Stem Cells Cure Paralyzed Rats
An anonymous reader writes "According to an article on Forbes as well as other sources, 'Scientists have used [embryonic] stem cells and a soup of nerve-friendly chemicals to not just bridge a damaged spinal cord but actually regrow the circuitry needed to move a muscle, helping partially paralyzed rats walk.'"
If only they put this much time and effort into finding cures for human conditions instead of wasting it all on rodents. Bloody mice get all the breaks.
For those rats who did not regain use of their limbs after the experiment, little miniature wheelchairs and sticks were provided.
Let's just tell the animal rights protestors that anyway.
We must immediately ensure that this life-changing new medical technology is placed under a raft of arbitrary and politically motivated legal restrictions.
We must do this as quickly as possible. For science!
Gender? o.O
Slightly disreputable, albeit gregarious
Life imitates Art yet again.
From the article ""They did something that people have been trying to do for at least 30 years and literally hit a brick wall until now," said Dr. Naomi Keitman..."
Is this why they developed an interest in repairing spinal cord injuries? I think we should be told...
"bridge a damaged spinal cord" so if anyone is thinking of sticking their head in a life sized rat trap... good news!
Users... the only thing keeping 1st level support from being the bottom feeders.
a Surface mount chip.
Its always going to be messy and you will likely fuse the wrong things together.
But having some movement/sensation is good so Thumbs (and index finger) up to this research.
liqbase
Now, when a mouse is hit by a broom, there is a shred of hope that the little fella will walk again. *sniff* Walk, WALK! *sniff* *sniff*
One day the toilets of the world will rise up... And I'm going to nuke them.
Who paralyzes the rats in the first place? Do the scientists step on 'em?
This article (well maybe not this article, but same research) was posted on slashdot about a year ago. Thus is this research a nice copycat or just a person who hasn't done it's homework? Still nice development.
"Pied Piper inc. is reportedly suing John Hopkins University under Chapter 11 of the NAFTA trade agreement, for fears that this will have an adverse effect on the rat-catching market as a whole. The Piper could not be reached for comment."
...would viagra go out of business...?
I love humanity, it is people I hate
No longer will they be the 3 blind mice group, someday?
And if the mice step out of line... No Soup For You!
[an error occurred while processing this sig]
You sir, are an idiot.
I guess today is a passable day to die.
So are they rats or mice? Headline says mice, summary says rats. They're not the same thing. Think before you write!
Slashdot: 24 hours behind every other site or your money back!
Really, this exemplifies the sort of research we've been talking about when it comes to stem cells. Unfortunately, the actual scientific possibilities were overshadowed by a bunch of political bullshit.
Stem cells, biology (evolution!), global warming...The subjection of science to political considerations has to stop.
Gifts for Geeks - Stuff that really matters!
I really do hope that in however many years when use of stem cells grows to a point where they're used in common surgery, they'll be able to cure or at least help with RSI. What I wouldn't give for my wrists will once more be able to handle an hour of Xbox useage again.
Now try this science out on my cat please!
Umm article says stem cells, halfway down they are talking about embroynic stemcells.
:(
which ones did they use to help the rats walk.
stem cells are legal to use.
embroynic stem cells can be used but require private funding.
article doesn't distinguish wich ones are used on the rodents
Don't be silly. Jesus cured those rats, and He would have cured even more of them if those godless scientists hadn't been mucking about with evil stem cells...
thats what i'm going to call long island ice tea from now on.
The guys at Valve totally rock with their Stem technology.
They are already moving to the next step, testing it on humans.
getting the government out of the way has opened more doors.
many don't realize the numbers of restrictions and amounts of red tape that come with government funding. So while the motive for limiting federal participation in stem cells may be political/religous/etc in basis it does also follow the theme of letting private industry take the risks and reap the rewards.
making people well is big business but along with that comes great cost and time. Innovations come from those who are not bound by restrictions and having the government looking over one's shoulder.
look at it this way, with private entities doing the work, competeing with each other, we will may end up with different cures for the same problems allowing a broader range of people to benefit. we also have multiple avenues to not being impacted in the future by the government agencies as the work was performed in the free market.
* Winners compare their achievements to their goals, losers compare theirs to that of others.
Welcome our recently unparalyzed rat overlords.
Every human ever treated with embryonic stem cells developed terminal cancer in a few months. We'll see how long until these rodents die of cancer.
