using my panties to cum in, I would check them. If I found a recent stain, I would taste it. I love your scent and taste Daddy, but now I want fresh. She pulled her toes away and we left.

    In the truck, Dawn was doing everything she could to influence my decision. She opened her blouse and tempted me with her hard nipples that were showing through the sheer material of her bra. She slid her skirt up far enough, so I could just see the start of her panties. She would put one hand under her skirt and rub herself, while caressing her breasts with the other. She would moan with pleasure and say, "these could be your hands making me moan Daddy. "

    I was in agony as the miles went by. Hormones were winning out over reason. With a few miles to go, I knew I would turn off. I couldn't help myself. I wanted to fuck... and be sucked... by my stepdaughter so bad, I would risk everything. As the Clear Lake road came into view, the sun had just set. As I put my blinker on and slowed, Dawn screamed. She quickly slid over next to me and started kissing my neck and rubbing my cock with her hand.

    "You will never regret this Daddy. I will be yours anytime you want me. Oh... I love you so much! I never thought I would have you. I'm so happy, so excited. Hurry up and get this truck parked. "

    As she said that, she unzipped me and started sucking on my cock.

    I would cum soon. Dawn was doing a super job fondling my balls while she sucked my cock. As I put the truck into reverse to back into a secluded part of the park, Dawn stuck a finger up my ass and that's all it took. I hit the brakes, closed my eyes and filled my stepdaughters mouth with my cum.

    "Oh... fuck Sweetie, suck me, suck Daddy's hot cock. I'm cumming Sweetie, I'm cumming!" I pulled her head down on my spurting cock and Dawn swallowed most of it. What she missed she quickly licked up. When she finished, I finished parking the truck.

    "Did you enjoy the way I sucked your cock, Daddy?"

    "Oh... very much so Honey! That was the most explosive orgasm I can remember. "

    "I'm so happy Daddy, you tasted so... good. All you have to do is ask Daddy and I'll suck your cock anytime. I'm all yours. "

    Dawn then slid into my arms and we started kissing. The taste of my own cum was still in her mouth as our tongues met. I was stimulated by it's taste, which excited my cock and made it start to grow. As I caressed Dawn's breasts, she pulled my shirt over my head. She then unsnapped my pants, giving off a soft moan, as she noticed my now hard cock.

    "Lift up Daddy so I can get your pants off. "

    I obeyed and soon I was naked.

    "You have a great body for your age, Daddy. "

    I was 48 and did jog and bike, so I was in pretty good shape.

    "Thanks Honey! So do you. Now I want to see more of what I've been dreaming of for years. " I removed her blouse. Her tits sure looked hot in her sheer red bra. "I should tell you that your sexy lingerie really excites me Dawn. "

    "I know Daddy. That's why I wear them. Mom mentioned one time how you like them. "

    "You wear them just for me Honey?"

    "Not just for you Daddy. I love the look and feel of lingerie on me too. They make me feel sexy and naughty. "

    We started kissing again and this time I dropped my hand to her legs and started feeling my way upwards. As I neared her pussy, Dawn squeezed her legs shut, halting my assent.

    "I trust you Daddy, because I love you so much. Please don't hurt me?"

    "Never Honey. I love you too. Why would I hurt you?"

    Dawn opened her legs and as my hand continued, she pulled me to her and kissed me hard. I reached her panties and as I slid my fingers between her legs, expecting to find and massage her clit, I found a big clit in the shape of a hard cock. I broke off our kiss and gave Dawn a surprised look.

    "I'm sorry Daddy. I wanted you so... bad, I couldn't tell you. "

    Before Dawn could say anymore I pulled her to me and kissed her. I found myself very excited. I continued to rub her cock through her sexy panties.

    Before I go any further, let me tell you about my fascination with transsexuals. We got our very own PC a few years ago and while exploring the internet, I came across a site with shemales. The site of these beautiful, sexy woman with cocks excited me greatly. I found more and more sites and the more I looked, the more I fantasized. I wanted to experience loving one of these gorgeous transsexuals. I don't figure I'm gay, because the sight of a naked man doesn't excite me. But the sight of a hard cock on a beautiful woman makes me want to suck it.

    My fantasies were coming true.

    The feel of Dawns cock through her panties was really turning me on. It was doing wonders for Dawn too, as she was beginning to moan. "Will you suck my cock now, Daddy?"

    I slid Dawn over on the seat and removed her skirt. She looked so hot in her sexy red lingerie. The sight of her hard cock pressing against her panties was almost enough to make me cum again without touching it. I started to peel Dawns panties down and as I freed her cock, it sprang up. My cock is only about 6 1/2 inches and medium thickness. Dawns cock was a little smaller, but about the same thickness. An added turn on was, she was hairless.

    "Now Daddy, take me in your mouth and suck my cock. I want you to taste my cum. "

    I started by stroking her stiff cock. I've jacked off many times, so I knew what she would like. Next I lowered my mouth and began by licking and tasting some of her pre cum. Enjoying that, I opened my mouth and took Dawn's cock in. It was everything I thought it would be and more. I kept my mouth closed tight and while Dawn brought her hands to the back of my head and helped me by holding it steady, she slowly fucked my mouth. The feel of her cock sliding in and out of my mouth as I sucked it was driving me crazy. I used my tongue to tease the sensitive parts of Dawn's cock, which encouraged her moaning and talking dirty to me. "oh... yes, suck me Daddy, suck your little girls throbbing dick. That's it Daddy, lick the head, oh... don't stop. It feels so good. " I sucked, while she continued to slowly fuck my mouth. I was also caressing her tits and rubbing her legs and balls. I could sense my Honey was on the verge and so on I was rewarded with my first mouthful of cum.

    Dawn's body shook as she rammed her cock deep into my mouth, while holding my head screaming, "I'm cumming... Daddy!" I gagged a little, but swallowed most of Dawns seed. What I missed I licked up. I loved it. Her cum tasted so... good. It had a strong scent and was slightly salty.

    "Oh Daddy, you made me feel so... good and so... loved. "

    I raised up and kissed her. "I loved it too, Sweetheart. Your cock felt so good in my mouth and when you came, the warmth, the creaminess, the scent and taste of it made me want to drink it all down. "

    "Before we go, I want you to fuck me. I want to feel your cock up my ass when you cum Daddy. I've had many sexual objects up my ass, but I'm a virgin when it comes to a live dick. Be my first, Daddy?"

    "Anytime Sweetie. Your ass will be a first for me too. "

    Dawn reached into her purse a pulled out a bottle of jell. She put some into her hand and some into mine. "You get my ass ready, Daddy, while I get your cock ready to slide in. "

    I was so hard. Dawn's fingers felt so good as they readied my cock. I in turn used my finger's to lubricate her waiting ass. When all was in ready, Dawn got on her knees and offered her virgin ass to me. I got on my knees behind her and slid my cock to the entrance of her ass. Thank goodness there was plenty of room in the cab of this truck.

    "Now Daddy, slowly push in. "

    I did as I was told and slowly slid my cock into Dawn's waiting ass. It was tight, tighter then anything I've ever experienced with my cock. It was tight for Dawn too, but soon she relaxed her muscles and my cock slid in and out with more ease.

    "That's it, fuck my ass, Daddy. Oh... fuck me till you cum in me. I want to feel your hot cum in my ass. "

    "Your so tight Honey. I never felt anything so... good before. You may be spoiling me Sweetie. I may not want pussy again. " As my fucking grew more intense, I reached under Dawn and started to pump her now hard cock.

    "Oh Daddy, your hot cock sure feels better then the penis replicas I'm use to using. Keep fucking me Daddy and don't stop jacking me off. I want us to cum... together. "

    We were both close now. I could feel the cum in me about to explode into Dawn's ass. "I'm cumming sweetheart. I can't hold back any longer. " I shot my hot seed into my Stepdaughters accepting ass.

    "I'm cumming too Daddy" and her hot seed covered the seat of the truck. A waste I know, but this was my first time, forgive me.

    I continued to fuck her ass until my cock started to soften. I was disappointed to have to pull out, but I knew there would be many times to love Dawn. Dawn took out some towelettes from her purse and cleaned my cock. I wiped her ass clean.

    We did some more kissing and Dawn reassured me that she's mine whenever I wanted her. I also told her that I'm hers whenever she needed me. Then we dressed. Dawn threw on pants and sweatshirt for the ride home.

    Before we left Dawn said, "next time, I get your virgin ass, Daddy. "

    All I said to that was, "I hope it's soon Honey. "

    We talked on the way home and she told me how she came to be a pre-op transsexual.

    I asked her if she had any type of sexual experience before or was it strictly self pleasure.

    She told me of sex with a few of her girlfriends, but it was what she told me next that got me excited all over again. Her and her sister Anna have been having sex together for over 6 years now. They were sisters who were close and enjoyed pleasing each other. They also kept no secrets and Anna knew of her passion for me. Then she told me Anna found me sexy too and that someday, maybe, we could have a threesome.

    I told Dawn, "Someday Honey, but for now I want to love and enjoy you. You have so much to offer and I want to experience all of you. "

    My stepdaughter kissed me saying, "Anything you want Daddy. I Love You!"
    6623

  21. Cloned sheep Dolly, found dead at age 6 by Thud457 · · Score: 1

    I heard her evil twin did it!

    --

    the preceding comment is my own and in no way reflects the opinion of the Joint Chiefs of Staff

    1. Re:Cloned sheep Dolly, found dead at age 6 by Eccles · · Score: 5, Funny

      They don't know how many sheep they've actually cloned, you know. They tried counting the sheep, but they fell asleep...

      --
      Ooh, a sarcasm detector. Oh, that's a real useful invention.
  22. Happy Valentine's Day, Nigs!! by Anonymous Coward · · Score: 0

    Death By A Thousand CLITs up in da hizzle, nizzle -- fuck all y'all hataz

    I've been through two marriages in the past. My first wife died at an early age of 29 from a massive heart attack and my second marriage was a nightmare from hell, that I'm now free of. When I met Jeanie, I knew I had to take it slow and easy.

    Jeanie was a very nice lady in her early 40's. I myself was a few years older. Jeanie had two lovely girls. I had no children. I grew to love Jeanie and her girls and a few years later we were married.

    When I met Jeanie, one of her girls was a senior in high school. Anna was six months from graduation. She was good a good looking, bright student, but very spoiled. We got along fine and a few years after Jeanie and I were wed, Anna started calling me Dad.

    Jeanie's other daughter was living with her Dad some 1200 miles away. I didn't get to meet her till a few weeks before the wedding. When I met Dawn, I knew she was the free spirit of the family. Dawn was 4 years older then Anna, more mature and for sure, sexier. I'll have to be honest and admit that she did catch my eye and stirred reactions in my loins. She was a flirter and over time she did cause me to jack off thinking of her, many times.

    When Anna graduated from High school, Dawn moved back home that summer. Her and Anna were going to go to college in the fall. The school was a few hundred miles away and they would room together. It was during that summer that my lust for Dawn sprouted.

    I have a job that gives me the summers off. Jeanie worked days and so did Anna. Dawn was a bartender, so it meant she was home during the days with me. I didn't know if Dawn was actually showing off for me, or if that was who she was and how she acted. I was naive, so I decided it was for my benefit. She did dress more provocative when we were alone, then when others were around. Dawn was a beautiful girl. Her long curly reddish hair would swirl around her shoulders and shine in the light. The color of her hair also brought out her green eyes. Eyes that could rule me. Her lips were full and I fantasized many times about having them wrapped around my aching cock. Dawn was about 5'6" and I would guess under weight for her height. Her long legs, hips and breasts combined to makeup a very sexy body. I know I was married to her Mom, but this vixen was turning me on and I was wasting good cum into a Kleenex. It was a long... hot... exciting... summer.

    Fall came and we moved the girls into there dorm room. Anna and Dawn were grateful for my help. Both girls hugged me, but Dawn's hug was more. It was done when Jeanie and Anna had left the dorm room and was very seductive. She hugged and squeezed me like she was saying goodbye to a lover. Her warm, sexy body made my cock grow hard instantly as she pressed against me. She gave me a kiss on the cheek and a very wicked smile as she backed up and said, "Thanks Daddy!"

    Over the 4 years they were away at school, the flirting grew and became more intense. I, as Dawn's Stepdad, should of put a stop to it, but I couldn't, or wouldn't. I enjoyed it and even encouraged it. I was excited that a beautiful, young, sexy girl would find me attractive enough to want to flirt with me and perhaps want more?

    Dawn had no serious relationships during her college years. I assumed it was because she worked and studied hard. She was a smart girl and carried an "A" average. Dawn planned to pursue her education by going after her Masters Degree.

    Anna had a boyfriend and planned to move with him to Lansing, MI. Jeanie and I helped her move in June, soon after graduation. Dawn stayed in the apartment they had shared until Aug. , when she put her stuff in storage and went to find a place to stay in the new town her school was in. She found a nice 1 bedroom apartment. Dawn then came home and we made plans to move her. We rented a Ryder truck, got a ride to her stored stuff, then proceeded to load up.

    When we were finished and before we ate and left town, Dawn wanted to shower at her friends house. She said, "please Daddy, I feel so sweaty. "

    What could I do. I'd do anything for her.

    I took a short walk while I waited and when I returned Dawn was just coming out of her friends place. She looked like she was going to a party. All made up and dressed to kill. I couldn't figure out what was going on and I also didn't care. My cock was growing and by the time I got to her, it was at full hardness.

    "I can see your happy to see me Daddy! I hope the wait wasn't to long for you?" Dawn added.

    I tried to stop my eyes from ogling her body, but I couldn't. She was wearing a black silk blouse, knee length skirt with nylon stockings. Her lips were a soft shade of red and she smelled fantastic. I had never seen this side of my stepdaughter before. Oh don't get me wrong. I've seen her dressed up before and looking nice, but today she was more then that. She had this mature sexiness about her. Let's face it, she was downright gorgeous. It was going to be a long ride home, or was it?

    "No Honey, it wasn't, but why are you all dressed up?" I asked.

    "We are going to stop to eat and I wanted to look nice for you Daddy. Are you upset?" she asked.

    "Oh no Honey, I'm not upset. You look beautiful, but now I feel grubby. " I answered.

    "You look great to me Daddy, but if you want to freshen up, you can use my friends washroom. "

    "That would be a great idea Sweetie. I do smell. "

    I went in and took a quick shower. I had a clean shirt, but that was it. I left my underwear off as I slipped my pants back on. I felt better, but my cock was still slightly hard and aching. It was time to go.

    I got into the truck as Dawn said goodbye to her friend. I kept my eyes on my stepdaughter. I couldn't help myself. As Dawn was getting into the truck, her skirt hiked up showing me more of herself. I could see where her stockings ended and the red straps of what I assumed was a garter, holding them up. Her blouse also seemed to have a few more buttons undone then before. That allowed me to see that her bra was also red. I had found out earlier that Dawn loved to wear sexy lingerie. That's because, I've used her soiled panties many times to jack off.

    "All set Daddy, lets go. I'm starving!"

    "Me too Honey, " I said.

    To myself I was thinking, Me too Honey, but for you, not food.

    As we got out of the truck at the supper club, Dawn held my hand as we walked in. Feeling no resistance, she said to me, "I love you Daddy!"

    "I love you too, Honey!"

