Creating Prion-Free Cows
Science Daily is reporting that the U.S. Department of Agriculture's Agricultural Research Service (ARS) is reporting positive results from a recent study designed to create genetically engineered prion-free cattle. From the article: "ARS studied eight Holstein males that were developed by Hematech Inc., a pharmaceutical research company based in Sioux Falls, S.D. The evaluation of the prion-free cattle was led by veterinary medical officer Juergen Richt of ARS' National Animal Disease Center (NADC) in Ames, Iowa. The evaluation revealed no apparent developmental abnormalities in the prion-free cattle."
This is great! Now we can go back to feeding the cows a healthy diet of dead sheep, which was how the whole "mad cow" thing started.
... or you could just not feed them parts of their dead relatives?
I confess; I had to look up what a prion is.
A +prions%3F&btnG=Search
I'm so embarrassed.
http://www.google.com/search?hl=en&lr=&q=define%3
How many escape pods are there? "NONE,SIR!" You counted them? "TWICE, SIR!"
From Wikipedia: "a type of infectious agent made only of protein."
"Mad cow disease" is a prion disease.
'Thats they exact same thing a banana wrench monkey.'
Oh, that was "prion"? I was trying to figure out how cows were getting "pron", and why we'd want to take it away from them anyway.
or Mad Cow Disease for those of you like myself who had no idea what the headline was about.
The actual article headline "Mad Cow Breakthrough?" really should have been followed by a story about mad cow scientists were developing a doomsday weapon to destroy humanity, or that mad cow armies were breaking through our outer defense perimeter or some such. Would have been much more interesting.
Do not try to read the dupe, thats impossible. Instead, only try to realize the truth
What truth?
There is no dupe
... welcome our not-so-mad cow overlords.
Hunt your preferred prey at Aliens vs Predator MUD. Join the war at avpmud.com port 4000
What is so new in those cows? Two heads? Fallout style?
"an experienced, industrious, ambitious, and often, quite often, picturesque liar" - Mark Twain
Not only dead sheep, but also dead cows! Another hypothesis was the spontaneous appearance of the new variant in a cow that went into the food chain of the cattle. Actually cattle was just doing cannibalism...
The farmers feed the cows RENDERED cow feed made in big factories. It's very easy to stop the factories rendering down cows and sheep into protein supplements.
Even a break of feeding rendered meat for 1 complete cow generation would clear the contamination out.
The problem is the renderers have a strong lobby group and want to continue the practice, however unsafe, so they got a compromise. Instead they promise to only feed dead cows and sheep that were healthy. So they continue to feed infected meat to cows, just as long as the prion infection was at a too early stage to be detected. The US executive branch has gone along with this 'voluntary' code and practically no inspections are made to check it's being done.
It's why I don't eat US beef, because the US views the problem as something to fix in the PR dept., not something to fix on the farm.
Yet it's so trivial to fix, switch to vegetation based protein supplements for 1 generation of cattle, and poof the problems gone.
Me and my fellow group, the PRIONIC SIX, strongly oppose this development.
-- prionic6
ARS, with assistance from researchers at Hematech and the University of Texas, evaluated the cattle using careful observation, post-mortem examination of two of the animals ...I'd be livid!
Donte Alistair Anderson Roberts - hi son!
Karma: Chameleon
Answer
Syllable 0.62 is here at last!!!
Since then I've found other reasons not to eat meat, namely a feeling that the animals would probably prefer not to be eaten, the environmental stuff, yadda yadda. But I'm basically selfish :)
Everything I needed to know about life, I learnt from Blake's Seven
Don't they usually start out without prions? You have to infect them. I went cow-shopping and I remember prions were strictly an option. They should call these "prion-proof cattle."
In 2005 a controversial paper in The Lancet introduced a theory that BSE might have originated in British cattle when they ate imported animal feed that included infected human remains from Hindu funeral ceremonies in India.
Bovine spongiform encephalopathy
This theory has some merit because scrapie from sheep does not appear to infect people, whereas BSE from cattle does.
Reduce, reuse, cycle
"Oh nos! Genetically modified aminals! What if they get into the food supply?! DO YOU WANT TO HAVE A BABY WITH TWO HEADS?!?!?! You can't predict what might happen so don't let the evil government/corporations/boogeymen use us as their GM guinea pigs!"
So how long until we get a new study that says Prions were indeed good things, and should have been left in our meat.
