Slashdot Mirror


Merck's Deleted Data

An anonymous reader wrote to mention a Forbes article describing a drug study tampering proven by software. From the article: "A top editor of The New England Journal of Medicine says that he was stunned to find out that data linking Vioxx to cardiovascular risk was deleted from a major study his journal published five years ago--and that it appears that Merck researchers may have deleted that data ... When you hover the cursor over the editing changes, the identity of the editor pops up, and it just says 'Merck'"

200 comments

  1. Nothing for you to see here. Please move along. by NastyNate · · Score: 5, Funny

    It looks like Merck deleted this submission.

    1. Re:Nothing for you to see here. Please move along. by Anonymous Coward · · Score: 3, Insightful

      An entire multi-national corporation brought down by Microsoft's TrackChanges feature...

    2. Re:Nothing for you to see here. Please move along. by technoextreme · · Score: 4, Funny
      An entire multi-national corporation brought down by Microsoft's TrackChanges feature...

      Im sure a large group of people on slashdot would also like to see Microsoft be brought down by their TrackChanges feature also. This is a horribly bad joke and I doubt anyone is going to find it funny....
      --
      Ooo man the floppy drive is broken. No wait. The computer is just upside down.
    3. Re:Nothing for you to see here. Please move along. by ackthpt · · Score: 2, Interesting
      It looks like Merck deleted this submission.

      Yes, but which body done it?

      We can already guess the why, which goes something like this:

      Damn what the research tells you! We've got a lot of money riding on this and I'm not going to see my stock options or year-end bonus dragged down by a bunch of words.
      (A similar thing happened at Intel years ago, but I don't think it lead to very many heart attacks.)
      --

      A feeling of having made the same mistake before: Deja Foobar
    4. Re:Nothing for you to see here. Please move along. by A+nonymous+Coward · · Score: 5, Funny

      (A similar thing happened at Intel years ago, but I don't think it lead to very many heart attacks.)

      Actually, my Pentium tells me there were .00010183 heart attacks, but I think it's estimating.

    5. Re:Nothing for you to see here. Please move along. by IAmTheDave · · Score: 2, Informative

      On Slashdot, we often are willing to relate anything anti-MS to funny, insightful, interesting, or underrated.

      --
      Excuse my speling.
      Making The Bar Project
    6. Re:Nothing for you to see here. Please move along. by ackthpt · · Score: 1
      Im sure a large group of people on slashdot would also like to see Microsoft be brought down by their TrackChanges feature also. This is a horribly bad joke and I doubt anyone is going to find it funny....

      They may be. Corporations may shelve Microsoft because it keeps evidence against them.

      The bodies are buried in a landfill and the money is in the caymans^H^H^H^H^H^H^H^H^H^H^H^H^H^HWe are an upstanding and honest company with great integrity

      --

      A feeling of having made the same mistake before: Deja Foobar
    7. Re:Nothing for you to see here. Please move along. by metlin · · Score: 1


      That's probably because Intel's having a heart attack by all those $100s that they're gonna lose. ;)

    8. Re:Nothing for you to see here. Please move along. by secolactico · · Score: 1

      They may be. Corporations may shelve Microsoft because it keeps evidence against them.

      Or this might be the ammo that MS needs to combat Open Document format. (It's funny. Laugh)

      --
      No sig
    9. Re:Nothing for you to see here. Please move along. by Anonymous Coward · · Score: 0

      Sorry but yer still far too intimidate. might want to touchtype less and look at your screen. ya must backsapce alot more than that to cover the tracks of your dastardly deed.

      The bodies are buried in a landfill and the money isWe are an upstanding and honest company with great integrity

      ______________
      Tis a shame I wasted those precious moments of my life posting this message.

    10. Re:Nothing for you to see here. Please move along. by ImaLamer · · Score: 1

      Im sure a large group of people on slashdot would also like to see Microsoft be brought down by their TrackChanges feature also.

      It's already happened.

      It seems, after looking at the files directly, the "Halloween" memos were started at the bottom of Microsoft's employee pool and went upwards. The document was a rant about how great Linux and the entire open source movement around the GPL was. Before they were sent to Eric Raymond there are drastic edits to the memo by a user known only as SBallmer. Somehow we got this.

    11. Re:Nothing for you to see here. Please move along. by solowlr · · Score: 1
      This isn't the first time hidden data has bit someone in the ass.

      White House accidentally exposes data in PDF file

      --
      -Solo
  2. They deleted the slashot page too! by Anonymous Coward · · Score: 4, Funny

    I got a 404 error when clicking on the 'Read more...' link. Damned multinationals!

  3. Edit changes... by Scoth · · Score: 3, Insightful

    You'd think after all the high profile cases of stuff like this happening, companies would be more careful with the revision history system. Guess not...

    1. Re:Edit changes... by smittyoneeach · · Score: 2, Insightful

      You seem to think the companies a) have much technical understanding of the issues b) have awareness of the understanding of outsiders.
      SonyBMG wasn't an isolated incident of cranial rectalitis.

      --
      Get thee glass eyes, and, like a scurvy politician, seem to see things thou dost not.--King Lear
    2. Re:Edit changes... by guardiangod · · Score: 2, Informative

      If you RTFA, you will notice that the said article was submitted in 2000.

    3. Re:Edit changes... by crawling_chaos · · Score: 1

      Hard to, when the IT folks who understand the business have all been laid off in favor of an outsourcing firm to boost short term profits. They don't have anyone writing policys anymore, but management did get a Squishy with the outsourcing deal.

      --
      You can only drink 30 or 40 glasses of beer a day, no matter how rich you are.
      -- Colonel Adolphus Busch
  4. comments? by terrymr · · Score: 0, Redundant

    It looks like they deleted the comments on this story too.

  5. drugs is money by Anonymous Coward · · Score: 1, Insightful

    This shows that the drug industry is only after one thing: money. And lots of it.

    1. Re:drugs is money by Philip+K+Dickhead · · Score: 2, Funny

      Hey, man. This is the self correcting market, with it's free hand at work! Stop complaining, and sorry all you dead heart-attack guys.

      --
      "Speaking the Truth in times of universal deceit is a revolutionary act." -- George Orwell
    2. Re:drugs is money by Anonymous Coward · · Score: 0

      Was it the same hand that pressed the apostrophe key when you really meant to type ITS???

    3. Re:drugs is money by Arandir · · Score: 2, Insightful

      All industries are after lots of money. Grow up and get a clue. What makes Merck wrong in this instance is that they decided that the money was more important than the ethics.

      I could care less how you or anyone else makes money, so long as you do it legally and honestly.

      --
      A Government Is a Body of People, Usually Notably Ungoverned
    4. Re:drugs is money by Philip+K+Dickhead · · Score: 1

      No. That was my MAGIC hand!

      --
      "Speaking the Truth in times of universal deceit is a revolutionary act." -- George Orwell
  6. ugh by breakspirit · · Score: 0, Redundant

    Yet another case of the world being run by big business.

    1. Re:ugh by lbrandy · · Score: 5, Insightful

      I know this thread is going to turn into a huge gripe on massive corporations and how corrupt and evil and bad they are... but... considering the company is being publicly humilated, it's stock is trading at half the price it was a 2 years ago, and it's hemorrhaging jobs. I think it's fair to say the free market is correctly punishing this big business that is supposedly "running the world". But that's just me.

    2. Re:ugh by Anonymous Coward · · Score: 5, Insightful

      And how many people had their health sacrificed to get us to this point? For that matter, what punishment is occurring to those who did the evil deeds?

      Nope, the free market is doing too little to late, as always.

      And, BTW - it's not the corporation that's corrupt and evil, it's the people at the top of the corporations, who are immune to the evil that they do, unless they make mistakes in covering up their deeds.

    3. Re:ugh by lbrandy · · Score: 0, Flamebait

      And how many people had their health sacrificed to get us to this point? For that matter, what punishment is occurring to those who did the evil deeds? Nope, the free market is doing too little to late, as always.

      Oh please tell me of the magical place (and substance) where the economic paradigm is capable of pre-emptively stopping bad people from doing bad things. Tell me more! I want to know of the amazingly perfect economic system whereby bad people are stopped, BEFORE they do bad things.

      Guess what, when people are getting hurt because of others stupidity, EVERY measure of correction is "too little too late". That is a fact of reality.. and blaming that on a particular concept (ie, the "free market") is completely and totally irrational.

    4. Re:ugh by Anonymous Coward · · Score: 1, Insightful

      And all the people they killed got up and went back to work... oh wait, no they didn't.

      Not one punishment dished out now will bring those people back to life, but if it will keep another drug company from ever trying another stunt like this, then we want it to be trading at 50 cents.

      In the end though, all that will happen is the company will be sued into oblivion, a handful of lawyers will get rich, a lot of hardworking people who did nothing wrong will be out looking for jobs, and the CxOs and upper management will go work for their golf buddies at some other drug company where they'll do it again, but this time they'll be more careful so nobody figures it out when all these old people start dropping like flies. It's time to stop treating corporations like they're special and ditch the corporate veil once and for all. Arrest the people who authorized the release of the drug without the heart attack warning and charge them with murder (premeditated, they knew this was a side effect and that precautions that could have been taken would not be without that information (like not prescribing it to people with a history of heart problems, or prescribing it in combination with a drug that could otherwise counteract the risk... or hell, just telling the patient that when they're on the drug, if they feel a pain in their chest, it's probably not the same kind of "heartburn" they might be used to)). Require them to sell their mansions and yachts and pay the lawsuit costs and settlements and declare personal bankruptcy while they're sitting around in prison wondering whether their greed was worth it.

    5. Re:ugh by dclydew · · Score: 4, Insightful

      I doubt the economy would keep bad people from doing bad things. However, if all corporate executives were held to task for their intentional failures, we would likely see less of this sort of thing. The problem, in my opinion, isn't capitalism, it seems more like the current incarnation of capitalism that has spawned mega-corporations where the "bad people" can often hide behind the faceless 'entity'. We're doing better now than we were at the start of the 20th century, but we still have much we can improve upon, personal responsibility and liability are at the top of the list (IMO).

      --
      Get a life, not a lifestyle. - Hikem Bey
    6. Re:ugh by sjames · · Score: 1

      I think it's fair to say the free market is correctly punishing this big business that is supposedly "running the world". But that's just me.

      Name any natural person who after killing thousands for profit would get away with only forfeiting half his assets!

      There's a big chair waiting for Merck, but prosecutors will never make it sit down.

    7. Re:ugh by SacredNaCl · · Score: 1

      I know this thread is going to turn into a huge gripe on massive corporations and how corrupt and evil and bad they are... but... considering the company is being publicly humilated, it's stock is trading at half the price it was a 2 years ago, and it's hemorrhaging jobs. I think it's fair to say the free market is correctly punishing this big business that is supposedly "running the world". But that's just me.