    The club wasn't very busy and we got a somewhat secluded booth. I was driving, so it was coffee for me. Dawn had a wine. Again I marveled at how beautiful she was, especially in the glow of candle light. We ordered, then Dawn said, "I have something to tell you Daddy and I don't want you to butt in till I'm done. "

    "Since I've met you Daddy, you have been more of a Father to me and Anna, then our real Dad. You are more caring, more loving and helpful. You don't criticize our decisions, instead you support them, right or wrong. You never judge us and only love us for whom we are. For what I'm going to say next, I'll need all these things from you, Daddy. " She paused then continued, "I want you to make love to me tonight, Daddy. I've wanted you for a long time now. I love you. "

    "I love you too Honey, but it would not be right. I know it wouldn't be incest, but what about your Mother? Could we handle this?"

    "I know it would be hard Daddy, but I want you so bad, that I'm ready to deal with it. I know you want me. I've seen the bulges in your pants and I've seen the cum stains in my panties. You can't deny it?"

    "No honey, I can't, I do want you, but flirting and fantasizing are one thing. To act on those feelings are another. "

    Our food came then. We continued to talk as we ate. After we were finished, Dawn laid her cards on the table.

    "You know where the Clear Lake roadside park is don't you. "

    "Yes, I know. "

    As she continued, her toes started to rub my aching cock. "We could pull off there and act like we were tired and getting some rest. It's hardly used anyways. It'll be up to you Daddy. If you want me, just pull in and all I have is yours for the taking. If you pass it by, I'll try to never put you in this position again. You'll have about 45 min. till we get there to decide. Agreed?"

    "Agreed, but you better stop rubbing my cock or I'm going to cum in my pants. "

    "I wouldn't want to waste it there Daddy. After I found out you were using my panties to cum in, I would check them. If I found a recent stain, I would taste it. I love your scent and taste Daddy, but now I want fresh. She pulled her toes away and we left.

    In the truck, Dawn was doing everything she could to influence my decision. She opened her blouse and tempted me with her hard nipples that were showing through the sheer material of her bra. She slid her skirt up far enough, so I could just see the start of her panties. She would put one hand under her skirt and rub herself, while caressing her breasts with the other. She would moan with pleasure and say, "these could be your hands making me moan Daddy. "

    I was in agony as the miles went by. Hormones were winning out over reason. With a few miles to go, I knew I would turn off. I couldn't help myself. I wanted to fuck... and be sucked... by my stepdaughter so bad, I would risk everything. As the Clear Lake road came into view, the sun had just set. As I put my blinker on and slowed, Dawn screamed. She quickly slid over next to me and started kissing my neck and rubbing my cock with her hand.

    "You will never regret this Daddy. I will be yours anytime you want me. Oh... I love you so much! I never thought I would have you. I'm so happy, so excited. Hurry up and get this truck parked. "

    As she said that, she unzipped me and started sucking on my cock.

    I would cum soon. Dawn was doing a super job fondling my balls while she sucked my cock. As I put the truck into reverse to back into a secluded part of the park, Dawn stuck a finger up my ass and that's all it took. I hit the brakes, closed my eyes and filled my stepdaughters mouth with my cum.

    "Oh... fuck Sweetie, suck me, suck Daddy's hot cock. I'm cumming Sweetie, I'm cumming!" I pulled her head down on my spurting cock and Dawn swallowed most of it. What she missed she quickly licked up. When she finished, I finished parking the truck.

    "Did you enjoy the way I sucked your cock, Daddy?"

    "Oh... very much so Honey! That was the most explosive orgasm I can remember. "

    "I'm so happy Daddy, you tasted so... good. All you have to do is ask Daddy and I'll suck your cock anytime. I'm all yours. "

    Dawn then slid into my arms and we started kissing. The taste of my own cum was still in her mouth as our tongues met. I was stimulated by it's taste, which excited my cock and made it start to grow. As I caressed Dawn's breasts, she pulled my shirt over my head. She then unsnapped my pants, giving off a soft moan, as she noticed my now hard cock.

    "Lift up Daddy so I can get your pants off. "

    I obeyed and soon I was naked.

    "You have a great body for your age, Daddy. "

    I was 48 and did jog and bike, so I was in pretty good shape.

    "Thanks Honey! So do you. Now I want to see more of what I've been dreaming of for years. " I removed her blouse. Her tits sure looked hot in her sheer red bra. "I should tell you that your sexy lingerie really excites me Dawn. "

    "I know Daddy. That's why I wear them. Mom mentioned one time how you like them. "

    "You wear them just for me Honey?"

    "Not just for you Daddy. I love the look and feel of lingerie on me too. They make me feel sexy and naughty. "

    We started kissing again and this time I dropped my hand to her legs and started feeling my way upwards. As I neared her pussy, Dawn squeezed her legs shut, halting my assent.

    "I trust you Daddy, because I love you so much. Please don't hurt me?"

    "Never Honey. I love you too. Why would I hurt you?"

    Dawn opened her legs and as my hand continued, she pulled me to her and kissed me hard. I reached her panties and as I slid my fingers between her legs, expecting to find and massage her clit, I found a big clit in the shape of a hard cock. I broke off our kiss and gave Dawn a surprised look.

    "I'm sorry Daddy. I wanted you so... bad, I couldn't tell you. "

    Before Dawn could say anymore I pulled her to me and kissed her. I found myself very excited. I continued to rub her cock through her sexy panties.

    Before I go any further, let me tell you about my fascination with transsexuals. We got our very own PC a few years ago and while exploring the internet, I came across a site with shemales. The site of these beautiful, sexy woman with cocks excited me greatly. I found more and more sites and the more I looked, the more I fantasized. I wanted to experience loving one of these gorgeous transsexuals. I don't figure I'm gay, because the sight of a naked man doesn't excite me. But the sight of a hard cock on a beautiful woman makes me want to suck it.

    My fantasies were coming true.

    The feel of Dawns cock through her panties was really turning me on. It was doing wonders for Dawn too, as she was beginning to moan. "Will you suck my cock now, Daddy?"

    I slid Dawn over on the seat and removed her skirt. She looked so hot in her sexy red lingerie. The sight of her hard cock pressing against her panties was almost enough to make me cum again without touching it. I started to peel Dawns panties down and as I freed her cock, it sprang up. My cock is only about 6 1/2 inches and medium thickness. Dawns cock was a little smaller, but about the same thickness. An added turn on was, she was hairless.

    "Now Daddy, take me in your mouth and suck my cock. I want you to taste my cum. "

    I started by stroking her stiff cock. I've jacked off many times, so I knew what she would like. Next I lowered my mouth and began by licking and tasting some of her pre cum. Enjoying that, I opened my mouth and took Dawn's cock in. It was everything I thought it would be and more. I kept my mouth closed tight and while Dawn brought her hands to the back of my head and helped me by holding it steady, she slowly fucked my mouth. The feel of her cock sliding in and out of my mouth as I sucked it was driving me crazy. I used my tongue to tease the sensitive parts of Dawn's cock, which encouraged her moaning and talking dirty to me. "oh... yes, suck me Daddy, suck your little girls throbbing dick. That's it Daddy, lick the head, oh... don't stop. It feels so good. " I sucked, while she continued to slowly fuck my mouth. I was also caressing her tits and rubbing her legs and balls. I could sense my Honey was on the verge and so on I was rewarded with my first mouthful of cum.

    Dawn's body shook as she rammed her cock deep into my mouth, while holding my head screaming, "I'm cumming... Daddy!" I gagged a little, but swallowed most of Dawns seed. What I missed I licked up. I loved it. Her cum tasted so... good. It had a strong scent and was slightly salty.

    "Oh Daddy, you made me feel so... good and so... loved. "

    I raised up and kissed her. "I loved it too, Sweetheart. Your cock felt so good in my mouth and when you came, the warmth, the creaminess, the scent and taste of it made me want to drink it all down. "

    "Before we go, I want you to fuck me. I want to feel your cock up my ass when you cum Daddy. I've had many sexual objects up my ass, but I'm a virgin when it comes to a live dick. Be my first, Daddy?"

    "Anytime Sweetie. Your ass will be a first for me too. "

    Dawn reached into her purse a pulled out a bottle of jell. She put some into her hand and some into mine. "You get my ass ready, Daddy, while I get your cock ready to slide in. "

    I was so hard. Dawn's fingers felt so good as they readied my cock. I in turn used my finger's to lubricate her waiting ass. When all was in ready, Dawn got on her knees and offered her virgin ass to me. I got on my knees behind her and slid my cock to the entrance of her ass. Thank goodness there was plenty of room in the cab of this truck.

    "Now Daddy, slowly push in. "

    I did as I was told and slowly slid my cock into Dawn's waiting ass. It was tight, tighter then anything I've ever experienced with my cock. It was tight for Dawn too, but soon she relaxed her muscles and my cock slid in and out with more ease.

    "That's it, fuck my ass, Daddy. Oh... fuck me till you cum in me. I want to feel your hot cum in my ass. "

    "Your so tight Honey. I never felt anything so... good before. You may be spoiling me Sweetie. I may not want pussy again. " As my fucking grew more intense, I reached under Dawn and started to pump her now hard cock.

    "Oh Daddy, your hot cock sure feels better then the penis replicas I'm use to using. Keep fucking me Daddy and don't stop jacking me off. I want us to cum... together. "

    We were both close now. I could feel the cum in me about to explode into Dawn's ass. "I'm cumming sweetheart. I can't hold back any longer. " I shot my hot seed into my Stepdaughters accepting ass.

    "I'm cumming too Daddy" and her hot seed covered the seat of the truck. A waste I know, but this was my first time, forgive me.

    I continued to fuck her ass until my cock started to soften. I was disappointed to have to pull out, but I knew there would be many times to love Dawn. Dawn took out some towelettes from her purse and cleaned my cock. I wiped her ass clean.

    We did some more kissing and Dawn reassured me that she's mine whenever I wanted her. I also told her that I'm hers whenever she needed me. Then we dressed. Dawn threw on pants and sweatshirt for the ride home.

    Before we left Dawn said, "next time, I get your virgin ass, Daddy. "

    All I said to that was, "I hope it's soon Honey. "

    We talked on the way home and she told me how she came to be a pre-op transsexual.

    I asked her if she had any type of sexual experience before or was it strictly self pleasure.

    She told me of sex with a few of her girlfriends, but it was what she told me next that got me excited all over again. Her and her sister Anna have been having sex together for over 6 years now. They were sisters who were close and enjoyed pleasing each other. They also kept no secrets and Anna knew of her passion for me. Then she told me Anna found me sexy too and that someday, maybe, we could have a threesome.

    I told Dawn, "Someday Honey, but for now I want to love and enjoy you. You have so much to offer and I want to experience all of you. "

    My stepdaughter kissed me saying, "Anything you want Daddy. I Love You!"
    24455

  23. Age by Anonymous Coward · · Score: 0

    How long do sheep normally live?

    1. Re:Age by Anonymous Coward · · Score: 0

      How long do sheep normally live?

      10-12 years

  24. I'll show you by Anonymous Coward · · Score: 0

    what my prick has to do with (and to) a cloned sheep. Or a good-ole-fashioned home grown sheep as well. Hell a little lamb, and when I'm done I'll turn that slut Mary into a pincushion. I'll pump them all so full of air that you'll mistake them for a Macy's parade balloon, then flip em over and try to pop them!

  25. Life Imitating Art by TWX_the_Linux_Zealot · · Score: 3, Funny

    Remember, Blade Runner (and Do Androids Dream of Electric Sheep?) had such first...

    In fact, isn't it a bit ironic that a sheep is prematurely aging, versus the mechanical fake sheep (and title) in Philip K. Dick's novel?

    --

    IBM had PL/1, with syntax worse than JOSS,
    And everywhere the language went, it was a total loss...
    1. Re:Life Imitating Art by Anonymous Coward · · Score: 0

      Not really, no. But it was a nice try anyway, Alanis.

  26. raelian cloning by circletimessquare · · Score: 3, Funny

    this is good...

    i was all set to make believe i saw ufos so i could join up with the raelians. i don't know how long i could have maintained that lie. but since these are the only folks who will cut off the head of my clone and put my brain in his shell, what can a craven mortal do?

    since it looks like all this cloning stuff won't give me unlimited life yet, now i don't have to maintain the charade.

    i'm going to tell those raelians the truth and give them a piece of my mind!

    oh wait, er...

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
  27. That'll do sheep. by The+Salamander · · Score: 2

    That'll do.

    1. Re:That'll do sheep. by EvilTwinSkippy · · Score: 1

      (In the background we hear the tune of "Sheep may safely graze")

      --
      "Learning is not compulsory... neither is survival."
      --Dr.W.Edwards Deming
  28. Average lifespan for a sheep... by akiaki007 · · Score: 3, Interesting

    is 10-14 years. Dolly lived to be 6+.

    Not to draw any conclusions, but I don't think too many people will be taken back by this, unless of course you were one of the people who helped create Dolly and actually thought that she was completely normal.

    Despite the fact I am against cloning, I would like to find out more results to this. What would the avg. lifespan be if there were 100 Dolly's (and I suppose 1,000,000 failed attempts as well). It might be interesting to know, though somewhat dusgusting to get to.

    End result - this won't bode too well for cloning simply because Dolly developed this disease only half-way through her life. What will be much more interesting is to follow her child - I believe she gave birth to a female sheep in 1998 - 2 years after Dolly's birth.

    --
    "Time is long and life is short, so begin to live while you still can." -EV
    1. Re:Average lifespan for a sheep... by astrotek · · Score: 1

      The human birth rate is even lower if you take into account "attempts" every time a woman has a period a potential "life" is lost. Every time you beat off, millions of "lives" are lost. Whats your point if they fuck up while trying to make a clone? Thats what happens in humans, the baby aborts itself resulting in a miscarriage.

    2. Re:Average lifespan for a sheep... by frank_adrian314159 · · Score: 2, Insightful
      It might be interesting to know, though somewhat dusgusting to get to.

      Not to be trollish, but why? It's a frickin' sheep, for God's sake. It's not like it wasn't going to eaten or put into dog food at the end anyway, right? Same for a million of them (or their genetic material which could easily be thrown down a drain or allowed to decompose). It might be a huge amount of effort (with 1,000,000 trials), but how one gets from that to disgusting, I don't see. Don't tell me - you didn't grow up in a farming community, huh?

      --
      That is all.
    3. Re:Average lifespan for a sheep... by akiaki007 · · Score: 1

      The point is, their lost lives were embryo's, not semen or eggs. They were fully feeding embryo's.

      Abortion is the only thing that compares to that.

      --
      "Time is long and life is short, so begin to live while you still can." -EV
    4. Re:Average lifespan for a sheep... by akiaki007 · · Score: 1

      a million dead embry's from failed cloning attempts, in my mind is rather disgusting (goes with the idea that I personally am against cloning, because the entire concept to me is disgusting) - all the "it can be good for humanity" speeches need not be said.

      It's the idea of cloning that makes the 1 million dead bodies disgusting. I'm not particularly bothered by the 1 million dead animals - hey, that happens at the slaughter houses everyday anyway.

      --
      "Time is long and life is short, so begin to live while you still can." -EV
    5. Re:Average lifespan for a sheep... by Anonymous Coward · · Score: 0

      An attempt is not a life lost...to lose a life, a life has to be there in the first place. An egg or a sperm is not a big deal, lest you are a very strict catholic. A zygote is grey area, and a fetus is a human being by alot of people's definition.