From TFA: "Prions are proteins that are naturally produced in animals."
Hmm... Removing natural things... Nope, doesn't sound like a good idea to me. I just can't wait until they find out that Prions actually helped prevent cancer or something and everyone on the planet now has a timebomb in their body.
Seriously, they'd better do some SERIOUS studies on this before feeding this crap to me.
"If you make people think they're thinking, they'll love you; But if you really make them think, they'll hate you." - DM
A google search will tell you, but so will the fucking article.
*sigh*
Its posts like these that make me consider moving to digg.
As some other posters noted, these prions improve/allow memory. One must wonder, if they can do this with cattle, how long it is until they figure out how to do it to humans...
/tinfoilhat
Great Intellect...
...is tasty!
t icleEEF238D9C90E4B2989F5E473D3145A16.asp
In all seriousness, you make a good point. BSE was first spotted among the cannibals of Papua New Guinea (where eating of the dead was a sign of respect).
http://www.gwinnettdailyonline.com/GDP/archive/ar
Here are a ton of articles on BSE & vCJD:
http://www.newscientist.com/channel/health/bse
erggggghlglghgallgglhgggl
Green piss.That ain't right.I always say,if god didn't want me to eat meat,he wouldn't have made it taste so good.
That's the PRIONs 'memory' you're talking about. It has a good memory that replicates whether its Bovine spongiform encephalopathy (BSE) prion or a Creutzfeldt-Jakob disease (CJD). Not our memory!
I think you've been eating too much beef.
An important point is that a lot of work on artificial/cultured muscle research is dependent on using fluids derived from cows as a growth medium, both from a compatibility and cost standpoint. However, a large barrier to commercial artificial meat research/production is keeping that fluid free of prions both in a small lab setting as well as in industrial quantities. This is the reason why when those scientists cultured meat and cooked it, they weren't allowed to eat it due to prion safety.
If they can sucessfully remove prion issues, then commercial artificial meat is a real possibility (though those issues dissappear once the culture medium fluid can be reliably and cost effectively made through wholely artificial means).
I for one welcome our vat-grown meat progenitors.
....but in it's place will despressed and miserable cow disease.
Didn't they make a movie about that?
No, I guess that was mind control. Black power, Brother!
Is it just my observation, or are there way too many stupid people in the world?
Beautiful!
A bigger worry is the fact that a company (read capitalism) will be holding the patents on our food supply. Much like what big agra has on corn, soybeans, etc.
I too wondered why "big science" would try to come up with a way to create cattle that can still be fed 'cannibal chow' without getting sick, instead of just changing the feed to something healthy, when I realised there are no IP licensing rights for natural, healthy cattle. This 'super cow' is surely patentable :(
My other disappointment is that so much time & resourcefulness was spent on this rather than a way to prevent prion diease from taking it's toll on the untold people who have eaten infected 'industrial-beef' through fast food & other sources but won't show symptoms for many years.
... it doesn't work everywhere. I'd rather eat a certain amount of meat which I can produce locally, than buy in lots of vegetables that I can't. Not all farmland is arable.
I can't help but think it's more than a coincidence that most of the vegetarians and all of the vegans I know always look skinny and underfed, and seem to be allergic to lots of things. They also seem to be ill with something nearly all the time. I don't know if anyone else has noticed, but vegans tend to have a particularly unhealthy pallor, a kind of pale shiny skin thing going on.
"Doesn't seem that hard, really, but people are pretty stupid."
Do you exclude yourself from that statement, as a matter of habit?
my friend died a few years ago with this terrible disease, did it stop me from eating beef ... only until i reliesed i cant avoid the stuff..
If that does not sound like wishful thinking, I don't know what does. Also keep in mind that they have a really strong interest in not finding anything....
Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
What is concerning is that it's great that they have removed the coding for the cows to create Prions. It's even amazing that thus far they are healthy and alive. What is a bit worrisome is that we do not know what potential for other diseases or impacts may result from modifying the genetic code of a creature that evolved that code over tens of thousands of years. We cannot see this as a panacea. Prions may have been there at some point for a reason. Perhaps not. I'm not trying to be a Luddite, but I would be cautious before jumping for joy.
Cally
--Cally
showing vegetarians lived 10-15% longer
Yeah, but smug self-satisfaction knocks about 10% off the lifespan, provided you're not punched by an offended meat-eater beforehand. So it's basically a wash.