      The invisible hand of the market can not raise the dead, and in this case, those most severely injured are dead, and more of them than our losses in the Vietnam war. The executives will have transferred much of the assets into tangibles elsewhere and immune from the rightful wrath of the legal system, much like how money at Enron was transferred. Instead of punishing the people responsible with death, or long imprisonments, the punishment will be meted out by reducing the savings of those who invested in the company, grandma and granpa's retirement fund, employees not smart enough to see the writing on the wall...

      I suppose that is the kind of "anti-corporate" rant you expect. However, the shoe fits.

      --
      Freedom is merely privilege extended unless enjoyed by one and all.
    8. Re:ugh by Anonymous Coward · · Score: 0

      Indeed, the whole concept of a business as a pseudo-person seems bogus to me, and it's not an inherent part of capitalism at all, despite what many people think.

    9. Re:ugh by Esion+Modnar · · Score: 1
      it's not the corporation that's corrupt and evil, it's the people at the top of the corporations

      I see little value in that distinction. For all intents and purposes, the executives ARE the corporation. They are responsible for what goes on. Much like the captain of a ship is responsible for the misdeeds of the lowest-ranked sailor. (Of course, executives work under the influence of the shareholders, but when the shit comes down, the executives go to jail, not the shareholders.)

      --

      They say the first thing to go is your penis. Well, it's either that or your brain. I forget which...
  7. See! by DrEldarion · · Score: 4, Funny

    And you guys said that this feature was bad! They're just looking out for us, bless their hearts!

  8. oopse ! by UberHoser · · Score: 0

    Data, what data ?? I see no data here officer...

    --
    Guns are for wimps... Use a crossbow.. this way you can pin them to their chair when you go postal.
  9. Merck? by tradiuz · · Score: 1

    Someone forgot how to empty the recycle bin in other news.

  10. They must have forgot... by OakDragon · · Score: 4, Funny

    The researchers must have forgotten to slide the little "write protect" tab on the diskette.

    1. Re:They must have forgot... by Anonymous Coward · · Score: 0

      I was fired from Merck in October of 2000 after refusing to issue a TSM command. It was 'del vol * stgp='FDA.VIOXX.CLIN.DATA.FINAL' discardd=y'. I wonder how much my copies of those volumes would fetch on Ebay?

  11. Yet another reason to use OO.o by Benanov · · Score: 1

    ...it's easier to delete user data. :)

    1. Re:Yet another reason to use OO.o by MsGeek · · Score: 3, Funny

      Open Office is great for "fixing" broken Word documents. Macro virus? Corruption? No problem! Save as Oasis,then save back as .DOC. Problem solved. I'm sure Open Office can also "fix" version tracking as well.

      Only goes to show you that it pays to use F/OSS.

      --
      Knowledge is power. Knowledge shared is power multiplied.
    2. Re:Yet another reason to use OO.o by Anonymous Coward · · Score: 0

      Yep. Because it also "fixes" my carefully prepared layout by completely rearranging the page. Way to go F/OSS!

  12. Edited by... by TheZeusJuice · · Score: 1

    Kinda off-topic, but this reminds me of the time I found a usb memory stick in one of the school clusters. I was able to identify the owner and return it to him because of the "edited by" info in some of the word documents inside it.

    Well, it seems like at least one of the gazillion stupid features included in Word has a use after all.

    1. Re:Edited by... by Anonymous Coward · · Score: 0

      Holy crap, there are still honest people in the world. I didn't think it possible.

  13. Viability of Testimony by mrshoe · · Score: 5, Funny


    The researchers still aren't sure whether Clippy's testimony will hold up in court.
    .

    --
    There are two types of people in this world: those that categorize other people and those that don't.
    1. Re:Viability of Testimony by hunterx11 · · Score: 4, Funny

      It appears that you are writing an amicus curiae brief. Are you sure you don't really want to use Word Perfect?

      --
      English is easier said than done.
    2. Re:Viability of Testimony by Anonymous Coward · · Score: 0

      Plenty of law offices still use WordPerfect... especially for long documents like briefs.

      The reason is that table of contents and other formatting in Word has a penchant for freaking out after your page count gets really high... or it might just be that it freaks out trying to track too many levels of "UnDo"

    3. Re:Viability of Testimony by Geoffreyerffoeg · · Score: 1

      The reason is that table of contents and other formatting in Word has a penchant for freaking out after your page count gets really high...

      Yeah, I've seen that first hand trying to convert War and Peace from Gutenberg to Microsoft Reader, and hopefully having a nice, paginated table of context. Once you do too many things, Word lags more than correspondence chess.

    4. Re:Viability of Testimony by Anonymous Coward · · Score: 0

      Wow... I think that's the first Clippy joke I actually laughed at...

      Kudos. The WordPerfect bit for legal briefs really sold it.

    5. Re:Viability of Testimony by loraksus · · Score: 1

      *golf clap*

      I say well done Sir!

      --
      1q2w3e4r5t6y7u8i9o0pqawsedrftgthyjukilo;p'azsxdcfv gbhnjmk,l.;/
    6. Re:Viability of Testimony by zCyl · · Score: 1

      It appears you are trying to fudge the results of your study. Would you like assistance from a Microsoft-certified professional?

    7. Re:Viability of Testimony by Muhammar · · Score: 1

      No no. Word is subtle, malicious he is not.

      --
      I doubt that we will ever figure out - and I suspect that even if we did figure out we couldn't do much about it
  14. Re:In other news by Anonymous Coward · · Score: 0

    Depends on what you mean by "WMD", "war" and "lie".

  15. A win for animal rights.... by joe+155 · · Score: 5, Funny

    they are now testing on humans...

    --
    *''I can't believe it's not a hyperlink.''
  16. Editors/Reviews are at fault as well by karvind · · Score: 3, Insightful
    From TFA

    "I was somewhere between surprised and stunned," Dr. Gregory Curfman, executive editor of The Journal, says. "They allowed us to publish an article that was just incomplete and inaccurate in some respects and was misleading and may have contributed to the detriment to the public health. " (emphasis added)

    Now why would you allow to publish such inconclusive studies at all ? Is this journal peer-reviewed ? It would be interesting to see if they also publish the comments from the anonymous reviewers ? Did they agree about the paper before it got published ?

    1. Re:Editors/Reviews are at fault as well by GrnArmadillo · · Score: 3, Insightful

      All but one of the authors of the study were either employed by or consultants for Merck. The company decided that the article would technically be telling the truth (X patients died DURING THIS TRIAL) without mentioning the deaths that occured between the scheduled end of the trial and the publication of the paper. Short of the peer reviewers conducting their own clinical trial, at the cost of hundreds of millions of dollars, there was no way for them to know that information had been withheld.

    2. Re:Editors/Reviews are at fault as well by spirit_fingers · · Score: 5, Informative

      You missed the point entirely. The Journal was given a hard copy of the study by Merck four months before the issue came out. This was in the days before the publication worked from digital submissions.

      Merck knowingly gave the Journal incomplete data and the editors have only now discovered the discrepancy by going back and examining the original computer document.

    3. Re:Editors/Reviews are at fault as well by lbrandy · · Score: 4, Informative

      Now why would you allow to publish such inconclusive studies at all ? Is this journal peer-reviewed ? It would be interesting to see if they also publish the comments from the anonymous reviewers ? Did they agree about the paper before it got published ?

      Do you expect scholarly journals to reproduce all experiments before publishing the data? It's only inconclusive and misleading because some data was conviniently deleted. There is no way for a journal to know this without reproducing the study.. and that is not the purpose of "peer-review" in the "peer-reviewed journal". The work, itself, is taken on honor, and the "peer-review" is there only to make sure the experiment, as explained, is scientifically interesting and accurate... the data itself is taken at face value until it is either independantly confirmed or denied.

    4. Re:Editors/Reviews are at fault as well by budgenator · · Score: 2, Interesting

      The data was about events that occured after the study, so while Merck was technically correct to delete the data, there is an air of amorality about it. Dr. Claire Bombardier's, and the University of Toronto's reputations are going to be severly tarnished by this incident. Now because people have presumably died or have been physically injured because of the ommission of the data it isn't a streach to imagine neglegent homicide and criminal conspiracy to be looked at by prosecuters. Even if Merck had final edit rights on the paper and a NDA, I'm sure that Bombardier is going to wish she had written a letter to the editor about the data occuring after the study ended. The, they the article refers to is Merck/Bombardier, not the peer reviewers. There is no way for the peer reviewers to have known that pertainent data was withheld, the NEJM seems to be on solid ground here. This is a Good reason to use LaTeX!

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
    5. Re:Editors/Reviews are at fault as well by Boghog · · Score: 3, Informative
      http://www.corante.com/pipeline/archives/2005/12/0 9/a_vioxx_bomb_drops_or_does_it.php

      While this story makes Merck look bad, idiotically bad, on closer inspection there isn't as much here as you'd think. The data in question are three heart attacks in the final weeks of the VIGOR trial. But the adverse cardiovascular event data in the paper, as published, didn't reach statistical significance, and they don't seem to reach it with these added in, either. On top of that, these data were submitted to the FDA during the drug's approval process, and (according to Point of Law) are on the Vioxx package insert itself.

    6. Re:Editors/Reviews are at fault as well by WebHostingGuy · · Score: 1

      Yeah, but no one wants to hear the truth like that, they want them to be bad and be caught doing something bad. No will ever take into account that the Journal prints what they want to print; has a history of dropping all sorts of relevant data they don't think necessary and can and always print anonymous retorts attacking the study.

      --
      Quality Hosting e3 Servers
    7. Re:Editors/Reviews are at fault as well by Rich0 · · Score: 1

      The argument is that the Journal apparently had some kind of cutoff date for data, and these particular events happened after that date. Other CV events from before the date were included.

      Now, if somebody can show that data after the cutoff was still selectively included if it were positive, and suppressed if it were negative, that would certainly be something. However, in any large trial, if you wait a month there will always be an extra adverse event (whether a drug is safe or not). At some point you need to draw a line.

      Merck also claims that the data was made public at a later date.

      In the pharma industry, I understand that one of the big principles with presenting data is to religiously follow the rules. If some guideline says not to report data below a particular threshold, then it won't get reported even if it is known that the data is still meaningful. If the guideline says to report above some threshold, then it will get reported even if it is known that it is not meaningful. The whole process has a ton of rules and conventions associated with it, and ever since the Barr decision the trend has been to follow the rules whether it makes sense or not.

      If audited by the FDA, they would look at whether Merck followed their published policies to the letter, and whether the policies were declared to the FDA. If so, at worst they might be asked to change their policies in the future.

      In theory the whole reason the FDA exists is so that there can be some standard of approval for drugs, and a single regulatory body. The problem with the tort system is that the government can say that a particular action is legal, and at the same time a company can get sued to death for it. There really needs to be a single documented standard for everybody to follow...

  17. I for one... by dirtydog · · Score: 0, Offtopic

    welcome our new heart destroying, document tampering overlords.

    I'm here till Thursday, try the veal!