Andy Out!
grow up
Why haven't you all see that episode of Southpark where superman sucks the juice out of fetuses? *shudders
I wish I could be a rat, they can cure paralysis, aids, being overweight, being underweight, many types of cancer, mood disorders, aggression, lots of diseases and I even think baldness.
Groups like Peta think that rats are abused in laboratories, but they don't realize how easy a life they have it. Scientists are curing all sorts of problems in rats, making it easier for rats to survive. Billions of dollars are spent every year to cure rat problems.
I just wish that scientists would start curing stuff in humans, it would be nice if one of these days they started applying these discoveries on humans and maybe helping the human race out. If they could just take some of those billions spent on rat research and put it towards humans, what a wonderful world it would be.
So, hurray, scientists cure something else in some lab rat! Let me know when they start working on humans.
I haven't thought of anything clever to put here, but then again most of you haven't either.
Can you quote the sources?
A CC-licensed illustrated horror novel
When I first read the topic I thought a "Stem Cell Cure" did paralize the rats.
Please editors - English is NOT a case insensitive language.
If they can get a similar process in place for humans it'll cut the legs out from under the luddites opposing stem cell research (no pun intended). It's amazing how many people will decide the ethics of stem cell research aren't that much of a problem when they have the chance to see loved ones walk again, or recover from illnesses like Alzheimer's or Parkinson's.
It's not just medical research that's being handicapped by the politicisation of the stem cell issue in the US. Stem cell research has the potential to generate billions in revenue in the future. For example, in my University and some others in Sweden and Germany (Including the pre-eminent Karolinska institute), the EU has started and is funding a project to use embryonic stem cells to analyse drug toxicity and metabolism. The eventual goal is to replace animal testing with cell culture testing.
Results would be much more accurate, at the moment hundreds of animals are used to generate enough statistically safe data about drugs being tested, with embryonic stem cells many more tests could be run at a fraction of the cost, with much higher accuracy (as the cells would respond as a human cell would, and not as an animal cell would.) Drugs could be ready for the market place in a much shorter time, and pharmacy companies would save billions while also saving many hundreds of thousands of animals lives AND getting more accurate results to give consumers more safety.
The US Government is shooting itself in the foot here. There are so many fantastic areas where stem cells can deliver so much, and it's a race that they have not yet started in, while the rest of the world is already competing.
Really, this exemplifies the sort of research we've been talking about when it comes to stem cells. Unfortunately, the actual scientific possibilities were overshadowed by a bunch of political bullshit.
The source of stem cells is a profoundly important debate. Do we really want to breed and sacrifice a race of sound humans to fix broken bodies already deselected by nature?
Stem cells, biology (evolution!), global warming...The subjection of science to political considerations has to stop.
The debate over evolution will end once the science starts getting a better defense. Global warming is political by nature. It is a scientific growth industry which obtains venture capital by spreading fear. Its track record of prediction is among the worst in all of science. It is also the primary tactic of a "green movement" whose real motive is to foist a weird, agrarian, impoverished ideal on prosperous industrial society.
an ill wind that blows no good
About 3 years ago I was driving and saw a woman in a wheelchair (electric) driving along the sidewalk. As I passed her I noticed a small dog in front of her with a wheelchair as its hind legs!
I have come to question how one aquires a paralyzed dog? Usually a household pet will be saved and given some sort of help, but the dogs you find at the pound would be put down if they were "broken" from the waist down (although I don't agree with it, it is true). I mean, you couldn't obtain a paralyzed dog from the vet/shelter/pound/breeder. So where did this woman find a paralyzed dog?
I like to believe that it was given to her by some society that helps out those wheelchair bound, but I think the sad truth is that A) That dog doesn't need a wheelchair, she likes it in there... or B) She broke that dogs legs.
Wouldn't that be NIMH? Unless of course you meant the New Iceland Heritage Museum?
Sheez.. Thanks for changing the headlines afterwards... It said MICE in the headline and RATS in the text.
To Terminate, or not to Terminate, that's the question - SCSIROB
The very Christian fundamentalists who violently oppose biomedical research are ensuring the Darwinian survival of the fittest they themselves deny exists.
I say we make everyone who's against stem-cell research sign a pact that they will never use nor benefit in any form or fashion from the results of this research.