Isn't Prion the name of that hybrid fuel car from Toyota? I didn't think it was big enough to drive cows around in anyway...
"All those moments, will be lost in time...like tears in rain..."
wouldn't you have to ensure it has no proteins of any type.
Now, if the article title/blurb said "no mad-cow prions", I wouldn't be so picky, but this said no prions, without qualifier.
"Aye, the cow aint got no prions! 'course 'ees dead, but thar be no prions in that thar cow!"
(yes, I read TFA, I know they meant mad-cow prions, not prions in general).
34486853790
Connection too slow for X forwarding? Try "ssh -CX user@host"
My fiancee and I would like to reduce the amount of meat in our diet. However, she has a severe allergy to nutritionally significant amounts of soy protein (especially tofu), and a serious (but not as severe) allergy to most other legumes (peanuts being least serious, but even then, she could not subsist on peanut protein alone). How would she go about getting the proper amounts and kinds of protein into her diet without soy or legumes?
She has asked this question of vegans and vegetarians in the past. The usual response has been on the lines of "go away, troll", as they think that she's just presenting them with an impossible situation in order to justify her eating of meat. If there is a reasonable answer, we would genuinely love to hear it.
We can believe in you for 3 minutes, but beyond that, even the King of All Cosmos can't be expected to wait.
Prions are those things Scientologist have been warning us about.
If we flush them all out, we are much healthier.
but not all proteins are prions.
So no, you would not have to eliminate all proteins to eliminate all priors. New prions are very very rarely created, there are only a few known ones.
Dear AC parent:
WHOOOOOOSH!
Logically it appears changing diet is the one thing you haven't tried. Maybe you're the one to discover your family is genetically of a blood group A, protein dependent stock..
:-). I need exercise, even if it's just walking outside for an hour..
..
Alternatively, you may be like me. I've spent the last few weeks working away at the a project, nil exercise. The result is that I'll have to work quite hard as soon as this is over, before there's no difference in width between my shoulders and my gut
Happy New Year
Insert
The prions that cause BSE are externally introduced through cattle feed. You'd have to have all the components of cattle feed be produced from prion free animals also. Not likely unless all cattle feed was constantly tested for the presence of any prions at all.
Normal high tempurature sterialization of surgical instruments that have been used for brain surgury doesn't destroy prions. You have to use more exotic techniques that are a little rougher on surgical instruments. It's a big problem for hospitals. So mere cooking wouldn't affect prions.
In America not one person had died from MAD cow disease, this will likely only lead to more laziness so we can all have cheaper food. On another note, I guess the lactating men from Europe can eat beef again?
Yeah, I can't figure out whether a Prion is a Honda or a Ford. I think my grandma had one...
Excuse me, but please get off my Pennisetum Clandestinum, eh!
What sort of pri0n do cows watch anyways?
Out of curiosity, what is the purpose of getting your protein from eggs?
I mean, if you're morally opposed to eating chickens, why wouldn't you be opposed to eating their abortions?
Do daemons dream of electric sleep()?
can still be exposed to prions from external sources and continue to produce prions.
Check out protein folding and how one prion causes other proteins to fold wrong. A sort of catalytic and catastrophic effect. Use your spare CPU or GPU cycles (or even game console cycles) to help find a solution. folding.stanford.edu
There is nothing shameful about learning.
Computers are useless. They can only give you answers.
-- Pablo Picasso
Also there *ARE* good tests to determine the ESB both faster than the biopsy and not needing to put down the cow, much better than clinical observations.
Intensive research has been done in German and Swiss laboratories. The first test working on live animal has been developped in Göttingen, Germany. Thus sadly, the information is only available in the German version of wikipedia. (Though the german article mentions a later Texan discovery).
"Sufficiently advanced satire is indistinguishable from reality." - [Tips: 1DrYakQDKCQ6y52z6QbnkxHXAocMZJE61o ]
You'd be surprised how products in modern culture use bovine byproducts- many kinds of foods, cosmetics, leather clothing, medicine... I saw a list of several hundred once. To avoid such you basically have to back to the pre-20th century where people made most of their own stuff.