  18. Haha by ph4s3 · · Score: 2, Interesting

    Nothing like getting busted by a your own inability to use secure document authoring tools.

  19. Re:In other news by Anonymous Coward · · Score: 0

    Depends on what you mean by "depends."

  20. Firestone ? by Chaffar · · Score: 2, Interesting
    Some analysts have estimated Merck's potential liability in the tens of billions of dollars. Others say that the risk to the drugmaker, once the most esteemed name in the pharmaceutical business, is impossible to know. The news that the once-popular arthritis drug may have caused thousands of heart attacks led to a firestorm about drug safety.

    Could this be the drug industry's "Firestone"? Yet another example of he classic irresponsible/corrupt/greedy corp. that tries to cover up its own blunders.

    1. Re:Firestone ? by mkw87 · · Score: 1
      Could this be the drug industry's "Firestone"? Yet another example of he classic irresponsible/corrupt/greedy corp. that tries to cover up its own blunders.

      The firestone debacle was really ford's fault b/c their engineers were too lazy to design a smooth riding suspension system so they simply recommended that the users run ~26 psi in their tires =/ At least thats what I have always been told.

      --
      Arguing with an engineer is like wrestling a pig in mud. Soon, you realize the pig is dirty, and he likes it.
    2. Re:Firestone ? by Ironsides · · Score: 1

      Could this be the drug industry's "Firestone"? Yet another example of he classic irresponsible/corrupt/greedy corp. that tries to cover up its own blunders.

      If Merck is as you say, they wouldn't be running this program for free.

      --
      Fly me to the moon Let me sing among those stars Let me see what spring is like On jupiter and mars
    3. Re:Firestone ? by Anonymous+Codger · · Score: 1

      I think what the parent is trying to say is that, in the Firestone/Ford Explorer debacle, the wrong company got burned. Firestone got most of the bad press for having sold faulty tires, but the real culprit was Ford. There's no excuse for selling a vehicle that will roll over when you have a flat tire, no matter how catastrophic the tire failure.

      But Ford suffered virtually no ill effects from this, in spite of all the deaths they caused. So if this current scandal is Merck's Firestone, I guess some other company is going to get the shaft, not Merck...

      --
      No sig? Sigh...
    4. Re:Firestone ? by Anonymous Coward · · Score: 0

      "Could this be the drug industry's "Firestone"? Yet another example of he classic irresponsible/corrupt/greedy corp. that tries to cover up its own blunders."

      Well, does Merck have a large partner with an established army of Washington lobbyists who will see that Merck takes the blame for vehicles that tumble and crush their occupants due to tire failure? Then yeah, I guess it could be the drug industry's "Firestone".

    5. Re:Firestone ? by Anonymous Coward · · Score: 0

      Nobody seems to have admitted that the problem is women drivers who were speeding and failed to control their vehicles.

    6. Re:Firestone ? by zippthorne · · Score: 1

      actually, it was about control:

      The vehicles tended to slip when turning at full tire pressure, so they specified a lower pressure. Ford initially estimated that the increased wear from the lower than recommended tire pressure was an acceptable tradeoff. Of course, if they'd bothered to mention that explicitly somewhere, they wouldn't have been as exposed, but they probably also wouldn't have sold as many units.

      also, an experiment I don't recommend you try: let out some pressure on your own tires and see how smooth the road becomes. I think you'd be surprised. (speaking as someone who had to buy those low-pressure indicator caps because I forget to check often.)

      --
      Can you be Even More Awesome?!
    7. Re:Firestone ? by symbolic · · Score: 1


      I wonder which politician was in bed with them at the time...after all, Rumsfeld did the nearly the same thing with GD Searle, who at the time was trying to get Nutrasweet approved.

  21. Crazy molecular office assistant was overheard by chunews · · Score: 1

    "it looks like you're defrauding the journal"

  22. The Merck knows. Oh it knows. by Japong · · Score: 2, Funny

    "At 3:00 P.M. today, Curfman and two other editors released an editorial on The New England Journal's Web site entitled "Expression of Concern," which calls on the VIGOR authors to submit a correction of the 2000 manuscript. "Taken together, these inaccuracies and deletions call into question the integrity of the data on adverse cardiovascular events in this article," it read. "

    The editorial, however, is also strangely missing. In its place was a message: "Silly Scientists - morality is for kids! Love, Merck."

  23. MS Word by Anonymous Coward · · Score: 0

    I'm assuming that this is a word document.

    As if I don't have enough other reasons to never use Word, my tinfoil hat always tingles whenever I have to do something with a .doc file.

    While I can see why knowing the author or history of a document can SOMETIMES be extremely useful, it really should be something that you have to explicitly put into the metadata. There is a huge privacy risk that is here, and MS doesn't exactly make it easy to be sure it's all turned off, if indeed it can be.

  24. This is my "surprised" face. by Anonymous Coward · · Score: 1, Insightful

    Is anyone here shocked by this?

  25. It was fairly conclusive though by technoextreme · · Score: 1
    Now why would you allow to publish such inconclusive studies at all ? Is this journal peer-reviewed ? It would be interesting to see if they also publish the comments from the anonymous reviewers ? Did they agree about the paper before it got published ?

    You see it was fairly conclusive though after they omitted the whole part about people dropping dead....
    --
    Ooo man the floppy drive is broken. No wait. The computer is just upside down.
  26. Accept Track Changes by jaygatsby27 · · Score: 1

    Don't they know anything? Did they take a handful of Vioxx and lose their minds?

    1. Re:Accept Track Changes by Ruff_ilb · · Score: 1

      Looks like they'll need some Prozac after this.

      --
      http://www.TheGamerNation.com/Forums
  27. Next Headline: Merck Moves to OpenOffice by nonsense28sal · · Score: 1

    I'm guessing the hovering cursor refers to a MS Word document. Who knows...maybe this incident could be good news for OpenOffice or some other non-MS alternative, since OpenOffice and other office apps lack such ^H^H^H^H^H^privacy issues^H^H^H^H features...

  28. well... by flynt · · Score: 5, Interesting

    It wasn't so much the data that was tampered with. I can almost guarantee you that Merck was not unblinded during the trial, and therefore wouldn't know which data to change. This article is talking about a scientific publication based on the study results, there are usually many publications resulting from any study. At this point, several institutions, including Merck, a data safety board, and an independent statistical data center would complete copies of the original data, so any changes at Merck would be caught by these people (in theory).

    What the Journal found, was that someone at Merck had included a table on CV events in an early version of the manuscript, and then deleted it. So this isn't really tampering with data, it's not including all the data in your conclusions. It's not including data that shows potential harm to patients. It could be argued that this is tantamount to the same thing, which I'm not disagreeing with. Merck's defense is that the events in question occured after some pre-specified cut off date for analysis, who knows if that is true or not.

    1. Re:well... by Anonymous Coward · · Score: 5, Informative

      Yeah... I work in data management for a central lab, and I don't think data can really ever be "deleted". We certainly never delete ANY data (not for at least 15 years anyway), and as a central lab, we don't answer to a single sponsor and DO answer to federal regulations and are subject to random audits at any time. So, we would have the data, and the CRO (contract research organization) would have the data at least. What Merck or any other drug company does with the data is not really our concern but it's effectively impossible for clinical data to really be wiped out totally because it will be in the hands of many independent organizations.

      I'm just a database monkey so I'm pretty ignorant about the process with these journals and such, but it sounds like the data was deleted because it was past a cutoff date; maybe at that level thats a no-no, but for us it's pretty much standard procedure that if we have data that has some outstanding issue and we are waiting for some confirmation/reconciliation, we just suppress it until the issue is resolved, which is preferable to sending erroneous data.

      Also, to troll it up: maybe if it was possible to recall a drug without necessarily opening up yourself to billions of dollars of liability lawsuits, drug companies would have more incentive to take recall actions sooner rather than waiting until the evidence is overwhelming. By making the price of admitting there MIGHT be a problem with the drug so high, it's inevitable they would try to delay a recall for as long as possible. I'm not defending it - I'm saying it's inevitable and logical. The tort system takes it's toll in lives as well as dollars.

    2. Re:well... by budgenator · · Score: 1

      Just pay some clown to sue you for patent infringement, stop making it and say no comment due to pending litigation; or just stop making it without comment. Hygenic just quit making Novus, denture soft lining material no reason given. I did notice that some patient's liners had a bizare coating of what appeared to be mucus and calculus that I assumed to be due to alergey issues, then they just quit making it. The rumors that one of the suppliers went out of business that did circulate, were bogus because this was the same material that they used in the space shuttle's SRB orings.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
    3. Re:well... by PitaBred · · Score: 1

      So, if I read what you wrote correctly, Merck is saying "Why should we worry about the people, money was at stake!"?

    4. Re:well... by RedWizzard · · Score: 1
      By making the price of admitting there MIGHT be a problem with the drug so high, it's inevitable they would try to delay a recall for as long as possible. I'm not defending it - I'm saying it's inevitable and logical. The tort system takes it's toll in lives as well as dollars.
      I don't agree with your logic. When the cost of liability is so high it should encourage companies to play it safe and pull drugs as soon as they suspect there might be an issue, because in that case they can legitimately claim to have done everything they could to limit damage. That would make settlements very difficult. That's what it looked like in the Vioxx case. But now Merck seem to have concealled evidence. By covering up the evidence a company is opening itself to tabacco-style settlements - it becomes a willful endangerment type of situation. A far riskier proposition, and one that could open executives up to criminal charges in some cases.
    5. Re:well... by Anonymous Coward · · Score: 0

      Bzzt. Admitting something might be bad early and often is no defense against "But my daddy died!!!"

    6. Re:well... by Llywelyn · · Score: 1

      While I don't know what kind of study they were doing, it should be noted that in survival studies, this kind of thing is routine.

      If you have a 30 day mouse study, and a mouse dies on day 31, when it goes to publication the mouse "survived the study."

      Now I don't know what kind of study merck was doing, and I don't know that they had this cut-off date pre-specified, but the possibility that there was such a cutoff date and that these heart attacks just happened to fall after and were therefore excluded it is entirely possible and, AFAIK, are not illegitimate scientifically.

      --
      Integrate Keynote and LaTeX
    7. Re:well... by Anonymous Coward · · Score: 0
      Bzzt.
      Dickhead.
      Admitting something might be bad early and often is no defense against "But my daddy died!!!"
      Of course it is. Being able to say "We did everything we could to ensure this drug was safe. And when we did find something wrong we pulled it" is clearly a much better defense than "We knew this drug was unsafe, but we concealed the evidence and continued to sell it".
  29. Data Recovered by JiffyPop · · Score: 0

    It reads:

    lol no its not its inconvenient data

    <reality>
    I'm so ashamed... but I couldn't resist the joke.
    </reality>

    <absurdity>
    My daughter will only allow one of her dolls in her play crib at a time. I have patented this process and will be selling implementations of the "Dolly-Exclusion Priciple" in the near future.
    </absurdity>

  30. Good old slashdot by A+nonymous+Coward · · Score: 0

    They have provided us with this dup. Nobody expects the Slashdot duplication!