Architectural Renderings
Scientists have discoverd that Christopher Reeve has been reincarnated as a rat.
"Was it a millionaire who said 'Imagine No Posessions?'" -- Elvis Costello
I like this approach better: http://www.courier-journal.com/apps/pbcs.dll/artic le?AID=/20060308/NEWS01/60308003
I've met these folks. They are getting great results with procedure that is easy to duplicate AND the method uses the patient's own cells. Not only does that avoid the pesky ethics issues, there's no tissue rejection issues.
The world is made by those who show up for the job.
If you read the entire article, you will see that the treatment was only effective on 11 of the 15 rats in the primary experimental group (a 73% success rate). Further, the description of the abilities restored by the treatment states: "The paralysis wasn't completely gone, but six months after treatment, 11 of the 15 animals could bear weight, take steps and push away with the affected leg." I would hardly call this a "cure." It is misleading to use the term "cure" recklessly like this. A better term would be "treatment" since the rats showed improvement, but were not completely free of their affliction. But then again, saying "stem cells show promise for improving mobility in paralyzed rats" isn't nearly as cool sounding as "Stem Cells Cure Paralyzed Rats."
I read the summary title to mean, "The cure for stem cells have been found to paralyze rats."
This is a bit off topic but does anyone know of any follow up papers on Hwang Mi-Soon? She was the woman from South Korea who after being paralyzed for 20 years was able to walk again. Here is one story about it.
I'm not sure how reliable the Christian Post is with regards to stem cell reporting but I recall it being elsewhere and maybe even on slashdot. It was the sort of achievement that seemed almost too good to be true at this point in time and I was hoping someone could tell me if it in fact was.
If something like this research was to get into the mainstream, it could definately fix some things that have been bothering the human race for at least a good deal of it's life span. But we also have to think of who this would benefit. Sure, if we can get around the political and legal and moral bullshit that all the "Animal Rights" people, Puritans, and the political puppets who listen to them, and get a thing like this out into the public to cure, can we simply deny giving it to the aforementioned people?
"Please, please help! I lost use of my legs after an accident freeing some lab fruit flys and burning down abortion clinics!"
"Well, then you will not get any of the product that you tried to get rid of. Have fun!"
Can we honestly and morally do that?
If it ain't broke, it will be soon enough. And if it is, duct tape can fix it.
The Israelis did this years ago. Norm MacDonald even made a joke about it on SNL's Weekend Update. Something to the effect of "That's good news isn't it? Getting all those rats up and around again..."
Rats and Mice are different species, not different sexes of the same one.
Not people.
The religious rightists are killing real people with this "moral code" that blocks desperately needed medical research for cures for terrible diseases. It is not a secular moral code of any sort, it is simply a purely religious belief that a soul is created in the human egg cell when a human sperm cell enters it.
These cells are created and expired all the time in fertility clinics, the religious rightists would prefer that these cells be thrown in the trash rather be used to help cure disease.
There is no basis for the rightists assignation of human being status to these cells other than their particular religious belief in the timing of soul creation. Restricting federal funding based on this religious belief is the establishment of religion, anyone who has sworn to uphold the US Constitution should be dismissed for enforcing this religious belief in the United States.
The "innocent people" in the moral equation are the ones with diseases who are being denied cures due to the beliefs of the religious fundamentalists.
When the country falls into chaos, politicians talk about 'patriotism'. Lao-Tzu
Democratic Party Rejoices
Maybe we have a fighting chance!
"...objectivity resides in recognizing your preferences, subjecting them to especially harsh scrutiny." -Gould
Two mice are wanted for questioning on this...
Scientists are using adult stem cells in clinical trials. Kind of interesting that the cures which show the most progress are the least morally problematic.
I've always wondered why, embrionic stem cell research advocates remain so adamant about pushing a morally questionable practice when adult stem cell research show much more promise of creating cures today. Sure, the theoretical possibility of curing paralysis 20 years from now is a nice thought, but how does it help someone who will be dead by then? Or is it that they are more concerned with the research than with actually producing something beneficial?
The society for a thought-free internet welcomes you.
I don't want to grow up `cause I'm a Toys `R Us kid ... there's a million toys at Toys `R Us that I can play with ... from bikes to trains to video games it's the biggest toy store there is, gee wiz ... I don't want to grow up `cause baby if I did, I couldn't be a Toys `R Us kid.