      A miscarriage is a loss. That would count as a failed attempt, IMHO.

      Menstruating and spanking the monkey is not really much of a loss to most people. There was never a zygote or fetus to "lose".

      Now, just to get this off my chest - calm your ass down and start looking at it reasonably. Seriously...do ya have to throw in profanity? It REALLY makes you sound like an profound intellectual.

    6. Re:Average lifespan for a sheep... by bm_luethke · · Score: 1

      Well, the problem is that the "errors" would appear to, well, not be quite unpainfull. In the end it is still alive. While I personally beleive we have every right to eat them and use them (I hunt/fish and regulalry eat/wear parts of them, some medical research is also OK) we have a responsibility to be humane. If you can humanely clone the animal - go for it. If you can't there better be a REALLY good reason to submit an animal to torture.

      If you grew up in a farming community would you begin butchering the animal alive? beat it to death? at least the one I grew up in no, you tried to, as humanely as possible, kill the animal. While nature can, and is, very violent, we do not have to be. A croc can do no better than to try and eat a wildbeast alive, we are able to do better.

      --
      ------- Sorry about the spelling, I suffer from two problems. Dyslexia makes it difficult to spell well, lazy makes it
  29. A tribute to sheep by LordYUK · · Score: 1

    There was a man shipwrecked on an island with only his dog to keep him company. After weeks and weeks of being alone, he finally found some sheep grazing in a field. The man had once heard that if you fsck a sheep it sorta feels like a woman. Being desperate, he started towards the herd. His dog immediate runs up, barks, and they all run away. The man scolds the dog, and decides to try again the following day. Again, he finds the sheep, and as he approaches, his dog again barks and chases them all away. This time the man is really pissed, and kicks the stupid dog. The following day the man decides to try again, only this time when he gets to the field, there is a beautiful woman surrounded by a pack of wolves. Thinking quickly, the man grabs his dog by the tail and uses it as a club to beat off the wolves. Grateful, the woman offers to do anything he wants. Elated, the man replies "here, hold my dog"!

    =)

    (I have no idea where this joke came from)

    --
    This is my sig. Its pathetic.
    1. Re:A tribute to sheep by Anonymous Coward · · Score: 0

      That's one bad joke.

  30. GB2AOL by Anonymous Coward · · Score: 0
    > Should of dropped her in the dirt

    Should have. Should have.
    • SHOULD HAVE!1!
    Why are so many people unable to grasp even the simplest of grammar rules?
    1. Re:GB2AOL by TheDick · · Score: 1

      Because I'm trolling on SlashDot with a damn modified nursery rhyme?

      Could that be why?

      COULD IT?!?!?!

      --

    2. Re:GB2AOL by Anonymous Coward · · Score: 0

      No, I think it's more likely that you're just an ignorant dipshit.

    3. Re:GB2AOL by Anonymous Coward · · Score: 0

      Why are so many people unable to grasp even the simplest of grammar rules?

      Because they grew up in uneducated households, probable headed by a blue-collared father, if indeed a father was present at all. Not everyone has had the same opportunities as you or I to have learned cultured speech.

  31. Happy Valentine's Day, Nigs!! by Anonymous Coward · · Score: 0, Informative

    Death By A Thousand CLITs up in da hizzle, nizzle -- fuck all y'all hataz

    I've been through two marriages in the past. My first wife died at an early age of 29 from a massive heart attack and my second marriage was a nightmare from hell, that I'm now free of. When I met Jeanie, I knew I had to take it slow and easy.

    Jeanie was a very nice lady in her early 40's. I myself was a few years older. Jeanie had two lovely girls. I had no children. I grew to love Jeanie and her girls and a few years later we were married.

    When I met Jeanie, one of her girls was a senior in high school. Anna was six months from graduation. She was good a good looking, bright student, but very spoiled. We got along fine and a few years after Jeanie and I were wed, Anna started calling me Dad.

    Jeanie's other daughter was living with her Dad some 1200 miles away. I didn't get to meet her till a few weeks before the wedding. When I met Dawn, I knew she was the free spirit of the family. Dawn was 4 years older then Anna, more mature and for sure, sexier. I'll have to be honest and admit that she did catch my eye and stirred reactions in my loins. She was a flirter and over time she did cause me to jack off thinking of her, many times.

    When Anna graduated from High school, Dawn moved back home that summer. Her and Anna were going to go to college in the fall. The school was a few hundred miles away and they would room together. It was during that summer that my lust for Dawn sprouted.

    I have a job that gives me the summers off. Jeanie worked days and so did Anna. Dawn was a bartender, so it meant she was home during the days with me. I didn't know if Dawn was actually showing off for me, or if that was who she was and how she acted. I was naive, so I decided it was for my benefit. She did dress more provocative when we were alone, then when others were around. Dawn was a beautiful girl. Her long curly reddish hair would swirl around her shoulders and shine in the light. The color of her hair also brought out her green eyes. Eyes that could rule me. Her lips were full and I fantasized many times about having them wrapped around my aching cock. Dawn was about 5'6" and I would guess under weight for her height. Her long legs, hips and breasts combined to makeup a very sexy body. I know I was married to her Mom, but this vixen was turning me on and I was wasting good cum into a Kleenex. It was a long... hot... exciting... summer.

    Fall came and we moved the girls into there dorm room. Anna and Dawn were grateful for my help. Both girls hugged me, but Dawn's hug was more. It was done when Jeanie and Anna had left the dorm room and was very seductive. She hugged and squeezed me like she was saying goodbye to a lover. Her warm, sexy body made my cock grow hard instantly as she pressed against me. She gave me a kiss on the cheek and a very wicked smile as she backed up and said, "Thanks Daddy!"

    Over the 4 years they were away at school, the flirting grew and became more intense. I, as Dawn's Stepdad, should of put a stop to it, but I couldn't, or wouldn't. I enjoyed it and even encouraged it. I was excited that a beautiful, young, sexy girl would find me attractive enough to want to flirt with me and perhaps want more?

    Dawn had no serious relationships during her college years. I assumed it was because she worked and studied hard. She was a smart girl and carried an "A" average. Dawn planned to pursue her education by going after her Masters Degree.

    Anna had a boyfriend and planned to move with him to Lansing, MI. Jeanie and I helped her move in June, soon after graduation. Dawn stayed in the apartment they had shared until Aug. , when she put her stuff in storage and went to find a place to stay in the new town her school was in. She found a nice 1 bedroom apartment. Dawn then came home and we made plans to move her. We rented a Ryder truck, got a ride to her stored stuff, then proceeded to load up.

    When we were finished and before we ate and left town, Dawn wanted to shower at her friends house. She said, "please Daddy, I feel so sweaty. "

    What could I do. I'd do anything for her.

    I took a short walk while I waited and when I returned Dawn was just coming out of her friends place. She looked like she was going to a party. All made up and dressed to kill. I couldn't figure out what was going on and I also didn't care. My cock was growing and by the time I got to her, it was at full hardness.

    "I can see your happy to see me Daddy! I hope the wait wasn't to long for you?" Dawn added.

    I tried to stop my eyes from ogling her body, but I couldn't. She was wearing a black silk blouse, knee length skirt with nylon stockings. Her lips were a soft shade of red and she smelled fantastic. I had never seen this side of my stepdaughter before. Oh don't get me wrong. I've seen her dressed up before and looking nice, but today she was more then that. She had this mature sexiness about her. Let's face it, she was downright gorgeous. It was going to be a long ride home, or was it?

    "No Honey, it wasn't, but why are you all dressed up?" I asked.

    "We are going to stop to eat and I wanted to look nice for you Daddy. Are you upset?" she asked.

    "Oh no Honey, I'm not upset. You look beautiful, but now I feel grubby. " I answered.

    "You look great to me Daddy, but if you want to freshen up, you can use my friends washroom. "

    "That would be a great idea Sweetie. I do smell. "

    I went in and took a quick shower. I had a clean shirt, but that was it. I left my underwear off as I slipped my pants back on. I felt better, but my cock was still slightly hard and aching. It was time to go.

    I got into the truck as Dawn said goodbye to her friend. I kept my eyes on my stepdaughter. I couldn't help myself. As Dawn was getting into the truck, her skirt hiked up showing me more of herself. I could see where her stockings ended and the red straps of what I assumed was a garter, holding them up. Her blouse also seemed to have a few more buttons undone then before. That allowed me to see that her bra was also red. I had found out earlier that Dawn loved to wear sexy lingerie. That's because, I've used her soiled panties many times to jack off.

    "All set Daddy, lets go. I'm starving!"

    "Me too Honey, " I said.

    To myself I was thinking, Me too Honey, but for you, not food.

    As we got out of the truck at the supper club, Dawn held my hand as we walked in. Feeling no resistance, she said to me, "I love you Daddy!"

    "I love you too, Honey!"

    The club wasn't very busy and we got a somewhat secluded booth. I was driving, so it was coffee for me. Dawn had a wine. Again I marveled at how beautiful she was, especially in the glow of candle light. We ordered, then Dawn said, "I have something to tell you Daddy and I don't want you to butt in till I'm done. "

    "Since I've met you Daddy, you have been more of a Father to me and Anna, then our real Dad. You are more caring, more loving and helpful. You don't criticize our decisions, instead you support them, right or wrong. You never judge us and only love us for whom we are. For what I'm going to say next, I'll need all these things from you, Daddy. " She paused then continued, "I want you to make love to me tonight, Daddy. I've wanted you for a long time now. I love you. "

    "I love you too Honey, but it would not be right. I know it wouldn't be incest, but what about your Mother? Could we handle this?"

    "I know it would be hard Daddy, but I want you so bad, that I'm ready to deal with it. I know you want me. I've seen the bulges in your pants and I've seen the cum stains in my panties. You can't deny it?"

    "No honey, I can't, I do want you, but flirting and fantasizing are one thing. To act on those feelings are another. "

    Our food came then. We continued to talk as we ate. After we were finished, Dawn laid her cards on the table.

    "You know where the Clear Lake roadside park is don't you. "

    "Yes, I know. "

    As she continued, her toes started to rub my aching cock. "We could pull off there and act like we were tired and getting some rest. It's hardly used anyways. It'll be up to you Daddy. If you want me, just pull in and all I have is yours for the taking. If you pass it by, I'll try to never put you in this position again. You'll have about 45 min. till we get there to decide. Agreed?"

    "Agreed, but you better stop rubbing my cock or I'm going to cum in my pants. "

    "I wouldn't want to waste it there Daddy. After I found out you were using my panties to cum in, I would check them. If I found a recent stain, I would taste it. I love your scent and taste Daddy, but now I want fresh. She pulled her toes away and we left.

    In the truck, Dawn was doing everything she could to influence my decision. She opened her blouse and tempted me with her hard nipples that were showing through the sheer material of her bra. She slid her skirt up far enough, so I could just see the start of her panties. She would put one hand under her skirt and rub herself, while caressing her breasts with the other. She would moan with pleasure and say, "these could be your hands making me moan Daddy. "

    I was in agony as the miles went by. Hormones were winning out over reason. With a few miles to go, I knew I would turn off. I couldn't help myself. I wanted to fuck... and be sucked... by my stepdaughter so bad, I would risk everything. As the Clear Lake road came into view, the sun had just set. As I put my blinker on and slowed, Dawn screamed. She quickly slid over next to me and started kissing my neck and rubbing my cock with her hand.

    "You will never regret this Daddy. I will be yours anytime you want me. Oh... I love you so much! I never thought I would have you. I'm so happy, so excited. Hurry up and get this truck parked. "

    As she said that, she unzipped me and started sucking on my cock.

    I would cum soon. Dawn was doing a super job fondling my balls while she sucked my cock. As I put the truck into reverse to back into a secluded part of the park, Dawn stuck a finger up my ass and that's all it took. I hit the brakes, closed my eyes and filled my stepdaughters mouth with my cum.

    "Oh... fuck Sweetie, suck me, suck Daddy's hot cock. I'm cumming Sweetie, I'm cumming!" I pulled her head down on my spurting cock and Dawn swallowed most of it. What she missed she quickly licked up. When she finished, I finished parking the truck.

    "Did you enjoy the way I sucked your cock, Daddy?"

    "Oh... very much so Honey! That was the most explosive orgasm I can remember. "

    "I'm so happy Daddy, you tasted so... good. All you have to do is ask Daddy and I'll suck your cock anytime. I'm all yours. "

    Dawn then slid into my arms and we started kissing. The taste of my own cum was still in her mouth as our tongues met. I was stimulated by it's taste, which excited my cock and made it start to grow. As I caressed Dawn's breasts, she pulled my shirt over my head. She then unsnapped my pants, giving off a soft moan, as she noticed my now hard cock.

    "Lift up Daddy so I can get your pants off. "

    I obeyed and soon I was naked.

    "You have a great body for your age, Daddy. "

    I was 48 and did jog and bike, so I was in pretty good shape.

    "Thanks Honey! So do you. Now I want to see more of what I've been dreaming of for years. " I removed her blouse. Her tits sure looked hot in her sheer red bra. "I should tell you that your sexy lingerie really excites me Dawn. "

    "I know Daddy. That's why I wear them. Mom mentioned one time how you like them. "

    "You wear them just for me Honey?"

    "Not just for you Daddy. I love the look and feel of lingerie on me too. They make me feel sexy and naughty. "

    We started kissing again and this time I dropped my hand to her legs and started feeling my way upwards. As I neared her pussy, Dawn squeezed her legs shut, halting my assent.

    "I trust you Daddy, because I love you so much. Please don't hurt me?"

    "Never Honey. I love you too. Why would I hurt you?"

    Dawn opened her legs and as my hand continued, she pulled me to her and kissed me hard. I reached her panties and as I slid my fingers between her legs, expecting to find and massage her clit, I found a big clit in the shape of a hard cock. I broke off our kiss and gave Dawn a surprised look.

    "I'm sorry Daddy. I wanted you so... bad, I couldn't tell you. "

    Before Dawn could say anymore I pulled her to me and kissed her. I found myself very excited. I continued to rub her cock through her sexy panties.

    Before I go any further, let me tell you about my fascination with transsexuals. We got our very own PC a few years ago and while exploring the internet, I came across a site with shemales. The site of these beautiful, sexy woman with cocks excited me greatly. I found more and more sites and the more I looked, the more I fantasized. I wanted to experience loving one of these gorgeous transsexuals. I don't figure I'm gay, because the sight of a naked man doesn't excite me. But the sight of a hard cock on a beautiful woman makes me want to suck it.

    My fantasies were coming true.

    The feel of Dawns cock through her panties was really turning me on. It was doing wonders for Dawn too, as she was beginning to moan. "Will you suck my cock now, Daddy?"

    I slid Dawn over on the seat and removed her skirt. She looked so hot in her sexy red lingerie. The sight of her hard cock pressing against her panties was almost enough to make me cum again without touching it. I started to peel Dawns panties down and as I freed her cock, it sprang up. My cock is only about 6 1/2 inches and medium thickness. Dawns cock was a little smaller, but about the same thickness. An added turn on was, she was hairless.