  31. obligatory by GungaDan · · Score: 3, Funny

    $sys$data_unfavorable_to_merck

    --
    Eloi are stupid, throw morlocks at them!
  32. Re:In other news by lbrandy · · Score: 1

    One of the more skillful completely arbitrary Iraq connections for karmawhoring you will ever see. Grats.

  33. Cardiovascular problems? by Zarhan · · Score: 3, Funny

    Well, I'm glad that the issues has finally come to light. I heard someone else suspected something along these lines before, but he became Fugitive when he murdered his wife.

    1. Re:Cardiovascular problems? by Anonymous Coward · · Score: 0

      but he became Fugitive when he murdered his wife

      (about to jump) I did not throw a chair!
      -I don't care!

      No, wait, that wasn't it...

  34. Easily Forged by ShawnDoc · · Score: 4, Insightful

    The only problem with this is that this information is easily forged. It would be VERY EASY for someone to frame someone else this way. I'm not saying Merck didn't do it in this case. I'm just saying that even someone with no computer knowledge can change their user name in Word, make some changes, and have it appear as if someone else made the edit.

    1. Re:Easily Forged by CheshireCatCO · · Score: 1

      Agreed. I also find it rather unsettling that the editor of the file was apparent just called "Merck" in the installation of Word. It could be that Merck really does make the user name "Merck" on all of its machines, but I can't help but feel that this looks like a half-assed framing attempted. Not that I think Merck is innocent, just that it has a surreal quality to it.

    2. Re:Easily Forged by PhreakOfTime · · Score: 1

      Time stamps in the software indicated that the table was deleted two days before the manuscript was submitted to The New England Journal on May 18, 2000

      So, using your line of thinking, did someone with no computer knowledge go back in time 5 years and change these things? Because, after all time travel is such a common occurance it is only logical that after the confusion came out last september about vioxx, that someone would go back in time to plant evidence against merck.

      But they were clever about it, they were thinking long term. The data that was deleted was beneficial to merck at that time 5 years ago. So even though it would have screwed over the sabateour for 5 years, the time has finally come to reap the benefits?

      Cliche perhaps, but have you ever heard of the principle of Occams razor?

    3. Re:Easily Forged by Duhavid · · Score: 1

      It's even probable that the user name is "Merck".

      I recall doing IT for a relatively small shop in the early
      eighties, and after a while, I stopped putting user's names
      on the software installed. I just put in the company name
      for the user name as well. I can imagine that a big place
      like Merck might well stockpile and "recycle" machines,
      and would probably not put user names in, not having them
      at the time of setup.

      So, now to the hopefully humourous part:

      To properly incriminate someone, run some incriminating
      google searchs from their machine. Follow that with a
      few documents with tracking changes "on" where i erase
      some incriminating statement and leave that in place but
      just in the changes, so it looked like they were erased.

      Anything else?

      --
      emt 377 emt 4
    4. Re:Easily Forged by CheshireCatCO · · Score: 1

      Ah, well. Silly, but reasonable in its way. It does render part of the track-changes feature pointless, though, to not insert some unique identifier.

    5. Re:Easily Forged by Duhavid · · Score: 1

      It does, but who thinks of that when rebuilding a box?

      It would not have occured to me, until this thread.

      --
      emt 377 emt 4
    6. Re:Easily Forged by CheshireCatCO · · Score: 1

      It would have occured to me when I was using Word as the machine's usual user. If not right away, sometime when I was ditzing with settings or when I noticed that my comments in version-controlled papers were ascribed to "Merck". :-)

  35. Sarbanes-Oxley by DingoBueno · · Score: 3, Interesting

    Although targeted at financial data, legislation such as the Sarbanes-Oxley Act is precisely what is needed in such high-risk industries. It imposes strict information controls and audit requirements, and makes an effort at putting the responsibily where it belongs, namely at the Director and Executive levels.

    --
    ascii art
    1. Re:Sarbanes-Oxley by twotommylong · · Score: 5, Interesting
      Although targeted at financial data, legislation such as the Sarbanes-Oxley Act is precisely what is needed in such high-risk industries. It imposes strict information controls and audit requirements, and makes an effort at putting the responsibily where it belongs, namely at the Director and Executive levels.

      Err, there is the congressionally mandated little outfit called the Food and Drug Administration (FDA), and their code of federal regulations (21 CFR et al). No need for congress to rush out and write laws... the work is done.
      A quick read (chuckle) would point out that officers of a Pharma that knowingly submit incomplete or falsified data, are subject to fine and/or imprisonment, and even it was unknowingly falsified... the company can be effectively barred from producing/selling any product until the revalidation of all quality processes are complete. Not the sort of thing stockholders like to hear about.
    2. Re:Sarbanes-Oxley by DingoBueno · · Score: 1

      And before SOX, there was the SEC. Just as the SEC was formed during a time when "information technology" meant "file clerk", the FDA has grown inefficient. (This includes bringing new drugs to market, not just dealing with practices of the industry.) Now that attention has been called to this issue, we need to focus on improving the process. Congress is going to write laws anyway--let's try to shift attention toward the important issues.

      --
      ascii art
    3. Re:Sarbanes-Oxley by Anonymous Coward · · Score: 0

      SOX is precisely what we don't need. Adding more bloated regulations isn't going to help the situation, only make it harder to track down bad decisions, waste tax payer dollars, waste capital investments and in the end it won't really help the consumer at all.

      What we do need are laws that protect us, not laws that make the monkeys roll for more time in the cage; and may the number of laws be few and far between.

  36. Re:In other news by Arandir · · Score: 2, Insightful

    Which president? Both Clinton and Bush strongly asserted that Iraq had WMDs during their tenure.

    --
    A Government Is a Body of People, Usually Notably Ungoverned
  37. That's why... by animeshpathak · · Score: 1

    ... I use LaTeX. The commented text stays only in my .tex file.
    %% Write something witty that can be modded as "Funny"

    --
    "- What's so unpleasant about being drunk?"
    "- You ask a glass of water."[from h2g2]
    1. Re:That's why... by wayward · · Score: 2, Interesting

      Maybe they just deleted the table from the article because they couldn't figure out how to format it in LaTEX.

  38. Re:In other news by GungaDan · · Score: 1

    yet only one unwisely invaded without provocation to decisively prove himself wrong on the issue...

    --
    Eloi are stupid, throw morlocks at them!
  39. Unlikely the researchers did it by Call+Me+Black+Cloud · · Score: 1


    I don't believe the researchers deleted the text. It was probably a manager handling the submission. If the researchers wanted to supress the data they would have just left it out of the article altogether.

    The submission was on paper and on diskette. The paper version was edited, and that's what was used for publication. The diskette version was not edited and had the complete original text. http://news.yahoo.com/s/nm/20051209/hl_nm/medical_ journal_says_merck_deleted_dc_1

    That does seem odd, though, because it means that unless Merck submitted camera-ready print someone had to re-type the article.

    1. Re:Unlikely the researchers did it by deimtee · · Score: 1

      It is very unlikely that they use Word to lay out their Journal, and word documents are a pain to directly convert into decent typesetting program files.
      The usual procedure in places I have worked that need to do this is to open the document in word, select all the text and copy and paste into Quark/Framemaker/Indesign/Whatever.
      You will have to re-apply all the formatting and styles, but you usually have to do that anyway in the Journal's style, and you can generally do it a paragraph or more at a time.
      Then the graphics/tables are done separately. The only way I have found to get decent quality graphics back out of word is to print the whole thing to a postscript file and cut out the bits you need. Word seems to deliberately damage embedded graphics if you cut and paste them to a non-office program.
      If they operate this way, which I strongly suspect they do, then any hidden text or data is automatically left behind.
      The document will usually then be proof-read against the hard copy supplied and "OK'ed" from that.

      --
      I'm guessing that wasn't on their radar screen...
  40. Contrast that with the Viagra makers studies by LM741N · · Score: 3, Funny

    In related news the makers of Viagra were saying that their studies posted on the internet were "standing up" really well.

  41. Happens all the time by Anonymous Coward · · Score: 0
    I'm posting Anon because this happened to a client of mine awhile ago. They are supposed to give us all program content in Microsoft Word, with all changes accepted and track changes turned off.

    They don't always do this. When you then take that document and export it as text, all of the old changes come with it. Since the editors like to write their comments inline with the text...some big bloopers made it through quality control.

    "I don't care if it's messed up or not, let the programmers deal with it"
    "Frank doesn't know what the fuck he is talking about"
    and other gems. All of which made it into various parts of an educational CD-ROM. Luckily, we caught them all before going to print.

  42. oh no! by legalize.ganja.now. · · Score: 3, Funny

    they should have deleted lore instead!

  43. the other one.... by HBI · · Score: 0, Troll

    While the other one randomly lobbed missiles into the country and conducted airstrikes, to deflect attention from his then proceeding impeachment for lying under oath.

    --
    HBI's Law: Frequency of calling others Nazis is directly correlated with the likelihood of the accuser being Communist.
    1. Re:the other one.... by geekoid · · Score: 1

      "randomly lobbed"?

      Christ do you people even hear yourself talk? Putting aside the point that the targets were activly making hostile manuevers and violating air space, using the term 'randomly lobbed' clearly indicates that you are grasping at straws to 'prove' our current president isn't so bad.

      Interesting that he was impeached for lying under oath about conducting an improper relation with an intern, yet the other one lies to get us into war, 1000's of americans die, gives a corporation no bid contracts and there is no impeachment? And the press says very little about this compared to how the raked the prevoius president through the coals over a sexual affair.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  44. no laughing matter (and how to avoid it) by conJunk · · Score: 5, Informative
    An entire multi-national corporation brought down by Microsoft's TrackChanges feature...

    where i work, we enforce use of the Remove Hidden Data Tool to prevent this happening

    we once got some documents from DOJ that were supposed to go up on our website that had obvious edditing changes in them

    1. Re:no laughing matter (and how to avoid it) by starm_ · · Score: 1

      So you admit that you work at a place that uses illegal practices? Someone should really do a survey of documents with TrackChanges found on company web sites. It could give us emperical data about the standard of ethics in corporations.

    2. Re:no laughing matter (and how to avoid it) by sam0737 · · Score: 1

      Why not publish it into .ps or .pdf? A better compatibility with readers is a plus.

    3. Re:no laughing matter (and how to avoid it) by hey! · · Score: 4, Interesting

      That's like saying that pleading the fifth means your guilty. People believe that because they're too naive to know what a skilled lawyer with money (== time) to burn can do with your normal innocent activites. Much less the ones you aren't quite sure of. So -- if you're smart, you certainly don't count on mere innocence to protect you from the prosecutor or the courtroom privateer pursuing lawsuit booty.