... or the intelligence to wield said tools.
... :-P
Despite my little digression there I still stand behind my earlier statement. Close-minded, conservative, religious nuts are killing scientific advancement. If God didn't want us to use these tools he wouldn't have given them to us
(now back to our regularly scheduled immaturity)
You grow up
Contrast this bit of news with the story in the current Scientific American that links stem cells with cancer. The current working theory is that most cancers arise due to stem cell mutations... more stem cells, higher probability of cancer.
For every kid with a balloon, there's always some joker with a needle lurking around the corner...
One could just as easily say "Ach, mein Fuerher, too bad the actual scientific possibilities of eugenics were overshadowed by a bunch of moral concerns."
Nice toss-in of the Hitler reference, there. Nothing subtle about that. It's not like this is an area where moral people might differ; people who think embryonic stem cells from infertility procedures are even a grey area are to be equated with Hitler's willing sycophantic minions, period. So it seems.
You go on to dismiss "a lot of Slashdot posters" for their straw man willingness to junk "whatever moral notions they have about the dignity of the human person." That's interesting. It's precisely my unwillingness to dismiss my own notions about human dignity which lead me to think this might be a little more complicated than any authoritarian or absolutist stance. Same with abortion, on much the same lines.
(By the by, despite all sorts of noisiness about birth control, for the most part America's religious communities were pretty sympathetic with the eugenics movement. Take a look at "Evangelical Engagements With Eugenics, 1900-1940":
The same people who today take questions like stem cells as set in stone were quite willing to entertain eugenics. I've got a book in the basement at home that phrases eugenics in very religious terms, handed down to me by the Missouri Synod Lutheran side of the family. It's a very weird read.)
"Fundamentalism" isn't about divine morality. It's about human authority.
Goddamn rats are giving false hope to humans that embryonic stemcell therapies can make them walk again. Everyone knows that embryonic stemcells have never cured anyone. It's just part of the rat plan to take over the world with superior healing powers for them, and fake medical research for us.
--
make install -not war
Stem cells cure(noun) paralyzed(verb) rats
My god! stem cells are worse than we thought!
Stem cells cure(verb) paralyzed(adj) rats
Oh, nevermind...
-Although the first poster's mistake brings up an interesting question as to whether a literal gender change might be aided using stem cells.
If they can grow nerve cells, it's an interesting question what else they might be able to eventually grow.
One of the (many) obstacles to making this work has been the problem of getting through the tough, thick wall of scar tissue that the body builds around the injury site.
So there is a physical wall involved, rather than a metaphorical one.
Though the word "literally" does conjure up a picture of bricks in someone's spine.
to say a mass of undifferentiated cells are not a human being. It is a clear scientific demarcation. A bit of cells from my arm are not a human being, a cancer cell (which has unique DNA) is not a human being. Fertilized eggs have no potential unless implanted into a mother's womb.
They are routinely discarded by fertility clinics, this is an established practice with established laws surronding it.
Various things are opposed by all sorts of fringe groups. The only group of anti-stem cell research advocates that has any large membership and ability buy votes are the ones who believe the fertilized egg has a soul. If not for this group, the research would proceed apace.
The only real opposition is religious, not scientific. Medical scientists are the ones best positioned to judge whether research has medical potential, not religious groups. The NIH assembles teams of expert researchers to judege whether a proposed avenue of research is worth spending money on, only with stem cells this process is poluted with arbitrary limits, which are based on purely religious beliefs.
At least be honest about your motivations: you want to impose your beliefs on the time of soul creation on eveyone else, and you don't care a bit if valuable research is blocked due to your imposition, and people die or lead needlessly limited lives because of it (which Christian Fundamentalists* rationalize by believing that a short life of pain is followed by eternity of pleasure in paradies--for those who prove themselves worthy by imposing their beliefs on anyone they can't convert).
When the country falls into chaos, politicians talk about 'patriotism'. Lao-Tzu
Sure, if they're Catholic they probably should believe what the Magisterium says, but not all of them do. My friend's family are all devote Catholics who go to mass once a week, yet when she got pregnant out of wedlock they practically dragged her to an abortion clinic. You might not call them Catholic, but do your statistics count them? How many people go to church or mass every week out of habit and don't really believe what their paster or priest or whoever says? We have no idea. You can't use a survey that doesn't take into account individual beliefs and assume that everyone surveyed believes the way you think they should. Go find a survey that asks people their feelings on abortion and stem cell research (they do have those!) because that's way more useful. Though I bet you'll find that pro-lifers don't have the overwhelming majority you seem to think they have.