    "Now Daddy, take me in your mouth and suck my cock. I want you to taste my cum. "

    I started by stroking her stiff cock. I've jacked off many times, so I knew what she would like. Next I lowered my mouth and began by licking and tasting some of her pre cum. Enjoying that, I opened my mouth and took Dawn's cock in. It was everything I thought it would be and more. I kept my mouth closed tight and while Dawn brought her hands to the back of my head and helped me by holding it steady, she slowly fucked my mouth. The feel of her cock sliding in and out of my mouth as I sucked it was driving me crazy. I used my tongue to tease the sensitive parts of Dawn's cock, which encouraged her moaning and talking dirty to me. "oh... yes, suck me Daddy, suck your little girls throbbing dick. That's it Daddy, lick the head, oh... don't stop. It feels so good. " I sucked, while she continued to slowly fuck my mouth. I was also caressing her tits and rubbing her legs and balls. I could sense my Honey was on the verge and so on I was rewarded with my first mouthful of cum.

    Dawn's body shook as she rammed her cock deep into my mouth, while holding my head screaming, "I'm cumming... Daddy!" I gagged a little, but swallowed most of Dawns seed. What I missed I licked up. I loved it. Her cum tasted so... good. It had a strong scent and was slightly salty.

    "Oh Daddy, you made me feel so... good and so... loved. "

    I raised up and kissed her. "I loved it too, Sweetheart. Your cock felt so good in my mouth and when you came, the warmth, the creaminess, the scent and taste of it made me want to drink it all down. "

    "Before we go, I want you to fuck me. I want to feel your cock up my ass when you cum Daddy. I've had many sexual objects up my ass, but I'm a virgin when it comes to a live dick. Be my first, Daddy?"

    "Anytime Sweetie. Your ass will be a first for me too. "

    Dawn reached into her purse a pulled out a bottle of jell. She put some into her hand and some into mine. "You get my ass ready, Daddy, while I get your cock ready to slide in. "

    I was so hard. Dawn's fingers felt so good as they readied my cock. I in turn used my finger's to lubricate her waiting ass. When all was in ready, Dawn got on her knees and offered her virgin ass to me. I got on my knees behind her and slid my cock to the entrance of her ass. Thank goodness there was plenty of room in the cab of this truck.

    "Now Daddy, slowly push in. "

    I did as I was told and slowly slid my cock into Dawn's waiting ass. It was tight, tighter then anything I've ever experienced with my cock. It was tight for Dawn too, but soon she relaxed her muscles and my cock slid in and out with more ease.

    "That's it, fuck my ass, Daddy. Oh... fuck me till you cum in me. I want to feel your hot cum in my ass. "

    "Your so tight Honey. I never felt anything so... good before. You may be spoiling me Sweetie. I may not want pussy again. " As my fucking grew more intense, I reached under Dawn and started to pump her now hard cock.

    "Oh Daddy, your hot cock sure feels better then the penis replicas I'm use to using. Keep fucking me Daddy and don't stop jacking me off. I want us to cum... together. "

    We were both close now. I could feel the cum in me about to explode into Dawn's ass. "I'm cumming sweetheart. I can't hold back any longer. " I shot my hot seed into my Stepdaughters accepting ass.

    "I'm cumming too Daddy" and her hot seed covered the seat of the truck. A waste I know, but this was my first time, forgive me.

    I continued to fuck her ass until my cock started to soften. I was disappointed to have to pull out, but I knew there would be many times to love Dawn. Dawn took out some towelettes from her purse and cleaned my cock. I wiped her ass clean.

    We did some more kissing and Dawn reassured me that she's mine whenever I wanted her. I also told her that I'm hers whenever she needed me. Then we dressed. Dawn threw on pants and sweatshirt for the ride home.

    Before we left Dawn said, "next time, I get your virgin ass, Daddy. "

    All I said to that was, "I hope it's soon Honey. "

    We talked on the way home and she told me how she came to be a pre-op transsexual.

    I asked her if she had any type of sexual experience before or was it strictly self pleasure.

    She told me of sex with a few of her girlfriends, but it was what she told me next that got me excited all over again. Her and her sister Anna have been having sex together for over 6 years now. They were sisters who were close and enjoyed pleasing each other. They also kept no secrets and Anna knew of her passion for me. Then she told me Anna found me sexy too and that someday, maybe, we could have a threesome.

    I told Dawn, "Someday Honey, but for now I want to love and enjoy you. You have so much to offer and I want to experience all of you. "

    My stepdaughter kissed me saying, "Anything you want Daddy. I Love You!"
    9936

  32. DAMMIT TACO! by Anonymous Coward · · Score: 0
    This story is a DOOP!

    errrr... no it's not, sorry!

  33. So they couldn't resist by VEGx · · Score: 1

    ...and ate the sheep! :(

  34. I Know She'll Be Missed by 680x0 · · Score: 1

    Sheep are very loving animals. As someone who's raised a few, I can tell you they are wonderful animals to have around. A lot of work, though, especially if you aren't used to farmwork.

    1. Re:I Know She'll Be Missed by Flakeloaf · · Score: 3, Funny

      Sheep are very loving animals.

      Aye son, ye cannae deny tha'.

      --

      Am I the only one who heard Roxette to sing "I'm gonna get blitzed for some sex"?

    2. Re:I Know She'll Be Missed by Cruciform · · Score: 1

      I thought shepherds were very loving animals...

      Ooooooooh!

    3. Re:I Know She'll Be Missed by BeeShoo · · Score: 2, Insightful

      "Sheep are very loving animals"

      Are you sure you don't want to rephrase that a bit? ;-)

    4. Re:I Know She'll Be Missed by bm_luethke · · Score: 1

      You know the sad thing? I pictured a dwarf smoking a pipe saying that and then wondered "why would a dwarf say that?".

      --
      ------- Sorry about the spelling, I suffer from two problems. Dyslexia makes it difficult to spell well, lazy makes it
  35. Bladerunner by theCat · · Score: 3, Insightful

    Many of you will recall that replicants had 4 years to live. It was built-in and they knew it and hated it.

    I hate it when life immitates art, because some of our art is strange and the really good stuff is damn creepy. Dolly was cloned from a mature sheep, and the theory goes that she basically picked up where her...parent?...left off on the aging timeline. But that's not going to stop many wanna-be immortalists. So when some 80 y.o. geezer elects to have himself cloned the "new" baby will have the genetic signiture of an octagenarian, and probably 10 years to live a life of pain and senility.

    This stuff sucks, people. You don't have to be a flaiming Bible thumper or a neoLuddite to be freaking out about Dolly. I think about how giddy everyone is about their personal fsckig immortality and my skin crawls.

    Eat well, exercise, love someone with all your heart, have a good time. Have lots of great sex and leave a few really smart, well-adjusted children. Then go off and FUCKING DIE! OK? Just die and leave this earth to the next generation, born in the usual way with their own chance to live their own life their way, as nature had intended. Please!

    --
    =^..^= all your rodent are belong to us
    1. Re:Bladerunner by dissy · · Score: 1, Redundant

      > as nature had intended

      Just had to comment.

      If nature didnt intend for something to happen, it would not be possible.

      Things like the laws of physics are 'as nature intended' since they can not be broken.

      I would argue the speed of light is another, but as even that is questionable lets leave it be for now.

      Nature by definition is "The material world and its phenomena."
      http://dictionary.reference.com/searc h?q=nature

      This means, if something is able to happen, it instantly is catagorized as natural.

      Cloning is natural. It happens, it (mostly) works. It doesnt fully work as we want it to, but either a) give us time, or b) it is indeed unnatural and you dont have to be the one to worry about it being impossible or not.

      I cant communicate enough my anger at people who claim this and that is unnatural.

      If its unnatural really, it isnt gunna happen in any way, and there is nothing to worry about.

      If it is happening right now, _in nature_, it is clearly _natural_.

      Please do not confuse "The material world and its phenomena" with "The material world and its phenomena as long as a human had nothing to do with it"

      Humans are part of nature, and thus by extention anything we do is of natures doing.

      Lets try to be a little more careful about our choices of words, mmmkay?

      (Sorry for the rant, and I dont intend for this to sound like a personal attack. You just happened to be the straw on this camels back for the day) :)

    2. Re:Bladerunner by Anonymous Coward · · Score: 0

      Humans are part of nature, and thus by extention anything we do is of natures doing.


      Cool, that means we can wage war, murder, rape, plunder, enslave, and exploit.

      I am not trying to start a flame war. You may want to redefine/tweak your logic.

      Enjoy,

    3. Re:Bladerunner by Anonymous Coward · · Score: 1, Interesting

      Just because we CAN do something doesn't mean that we SHOULD. I think that there are certain levels of morality that we as humans (and current stewards of Earth) must pay heed to. Cloning in and of itself is not a bad thing. Cloning of organs for human transplants is one aspect of this science that I am particularly for. This can reduce human suffering immeasurably. However, attempting to clone an entire being is at best a dangerous undertaking for which our scientific, religious, political, and legal communities are completely unprepared.

      Your statement that "Cloning is natural. It happens, it (mostly) works. It doesnt fully work as we want it to, but either a) give us time, or b) it is indeed unnatural and you dont have to be the one to worry about it being impossible or not." is so far off the mark as to be quite comical. You seem to have confused the natural act of replication via sexual means with replication via asexual means, yet you then state that it is also unnatural and that we shouldn't worry about it.

      Replicating via natural means as you state is natural. Replication by any other means is simply getting nature's way and a recipe for disaster. Hell, how can we as a human race undertake to create life when we can't even support the lives of other members of our race? I think that cloning a human is the most selfish act man could ever conceive. Nature thrives on diversity, which I think you would agree is natural. Cloning is an act of similarity, which I think you would have the wisdom to see as something unnatural in the scheme of things.

    4. Re:Bladerunner by theCat · · Score: 1

      I choose my words with considerable care. Cellular nuclei moving from mature adult mammalian somatic cells into unfertilized egg cells that have no nuclei of their own is not natural, it is in fact impossible without medical science and a lot of failures in the process, and your pseudo religious nonsense about the manifest destiny of humanity doesn't make it less so.

      As for what nature "intends", nature intends (in a Darwinian kind of way) for us to reproduce with variation as it is the invention of novelty and not the promulgation of one genetic line that moves us forward. If our way was some other then we might be aphids and be born already pregnant with clones. For us, sexual union is good, birth is a new expression of chance, and death is part of life. The stuff in between is simply what you make of it.

      There is a difference between fantasy and reality, regarding which we seem to have finally lost our grip. And in case you hadn't been paying attention, it is the reality of what we do that becomes history and shapes the future.

      --
      =^..^= all your rodent are belong to us
    5. Re:Bladerunner by unspecified+poltroon · · Score: 1

      4 : the physical constitution or drives of an organism; especially : an excretory organ or function -- used in phrases like the call of nature http://www.m-w.com

    6. Re:Bladerunner by dissy · · Score: 2, Insightful

      Sigh, you totally missed my point.

      > Cellular nuclei moving from mature adult mammalian
      > somatic cells into unfertilized egg cells that
      > have no nuclei of their own is not natural, it is
      > in fact impossible without medical science

      You are correct.
      It is impossible without medical science.
      Fortunatly medical science is very possible.
      This means anything coming FROM medical science is also possible, and thus natural.

      Nature is the container of all that we are in.
      By the very fact cloning happens, means its playing by the rules of nature.

      Just because it requires a human to do it is totally irrelivent.

      Humans happen in nature too, thus we are possible (Fortunatly no one has argued that one yet)
      Thus, anything we (being of nature) do, is natural as well.

      I also find it funny you claim what i say is "pseudo religious nonsense" when in fact its most religons that argue the same point you are making, while science argues the point I am making.

    7. Re:Bladerunner by osgeek · · Score: 1

      it is in fact impossible without medical science

      Yeah, and it's impossible in humans unless you have a male and a female get together... so what? Is it the technology that troubles you? If I have to fly to Europe to conceive a baby with some baby, is that baby "unnatural" because it wouldn't have happened without technology?

      If man does it, it's natural.

    8. Re:Bladerunner by James+Lewis · · Score: 1

      I hear this "nature" arguement all the time and to be honest it really isn't very convincing. I mean basically your arguement is, "This is the way things are, so this is how they should be". Think of all the things that you enjoy, of all the ways your life has been improved, made more enjoyable, and LONGER because people weren't content with the way things are. For better or worse humanity will never be content with the way things are and will always strive to make every aspect of their lives, including the lengths of those lives, better. I think it is quite obvious that we are either going to wipe ourselves out or live forever to spread amung the stars. Anyone sitting around whinning about it will just be pushed to the side, just as people like them have always been pushed to the side. At the vert least we will outlive you.

    9. Re:Bladerunner by DunbarTheInept · · Score: 1
      His point can be better explained thusly:
      • If a plant grows a poisonous surface on it's leaves, and traps flies on this surface by snapping closed when they land on it, we call that natural.
      • If an animal of the mammal kingdom with big buck teeth and a wide flat tail alters his world by chewing down trees and building a dam, we call that natural.
      • If a moslty hairless ape with an enlarged brain begins reproducing in a new manner, we don't call that natural.

      Why the difference? We *are* nature.
      --

      Don't label something "offtopic" unless you know the topic well enough to tell what's on topic.

    10. Re:Bladerunner by Cyno · · Score: 1

      The difference is, and almost everyone agrees, Humans have a soul, a consciousness, that is capable of interacting with nature in very unnatural ways. Our ability to reason, use logic and take action, changing our environment and the objects around us goes far beyond any other naturally occuring lifeform, that we know of. Because of this we are blessed with the complexities of religion, divinity, etc. We think we're perfect because we're no longer a part of nature, no longer governed by its rules. However, we are still a part the natural order of the universe. As we explore the space outside our planet we learn more and more that we're not divine, we're not perfect. We're just another animal on a big rock, clinging onto it for our very survival.

      But we are different.

      I don't think you can say any action done by man could be naturally occuring. We are the observer of nature, not a participant, not for a long time, anyway.

    11. Re:Bladerunner by Cyno · · Score: 1

      Then tell me, what other animal is self aware and capable of learning more than one language? The soul is simply our ability to be creative, to be conscious, and to be self aware. Or how about show me an animal able to apply force to an object in any of the 3 dimensions at will. Or how about an animal that can design or build an engine, or even understand how or why it works. Show me one of those, then you might be on to something.

      Personally I think intelligent life exists out there, somewhere, but we may never find them. Are we even serious about the search? I don't care. There are many species on Earth that are extremely intelligent, but they all fall short of being able to use that intelligence as humans did by forming civilizations and using communication, social status and many other complex concepts to structure and organize itself into something capable of producing microchips and understanding its environment. A single human is not capable of doing this on their own. But what gives us this self awareness or ability to organize into civilization like we have? Or why do we create? Is that the soul? If not, then what is it?

      I'm an atheist, btw.

    12. Re:Bladerunner by drinkypoo · · Score: 1
      What does the soul have to do with science? It as yet has not been proven. The closest science has come to measuring the soul has been the idea that humans actually do have an aura of sorts, we are surrounded by a cloud of water vapor and we generate an extremely weak EM field.

      Also there is nothing which is most easily explained by the existence of a soul. As such it is most probable that there is simply no such thing. It is most likely that consciousness is an illusion; we go to sleep, and our brains do random things. If our memories changed when we slept, we would be an entirely different person because we are the sum of our experiences plus a body.

      We are different from other animals because we evolved to have a more complicated brain. Clever animals' curiosity is sometimes rewarded and that means that the behavior is self-reinforcing. We happen to have a well-developed brain in part because we were lucky, and in part because we used it.