      It seems to me whole premise of the adversarial legal system, and the fifth ammendment, is that nobody can be trusted to give a true and honest picture. So you set up a game with opposing sides. You set up rules to avoid fabrication and actually hiding evidence, and then you need a bit more rules help the defense because from the defendant's position you can't prove a negative. And when you're done, the game is still too slanted for the prosecution, so you need to make it possible for a cautious man not to get trapped. Of course, these rules probably on the whole benefit the unscrupulous, who are naturally more cautious. But when the honest man can't be bothered to play the game anymore, the system is utterly worthless.

      --
      Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
    4. Re:no laughing matter (and how to avoid it) by Dashing+Leech · · Score: 1

      Not all information you want to keep hidden is illegal. In fact, in the corporate environment, I would think illegal stuff would make up a negligible percentage of secret/proprietary information. Not to mention simple mistakes, wordings that someone wanted changed so as not to offend a client, or things of that nature.

    5. Re:no laughing matter (and how to avoid it) by conJunk · · Score: 1

      :) easy to say on slashdot... it's amazing what kind of emails you get when you *only* make documents available in pdf!

    6. Re:no laughing matter (and how to avoid it) by conJunk · · Score: 1
      So you admit that you work at a place that uses illegal practices?

      Not all changes are about illigal stuff. How about "The state agrees to pay $1,000,000^H^H^H^H^H^H^H500,000 for the whatever..."

      you don't want the casual reader to be able to see what sort of numbers were in various versions of the agreement before the final public document is ready

    7. Re:no laughing matter (and how to avoid it) by timeOday · · Score: 1

      I don't believe the 5th ammendment applies to corporations trying to hide knowledge of the danger of their products, at least not in civil court. The tobacco companies were crucified over the contents of their internal memos showing they knew nicotine was addictive. If Merck was proven to hide negative information about their drugs, maybe the 5th protects them from criminal prosecution (I don't know) but the ambulance chasing lawyers would have an absolute field day suing them into oblivion.

    8. Re:no laughing matter (and how to avoid it) by glitch23 · · Score: 0

      Incidentally I create a lot of docs for the DOJ (as a subcontractor) and we heavily use the TrackChanges feature to track updates to a document before they are approved. This can have a noticeable impact on the size of the document however I've noticed that saving the file to a new filename reduces the filesize (and I assume cleans up the tracking data). If you know about this method, can you say how it compares to the tool you mentioned?

      --
      this nation, under God, shall have a new birth of freedom. -- Lincoln, Gettysburg Address
    9. Re:no laughing matter (and how to avoid it) by ThaReetLad · · Score: 1

      In 1997, the Food and Drug Administration issued 21 CFR Part 11, the Final Rule on Electronic Records and Electronic Signatures. Part 11 applies to all electronic records that are created, modified, maintained, archived, retrieved, or transmitted in companies or departments that work under any kind of FDA regulation, as well as records submitted to the agency under the requirements of the Federal Food, Drug, and Cosmetic Act and the Public Health Service Act. All GxP-regulated industries (pharmaceutical companies, manufacturers of medical devices, analytical contract laboratories, etc.) must comply with these regulations.

      --
      You can't win Darth. If you mod me down, I shall become more powerful than you could possibly imagine
  45. Hello chunews, by GroeFaZ · · Score: 5, Funny
    it looks like you're trying to make a joke. Would you like to...

    • insert a punchline?
    • copy a (Score:5, Funny) comment from another thread?
    --
    The grass is always greener on the other side of the light cone.
  46. I got 10,000 shares to unload quick... by Anonymous Coward · · Score: 0

    Who wants some? No offer refused...

    1. Re:I got 10,000 shares to unload quick... by Nethead · · Score: 1

      How about 1 yen?

      --
      -- I have a private email server in my basement.
  47. He didn't lie! by mmell · · Score: 1
    We know there were WMD's in Iraq; our CIA (under George H. W. Bush) delivered them! We're just upset because now we don't know where they ended up (getting used).

    I'll bet there's a highly classified hand reciept for them stashed in some beaurocrat's desk drawer.

  48. Re:In other news by ScentCone · · Score: 1

    You must be referring to the one that said he was sure the weapons were there, said there was a nuke program, specifically said that his administration's policy was to see Saddam removed... and either:

    1) was lying about believing all of that, or
    2) didn't have the backbone to do anything about it, even as Saddam was regularly shooting at the US air patrols enforcing the terms of his surrender following their ouster from Kuwait, among many other violations

    He was probably too busy dealing with the terrorist attacks on the embassies in Africa, or the attack on the USS Cole... oh, wait, no, he wasn't busy doing anything along those lines, either.

    --
    Don't disappoint your bird dog. Go to the range.
  49. They were framed! by ThreeE · · Score: 0

    I think it's pretty weak to say that just because an edit tagged as being performed by "Merck" that it had anything to do with the company. Perhaps there is other evidence, but the tag alone is easy -- intentionally or accidentally -- to fake/get wrong.

  50. It's happened before... R. G. Serle by Jerry · · Score: 4, Interesting

    When Donald Rumsfeld was head of R.G. Serle they were doing FDA safety studies for Aspartame (later branded as NutraSweet). Several rodents in the safety study died of brain cancer, but Serle removed them from the study and the data. A PhD working on the project blew the whistle. Congress investigated, hiring two lawyers to continue their work. A couple years later the acting head of the FDA, as his final act before resigning, approved NutraSweet. He then appeared as the legal eagle for NutraSweet. Guess who his two assistants were... Right.

    Aspartame breaks down in warm water to release Methyl Alcohol, among other things, which causes cancers of the brain, eye, kidneys and liver. It can cause, like it did in me, a red flush over the upper half of the body and the face, and severe oil production by the Sebaceous glands, and a continual headach. It is associated with memory loss. My once nearly photographic memory is now gone.

    Rumsfeld got $6M for his "work".

    --

    Running with Linux for over 20 years!

    1. Re:It's happened before... R. G. Serle by guitaristx · · Score: 1

      Do you have some links for the above?

      --
      I pity the foo that isn't metasyntactic
    2. Re:It's happened before... R. G. Serle by Anonymous Coward · · Score: 0

      Aspartame breaks down in warm water to release Methyl Alcohol, among other things, which causes cancers of the brain, eye, kidneys and liver. It can cause, like it did in me, a red flush over the upper half of the body and the face, and severe oil production by the Sebaceous glands, and a continual headach. It is associated with memory loss. My once nearly photographic memory is now gone.

      Do you have Phenylketonuria? Can you provide a link to a reputable source to back up any of the above?

    3. Re:It's happened before... R. G. Serle by Anonymous Coward · · Score: 0

      Yes... but I've forgotten them.

    4. Re:It's happened before... R. G. Serle by RzUpAnmsCwrds · · Score: 1
      Since you don't believe the FDA, here's what the EU has to say:
      http://europa.eu.int/comm/food/fs/sc/scf/out155_en .pdf

      "It can cause, like it did in me, a red flush over the upper half of the body and the face, and severe oil production by the Sebaceous glands, and a continual headach. It is associated with memory loss. My once nearly photographic memory is now gone."


      The interesting thing about all of the websites that make threats about aspartame is the huge range of effects described:

      abdominal pain, anxiety attacks, arthritis, asthma, asthmatic reactions, bloating/edema, blood sugar control problems (hypoglycemia or hyperglycemia), brain cancer (Pre-approval studies in animals), breathing difficulties, burning eyes or throat, burning urination, can't think straight, chest pains, chronic cough, chronic fatigue, confusion, death, depression, diarrhea, dizziness, excessive thirst or hunger, fatigue, feel 'unreal', flushing of face, hair loss (baldness) or thinning of hair, headaches/migraines, hearing loss, heart palpitations, hives (Urticaria), hypertension (high blood pressure), impotency and sexual problems, inability to concentrate, infection susceptibility, insomnia, irritability, itching, joint pains, laryngitis, "like thinking in a fog," marked personality changes, memory loss, menstrual problems or changes, muscle spasms, nausea or vomiting, numbness or tingling of extremities, other allergic-like reactions, panic attacks, phobias, poor memory, rapid heartbeat, rashes, seizures and convulsions, slurring of speech, swallowing pain, tachycardia, tremors, tinnitus, vertigo, vision loss, and weight gain


      Wow! All that caused by two amino acids which are commonly found in other foods.

      One of the biggest problems is that aspartame is trashed so frequently on the internet that it becomes a self-perpetuating "problem". It is difficult to tell whether or not there is a real problem simply because there are so many bogus anecdotal reports.

      So, the next time you feel like posting your warning about the dangers of aspartame, post some actual scientific studies (and link to them). Claiming that the government conspired to approve aspartame - without providing evidence - and posting an anecdotal report about how your "near photographic memory" is now gone simply makes you look like a quack.
    5. Re:It's happened before... R. G. Serle by zCyl · · Score: 1

      One of the biggest problems is that aspartame is trashed so frequently on the internet... posting an anecdotal report about how your "near photographic memory" is now gone simply makes you look like a quack.

      Funny. Another problem on the internet is people calling someone else a "quack" after doing little more than a summary perusal of the literature themselves.

      Many of the studies referenced in the document you provided are severely lacking in experimental design. For example, while headaches from aspartame frequently come the day after consumption, a study was presented in which aspartame and placebo are switched every 24 hours, and then the placebo was shown to cause more headaches. This was provided as the sole and primary source of evidence that aspartame does not cause more headaches than a placebo, yet it did not actually test what is commonly experienced.

      As in the example of the Merck research, and in the case of some aspartame research, there is a significant problem with research being funded and directed by the food and drug companies that stand to profit from the results of the research. We are experiencing a significant problem with the quality of research performed in this way, and a change is required.

      It is known that aspartame's primary ingredient, phenylalanine, crosses the blood brain barrier and significantly disrupts normal neural function. This effect can be directly measured. For a slightly more extended summary perusal of the literature, you can start here or here.

      You'll find that studies exist which indicate significant caution about aspartame is warranted, with results such as seisures and headaches.

      If you pay attention, you'll also find that many of the other "studies" in the literature are far from impartial. For example, here's a nice flowery "scientific review" of the safety of aspartame, except that if you check the author affiliations, you'll find that they work for NutraSweet. Oh, and if you're paying a lot of attention, you'll even notice that S.S. Schiffman, the author of the study I was complaining about above that was used by the EU to "show" that aspartame doesn't cause headaches, is on that list of the authors working for NutraSweet.

      Please question your sources of information a little more carefully before you go throwing around the "quack" label next time.

  51. Clippy by mymaxx · · Score: 5, Funny

    It looks like you are writing a drug study document. Would you like help deleting data?

  52. I did not RTFA, Take with grain of salt. by Khyber · · Score: 1

    The simple *IDEA* of a large company responsible for...

    A. It's profits/shareholder's profits

    AND

    B. the lives of others that use their product

    just seems to naturally conflict with each other. In this case, it seems especially true of drug companies. Imagine this...