"What is Internet Explorer 7? Are you saying we can't access the normal internet?" - I love tech support. Really.
You mean human sized. Or else you have a very tiny head. Maybe both.
Meh, article is a dupe from last year anyway...
What he can't kill, he has sex on. Trent.
Think of where we would be if it was a "Fully open source" on stem cell research, since before Dolly! Lets open things up people, let them all "Go Nuts" its better for all humanity...
They're already working to get human clinical trials (bottom of the page) going on this. I'm strongly considering being a test subject for it if they can get a site set up near my area.
Considering how things are currently going in the US though, this could end up being the only chance many of us will have for getting this sort of treatment any time soon. Eventually, some self-righteous asshat is going to propose federal bans on this, forcing those of us suffering from this type of condition to either live with the problem as-is, or leave the country and pay for it out of pocket.
8==8 Bones 8==8
There is, perhaps, a loophole in your assumptions. Step by step:
You don't have a problem with voluntarily donating organs, do you? (No?)
And what if the family volunteers the organs (heart, liver, etc) from a recently deceased relative, to save your life, or your child's life, is that ok, too? (Yes?)
And what if the family of the deceased fetus donates his/her/its organs (heart, liver, stem cells, etc) to save your life, or your child's life, is THAT ok, too? (Yes.)
HOW the fetus died is a seperate issue.
I can understand how you might say abortion should be illegal, and therefore fetal tissue from abortions would not be legally unavailable. However, fetal tissue could come from accidental miscarriages (although nobody WANTS miscarriage to happen), or from cloning the existing cells.
Or other ways?? Who knows.
"Forgive us our trespasses, as we forgive those who trespass against us." -Jesus Christ The Lord's Prayer
From the latin, "gender" is based on the word "genus" or origin. It's only fairly recently that the word has come to refer to sexual identity.
However, it's not common to use the word to distinguish between species. I think the original poster's point was joking that if you could turn a mouse into a rat (as the original headline error implied), you could probably change a woman into a man. (of vice versa.)
The thing is, gene-splicing sex changes are probably not that far down the road. Figure out just the right hormone and chemical signals to send to stem cells (adult or embrionic) and you could probably grow an entire uterus for an adult male. It's probably too late, in an adult, to turn the testicles into ovaries, but it might someday be possible to simply replace them with new ovaries grown from the patient's own DNA.
Information wants to be anthropomorphized.
So when are the scientists gonna get off their asses and make a soup of Shaky's Pizza friendly chemicals?
You're breaking my balls!
If scientists could just bring Christopher Reeve back from the dead, then cure him. . .
"The question is, is there a way to please environmentalists and animal rights activists?"
That's easy. Take your pick:
A. Kill off the entire human species.
B. All of the above.
Parent,
While I can't believe you took the time to answer in such detail what I think was someones poor attempt at a joke, you brought up a very interesting points.
Do quadriplegics (guys) get erections? Do they have wet dreams? If they do, is there any type of satisfaction? Even thought they can't feel the ejaculation part of the pleasure, can they still have the afterglow feeling?
Nice toss-in of the Hitler reference, there. Nothing subtle about that. It's not like this is an area where moral people might differ; people who think embryonic stem cells from infertility procedures are even a grey area are to be equated with Hitler's willing sycophantic minions, period. So it seems
Keep in mind that eugenics were not just espoused by the Nazis. It was soundly approved of by US Academia in the early part of thelast century, as well as many in government - I even recall that a law was once proposed requiring the forceful sterilization of morons in the USA.
Eugenics was considered as much mainstream science as evolution is, in fact.
"I do not agree with what you say, but I will defend to the death your right to say it"
Stem Cells Cure: Paralyzed Rats
...some people disagree over whether some bits are actually yours. You say "her own body" as if there is universal agreement over what is and isn't "hers". I can say "I own X" as often as I like, but repeating it doesn't make it so.
Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
This is really quite amazing, as spinal cord injuries are one of the things for which there really is good evidence for the involvement of stem cells in repair. To show that it can work is great news -- this is the sort of thing that people talk about when talking about "the promise of stem cells". Men are a different beast, and scientists know that it is generally easier to "cure" mice of cancer, viruses, injuries, and other diseases, than it is to cure people, so I look forward to additional work on how this research can be translated to primates, and finally people.