It's not about creating prion-free cattle. It's about cheap meat. The meat industry is all about high density feedlots for cattle, pigs, and chickens. It's all about providing you with the cheapest meat, not necessarily the safest for you or the meat animals. The industry players want you to think that cattle spend all of their days frollicking on the range and munching on grass instead of being cooped up in their own shit and forced to eat antibiotics so they can eat corn which they did not evolve to eat. I'm a devout omnivore and won't stop eating meat, so those more rabidly zealous vegans can get stuffed. I can and will however eat safer and better raised meat.
Read Michael Pollan's The Omnivore's Dilemma . It has a fascinating account of Joel Salatin and his Polyface Farms. You can have a win-win situation between raising meat animals and the enviroment. Finally, everything you ever wanted to know about high density feedlots can be found in cartoon format at The Meatrix.
"You'll get nothing, and you'll like it!"
It's a recent piece - this lasts an hour I think, but it's worth it.
r /DD062206.mp3
/very/ short version is (listen, really), that they can only change genes crudely, you don't know what else has changed along with the intended one. The lack of controls, and the effects, will shock you. And this is recent, say, end of 2005.
http://media.libsyn.com/media/deconstructingdinne
A
Someday we'll all be negroes
What we usually call 'live feeds'... *ducks*
Defining Statistics and Social Research
What scares me about this is that in a few years, they'll probably declare prion-free, genetically engineered cattle safe to eat, and then 20 years from now half the population is going to develop something worse than CJD. I'm fine with them doing this stuff for research, but I don't like the idea that we're feeding livestock genetically engineered food because the next step is going to be feeding people genetically engineered food. Our understanding of biochemistry is still so full of holes and we're so short-sighted, we end up killing ourselves and our planet without proper forethought and consideration.
... that I only eat free range bison.
It is wonderful how they are figuring out to do things the wrong way like making it so they can feed cows to cows without fears of the cows on either end being mad.
One might wonder what potential effects there may be hidden down the road from knocking out the at gene. There may be garbage in the DNA, but there are also a lot of important pairs and scientists don't really understand the ramifications of playing with them. I'm all for technology, I enjoy the internet, but I'm not going to be their guinea pig.
Of course, this won't help with preserving genetic diversity and heritage breeds, bio-diversity, issues with mono-culturing, plagues, etc. What it will do is give some company the ability to own the genetics of cattle so that farmers have to pay the corporation every time we breed an animal much like is being done with plant genetics.
If the corp is smart they'll copyright the genes instead of patenting them since that monopoly lasts longer. Or they can just screw around with the patent system more to extend the patents to forever minus a day.
Me, I'll continue to breed my own livestock, grown clown-free, sans-genetic modifications and raised on pasture. I would suggest consumers get to know their local farmers who can be a source of high quality foods as well as keeping dollars in the local economy.
If posts like that makes him want to switch to digg. digg comments will want to make him "switch off his Internet".
[alk]
... who thought, "And why do we need pr0n-free cows again?"
Web 2.0 == Giant Blogspam Circle Jerk
I'm happy that we're *this close* [holds hooves together a couple millimeters apart] to finally splitting the cow atom. It's been a long road of discovery, from the Heifersburg uncertainty principle (you can have a cow, or a burger, but not both) to the realization that it is possible to cross a cattle grating, with careful quantized footing and a lot of federal funding.
The next big challenge: Sub-atomic cow fusion, and bringing subjugation to the lemur foe! Mooooo!
Any sufficiently advanced technology is insufficiently documented.
Don't they usually start out without prions? You have to infect them.
That depends on whether you define "prion" to mean "the prion protien" or "the prion protien folded into the pathological shape".
These are cows with the prion protien gene "knocked out" so the protien is not produced. They are thus "prion free" by the first definition.
They will also remain prion free (except for the introduced prions) by the second definition as well, since they won't amplify the prions by folding more instances of the protein into the same shape.
I went cow-shopping and I remember prions were strictly an option.
Check the basic option package - it's there as "protein feed suplement".
Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
Ok, so BSE damages prions which leads to all the characteristics of the disease. No prions, no disease. But does that necessarily mean no infection?
BSE can be passed to humans. Is it possible that these genetically modified cows are just modern day Typhoid Marys?
--JoeProgram Intellivision!
Factory-style production and distribution of food makes bad food, in my opinion.
I prefer to eat locally raised meat and produce. It tastes better. But the majority of people are just sucking down whatever overprocessed swill is cheap at walmart this week, so my choices won't make much difference on a global scale.
I wish everyone had to kill their own food or go hungry...