    MERCK: "Hey! We've invented VIOXX! This will help osteo-arthritic patients!!"
    RESEARCHERS: "Ahh, yes, but it *WILL* also pose a potential threat to our customer's hearts/cardiovascular system! We need more testing!"
    MERCK: "Eh, forget that! Everything comes with a risk or a side effect! Just let that data slide, we'll cover the expenses!"

    Not to say that's what actually happened, but having run my own business (NOT in a realted field, but as it's said, business is business) I've even done a few "quickies" that I had to do some serious explaining about before I got my ass canned or sued. I'll bet/wager/gamble a little bit of money that Merck KNEW what they were doing, were prepared for the potential suit, and they just wrote it off as "acceptable risk."

    I can only hope this "acceptable risk" of gambling with people's lives does not go unpunished.

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
    1. Re:I did not RTFA, Take with grain of salt. by cnerd2025 · · Score: 1

      This scenario was on Numb3rs about a week ago.

    2. Re:I did not RTFA, Take with grain of salt. by Khyber · · Score: 1

      I don't watch TV, so I'd be a bit unaware of that screenplayed scenario.

      --
      Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
    3. Re:I did not RTFA, Take with grain of salt. by Anonymous Coward · · Score: 0
  53. Re:News for nerds? by Anonymous Coward · · Score: 0

    There are more kinds of nerds than computer nerds here. Some of us are law nerds, and the researcher nerds would be quite interested also.

    Just because you aren't that kind of nerd doesn't mean there isn't one out there!

    He's just appealing to a greater number or nerds than there are in your small view.

  54. Re:Next Headline: Merck Moves to OpenOffice by Anonymous Coward · · Score: 0

    "OpenOffice and other office apps lack privacy is features..."

    I don't get it.

  55. Re:News for nerds? by Nethead · · Score: 1

    You're new here? I'm in a pissy mood today and have karma capital burn.

    --
    -- I have a private email server in my basement.
  56. links by Anonymous Coward · · Score: 0
    http://www.dorway.com/
    The report of the Task Force submitted in March of 1976 in essence constituted a stinging indictment of Searle and it contained various recommendations for regulatory action including referral to the Justice Department for review of possible criminal violations of the law.
    Searle nearly got taken to criminal court - yet 30 years later, and you see everyone still drinking Diet Cola products with Aspartame.
  57. On slashdot? You don't think that will be Funny? by irritating+environme · · Score: 1

    Please, that is 4x funnier than practically every Score5 funny on active stories right now. At least your joke makes a point.

    --


    Hey, I'm just your average shit and piss factory.
  58. Re:Next Headline: Merck Moves to OpenOffice by Anonymous Coward · · Score: 0

    It was meant as a joke...in other words Merck might move to Open Office since it lacks the "feature" of tracking changes. Get it...it's a "feature" in MS Office that has caused this sort of problem in the past. I think the Parent Post meant that this bad press for MS could be good press for Open Office. Relax it's Friday, laugh a little. Shhheeesh.

  59. Read "Overdosed America" by rekky · · Score: 3, Informative

    When I heard this news about Merck, my impression was "deja vu". I recently read a book entitled "Overdosed America: The Broken Promise of American Medicine" by John Abramson. The author is not some quack. He teaches medicine at Harvard Medical School. He makes a strong point that drug tests which used to be funded by unbiased sources and now mostly funded by drug companies. They tailor the tests and massage the results to arrive at the conclusions that they are looking for. Before you take any prescription medicines, I strongly recommend that you read that book!

    1. Re:Read "Overdosed America" by westyvw · · Score: 2, Interesting

      I would agree with Parent's Post.
      Overdosed America is a good read. Abramson is a capable writer, and is an illuminating book both on the problems with the US health care system, and the doctor - patient relationship as well. He helps educate the reader on the disease and the history of treatment as he discusees the therapy.

      I have read several resports, articles, and books on the commercialism of our health care system. Why do we spend the most money (by far) on medicine in this country only to find ourselves ranked fairly low in the industrial countries in terms of actual health?

      Is it any suprise that many countries ban advertising of drugs, while in our country samples are given to doctors and ads are placed where consumers will see them, while at the same time Journal writers are on the drug companies pay roll, and members of the FDA have stock portfolios filled with thier (guess what) former employers, the drug companies?

    2. Re:Read "Overdosed America" by Anonymous Coward · · Score: 0

      These cases with Vioxx, etc, are the reason why I try to avoid any drug that is less than ten years FDA approved. My rationale is to let other "my back hurts...give me drugs NOW" people be the guinea pigs, before I am put at risk. Unfortunately, the FDA website is also nearly impossible to navigate to find what drugs are old enough.

    3. Re:Read "Overdosed America" by ScrewMaster · · Score: 1

      Just get hold of a ten year old copy of the Physician's Desk Reference. If it's in there, you can take it. If it's not, don't.

      --
      The higher the technology, the sharper that two-edged sword.
  60. Cover Up? by WebHostingGuy · · Score: 1

    What cover up?

    If you read the last paragraph of the it says they provided ALL the data to the FDA. I guess if you provide data publicly to a federal agency in which anyone can look it up that's a cover up nowdays. The fact that Curfman states that he is not buying into the fact that is was publicly available knowledge really shows his bias.

    "Nevertheless, the additional events were disclosed to the FDA in 2000, presented publicly to the FDA's Advisory Committee in February 2001 and included in numerous press releases subsequently issued by Merck. We also note that these additional events did not materially change any of the conclusions in the article."

    Curfman responded, "We're not buying into that."

    --
    Quality Hosting e3 Servers
  61. Re:In other news by Darby · · Score: 1

    He was probably too busy dealing with the terrorist attacks on the embassies in Africa, or the attack on the USS Cole... oh, wait, no, he wasn't busy doing anything along those lines, either.

    I assume, of course, you mean nothing besides:

    Sending over John O'Neill, director of counterterrorism for the FBI's New York office as head of an FBI team. Accompanying O'Neill to Yemen were over 100 FBI agents, laboratory experts and forensics specialists, as well as FBI Director Louis J. Freeh.
    He was convinced that OBL was in fact responsible.
    He was also convinced that all the answers were to be found in Saudi Arabia, which was why as soon as Bush got into power he blocked all investigation along those lines. Including refusing to allow John O'Neill, head of the investigation back into Yemen after he had returned home for the holidays.

    That's actually quite a lot given that the bombing took place in October of 2000. Wouldn't want to allow any facts to get in the way of a nasty little anti-Clinton rant, now would you?
    Especially since the facts all point to Clinton actively supporting the investigation and Bush protecting his good terrorist buddies, the Saudis.

    The arrest and subsequent prosecution of a number of the perpetrators in the Embassy bombings are, of course, also nothing.

    Where you extremist right wing nutjobs get off defending terrorists yet claiming patriotism is so far beyond rationality as to sicken any decent person.

    I mean can't you at least *try* to make up a believable lie?!?

  62. Aspartame by smellsofbikes · · Score: 5, Interesting
    I'm not trying to minimize your symptoms: aspartame does have effects on people. I'm also not trying to defend Searle. The approval process for aspartame was pretty damned sketchy, with a very uncomfortable number of high-ranking people changing jobs back and forth between Searle and the FDA during and immediately after the approval process. It wasn't just Rumsfeld, it was also Ronald Reagan and Arthur Hayes who essentially ramrodded the approval process.

    With that said, aspartame *can* break down into methanol, but usually only does so at extreme pH or temperature. Warm water alone very slowly hydrolyzes aspartame. I'm trying to find some good kinetics studies; this one indicates 90% hydrolysis after 53 days at 25 degrees C which is a good argument for only drinking refrigerated pop.

    But the sheer amount you'd have to drink to produce blindness is astounding. I once calculated that with 100% hydrolysis, it would take 20 cans of pop per hour to build up and maintain harmful concentrations of methanol in the blood. EPA studies have indicated that 0.5g/kg/day doesn't result in observable health problems. There are (Google calculator r00lz) 0.014g of methanol per can of 100% hydrolyzed Coke. Hm, so that indicates that you probably don't want to drink more than 35 cans per day or you'll be above the no-observed-adverse effect level.

    The official Materials Safety Data Sheet for methanol lists "Carcinogenicity: Methyl Alcohol - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA." That doesn't mean it's not carcinogenic, but it does mean that none of them has ever found any evidence for it being carcinogenic, as opposed to things like the nitrites in bacon, which have definite carcinogenic activity. The point being: we're eating things that are probably orders of magnitude more carcinogenic than the released methyl alcohol in aspartame; our bodies produce more methyl alcohol and its metabolites naturally than any but the most aggressive pop drinker will ever experience.

    I'm not defending aspartame's use, but if you're going to attack what the FDA did when they certified it for use, attack it on other grounds, like your observed reaction to it, rather than because of methanol.

    --
    Nostalgia's not what it used to be.
    1. Re:Aspartame by InfinityEdge · · Score: 1

      Methyl alcohol itself doesn't cause cancer, but it metabolizes into formaldehyde which does.

    2. Re:Aspartame by deimtee · · Score: 1

      I think you may have misplaced some units here.
      The no-harm figure from that page that you quote is 0.5mg/kg/day.
      Meaning you wouldn't want to drink more than 0.035 fully hydrolysed cans per day.

      Unless you are quoting the animal dose figures, which only specify no brain or liver effects at 500 mg/kg/day,(but which is then contradicted by the studies quoted further down)
      I think this is unlikely given that the lethal dose for humans is quoted as 80 - 150 ml. i.e. about 1000mg/kg.

      --
      I'm guessing that wasn't on their radar screen...
    3. Re:Aspartame by PostItNote · · Score: 1

      My favorite conspiracy theory about aspartame is that the Diet Coke that the Coca Cola Corp. sent over to support our troops in the first Gulf War was stored in the sun and then later refrigerated. And that Gulf War Syndrome is ACTUALLY methyl alcohol poisoning from the denatured Diet Coke.

      Monsanto colluding with the government to poison US soldiers. You don't get better conspiracy theories than that.

    4. Re:Aspartame by smellsofbikes · · Score: 1

      I think the established no-harm recommendation is 0.5mg, which is 1/1000 the observed no-harm level as measured in rats (which don't have good feedback mechanisms for saying "I itch all over and my eyes hurt.") I may be reading it wrong. Other sources have indicated a *significantly* higher LD50 for humans, more like 2500-3000 mg/kg. But, hey, that's the thing about killing stuff off with poison: it's variable.

      --
      Nostalgia's not what it used to be.
    5. Re:Aspartame by smellsofbikes · · Score: 1

      I seriously don't believe that Monsanto/Searle thought there was anything wrong with aspartame (unlike Merck, apparently.) They just believed that they knew better than anyone else, and getting this on the market was more important than listening to nervous people, (who might very well be right, as it turns out.) Most of MY conspiracy theories involve malice and forethought, like, oh, say, financially massively overextending the government by engaging in two-front wars, pushing the US close enough to bankruptcy that massive cuts in Social Security and Medicaid become 'necessary' -- tidy, insofar as it gets us involved overseas AND gives a good excuse for a politically very unpopular decision. Now THAT'S a good conspiracy theory. And they're planning on offering us up as snacks to the aliens, who have spycams implanted in our cats.