      So whether or not you think the soul exists and/or it is responsible for our ability to be more destructive than other animals (I don't think it's fair to attribute a soul to mankind but not to other living creatures, by the way. So narrow-minded. where do you draw the line?) it is unnecessary to explain it and thus is silly to even mention.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    13. Re:Bladerunner by the+gnat · · Score: 1

      So when some 80 y.o. geezer elects to have himself cloned the "new" baby will have the genetic signiture of an octagenarian

      But it won't be the same person. You won't get real immortality this way, the way the bad guy does in the Schwarzenegger pic "The Sixth Day". Perhaps you could make your genetic material last perpetually, but this is just stupid.

      Rael was on MSNBC talking about exactly this type of thing, and I was so pissed I threw my remote across the room. There's just no basis in biology for any of that crap.

    14. Re:Bladerunner by SecurityGuy · · Score: 1

      I cant communicate enough my anger at people who claim this and that is unnatural.


      I can't understand why you let it bother you. It's only natural for them to make such a claim.


      You might look into getting a bigger camel.

    15. Re:Bladerunner by Anonymous Coward · · Score: 0

      Anyone sitting around whinning about it will just be pushed to the side, just as people like them have always been pushed to the side. At the very least we will outlive you.

      I doubt it. I think history has shown that the people shouting out against new technologies before they have practical aplication to their lives are usually pretty quick to take advantage of them once they do.

    16. Re:Bladerunner by Reziac · · Score: 1

      Just a good example of how early attempts at any new technology usually don't work very well. But you won't ever REACH any more-refined or more-reliable techniques unless you're willing to try those early, and often doomed, experiments. Then learn from them and try again.

      Hell, look at the earliest airplanes. They were downright scary by any standards, and even at best crashed early and often. Does that mean we should have given up all attempts to fly??

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    17. Re:Bladerunner by lastberserker · · Score: 2, Funny
      You see, your logic doesn't hold water. Here is why, I would not say better:
      Man had always assumed that he was more intelligent than dolphins because he had achieved so much... the wheel, New York, wars, and so on, whilst all the dolphins had ever done was muck about in the water having a good time. But conversely the dolphins believed themselves to be more intelligent than man for precisely the same reasons.
      -- Douglas Adams
      --
      My other Beowulf cluster is... er...
    18. Re:Bladerunner by lastberserker · · Score: 1

      Sorry, I replied to your parent, please, read one level up ~:-)

      --
      My other Beowulf cluster is... er...
    19. Re:Bladerunner by Anonymous Coward · · Score: 0

      I think history has shown that the people shouting out against new technologies before they have practical aplication to their lives are usually pretty quick to take advantage of them once they do.

      Heh heh:

      ZEALOT: This (INSERT NEW TECHNOLOGY HERE) is EEEEEVIL! It should be BANNED! Think of the CHILDREN!

      SCIENTEST: But it'll give you a life span of 500 years and a schlong as long as your arm.

      ZEALOT: Uh. . .well, actually, it's important to keep an open mind about these things. Where do I sign up for this again?

    20. Re:Bladerunner by sjames · · Score: 2, Insightful

      The difference is, and almost everyone agrees, Humans have a soul, a consciousness, that is capable of interacting with nature in very unnatural ways.

      The conversation is now leaving science and entering natural philosophy or religeon.

      Continuing from that point, we cannot know the 'intent' of an anthropomorphised nature. Who is to say that the entire purpose of Darwinian evolution wasn't to create a species that was capable of directing further improvements intelligently? It may even be that the entire purpose of the human race is to create a machine race capable of directing it's own evolution ever more intelligently. Or perhaps to become that machine race itself.

    21. Re:Bladerunner by sjames · · Score: 1

      Cool, that means we can wage war, murder, rape, plunder, enslave, and exploit.

      That is only true if you believe that natural == good in all cases. Destruction from natural disaster is (by definition) natural, but few consider it wrong to try to minimise it, or consider it right that it does happen.

  36. Hello everyone! by YourMissionForToday · · Score: 0, Insightful

    Most noble thr0d ps1t, I must salute you and all the wonderful people who make Valentine's Day so special.

    All you love bunnies out there, come and visit My Journal.

  37. Re:"Linus Torvalds": Absurd Liberal Myth by Anonymous Coward · · Score: 0

    Too long, didn't read.

  38. CLONE HAIKU TIME!!!! by Bastian · · Score: 1

    I am a sad clone.
    Why do people hate me so?
    I am human too.

    The sheep was useful,
    but reporters stopped coming.
    Then we got hungry.

    Millions of dollars
    of research grants is a lot
    to spend for haggis.

    The girl is not her
    mom, The scientists, just baked
    Scientologists.

    1. Re:CLONE HAIKU TIME!!!! by fudgefactor7 · · Score: 1

      Dolly the sheep died,
      Now we investigate why,
      May she(ep) rest in peace.

      This lame haiku brought to you by bordom and the numbers 5, 7, and 5...

    2. Re:CLONE HAIKU TIME!!!! by Blob+Pet · · Score: 1

      Oh, give me a clone
      Of my own flesh and bone
      With its Y chromosome changed to X
      And When it is grown
      Then my little clone
      Will be of the opposite sex

      Clone, clone of my own,
      With its Y chromosome changed to X
      And when I'm alone
      With my little clone
      We will both think of nothing but sex.

      ---Issac Asimov

      --
      "...today consumers have been conditioned to think of beer when they see a bullfrog..."
    3. Re:CLONE HAIKU TIME!!!! by Anonymous Coward · · Score: 0

      That certainly is an interesting way to masturbate.

  39. What speculation? by tuxlove · · Score: 1, Insightful

    While one should be cautious about drawing conclusions from a single data point, its interesting to speculate.

    No speculation required. As you age, your DNA deteriorates, no questions asked. If you take that aged DNA and put it into an embryo, when it develops you'll have an organism with a young body and an old roadmap for building it. It's going to exhibit any number of symptoms of old age.

    It's agreed by anyone with any credibility on the subject that you would have to grab the DNA of a newborn infant to have any chance of creating a clone that's not going to be screwed up this way.

    1. Re:What speculation? by p3d0 · · Score: 2, Insightful
      Ok, so as long as you're not doing any speculating, then how does regular reproduction work? Re-read everything you just wrote and imagine you're talking about normal sexual reproduction. From that point of view, it's simply 100% incorrect.

      Clearly there's more to genetics than you know.

      --
      Patrick Doyle
      I mod down every jackass who puts his moderation policy in his sig. Oh, wait a sec....
    2. Re:What speculation? by tuxlove · · Score: 1

      Ok, so as long as you're not doing any speculating, then how does regular reproduction work? Re-read everything you just wrote and imagine you're talking about normal sexual reproduction. From that point of view, it's simply 100% incorrect.

      First of all, the mother's egg contains half of a child's DNA. The eggs are present in the mother's ovary at the time of her birth, and do not replicate. That genetic information isn't subject to replication error and hence doesn't "age". In other words, a female baby is born with all of the eggs she'll ever have, and they already contain the genetic material they need to create a baby.

      As for the father's sperm, I have no idea how the DNA in sperm is not "aged" like the father's own DNA. I'm certainly not an expert in that area, but I don't have to know *why* it's that way; I only need to know that it is, which I do happen to know. But the fact remains, the father's and mother's gametes both contain "young" genetic material. When they fuse, the zygote has a full complement of "young" genetic material for a brand new baby.

      Clearly there's more to genetics than you know.

      You're not one of those Raelian nutcakes who claim they've solved the problem of cloning a baby from old DNA, are you?

      There's more to genetics than anybody knows. I have a degree in biology, but don't claim to be an expert. I have taken advanced courses in developmental biology and various areas of genetics, so I think I grasp the general issues here fairly well. My beliefs are based on the research of the more credible scientists, though it's certainly not unknown for scientists to err. However, I think it's unlikely that anyone will ever disprove that DNA from an older person/animal is unsuitable for cloning.

    3. Re:What speculation? by Anonymous Coward · · Score: 0

      First of all, the mother's egg contains half of a child's DNA. The eggs are present in the mother's ovary at the time of her birth, and do not replicate. That genetic information isn't subject to replication error and hence doesn't "age".


      It is obviously subject to replication error since the mother started life as a single fertilized egg, yet is born with a lifetime's supply of eggs.

      The error rate must be a lot lower for the generation-to-generation replication of this material than it is for replication of other cells within your body within your lifetime. But "a lot lower" != 0.
    4. Re:What speculation? by p3d0 · · Score: 1
      As for the father's sperm, I have no idea how the DNA in sperm is not "aged" like the father's own DNA. I'm certainly not an expert in that area, but I don't have to know *why* it's that way; I only need to know that it is, which I do happen to know.
      It is what? Not aged? Ok, so let's consider how that happened. The testicles' DNA must age, and clearly they are capable of producing "young" DNA for sperm anyway, so again I say there's more to the story than your simplistic "old/young DNA" dichotomy.

      (Or, if you want to claim that testicles' DNA doesn't age, then why not clone babies from testicle cells?)

      Clearly there's more to genetics than you know.
      You're not one of those Raelian nutcakes who claim they've solved the problem of cloning a baby from old DNA, are you?
      I'm not claiming I know anything about cloning. I probably know less than you do. I'm just claiming that you don't know enough to say cloning is impossible. Your argument from your first post doesn't hold water, because if that argument were sufficient, then it would also rule out sexual reproduction.

      You are speculating. There's nothing wrong with that, unless of course you try to claim that you are not speculating.

      --
      Patrick Doyle
      I mod down every jackass who puts his moderation policy in his sig. Oh, wait a sec....
    5. Re:What speculation? by tuxlove · · Score: 1

      The testicles' DNA must age, and clearly they are capable of producing "young" DNA for sperm anyway...I'm just claiming that you don't know enough to say cloning is impossible.

      I never said it's impossible. It's just not possible to take DNA that is frought with replication errors and expect to create a clone that doesn't have those. Read up on replicative senescence and then come back and see if you still disagree. How "old" testicles produce sperm with "new" DNA is unknown to me. Perhaps it has something to do with telomerase repair. This is actually a hot area of research, because there is good reason to believe that somehow applying telomerase to repair aging DNA may extend an organism's lifespan. It could also have implications for using "old" DNA for truly successful cloning. But certainly, without repairing "old" DNA before using it to create a clone, something nobody yet knows how to do, you're going to get an imperfect copy of the original organism as of the time of its birth; an imperfect copy that, while still young, will suffer from whatever age-related effects one might expect from replicative senescence.

    6. Re:What speculation? by tuxlove · · Score: 1

      The error rate must be a lot lower for the generation-to-generation replication of this material than it is for replication of other cells within your body within your lifetime. But "a lot lower" != 0.

      Well, okay, if you want to be nitpicky about it, you may be correct. But clearly, whatever errors occur in the creation of the mother's eggs is somehow compensated for, or after N generations all eggs produced by all mothers would suffer from replicative senescence. Not being an expert on this, I can't say exactly how this is managed, but clearly it is or we'd be extinct. That's not to say that mutations caused by replication are necessarily "fixed" in the process (that's actually an important part of evolution), but the DNA's ability to replicate is maintained across generations by a process I am not privy to. I don't actually know if anyone knows how it works. Regardless, whatever process takes place does not take place in the mother's own cells or there would be no replicative senescence, a process we know to exist. Which is why cloning an adult is so problematic.

  40. Dolly this week, Matilda last week by hpulley · · Score: 2, Informative

    More than one data point. Dolly is actually the second cloned sheep to die in a week. Matilda, a cloned sheep born in the year 2000 in Australia died last week. Autopsy results were inconclusive. Matilda's passing.

    --
    $#!^ happens, but why does it always have to happen to me???
  41. Sad news, Dolly the Sheep dead at 6 by Anonymous Coward · · Score: 2, Funny

    I just heard some sad news on talk radio - the cutting edge cloned mammal Dolly was found dead in her Maine home this morning. There weren't any details. I'm sure we'll all miss her, even if you weren't a fan of her creators' work there's no denying her contribution to popular culture. Truly an American icon.

  42. Clarification on telomeres/telomerase by Anonymous Coward · · Score: 0

    Telomeres are THE yardstick by which to measure a a cell's reproductive potential. Past a particular threshold, cells will go into senescence (non-dividing) states. The majority of cancer cell lines will overexpress/overregulate telomerase, which is responsible for maintining telomere length. This effectively gives them immortality, in cell culture terms (the ability to divide indefinitely).

    To give a little background, telomeres are the end of the DNA. Their entire purpose is to shield the main coding sequences from getting cut off. The ends of our chromosomes are cut off during each replication of DNA because of an inherent "flaw" in the machinery. Because DNA synthesis requires a primer (usually of RNA, which is then excised after replication), and is unidirectional, you will always be unable to copy the very beginning. Telomeres provide the primer for the "beginning" sequences, which allows for those regions to get copied. This unfortunately results in a progressive shortening of the telomeres.

    Now, in a clone - imagine that you started from a cell already halfway through its telomeres. If you didn't have the forsight to somehow relengthen them, you would be effectively aging the early cells. My speculation is that each length of telomeres triggeres specific age-related genes/effects, and that by starting at a lower length you are turning these on early. I am sure that this is the same conclusion these guys have reached.

    Thought this might be useful for the non-bio part of the /. crowd :)

  43. *Not* Carol Channing? by island_earth · · Score: 1, Funny

    Whew. For a second there, I misunderstood that headline. What a relief. Although she is getting on in years... Who2 Profile

  44. The important thing is... by ah.clem · · Score: 2, Insightful

    ... that she existed at all. Without this research no one would have known that this was an issue with cloning. Imagine how much more we as humans would know if *all* research was unfettered by government regulation and/or religious superstition.

    --
    "Life is not magic." Dr. Ron Weiss - "If we don't play God, who will?" Dr. James Watson
    1. Re:The important thing is... by meehawl · · Score: 1

      Imagine how much more we as humans would know if *all* research was unfettered by government regulation and/or religious superstition.

      Yeah right on. There are a few people who agree with you. Enjoy the company.

      --

      Da Blog
    2. Re:The important thing is... by jericho4.0 · · Score: 1

      Nice comeback.

      --
      "A language that doesn't affect the way you think about programming, is not worth knowing" - Alan Perlis
    3. Re:The important thing is... by jcr · · Score: 1

      Regarding your citations: your analogy is Bullshit. Atrocitites committed by governments is not a counterargument to someone arguing for freedom to conduct research.

      -jcr

      --
      The only title of honor that a tyrant can grant is "Enemy of the State."
    4. Re:The important thing is... by meehawl · · Score: 1

      Atrocitites committed by governments is not a counterargument to someone arguing for freedom to conduct research.

      Government by written constitution or by an unwritten agreement between individuated supernerds that THERE SHOULD BE NO LIMITS is still government. Remember kids, government is the complex of political institutions, laws, and customs through which the function of governing is carried out. Nobody said it had to be Big Government... tiny anarcho-syndicalist research-oriented communes are just as capable of governing their members, and of influencing them towards atrocities, as "typical" Western Nation State top-down Big Governments.

      --

      Da Blog
    5. Re:The important thing is... by Strigiform · · Score: 1

      I think Mike was saying that groups other than governments are also capable of being involved in atrocities. If you look specifically at the eugenics movement, it was a (relatively) popular movement that managed to influence policy in several parts of the world.

      Such groups can influence others via offering help (e.g. funding) or threatening to remove resources (e.g. cutting off funding, denying access to a laboratory or library).