I thought it was Not Invented Here Mantra.
There is no right to feel safe thru security vaudeville at the expense of everyone's freedom, privacy and tax money.
You just interpreted the header wrong:
Stem Cells Cure Paralyzed Rats
A potential cure for the degenerative disease known as "Stem Cells" was found to cause paralysis in rats, a recent Tobacco Industry study showed. "All test rodents suffered from Stem Cells since birth," a researcher commented, "but upon administering the cure, most of the subjects, particularly the rats, became paralyzed." The potential Stem Cells Cure was in the process of being approved. FDA officials declined to comment.
"This is not a complete dead end," notes Pharmaceutical CEO John Doe. "We are not yet certain this potential cure causes paralysis in humans also." Doe added that penicillin is 100% fatal to guinea pigs, despite the unquestionable value it has for humans. "If the FDA were around a hundred years earlier, penicillin would have never been approved."
Meanwhile, PETA demonstrators are rallying at the offices of Megacorp Co., the company that conducted these experiments. "What these so-called scientists have done to these once-functional rats is reprehensible!" decries Wanda Bea Anne Activist. "These researchers should be testing on humans first!" PETA intends to conclude the protest by volunteering their own members for testing the Stem Cells Cure.
I think I've been reading the Onion too much.
Solomon Chang
"Twice half-assed makes an ass whole." --Solomon K. Chang
People use those sticky-paper traps and let the rats starve/dehydrate there because they'd be too freaked out to see a rat with a broken neck. It's not for the rats' benefit, it's for theirs.
Analogously, in societies that practiced infanticide (ancient Sparta, recent China), infnats are generally left to die of exposure in a jar on a hillside. Not because it's more humane for the infant, but because the people doing the killing are too squeamish to do it humanely. I think that's irony.
Laws do not persuade just because they threaten. --Seneca
im not necessarily saying every little whore should be able to go down to the abortion clinic and sort of use it as a form of contraception, but it should be available for necessary cases.
Your generosity knows no bounds. I may cry, I'm so glad to have you around to tell us when it's "necessary" and when it's not.
Laws do not persuade just because they threaten. --Seneca
It is not a "judgement call" to say a mass of undifferentiated cells are not a human being. It is a clear scientific demarcation.
The rat study we are talking about did not use "undifferentiated cells." The cell line used was made in 1998 from human fetal cells grown on a mouse cell feeder layer. [1,2] The fetal cells were obtained from 5-9 week old human fetuses. Presumably the fetuses were aborted in a clinic or hospital, but I don't know for sure. These cells are not undifferentiated. They are pluripotent stem cells, not totipotent.
Of course, The Fine Article does not bother to tell you that the cells they used are human, let alone that they came from 1-to-2-month-old human fetuses rather than the undifferentiated cells of blastula stage embryos.
Why the HELL do I have to go to the scholarly articles to find this out? Practically all the newspaper articles are cribbed from the Johns Hopkins press release, which carefully avoids saying any mention whatsoever of what sort of stem cells were used. How am I supposed to take these scientists' ethics seriously when their university unaccountably keeps important facts like this out of their press releases?
References
[1] Deshpande D, Kim YS, Martinez T, Carmen J, Dike S, Shats I, Rubin L, Drummond J, Krishnan C, Hoke A, Maragakis N, Shefner J, Rothstein J, Kerr D, "Recovery from Paralysis in Adult Rats Using Embryonic Stem Cells." Annals of Neurology, 60, 22-34. (2006)
[2] Shamblott MJ, Axelman J, Wang S, Bugg EM, Littlefield JW, Donovan PJ, Blumenthal PD, Huggins, GR, and Gearhart JD, "Derivation of pluripotent stem cells from cultured human primordial germ cells". Proc. Natl. Acad. Sci., 95, 13726-13731 (1998).
Actually, I see now that I might have been working from a 2001 article by the same lab, rather than the 2006 article. I can't tell for sure yet, since the journal won't actually publish the article for general subscribers online until June 26, so I'm working from a CDC summary of the embargoed article, and it is a bit ambiguous. (Grr...) Anyway, apologies if my information turns out to be mistaken.