      --
      Nostalgia's not what it used to be.
    6. Re:Aspartame by smellsofbikes · · Score: 1
      Guh. Formaldehyde's pretty nasty stuff. I hadn't read its MSDS before. Suxx0rs coz one of my favorite reactions, the mixed aldol condensation, uses loads of it. Hrmph.

      memo to self: no swigging methyl alcohol.

      I still maintain, however, that the amount a reasonable person consumes is going to be on par with the amount formed through normal metabolic processes. Although having said that, I can't remember which pathways produce methanol. My first thought was heme lysis and scavenging of the iron, but a quick check says that makes carbon monoxide. (I knew it was something nasty.) So I'm just going to have to wave my hands and claim that several references about methanol say it occurs on the ug/kg level naturally in humans.

      --
      Nostalgia's not what it used to be.
    7. Re:Aspartame by Anonymous Coward · · Score: 0
    8. Re:Aspartame by Anonymous Coward · · Score: 0

      Most of MY conspiracy theories involve malice and forethought, like, oh, say, financially massively overextending the government by engaging in two-front wars, pushing the US close enough to bankruptcy that massive cuts in Social Security and Medicaid become 'necessary' -- tidy, insofar as it gets us involved overseas AND gives a good excuse for a politically very unpopular decision. Now THAT'S a good conspiracy theory.

      No, no -- to qualify as a conspiracy, a plot must be secret.

    9. Re:Aspartame by zCyl · · Score: 1

      I seriously don't believe that Monsanto/Searle thought there was anything wrong with aspartame (unlike Merck, apparently.) They just believed that they knew better than anyone else, and getting this on the market was more important than listening to nervous people, (who might very well be right, as it turns out.)

      A conspiracy to intentionally be irresponsible with people's health and lives is still a conspiracy.

  63. Re:In other news by ponchietto · · Score: 1

    When i will see Bush fighting in Iraq among the soldiers
    I will admit he has a backbone.

    Not a brain, of course.

  64. you Do need to have a cut off date by ChrisA90278 · · Score: 1
    In thier defence...

    Let's say we do a small study. We let 100 people drink 8 oz. of name brand bottled water. Now if we find that 50 of them are dead seconds afterward we might conclude something is wrong with the water. But if all them are dead 200 years after drinking the water we don't conclude anyhting about the water. So at what point between two seconds and 200 years do you stop watching the water drinkers? The answer is "It doesn't mater but you DO have to select a time limit What happened here was that a drug company did not publish information about what heppend after the time cut off. My opinion is that this "out of bounds data" should have gone into a footnote, apendix or whatever but they have a point that what happens after the study period is over should not be included in a published account of the study.

    1. Re:you Do need to have a cut off date by NaruVonWilkins · · Score: 2, Informative

      So, you're saying that if the company can select a cutoff date that's too soon, they can avoid a lot of hassle using your system?

    2. Re:you Do need to have a cut off date by ChrisA90278 · · Score: 2, Insightful
      No. I'm saying you need to selct a cut off date. How you choose it depends on many factors. They did set a date, we don't know how the picked it but we do know they picked the date before the study started, No one is claimming it wa picked after the fact to hide lateer data. So far nothing wrong. The controversy is what to do with late post cutoff data. The technical legalistic answer was "We are reporting on a study, not on what hapend after a study" I think anything that happened after should have gone into some appendix simply for public relations or polical reasons to revent this kind of public fallout.

      I'm not arguing one side ot the other. My point is simply that there are two points of view and it is not so black and white.

    3. Re:you Do need to have a cut off date by Anonymous Coward · · Score: 1, Informative

      You are right in that optional stopping points are one of the most common methods of medical study fraud.

      However, according to the article, internal Merk documents indicate the heart attacks occurred 5 weeks before the study is over. At the end of the article, they quote Merk officals who are not under oath as telling reporters that they were outside the study, and that they reported the deaths to the FDA anyway.

      At this point in time, we have 1) a motive, in the money Merk made 2) a means to do it and 3) evidence of Merk officials lying in testimony and getting caught in it from the transcript of the trial in Texas. If you are still posting "in defense of Merk . . . " comments at this point, you must be a Republican.

  65. exactly by rosie_bhjp · · Score: 3, Informative

    The former CEO (left early 2005) walked off with some $17 million in compensation. Merck could be penalized hard but the guy who was in charge will have absolutely nothing done to him.

    --
    A radio maverick jumps to internet only. The Future of Rock n Roll
  66. Re:It's not the business that should pay by symbolic · · Score: 1


    It's those individuals who make stupid decisions. When businesses suffer, everyone loses, except the ones who probably deserve to lose the most.

  67. Question from a judicial law clerk by Anonymous Coward · · Score: 0

    Hello /.. I work for judges, my job is to research, draft, edit, and revise judicial opinions. We exchange multiple drafts, sometimes in Word with track changes. We publish an electronic copy of the final decision. It would be very bad if parties or others could "see through" to ealier drafts. Currently we have set word to notify if saving, mailing, or printing a document with tracked changes. Is this sufficient? We shred paper copies, but we are not as technologically savvy as the readers here clearly are. Any advice?

    1. Re:Question from a judicial law clerk by Qzukk · · Score: 1

      Well, to start with, I'd let the judge know that they really shouldn't use Word to keep notes like "defendant $5000, see about dismissal AM" in their court documents.

      Other than that, there's a program that MS put out that will strip all the hidden stuff from documents.

      --
      If I have been able to see further than others, it is because I bought a pair of binoculars.
  68. Too little too late? by Timmy+D+Programmer · · Score: 1, Insightful

    Better late than never.

    You blame this on a free market? I just blame it on dishonesty and stupidity.

    Has anyone else noticed 100 million gallons of carcenogenic fluid flowing from China lately?

    Of course you probabbly consider China not communist enough either.

    --


    (If at first you don't succeed, do it different next time!)
  69. Re:Next Headline: Merck Moves to OpenOffice by Anonymous Coward · · Score: 0

    ^H isn't like.. a border for removed words, dude. It's the onscreen value of the backspace character for terminals with a dumb cursor.

  70. Re:In other news by ScentCone · · Score: 1

    as well as FBI Director Louis J. Freeh. He was convinced that OBL was in fact responsible.

    Have you actually listened to Freeh talk about that period? He was, and is, furious that they weren't allowed to actually do anything meaningful about the intelligence they were coming across. They weren't allowed to work directly with the CIA or DOD, and his specific recommendation was to do essentially what Bush finally did do once the shock of 9/11 cast off any ridiculous worries that getting our intelligence agencies working together would be somehow Eeeevil.

    The arrest and subsequent prosecution of a number of the perpetrators in the Embassy bombings are, of course, also nothing.

    Essentially, yes. Nothing. After-the-fact, criminal-case type handling of the stupid pawns that carry this stuff out does virtually nothing to stop the organizations that work to fund them and train them. That was exactly Freeh's point, too. Those groups, and the states that fund and harbor them, have to be dealt with preemptively. You can't criminally prosecute your way back from hundreds, thousands, or worse dead. Countries like Iran (with a president that refers blythely to wiping Israel off the map) that gleefully pump money into Hamas, Hezbollah, and Al Queda - or, places like Syria that aren't going to stop funneling cash, loonies, and weapons into places like Iraq just because the FBI issues warrants - are completely outside the reach of the law enforcement. Clinton knew that, too - but didn't have the political capital or stomach to actually act.

    you extremist right wing nutjobs

    What makes you think I'm extreme, or right wing? You can sling around "nutjob" all you want, since I can just consider the source. But at least "right wing" is reasonable identifiable in pretty specific terms, just like "socialist left" or "liberal pacifist" are. But you're not even using labels that match what you're hearing, so there's not much point lecturing.

    defending terrorists yet claiming patriotism

    Defending terrorists? You're not even being lucid, here. Patriotism? Some people use that word to mean "dedication to the principles upon which this country was founded" and "pride in its successes", while other people are trying, very oddly, to redefine it as "anything that runs counter to what the other political party is doing, even if opposing it is irrational on the face of it." I'm a patriot because I find that our country is, on balance, a better and more liberty-minded place than any that history has ever produced or sustained, and I support those that seek to preserve its place in the world. To that end, I support all of those great amendments that most of us love so much, and scratch my head when other people think they're being patriotic by trying to shout down other's voices.

    I mean can't you at least *try* to make up a believable lie?!?

    What's the point? I speak facts, and you choose to ignore any sort of context or causality because it's making you feel more righteous in your dislike for the CinC. I had an incredible dislike for the slick, weasly charlatan that had the job last time around, so I understand the frustration. And I think the current guy has had some of his world view stunted by the post-drinking-days comfort he found in religion. But that doesn't make clamping down on suicidal, murderous retro-medieval Islamo-fascism any less important, and at least he's stepping up.

    --
    Don't disappoint your bird dog. Go to the range.
  71. The FDA is dead, long live the FDA by dada21 · · Score: 1

    Here's a rundown of the FDA:

    1. They are a bureacratic department that only has one power: coercion through force
    2. They delay, for years, drugs that are saving lives in other countries
    3. They keep drugs prescribed that are OTC in other countries, raising our prices
    4. They are more interested in CYA than efficiency and lives saved
    5. They are bribable as is any government official
    6. They are useless

    There are many here who think we need the FDA. I believe that they are useless. We use items every day far more dangerous than pills - hair drivers, lamps and microwave ovens. They're only sold by stores if they are UL listed. Underwriters Laboratory is a private company that has to do their job properly, competitively and at the right price. If not, competition will replace them.

    The Merck problem is the FDA's fault -- it happened on their watch. Now the free market will save their asses, again, by reducing faith in Merck's honesty and hitting them where it counts -- the bank.

    1. Re:The FDA is dead, long live the FDA by Anonymous Coward · · Score: 1, Insightful

      Holy crap I am tired of this libertarian bullshit that is so popular these days. Yeah, get rid of the FDA, and let a for profit company (no way anyone could bribe them, amirite?) do the testing etc..... god I can barely type a reply to this, it's so mind-numbingly stupid.

      Oh... and check the stock price of Merck and see just how much damage this whole thing has actually done. There is ONE GODDAMNED DIP, and it is when the FDA PULLED THE STOCK FROM THE SHELVES. Investors will continue to invest in companies that do despicable things because NEWSFLASH: people are greedy.

      You "the market will solve all our problems" people really confuse the hell out of me.

    2. Re:The FDA is dead, long live the FDA by Anonymous Coward · · Score: 0

      Cool!!! A private company concealed data, but it's not a problem with the private sector. It's the GOVERNMENT'S fault!

      Spoken like a true libertarian.