  45. And who is next? by TheVidiot · · Score: 0

    Mini-Me?

    Better hope the next sequel is already filmed!

  46. 'burry' or 'curry'? by sczimme · · Score: 2, Funny


    [homer]
    Mmmmm... la-a-amb... *drool*
    [/homer]

    Sorry - I don't know how to spell the 'raaghchchgh' Homer makes at drool time. D'oh.

    (Yes, I know 'bury' was misspelled, but 'cury' just wouldn't have worked.)

    --
    I want to drag this out as long as possible. Bring me my protractor.
  47. DNA Aging, DNA Rejuvenating? by PizzaFace · · Score: 5, Insightful

    If mature animals have "old" DNA, how do their offspring get "young" DNA?

    I think of DNA aging as a process of random decay over time, but somehow my old DNA and my wife's old DNA can produce a baby with young DNA.

    Does the combination of DNA during sexual reproduction clean up the strands from the parents? Or is something going on in their gonads to clean up their old DNA before packing it into gametes?

    There's a biological process here that I haven't heard anyone describe, or even identify. And yes, I want to patent it.

    1. Re:DNA Aging, DNA Rejuvenating? by shellac · · Score: 2, Informative

      Found here:

      Telomeres are found on the ends of chromosomes. They are a small sequence of DNA repeated many times. They act as protective "caps" and help to prevent chromosomal instability and damage. However the telomeres gradually shorten over the lifetime of the organism because they are not fully copied during cell division. The exception to this are germ-line cells, where telomeres are maintained so that full-length telomeres are passed on to the next generation.

      Pretty interesting.... I didn't know that myself. Anyhow, don't thank me, thank google.

    2. Re:DNA Aging, DNA Rejuvenating? by Anonymous Coward · · Score: 0

      This is exactly what I wonder too. I don't get how, even if the DNA packaged in the reproductive cells ages very little over time, the human race could survive for so long. There must be something 'cleaning up' the DNA before packaging into reproductive cells.

    3. Re:DNA Aging, DNA Rejuvenating? by PizzaFace · · Score: 1

      Thanks, Google, for saving me the fee of a patent lawyer.

    4. Re:DNA Aging, DNA Rejuvenating? by TheWhaleShark · · Score: 2, Informative

      Well, it's because your gametes produce "young" DNA.

      I'm sure everyone knows that the male and female gametes each produce one half of the genetic material of a single organism. The genetic material produced by the gametes is brand new; it hasn't aged yet, so the telomeres on the individual DNA strands are still intact. They recombine during fertilization and make a fresh, "young" copy of a complete DNA sequence.

      --
      "It never got weird enough for me." - HST (RIP)
    5. Re:DNA Aging, DNA Rejuvenating? by imnoteddy · · Score: 2, Insightful
      Your wife's old DNA does not produce a baby.

      DNA from her eggs makes a baby.

      All of the cells that develop into eggs are created in the
      fetus, and then wait until puberty to develop into eggs.

      --
      No electrons were harmed creating this post, though some may have been subjected to electrical and/or magnetic fields.
    6. Re:DNA Aging, DNA Rejuvenating? by AEC216 · · Score: 1

      Actually you are pretty on to it. Sex is the ultimate act of genetic healing. Say your deck of cards is missing a few 4's and queens. You meet a nice lady that decides to mate your 'cards' , Sex will refill & reshuffle the deck. (Plus you may have a few cards of the different brand now too.)

      --
      May I please have my frontal lobotomy if I bring back the ashtrays?
    7. Re:DNA Aging, DNA Rejuvenating? by Some+Dumbass... · · Score: 3, Funny

      There's a biological process here that I haven't heard anyone describe, or even identify. And yes, I want to patent it.

      Patent a biological process involved in sexual reproduction?

      Can you say "prior art"? :) :) :) :) :)

    8. Re:DNA Aging, DNA Rejuvenating? by INeedWeed · · Score: 0

      Google sucks. I don't wanna say tahnaks to google. It's not very useful anymore. Two years ago I found whatever I wanted with Google.

      Besides this, Google is just playing monopoly like M$. Or is anyone using a different one?

    9. Re:DNA Aging, DNA Rejuvenating? by Tablizer · · Score: 1

      Patent a biological process involved in sexual reproduction?

      Hell no! Hookers will then have to charge more to cover royalty payments.

    10. Re:DNA Aging, DNA Rejuvenating? by Tablizer · · Score: 2, Informative

      This is exactly what I wonder too. I don't get how, even if the DNA packaged in the reproductive cells ages very little over time, the human race could survive for so long. There must be something 'cleaning up' the DNA before packaging into reproductive cells.

      It is Darwinian evolution. If your reproductive cells go bad, you simply don't reproduce effectively and the messed up genetics cease to continue. (Except on rare occassions the "mistakes" may be beneficial.)

    11. Re:DNA Aging, DNA Rejuvenating? by liverkill · · Score: 2, Informative
      'DNA Aging' is nothing more than progressive telomeric shortening which is counteracted in the germ line by the action of telomerase. In the case of dolly, when she was 2 her telomeres were observed to be 80% of the length of a 'normal' sheep of that age. Not a massive difference, and not something which satisfactoraly explains her early death.

      The most important thing to remember about the production of gametes is that they are produced by germ-line cells. Mutation is a way of life and an important evoloutionary mechanism, indeed, mutation is utilised during gamete formation (through events such as Unequal Sister Chromatid Exchange) to create a unique arrangement of genes. There is therefore no need or desire by the species to 'clean up' the dna from these muations.

      In fact the lack of a mechanism for dealing with convertion of a methylated Cytosine to Thyamine has been one of the key facts which has been used to detect genes in eukaryotes - CpG islands are found with all the major housekeeping genes and ~40% of the tissue specific genes.

      so in short, there is no 'clean up' (known) of the dna in the germ line, there is however a stabilisation of telomeric length (acheved through the action of telomerase) at the higher end of the 5-20kb range, which is now being rapidly charicterised.

    12. Re:DNA Aging, DNA Rejuvenating? by Anonymous Coward · · Score: 0

      Each cell contains a "timer", telling the age of the whole organism. When this "timer" gets near to a certain value, it begins the autodestruction sequence. This autodestruction is obtained via the desintegration of DNA in each cell (parts of the DNA actually get loose). This may create some age-specific diseases or the so-called "Natural Death".

      When the genes combine to create a new organism, that "timer" is reset to 0.

      Theoretically, the body can produce and replace every cell (as recently proved, even neurons), so the immortality would be possible.

      The generation succession is Mother Nature's (or God's :-) way to ensure evolution.

    13. Re:DNA Aging, DNA Rejuvenating? by Duds · · Score: 1

      Could you demonstrate this prior art? ;)

    14. Re:DNA Aging, DNA Rejuvenating? by Anonymous Coward · · Score: 0

      Hookers are trying to avoid sexual reproduction as much as they can.

      Ever heard about a whore who gets a child every nine months? Didn't think so.

  48. Time to die by ColGraff · · Score: 4, Funny

    Baa, baa, baa!

    TRANSLATION:

    I've seen things you people wouldn't believe. Lab rats examined by laboratory technicians. I watched hay pour into my trough like a golden rain of food. All those moments will be lost in time, like tears in rain. Time to die. Oh, and uh, it's painful to live in fear, isn't it?

    --
    I'm the stranger...posting to /.
    1. Re:Time to die by moominpapa · · Score: 1

      Wish I had mod points to mod this up!

  49. Quit wasting time cloning! by ispepalocacoc · · Score: 2, Funny


    This may just be my opinion, but instead of wasting time cloning animals, scientists should be figuring out how to transplant brains into robotic bodies. Being able to live forever as a cyborg is far more important to me then having a clone of myself which will just grow old and pathetic.

    --
    I Love Alberta Beef
    1. Re:Quit wasting time cloning! by Anonymous Coward · · Score: 0

      Wouldn't it be better if they could transplant your brain into a clone of your body.

    2. Re:Quit wasting time cloning! by EvilTwinSkippy · · Score: 1
      Amen to that.

      Actually, who needs a body? Upload your psyche to a supercomputer and exist as a digital agent. It's a lot more scaleable. It could be like a digital afterlife, only your decendents can drop by and say "hi", and "where did you bury the treasure Grandpa?"

      Plus you could give agents a pretty good network connection, not to mention they could converse with all of the other people already uploaded to the system.

      When mankind travels to the stars, you could tarball your soul and ship it over FTP.

      Damn, that sounds like a concept for a Science Fiction novel, if it hasn't been done already.

      --
      "Learning is not compulsory... neither is survival."
      --Dr.W.Edwards Deming
    3. Re:Quit wasting time cloning! by Anonymous Coward · · Score: 0

      I don't understand why this was marked funny. It is a very viable and possible idea. And, if immortality is to be reached by use measly humans, I think that transfering ourselves into a digital format is the only way to do it. Biological life will always eventually die. Creating a perfect body is impossible.

    4. Re:Quit wasting time cloning! by HuguesT · · Score: 1

      Some people think consciousness requires quantum effects (read R. Penrose `the emperor's new mind') and that though processes are essentially non-computable phenomena.

      If this is true you'll have to wait until the advent of the quantum computer to envisage this transfer as a possibility. This is still a very distant proposition.

  50. And... by Anonymous Coward · · Score: 0

    I just have one thing to say :

    Man, don't try to play God. There is NO substitute.

  51. Which One Is The Clone? +1, Patriotic by Anonymous Coward · · Score: 0


    Mini-Me or The Moron

    Thanks in advance,
    W00t

  52. re: Goodbye, Dolly by bogie · · Score: 1

    I'd wager most /.ers don't even get that joke.

    --
    If you wanna get rich, you know that payback is a bitch
  53. No. by Eric_Cartman_South_P · · Score: 4, Funny
    Anti-cloning zealots are going to have a ball with this.

    No. They are going to have mint jelly with this.

  54. Forgive me by Sexy+Commando · · Score: 1

    In Soviet Russia, Sheep Clones YOU.

    1. Re:Forgive me by Anonymous Coward · · Score: 0

      In Soviet Russia, YOU are a sheep.

      Read Animal Farm by George Orwell for further details.

  55. I Agree With This Post! by Anonymous Coward · · Score: 0

    Truly an inspirational troll, sir! I think I'll go home now and eat some genetically engineered pork.

  56. And nothing funnier than ... by burgburgburg · · Score: 2, Funny
    a parent having to bury a clown.

    A little song, a little dance
    A little seltzer down the pants!

  57. Mods, this post seems to have been cloned! by Anonymous Coward · · Score: 0

    n/t

  58. On the euthinasia by theblacksun · · Score: 1

    A single case study means nothing. There are endless variables unaccounted for. Any anti-cloning people who use this example as an arguement should try deducing both sides of a quarter from a single coin flip.

    --
    Ignorance kills, complacency kills, hatred kills, but usually not the ones guilty of them.
    1. Re:On the euthinasia by Anonymous Coward · · Score: 0

      I can rephrase your statement to say the same thing for the opposite side.

      "A single case study means nothing. There are endless variables unaccounted for. Any pro-cloning people who use this example as an argument should try deducing both sides of a quarter from a single coin flip."

      So really inferring anything from dolly Pro or Con to cloning is hogwash ( or sheepwash in this case) .

  59. I hope... by 10Ghz · · Score: 1

    ...They remembered to make backup-copies.

    --
    Lesbian Nazi Hookers Abducted by UFOs and Forced Into Weight Loss Programs - -all next week on Town Talk.
    1. Re:I hope... by TaoTeCheese · · Score: 2, Funny

      They can't. That would be a violation of the DMCA.

  60. single DATUM point by kaltkalt · · Score: 0

    ..."drawing conclusions from a single data point" 'Data' is plural; the singular is 'datum' (I love being a dickhead)

    --

    Stupid people make stupid things profitable.
  61. Re:OT by Bastian · · Score: 2, Insightful

    I agree that a lot of veggie groups are nuts. . .

    but I agree with the McDonald's lawsuit. I'm veggie, and think that McDonald's attempted to decieve vegetarian customers. McDonald's had changed their ingredients list for their friench fries so that any mention of animal products was replaced by 'natural flavors' while leaving the beef products in. A lot of vegetarians and people who don't eat beef for religious reasons were duped into thinking that McDonald's fries were now safe to eat.

    I think it's fair for McDonald's to be sensitive to such things.

  62. Dear Dr. Fuck by Anonymous Coward · · Score: 0

    Dear Dr. Fuck,

    I really like this girl at work, but she doesn't seem to notice me. I'm a fecophiliac, so I thought it would be nice to leave a present for her on her desk. I even stuck a little sweet heart note and some candy in it, but she hasn't come running into my shit-covered arms. What should I do?

  63. yeah right by mondoterrifico · · Score: 1

    "While one should be cautious about drawing conclusions from a single data point, its interesting to speculate."
    This IS slashdot, isn't it? :P

    1. Re:yeah right by Anonymous Coward · · Score: 0

      No, this is not slashdot. Slashdot is a proper noun! You damn Linux zealot. Or is that GNU/Linux you freak?!

      [/ironic]

  64. Incept Date by rwiedower · · Score: 3, Interesting

    Wait a minute...I'm an identical twin who is 24. Does this mean that I should look forward to Carousel soon? Or that I should start harvesting my clone's organ farm...?

  65. What about humans flight by Anonymous Coward · · Score: 0

    If nature had intended for Man to fly, he would have been born with airline tickets!

  66. Obligatory Simpsons reference by Santos+L.+Halper · · Score: 1

    No, the best thing about cloning is being able to clone endless copies of Scratchy and send each copy into an auto-killing machine.

    --

    "Ask not for whom the bone bones. It bones for thee." --Bender
  67. Scotland Surrenders by NickFusion · · Score: 1

    I'm sure the Scots will be surprised to hear the sheep they cloned is an American icon.

    But hey guys...you can keep the haggis!

    --
    What were you expecting?
  68. Re:OT by Anonymous Coward · · Score: 0

    Normall I would argue that veggies are a bunch of nutcases anyway, but in this case you can't count on them to reveal everything in their food. They do reserve the right to say "natural flavors". Just like a hot dog can say "100% beef" and it will be. Beef entrails, hooves, snouts, all all sorts of other things that are beef that I wouldn't otherwise eat.

    If you NEED to know everything that that goes into what you eat, you'd better make it yourself.

  69. Re: Goodbye, Dolly by filmsmith · · Score: 2, Funny

    Hello, Obscurity!

  70. Mint Jelly Anyone? by Anonymous Coward · · Score: 0

    If you eat a cloned sheep, do you have the feeling that you've eaten it before?

  71. Sheep Farmer Says... by cburley · · Score: 1
    --
    Practice random senselessness and act kind of beautiful.
  72. Heaven? by Anonymous Coward · · Score: 0

    Do souless sheep go to heaven?

  73. Not unhappy... by Zelet · · Score: 1

    I know this is a science site - but I can't help but be happy that this clone had complications. I would like to see the end to full animal cloning. I think genetic engineering and posilby growing human organs in other creatures is a wonderful science but full animal cloning has nothing more to offer and borders on unethical. Hopefully there will be enought set backs that scientists wont risk the complications on human tests.

    --
    ...And when they came for me, there was no one left to speak out for me." - Martin Niemoeller (1892-1984)
    1. Re:Not unhappy... by OwlofCreamCheese · · Score: 1

      yeah, lets never try and learn anything that might be scary! who cares about progress!