    3. Re:The FDA is dead, long live the FDA by dada21 · · Score: 1

      NEWSFLASH: people are greedy.

      You nailed it.

      Greed is inherent in people. We take preference to making our own lives better.

      This is the nail in the coffin for any large, central government. Markets don't allow greedy people to us force against another, except through government allowance.

      I'm not a libertarian. I believe if UL let Vioxx pass and it was found fatal, they'd lose their business. UL is near my house and I've seen their facility, it is a serious place. I've performed government contracts until I learned about freedom, and most are full of nepotism, cronyism or just plain indifference.

    4. Re:The FDA is dead, long live the FDA by petermgreen · · Score: 1

      is there anything legally to stop stores selling stuff thats not approved by UL?

      if so then then the free market isn't going to be able to replace them!

      if not then why does anyone bother listening to them?

      --
      note: i'm known as plugwash most places but i screwd up registering that here somehow in the past and now can't register
  72. Re:News for nerds? by Anonymous Coward · · Score: 0

    I find it strange that you would complain about this story, given that it is actually A REAL STORY (with a bit of a "tech twist" to it even), and not an advertisement/repeat. Given the low value of your e-penis err... UID, you've definitely watched slashdot devolve into the steaming pile of shit it is now, and yet you choose to whine about this particular article? Confusing.

  73. Murder by Anonymous Coward · · Score: 0

    The Merck employee who deleted the incriminating data, and all managers in the chain of command who knowingly approved that action, should be charged with 1 count of negligent homicide for each person who died as a result of that action.

  74. Wikipedia on Aspartame oddly omitted by Google by Anonymous Coward · · Score: 0
    Yet another extraordinary thing in this interesting saga is that Wikipedia's detailed, informative article on Aspartame , which has been around for well over 2 years, is not even listed once in any Google searches for "Aspartame", not being mentioned even in a Google search for "Aspartame" articles on the Wikipedia English-language site itself.

    I wonder why the only result in that specific Google search is a link to the highly obfuscatory "Wikipedia:Talk" article which gives a very much more confusing picture than the actual Wikipedia article at http://en.wikipedia.org/wiki/Aspartame. By contrast many thousands of newer and less detailed Wikipedia articles on all sorts of other subjects are indexed by Google.

    Nobody should feel they have to consume "diet" soft drinks to lose weight, when the most effective and safer strategy is to drink water and to eat less food.

    1. Re:Wikipedia on Aspartame oddly omitted by Google by Anonymous Coward · · Score: 0

      I wonder why the only result in that specific Google search is a link to the highly obfuscatory "Wikipedia:Talk" article which gives a very much more confusing picture than the actual Wikipedia article at http://en.wikipedia.org/wiki/Aspartame. By contrast many thousands of newer and less detailed Wikipedia articles on all sorts of other subjects are indexed by Google.

      You raise an interesting question. But I wonder if it might simply be a factor of the number of times the word "aspartame" exists on the talk page in comparison to the regular page? There are also more nefarious possibilities, since I think it's possible to remove a Wikipedia page from google if you can submit an automatic-removal at a time when Wikipedia is returning a 404 error.

      Perhaps it will help if people place more links to the aspartame article in other locations.

    2. Re:Wikipedia on Aspartame oddly omitted by Google by Anonymous Coward · · Score: 0
      That's an interesting theory. Is frequency of appearance of search terms really a barrier to being indexed by Google? I seem to recall having been able to find numerous pages from search terms that appeared only once on each page.

      The omission of the Wikipedia article from Google is all the more surprising given its high link count -- there are many incoming links to the article from elsewhere inside Wikipedia, e.g. see http://en.wikipedia.org/wiki/Special:Whatlinkshere /Aspartame which normally guarantees being indexed. Since the article hasn't been indexed, it is obviously not possible to check Google for the number of incoming links from outside Wikipedia. Maybe there are none or very few, but it seems more likely that there would be a large number given the age, topicality and prominence of the article.

    3. Re:Wikipedia on Aspartame oddly omitted by Google by Anonymous Coward · · Score: 0

      As of today, it's in the top 10 links for a google search on aspartame... Amazing coincidence? :)

    4. Re:Wikipedia on Aspartame oddly omitted by Google by smellsofbikes · · Score: 1

      We have done our jobs well; now we get to ride off into the sunset with the smug grins of the self-righteous.

      --
      Nostalgia's not what it used to be.
    5. Re:Wikipedia on Aspartame oddly omitted by Google by zCyl · · Score: 1

      How's this to boggle your mind. This morning I remembered this conversation and checked the wikipedia aspartame pagerank in google, and it had a pagerank of 6 (which is fairly high). This evening, the wikipedia aspartame pagerank went from 6 to 0 and the page dropped out of the aspartame search list completely. Something really anomalous is going on there, and I wish I understood it...

  75. Re:well...nothing is what it seems by srone · · Score: 1

    I occasionally support the work of researchers looking for new drugs. I see them generate reams of data, looking for evidence to support the efficacy of a new drug. The basis for using Vioxx, Celebrex, Bextra and any other COX-2 inhibitor, is that they only inhibit the COX-2 enzymes, which are responsible for pain and inflammation. These drugs did not inhibit the COX-1 enzymes, that are related to stomach protection and blood clotting. If you had pain and inflammation before the COX-2 inhibitors arrived, you would take a NSAID (Non-Steriodal Anti-Inflammatory Drug such as Aspirin, Sodium Naproxen, Ibuprofen, etc.). These drugs would inhibit your COX-2 enzymes, to relieve your pain and inflammation, while at the same time inhibiting your COX-1 enzymes, thinning the mucous lining in your stomach and reducing your blood's ability to clot. As long as you didn't develop gastric problems or bleed to death, you were in good shape, but there are a large number of people that do have gastric problems or blood clotting disorders that NSAID's aggravate. Hence, Merck and many other drug companies were looking to market a drug that would only inhibit COX-2 enzymes. Bingo, they found several new drugs that met the new requirements. This is where the problems began, because these drugs worked too well. These Drug Companies
    are now being sued for intentionally marketing a pain reliever without the COX-1 inhibiting side effects of the older NSAID's such as aspirin.

    In my opinion FWIW, the vultures(ie. attorneys) have decided to sue Merck and others for making a pain killer that worked too well, without the side effects of previous pain killers. Never mind that some of the side effects of the older NSAID's, exacerbated stomach ulcers and prolonged clotting times. Part of the problem is that the drug companies, the doctors and the patients saw the COX-2 inhibitors as a solution to the problem of joint pain without the side effects of previous generation of drugs. What they did not see was that when they gave up the older NSAID's, they also gave up some of the side effects that were occasionally beneficial, especially for those people at an increased risk for heart attacks due to atherosclerosis.

    Sure, the drug companies are not angels, but a business cannot succeed without innovation. They probably spend more money on drug advertising than they should, but lawsuits such as these will only decrease the profit margin and minimize new research. Nothing is 100% safe and effective without harmful side effects. The critics always have 20/20 hindsight, but the people with foresight rarely do.

    "Endeavour to persevere"

    --
    "Endeavour to persevere"
  76. Do you hear yourself? by HBI · · Score: 1

    Umm, your boy said the exact same things about Iraq to justify his random lobbing of missiles and bombings in 1998. Care to hear the tape? For that matter, it wasn't just him. Kerry, Kennedy, the whole lot were spouting off back then. For that matter, the same crew mostly was saying the same shit in 2002-03.

    So, who was lying, and when?

    You're so full of shit your eyes are brown, like the rest of the leftist Bush-haters.

    --
    HBI's Law: Frequency of calling others Nazis is directly correlated with the likelihood of the accuser being Communist.
  77. Don't be naive... by Anonymous Coward · · Score: 0

    The U.S. Drug companies do what they want, as they have been very powerful and wealthy for a long, long time. ... nothing is done for "free", ever. There is always a reason, and a cost to be paid back.

  78. Re:In other news by Darby · · Score: 1

    He was, and is, furious that they weren't allowed to actually do anything meaningful about the intelligence they were coming across.

    Yes, which if you had actually bothered to look at the reasons for this, they were expressed quite clearly by O'Neill:
    "The main obstacles to investigate Islamic terrorism were US oil corporate interests, and the role played by Saudi Arabia in it,"

    In fact he resigned from the FBI because he believed that the Bush administration had stymied the intelligence agency's investigations on terrorism.

    So call Clinton incompetent all you want, but doing so in order to defend Bush who was actively involved with *interfering* with the terrorist investigations in order to protect his friends who are tied deeply into it is such an insanely amoral and utterly disgusting action as to defy rationality.

    What makes you think I'm extreme, or right wing?

    You're clearly both.
    You have at every opportunity I've seen leapt to the defense of Bush's actions and reasoning even though you have been proven wrong time and time again.
    When Iraq was all about WMds you were there defending nonsense lies.
    Once the lies were demonstrated, you were there leaping to the defense of the "liberation" hogwash.
    Hell, I knew for a fact since the day Bush was elected that we were going to war with Iraq. The members of the administration stated flat out while Clinton was still in office that they wanted to invade Iraq in order to ensure future US world domination and only needed a pearl harbor type situation to allow them to manipulate the American people into buying it. It's still up on their website for Christ's sake.

    So, yes. Given the fact that you have continually spread misinformation in order to deceive your fellow Americans and to advance flat out treasonous actions, I think extremist nutjob is hardly a starting point for an accurate description.

    When the administration committed treason by revealing the identity of a CIA operative, there you were claiming insider knowledge and stating that all the reporters already knew the identity and that nobody from the administration would have done such a thing.

    When the first news of torture came out, there you were whitewashing it. Now we have the AG promoting torture and Bush claiming that he will veto anti torture legislation and a string of torture camps throughout Europe. So again you were wrong. Again, you were on the side fighting tooth and nail against basic human decency.

    Damn dude.

    I'm a patriot because I find that our country is, on balance, a better and more liberty-minded place than any that history has ever produced or sustained, and I support those that seek to preserve its place in the world

    I'll have to disagree.
    You're not a patriot because you actively work to hide the truth.
    You actively seek to spread disinformation.
    You are an active supporter of the torture of people without even any regard as to their guilt or innocence.
    You also demonstrate a serious ignorance of US foreign policy if you can state that nonsense with a straight face.
    Torture schools in Central America? Assassination and overthrow of democratically elected leaders in order to establish brutal right wing dictatorships who proceeded to murder massive amounts of their own population with our smiling support since they were favorable to US corporate interests? Damn dude. You either haven't the faintest clue about the USs actions in the last century, or you do and again support torture and murder as long as it boosts profits.
    Seriously, dude, how is that not an extremist right wing terrorist supporting nutjob?

    But that doesn't make clamping down on suicidal, murderous retro-medieval Islamo-fascism any less important, and at least he's stepping up.

    Were that happening, you'd have a point, but he is actively working to promote islamo fascism.
    As long as he steps up it's good?!? Heaven forbid he actua