      --
      -You're wasting your time. Alfador only likes me.
    2. Re:Not unhappy... by Anonymous Coward · · Score: 0

      I am sure the fuhrer would just love this sort of progress! Cloning to create his perfect race!

  74. I propose a new addage by filmsmith · · Score: 1

    In order to clone a human, you have to kill a few sheep.

  75. So Long Dolly by HedRat · · Score: 1

    I'll never forget the run in I had with Dolly. It could have been ugly but I went to court and it reduced to "Following Too Close".

  76. Mod parent *GROAN* by nlinecomputers · · Score: 1

    We've got to get more MOD items to choose from...

    --
    Slashdot, home of supporters of free software, free music, and free speech.Except for Moderators that disagree with you.
  77. Release Dolly's Source Code by Anonymous Coward · · Score: 0

    Now that Dolly is dead I wonder if the scientific community will release her source code to the public?

  78. Re:OT by Anonymous Coward · · Score: 0

    And grow it yourself, too. Anything you buy at most stores is likely to have stuff in it that you didn't plan on eating...

  79. What about the problems with Genetic Engineering? by NigelJohnstone · · Score: 3, Interesting

    What about the risk with Genetic Engineering?

    A genetic engineer takes a gene sequence, millions of bases long, changes a few and observes the results.

    Imagine a hacker, taking a 10MB binary, disembling it by hand, randomly tinkering with a few bytes here and there, then looking for effects when they run it. Would you consider that app bug free?

    if anything the hacker has an advantage, we can't write a DNA person, but we can write a machine code program.

    Dolly's problems appeared in the first generation clone. But if no problems were observed after only a few generations of breeding from dolly it would have been declared safe.

    In nature though, the changes are slow and small and the testing much much longer, and even then whole species become extinct when some weakness become apparent.

    I reckon GE is a much bigger risk than cloning.

  80. "The light that burns twice as brightly... by TelevisioSledgicus · · Score: 1

    burns only half as long, and you have burned so very very brightly Roy." Speculation about two bodies sharing the same "soul" "spirit" (what-have-you) have been touched upon only in the various pieces of fiction until now. Did the Dolly clone use up some of Dolly's time on earth? Did the Dolly clone just meet her natural life expectancy, since she was pre-destined for a short life...just the luck of the draw this time around? Simply another lab screw-up in the long list of screwups by the boys in white playing "God"? Or was it a secret sect of the Vatican Secret Police that infiltrated and sabotaged the project? Or ... ?? Or maybe it's just the beginning of a cheap food source, mutton anyone?

  81. Re:What about the problems with Genetic Engineerin by docwardo · · Score: 1

    random mutations may be engineered when looking at a protein, but there is very little that is done in a random fashion with genetic engineering. they know what a section of DNA does they then replace that with the dna that does something different.

    It's hardly random.

  82. Re:"Dolly the Sheep": Absurd Liberal Myth by jsin · · Score: 1

    You forgot to add "I'm a fucking moron".

  83. Obligatory Seinfeld quote. by Stonent1 · · Score: 1

    MMMM. Gyro...

  84. Attack of the Dollys by Kaz+Riprock · · Score: 1


    I've heard that some genetic researchers are attempting to develop methods which would either extend the telomeres or in some other way give a normal aging process to the cloned animals.

    If we're to build an army of warriors capable of taking down the Trade Federation, IIRC, we *need* the premature aging so that they are ready to fight in time.

    --
    Mordor...a magical, mythical land where women are more rare than dragons--but where every man would rather find a dragon
  85. Telomeres and their relation to mitosis by fernd1 · · Score: 2, Interesting

    Ok, so every cell in your body goes through a process called mitosis. What Scientists have been doing so far is rip the nucleus out of a fertilized egg and replace it with the nucleus of a cell for the subject that is to be cloned. Well, as it may turn out, that cell has already gone the process of mitosis a number of times and each time its Telomeres(the end strands of DNA on a Chromosome) shorten. The funny thing is, all biological organisms have a way of repoducing already. In higher level organisms, such as mammals, this process is called meosis. Now every organism has number of chromosomes. Each chromosome comes with a homologous pair. When meosis takes place these pairs split in two. The thing about meosis is that we already know that the telomores are intact and don't cause premature aging. So instead of replacing the nucleus of a fertilized egg, why don't we take advantage of the process of meosis and with artifical insemination techinics, cause the subject to produce multiple eggs. The probobility that one set of the pair will end up in specific egg is 50:50. So if you have the subject produce multiple eggs, then it is quite likely that you will end up with an egg with one set of the pair and an egg with the other set. You take DNA from the egg with the other set, and you insert it into a sperm. Of course you would have to replicate it a number of times to have a successful insemination , but that wouldn't be anything we couldn't overcome with modern technology.

    1. Re:Telomeres and their relation to mitosis by GreyPoopon · · Score: 1
      So instead of replacing the nucleus of a fertilized egg, why don't we take advantage of the process of meosis and with artifical insemination techinics, cause the subject to produce multiple eggs.

      First off, the only cells that undergo meiosis in the human body are the sperm cells and ova. [Again, biology expert correct me if I'm wrong] What you are advocating is just a variation of insemination, except that I think you're proposing to either use two ova or two sperm cells to generate the viable offspring. The most important thing to note is that this isn't cloning. Cloning aims at making a genetic duplicate of the original. The process of meiosis, by design, produces haploid chromosome sets that are *not* identical, neither to each other, nor to the diploid chromosomes of the origin-cells. By using the technique you describe, you might end up with a product that was closer to the original, but definitely not identical. As I read your text more closely, it looks like you're attempting to compensate for this by choosing two of the products of meiosis such that a recombined product would have the same genetic makeup of the original. I'm not sure if this would work because I'm not sure if meiosis actually yields "parts" that could be combined in this manner. To further complicate things, the meiosis process in ova does not actually complete the final division until the egg is penetrated by a sperm, so your technique would be difficult. Perhaps something could be done to the egg that would convince it that it has been penetrated by sperm so that it completes meiosis. This is an interesting thread, though. I'd like to see what others have to say.

      --

      GreyPoopon
      --
      Why is it I can write insightful comments but can't come up with a clever signature?

    2. Re:Telomeres and their relation to mitosis by Anonymous Coward · · Score: 0

      Actually it sounds like what you propose would be pretty much impossible with "modern" technology. Keep in mind that this is an area of science where the forefront of genetic technology consists of soaking a bullet with wet DNA and firing it at some other DNA. It's not what you'd call subtle or even clever. It just barely works.

    3. Re:Telomeres and their relation to mitosis by Forgotten · · Score: 1

      Meiosis yields entire unpaired chromosomes that are (semi-)randomly reassembled from the organism's pair of that chromosome. The input chromosomes are unzipped and chopped up into bits, floated around shuffled, then put back together. A LOT of the output chromosomes will be nonviable (but estimates vary, and there may be mechanisms that protect certain genes).

      So no, you don't get the "original" chromosomes back. And this is really pretty much the point of sexual reproduction - remember that for this to have developed, asexual reproduction (cloning!) was already a solved problem. Considering the enormous cost (the movie tickets alone!) of sexual reproduction to organisms, the benefits have to be pretty incredible - and indeed they're all around you. It's sobering to note that this is the step cloning seeks to skip.

    4. Re:Telomeres and their relation to mitosis by fernd1 · · Score: 1

      The chopping to bits that you describe is called recombination or cross over. It is when the two chromosomes of a pair cross over and are recombined at the spot where the crossed over. This does happen quite often, but under an ideal situation, it doesn't. I am sure that there is some way to limit the recombination process. With that in mind, we could, perhaps as technology advances, initiate an artifical meosis process. One in which we control all of the variables. Then all we have to do is select the haploid chromosomes that are identical, and place them in their respective sex cells, one in the egg and one in the sperm, and then let nature take over. The result would be a genetically identical zygote, that when it reaches maturity won't have the telomere problem.

    5. Re:Telomeres and their relation to mitosis by Forgotten · · Score: 1

      It is when the two chromosomes of a pair cross over and are recombined at the spot where the crossed over. This does happen quite often, but under an ideal situation, it doesn't.

      Well, what I'm saying is that under an ideal situation, it does happen. Mixing and matching alleles is really the entire purpose of sexual reproduction and meiosis. It's going to be hard to remove that characteristic from a system that's entirely designed around the pursuit of it. And you're correct, I did oversimplify in the initial post - it's not really random at all but actually selects genes and their alleles to swap. In other words it's not just complex but directed, and the direction is exactly away from cloning.

      Then all we have to do is select the haploid chromosomes that are identical[...]

      (laugh) I'm sorry but to me this reads sort of like "then all we have to do is construct a living sheep from spare parts found in any kitchen!". It's a pretty tall order to do what you suggest. Modern gene recombinative work is almost unbelievably crude, and we're decades away from being able to do what you suggest. For perspective, consider that there already modern attempts to harness meiosis, in the form of modern IVF - but it still has about a 10-20% chance of conceiving even a normal meiotic embryo, let alone one that's been monkeyed with. The natural mechanisms to do this stuff work sublimely well (though they also discard many failures) - our attempts aren't even at the stone-tools level yet by comparison.

      This is also why I simultaneously fear GMO work and don't worry about it too much. On the one hand viable results are so rare that the chances of creating a monster are slim. On the other, if someone does manage to make some frankenzygote that takes off, it'll have been created without the checks and balances that have necessarily evolved into natural meiotic recombination, but might still take advantage of life's resilience and self propagation to spread far and wide. In many ways that scenario is the worst-case outcome of a success in the methods you describe.

    6. Re:Telomeres and their relation to mitosis by fernd1 · · Score: 1

      "then all we have to do is construct a living sheep from spare parts found in any kitchen!".

      I realize that current technology is probably not capable of this; however, technology is always advancing. All I am advocating is to look into alternate solutions. The fact that we can clone at all with our current technology is very impressive. But, we need to be looking forward, and trying new things. There might be a chance that our current technology causes premature aging. Your attitude is intolerant (laugh) I am sorry, but if this discussion was 10 years ago, then you would be on the side saying that cloning would never happen. There are two things that can be done to improve our ability to clone.

      A. Improve our current techniques, i.e. better initial techniques, or Telomere treatment (suggested to be on the horizon)

      B. Scratch our current techniques and start a new.

      All I am advocating is an open mind and to try something fresh.

  86. I am lost... by LinuxMacWin · · Score: 1, Interesting

    Either you are religious and hence you don't care about cloning.

    Or you are an atheist. You might clone a person just like you, but it is you who still gets sick, grows old and eventually dies. You do not get to enjoy that body and everything that goes with it. So how does it matter you got a clone? Is it just the satisfaction of creating a person just like you? But isn't most (not all) of the procreation because of religious reasons!

  87. Clarification (cont'd) by Brown+Eggs · · Score: 2, Interesting

    The cells that produce the gametes are "immortalized" cells, constantly producing telomerase (see my Anonymous post a little further up regarding immortalized cells). Because of this, there offspring (the gametes) have the proper telomere length, minus maybe one generation's length. So the sexual reproduction iteself has really no bearing on it, though many of the early cells during development do express telomerase (otherwise you may have cells by the time that you get to your fingertips or other extremeties that are really old! :P) Hope this give a little more clarification on why old parents don't necessarily have "old" DNA in their gametes.

  88. And a moment of silence was observed by drew_kime · · Score: 1

    Throughout New Zealand, Wales and West Virginia.

    --
    Nope, no sig
  89. BladeRunner Quote: by DJ+FirBee · · Score: 1

    What ? Aren't their Nerds here. Where is the BladeRunner quote or the Blade Runner joke or whatever ?

    What are you waiting for ?

    Please ??

    This is farging rediculous.

  90. What happens... by ATMAvatar · · Score: 1

    ...if Microsoft owns the cyborg industry and your body BSODs?

    --
    "They that can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety."
  91. WOOOOHOOO!!! by Dolemite_the_Wiz · · Score: 1

    Haggis for everyone!!!!

    Let's eat!!!

    Dolemite

    --
    Save the World! Use a Quote!
  92. Re:What about the problems with Genetic Engineerin by ATMAvatar · · Score: 1

    Imagine a hacker, taking a 10MB binary, disembling it by hand, randomly tinkering with a few bytes here and there, then looking for effects when they run it. Would you consider that app bug free? Now imagine 1 million hackers, taking 10MB binaries that are all slightly different, and communicating back and forth to see what the trends are between code differences and functional differences. Get them all to tinker with the programs, and... does this sound familiar yet?

    --
    "They that can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety."
  93. No official announcement on Dolly's website by Zerbey · · Score: 1

    It's interesting to note, that although most of the major news sites have picked up on this, no announcement has been put on the "official" site. That's just not right.

    I wonder if Dolly ever knew how important she was? I wonder what her view on all the excitement she generated would be?

  94. Obviously a sign by jforr · · Score: 1

    From our alien master creators that we should kill more sheep and eat lamb chops.

  95. does anybody know if Dolly got laid in her life? by lingqi · · Score: 2, Interesting

    It's actually a pretty important question, if you think about it, not even on the "at least give the sheep what it might want" sort of way. few examples:

    * does cloned animals retain "normal" sexual apetite? (i.e. would a cloned panda be more, or possibly even less willing to fuck than the one's we've got right now?)

    * If dolly does suffer from premature aging, would her offspring suffer the same thing? how would the offspring from a cloned animal be compared to an offspring of the source animal? (with the same "father," let's say)

    --

    My life in the land of the rising sun.

  96. Goodbye Dolly... by lasmith05 · · Score: 0

    It was nice debating over your short life time...

    --
    www.samuraidreams.com - My Blog
    www.samuraifiles.com - Get Some Videos Here
  97. British Consulate by rwise2112 · · Score: 1

    I was suprised by this story today, as just earlier I had noticed, for the first time, a huge sign on the british Consulate in downtown Ottawa, Canada promoting British technology.

    The line that sttod out was "from DNA to Dolly".

    I hope they didn't just put it up!

    --

    "For every expert, there is an equal and opposite expert"
  98. From What it Sounded Like on NPR by Greyfox · · Score: 3, Informative

    It wasn't that Dolly was a clone. Dolly was kept indoors with a bunch of other sheep (some clones, some not) and this virus was spreading in the whole population. It doesn't sound like the disease was directly related to her being a clone.

    --

    I'm trying to teach myself to set people on fire with my mind... Is it hot in here?

  99. Pictures here! by Chocolate+Teapot · · Score: 1
    --
    Modest doubt is called the beacon of the wise. - William Shakespeare
  100. more fancher by braintartare · · Score: 1

    TYRELL I'm surprised you didn't come to me sooner. BATTY It's not an easy thing to meet your maker. TYRELL And what can he do for you? BATTY Can the maker repair what he makes? TYRELL Would you like to be modified? BATTY Had in mind something a little more radical. TYRELL What's the problem? BATTY Death. TYRELL I'm afraid that's a little out of my... Batty cuts in with a whisper. BATTY I want more life, fucker. TYRELL Come here. Batty walks forward. TYRELL Sit down. Batty does. TYRELL The facts of life. I'll be blunt. To make an alteration in the evolvement of an organic life system, at least by men, makers or not, it fatal. A coding sequence can't be revised once it's established. BATTY Why? TYRELL Because by the second day of incubation any cells that have undergone reversion mutation give rise to revertant colonies -- like rats leaving a sinking ship. Th ship sinks. BATTY What about E.M.S. recombination? TYRELL We've already tried it -- ethyl methane sulfonate is an alkylating agent and a potent mutagen -- it creates a virus so lethal the subject was destroyed before we left the table. Batty nods grimly. BATTY Then a repressor protein that blocks the operating cells. TYRELL Wouldn't obstruct replication, but it does give rise to an error in replication, so that the newly formed DNA strand carries a mutation and you're got a virus again... but all this is academic -- you are made as good as we could make you. BATTY But not to last.

  101. Telemers by mumwahead · · Score: 1, Interesting

    Seems to me I recall a show on the discovery channel or in some backwater of a biology course I took that linked the degredation of telemer chains on the ends of chromosomes to the effects of aging. I wonder if perhaps taking the chromosomes from the original sheep, with depleted telemers, caused Dolly to age faster than a sheep with a newer supply. If anyone can substantiate this claim lemme know.

  102. The circle of Cloning is complete. by TheAwfulTruth · · Score: 1

    Artificially created life,
    artificially induced death.

    --
    Contrary to popular belief, coding is not all free blow-jobs and beer. Those things cost MONEY!
  103. 100 years ago mutton was more popular than lamb by DABANSHEE · · Score: 1

    It was considered much more flavoursome

    But cross breed sheep over time helped make lamb tastier than what it was

    Me I prefer saltbush hogget

    1. Re:100 years ago mutton was more popular than lamb by ckaminski · · Score: 1

      I thought it was the fact that modern lambs aren't allowed to MOVE at all, and that's what gives lamb-meat it's delicious and succulent flavor and tenderness.

      FTR: I hate veal, but love chops... go figure.
      -Chris

  104. Loser. by Anonymous Coward · · Score: 1, Insightful

    Then go off and FUCKING DIE! OK? Just die and leave this earthblahblahblahtypicalmindlesscrap

    *Rolls eyes* Oh, do shut the fuck up. Drama Queen.

    Science marches on weather your Luddite ass likes it or not. And if this sort of thing gets your panties all in a wad, I giggle when I think how you'll react in 15-20 years when we really get deep into eugenics via genetic engineering, and nanotech takes off. I guess you'll be in your bunker somewhere, cowering under the bed screeching "NOOOOOOO! IF de Lawd meant for us to be immortal/superintelligent/superstrong he would have made us that way! Sinners!"

    Sucks to be you.

  105. oops by Sludge · · Score: 2, Funny

    Looks like someone left a bug in Dolly's overloaded operator=

  106. Re:What about the problems with Genetic Engineerin by the+gnat · · Score: 3, Informative

    Wrong for two reasons:

    1. Genetic engineering is not "random". A better comparison would be a hacker taking 10MB of source code to some random program and adding an email client. (hey, like Emacs!)

    2. The genetic code can handle quite a bit of "random" mutation. There are cases where it is extremely sensitive to mutation, such as sickle-cell leukemia (single poylmorphisim that causes hemoglobin to form chains), but there are "silent" mutations and even amino acid mutations that will have no effect.

  107. Do Clones Dream of Clonic Sheep? Re:Bladerunner by ASeed · · Score: 1

    Tyrell: The light that burns twice as bright burns half as long. And you have burned so very very brightly, ___ Dolly. ...

    Gaff : It's too bad she(ep) won't live. But then again, who does?

    --

    --
    ACid
  108. Your logic is suspect by NullProg · · Score: 1


    Cool, that means we can wage war, murder, rape, plunder, enslave, and exploit.
    I am not trying to start a flame war. You may want to redefine/tweak your logic.


    Answer the question. Are immoral acts natural?

    --
    It's just the normal noises in here.
    1. Re:Your logic is suspect by drinkypoo · · Score: 1
      Answer the question. Are immoral acts natural?

      What are you really asking me? By your standard of morality, or by mine? Where does nature leave off, and where do we begin? Is a microbial septic system natural? Is organic planting of GM wheat natural? For that matter, almost nothing we eat was made by nature. My friend Rodent had in his sig something to the effect of "you are what you don't poop." Most of your veggies will run right through but you're made of protein, except your fat, which is usually made of bread, rice, or junk food. How much of what we're made of is natural? Yet I think you could still argue that if someone shed all their worldly posessions and went into the wilderness and lived among the fucking wolves or something they would be "one with nature". (I'm picturing Denis Leary, who is funny (unlike me tonight) saying this with a severe case of coke nose and making really exaggerated quotation marks with his fingers in mockery of that kind of behavior.) So then are you still natural if you pick up a stick and tie a rock to it? That's now more than a simple machine, you might actually be intelligent. Is that unnatural?

      SO back to your question, they're not unnatural, they're unusual. You could say that life is the opposite of entropy because it is so unlikely. We are little blobs of amazing states of order. While of course we are tremendously insignificant when compared to the universe at large, we do obey largely the same rules at some quantum level (we hope.) Where I'm going with all this wankery is to say that if it happens, it's part of the natural order, because it's possible. Whether we want that thing to happen is entirely a different question but it has nothing to do with what is natural.

      Consider also that there are numerous cases of sexual assault amongst the animal kingdom, which we consider to be one of the worst things which one being can do to another. Hell, we even have laws against doing it to animals, or the dead, or dead animals (surely it violates some health statute in nearly every jurisdiction) which demonstrates how important that is to us. Is sexual assault natural? It seems so. Is that at all significant? Not really.

      What is significant is what rules we decide to make and enforce as a society, not what is natural. Those rules should ultimately be some widely acceptable subset of what we all want. I think we can all agree on a number of them, though some of us will dicker over terms here and there -- not to say that terminology is not important, but at least our hearts are in the same place, so to speak.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
  109. its vs. it's by Anonymous Coward · · Score: 0

    "its" is the possesive of "it," while "it's" is a contraction for "it is" or "it has"

  110. technicality and the carnal side of clones by chloroquine · · Score: 1
    Ok, I know I'm being a bit of twit for pointing this out, but it isn't methylization, it is methylation. CpG methylation (putting methyl groups on CG nucleotides) can indeed be used for imprinting, but there have been very nice studies on this showing how these things work and don't work with cloned animals.

    You might enjoy reading this article in Genome Biology. I'm including a link to the abstract in pubmed. In this article Mann and Bartolomei review a whole bunch of neat stuff, which would be fun to read if I had a subscription to the journal in question. Science journals are annoying that way. (Darn publishers. Go biomed central!)

    Another review, this time from Science, comes from Jaenisch's lab out at MIT. It provides a nice explanation of epigenetics and why it is still pretty hard to get live birth clones.

    And, on a lighter note, one of my coworkers was out in Scotland a few years ago, and got to go see Dolly. He has a nice picture of him standing next to her which he keeps tacked up on the bulletin board by his lab bench. He also has another picture that is not posted. In this one he is pretending to hump Dolly.

    I guess he'll be mourning her in a special way this Valentine's Day.

  111. Silence of the Leg O' Lamb by CognitiveFusion · · Score: 1

    At least now the cloners and anti-cloners can discuss the implications over dinner, assuming whatever they put her down with doesn't leave a funky after-taste.

    --
    Fools ignore complexity; pragmatists suffer it; experts avoid it; geniuses remove it. ~A. Perlis
  112. Fuck this. by rice_burners_suck · · Score: 1

    I find cloning distasteful. Yes, it would be cool if they could grow your own organs for you when the ones you have break down or something. But if the new one is identical to the one that's all fucked up, then won't the new one fail too? Shit, let's say you live 100 years and then one day, your guts stop working for some reason. I don't know... some gear breaks or some belt comes loose or something. So they grow new guts for you in the body of some wild boar or antelope or something, and then you live another 100 years. Oh.... Ok, maybe cloning is a good idea after all.

  113. Either way by Anonymous Coward · · Score: 0

    Valentine's Day will never be quite the same.

  114. Hello, Lunch! by Reziac · · Score: 1

    My bologna has a first name, it's bio-research staff,
    My bologna has a second name, it's gas chromatograph,
    And I have wondered, so have you
    Why it tastes the way it dooooooo...
    Well, Oscar Meyer has a way
    With recombinant DNA!!

    --
    ~REZ~ #43301. Who'd fake being me anyway?
    1. Re:Hello, Lunch! by fuzdout · · Score: 1

      I will NEVER eat bologna again...

      --
      Fuzdout
      ..My sig ran away. Has anyone seen my sig?
  115. roadmap of things to come? by Anonymous Coward · · Score: 0

    So, to me, this animal was somewhat bread to die. How disgusting.

    "Come one, come all! Wait for this cloned human to die so we might study it then feast upon its meat."

    *shakes head* Sometimes, we should just leave well enough alone . . .

  116. OH MY GOD!! by gomoX · · Score: 0, Flamebait

    YOU KILLED DOLLY! YOU BASTARD!

    (this text included to avoid "dont use so many caps its like yelling" filter. Yelling, right, thats the idea)

    --
    My english is sow-sow. Sowhat?
  117. Cults Cloned Kids by Whitecloud · · Score: 1

    Where does this leave raliens cloned human children? Those kids cloned in the states will be pretty smart by the time they are 13, maybe smart enough to realise they might be dead by 21, horribly aged and wrinkled before the hormones kick in, but smart enough to sue the pants off their "parents" for the paltry life given them. the Irony.

    --

    Do you need a website upgrade?

  118. Um, dude? by Anonymous Coward · · Score: 0

    Eggs only have half the genes needed for a human. The other half is in the sperm - which aren't all there at the birth of a male child.

    Explain that, eh? As the parent said, there's somethin' funky going on in the groins o' people, and if we figure it out, we'll have unlocked the doors to successful cloning.

  119. on reversing aging by Tablizer · · Score: 2, Informative

    Even if this telomere function were well-established, it doesn't entirely explain the aging process. It seems that part of the process is due to oxidative damage caused by radical reactions in the mitochondria. But similar reactions happen in chloroplasts and some plants live for millenia!

    Aging is a tough problem to solve. It appears that cell reproduction errors build up over the life-time of an organism. Many of the symptoms of aging are the slowing of metabolism to reduce the chances of mistakes. If an organism is tweaked to bypass this slowdown, then cancer and similar deseases will probably end you because errors occure more often when metabolism is turned up high.

    Thus, aging is a balance between a rock (slower metabolism) and a hard place (cancer).

    The closest analogy that comes to mind is the basketball season. If a team plays too hard mid-season, they may have too many injuries by the time the playoffs come. And, if they don't play hard enough, they won't make it to (win enough games for) the playoffs.

    Perhaps the best solution against human aging would be to slow the body's metabolism, but not the brain's. Modern living usually requires less physical exertion than our body is tuned for.

  120. Dollywood by Anonymous Coward · · Score: 1, Interesting


    http://www.chrisbuck.com/archive2/index_dolly.ht ml

  121. The moral: by vistic · · Score: 1

    "What the scientists giveth, the scientists can taketh away"

  122. how old do sheep normally live by infocalypse1 · · Score: 1

    I may be the only actual sheep farmer to reply on this thread! This whole thing is totally silly for two basic reasons. (1) This type of pneumonia is relatively common. The average age of a working ewe is ~8 years. I have seen a number of sheep die from this condition at 6 years or less over the past few years. If you told me that any other 6 year old ewe died, it wouldn't be notable. (2) There is zero statistical basis to make any conclusions. What's the distribution of mortality in sheep, or even in Scottish sheep of this particular variety. The sample size required to say whether or not the event is statistically meaningful is quite large. This is thetype of stupid pseudo-science that I've come to despise. Logic, anyone?

  123. Oh no! by Ace905 · · Score: 1

    That's horrible, I can only imagine what the Rayliens multi-coloured hair scientist with no credentials has managed to do to those poor, anonymous human clones.

    --Doug

    --

    Ace
  124. Comment removed by account_deleted · · Score: 1

    Comment removed based on user account deletion

  125. Dolly, cloning, etc... by bikerguy99 · · Score: 1

    I've spent few years doing some experimental stuff related to cloning in a major academic research intstitution on the east coast. Dolly's life from cloning to premature departure from this to a better world is a remarkable event in the history of biological science. HEre is why: it took about 100 years to progress from 1869 Miescher's (sp?) description of nucleoprotein in pus cells to the Watson-Crick model of DNA. Since early 1960's the effort was to describe how the genetic information is tranformed into something that can be used to build cells, tissues, organs - RNA transcription, protein translation and biochemical machinery that does it. By today we have a pretty good general undertanding of how that stuff works but many important details are missing as yet. Cloning attempts are old by now (~70 years). From the very onset, the idea was to examine the mechanism of functional specialization of cells. Theoretically cells can either lose some DNA to achieve this goal or do something else. Cloning shows that at least some cells that can produce clones retain the whole developmental program from the embryo to a fertile adult. And considering the success of cloning of many mammals from various cell types, it is pretty safe to conclude that likely it is epigenetic modifications (non-genetic but stable modifications that can be propagated even when DNA is replicated) of the genome, such as DNA methylation, that are involved in cell specialization. Telomere length is another important consideration for both cloning and cancer biology. So what's the point you may ask by now? Here it is: Cloning of farm animals is only a smaller element of a bigger picture. You have to look beyond this. Success of cloning of Dolly and many other cloned animals demonstrated that early ideas of being able to design chemical drugs and biologicals that could affect development are reasonable. Death of Dolly, low efficiency of cloning, abnormalities of clones are the signs of a very complicated and as yet poorly understood mechanisms of epigenetic control and reprogramming of the genome (yes, reprogramming!) during normal development after fertilization and after nuclear transfer in cloning experiments. The whole media frenzy, right wing's negative reaction and idiotic claims of various docs, clans and biotechs is the reflection of a great scientific process that takes place in a number of labs around the world. There is a lot to learn and whatever we find - it will be really cool because the Nature designed it and beta-tested it for a long-long time. Likely winners of this search will be recipients of stem cell-based therapies, tissue degenerative disorders and cancer patients.

  126. Re:does anybody know if Dolly got laid in her life by Anonymous Coward · · Score: 0

    I recall that only primate and human female species can achieve orgasm - the sad reality of life for them is that they don't really care for the quality of sex but for the quality of life after sex for them and their kids. I bet ya many of human males share their experience in support of this notion too...

    But Dolly had kids - check: http://www.the-scientist.com/yr2001/aug/agres_p1_0 10820.html
    and I recall a pic of her with three lambs

    as far as telomere length - I don't remember if this was looked at but if it was it should be published somewhere

    but remember - she was cloned from an in vitro CULTURED cell that was taken from a sheep and spend many generations in the dish.

  127. Dolly's telomers were short. by Anonymous Coward · · Score: 0

    You are right that Dolly's telomeres were short compared to sheep her age that were produce by sexual reproduction. But the concept that telomere erosion causes aging is still contraversial. The evidence supporting that theory has grown dramaticaly in recent months, so stay tuned--At least we can say this: the idea is plausible and the key fact of Dolly's short telomeres is unambiguous. Unfortunately, we may never know what was going on with Dolly as her creaters have been less than forthcoming with negative findings. There is, for example, no scientific paper detailing her early arthritis, which we are now being told was not abnormal.

  128. Last Post! by alpg · · Score: 0

    The only justification for our concepts and systems of concepts is that they
    serve to represent the complex of our experiences; beyond this they have
    no legitimacy.
    -- Albert Einstein

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