Will organisms that eat BSE-infested beef eventually die off? The chances of getting sick from it are infinitestimally small. Somebody run the numbers, but my guess is more genertic information is transmitted by the increased reproductive success of not living near a volcano or subduction zone, or not getting hit by an asteroid, or not gorging on 3000-calorie breakfasts
Give a man a fish and you have fed him for today. Teach a man to fish, and he'll say "WHERE'S MY FISH, YOU IDIOT?"
Before all this DNA nonsense, scientists, or as they were known in the dark ages: farmers, used to crossbreed things to improve them. That's why carrots aren't purple anymore, and you can buy savoy cabbage.
A far cry from chocolate rabbits perhaps, but is Animal Husbandry going out of fashion?
(Waits for "Not here in..." joke.)
I don't know what "CR" or "boutique" are. I don't think bacteria are the problem, anyway. Didn't you read the post?
As far as I know, deer do not eat meat. Yet, CWD has been reported in deer in Wisconsin, along with warnings about not eating venison. Don't know about the latest hunting season.
Since cows are now able to be bred prion-free, that doesn't fix the other possible vectors for prion contamination. If my biology is correct: Prions are malformed proteins. Can such malformed proteings be cause by genetic mutations from other sources? Even though a BSE-resistant cow has been bred to be 'free' of prions, and the genetic code that causes malformed prions to be created by biological processes withint the cow, can the genetic struture of a BSE-resistant cow mutate through some other avenue, such as naturally occurring radioisotopes (You anti-nuclear assclowns can shut up. Radioisotopes [and other mutagenic compounds] *DO* occurr naturally in harmful amounts in the Earth--- long before reactors and nuclear weapons existed), ultraviolet radiation, free radicals, and other naturally occurring mutagenic compounds? In order to create a truly BSE-free heifer, wouldn't you need to eliminate all possible mutagenic compound exposure vectors? Disclaimer: If my biology is incorrect or inaccurrate, I am only human.
Knowing Google's lust for data collection, the Soviet Union is still alive and well inside the psyche of Sergey Brin....
In my day. . .
Cows ate grass.
Gary Larson would have a field day with this...
It must have been something you assimilated. . . .
A prion is an 'infectious' protein which causes similar proteins to change their structure, rather like seeding a supersaturated solution. What has been done is to clone cattle which lack the protein which could be altered by the prion.
Lazy Cows !
Not until we know the full effects it has in animals
Because people aren't animals.
what is this?
I couldn't access the mentioned paper, but I found another paper that I assume that review cited (Lindquist worked on both of them). The summary "CPEB prions might function in the formation of long-term memory" is probably though not certainly taken from:
R L&_udi=B6WSN-4C5RJXX-C&_coverDate=12%2F26%2F2003&_ alid=516758008&_rdoc=1&_fmt=&_orig=search&_qd=1&_c di=7051&_sort=d&view=c&_acct=C000051401&_version=1 &_urlVersion=0&_userid=1082852&md5=817b088d824d789 e3c68039a6e013561
i ?itool=AbstractPlus-def&PrId=3580&uid=12058449&db= pubmed&url=http://joi.jlc.jst.go.jp/JST.JSTAGE/jts /27.69?from=PubMed
http://www.sciencedirect.com/science?_ob=ArticleU
which talks about CPEB in Aplysia californica, the California sea slug. The results are pretty interesting, but it's unclear whether they apply to higher organisms. I haven't yet found anything where they test this in mice, but that doesn't mean the paper doesn't exist.
Another paper at
http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcg
found that: "Whereas the Zurich I Prnp null mice, as well as mice from a later PrP knockout line designated Edinburgh Prnp -/- (Manson et al., 1994) were clinically healthy, mice of other knockout lines, for example Nagasaki Prnp-/- (Sakaguchi et al., 1996) came down with ataxia and less of cerebellar Purkinje cells at 6-12 months of age. In the Zurich I and Edinburgh mice only the PrP open reading frame (ORF) was ablated or interrupted, while the lines developing ataxia had deletions extending from within the second Prnp intron to the 3' non-coding region [which runs into another gene called Doppel]."
To summarize: at this moment it doesn't seem that taking out only the coding region of PrP wrecks anything blatantly obvious in mice (though other papers I haven't cited show some other effects, not all of them neuro).
The floggings will stop when morale improves.
I do eat meat. I tried vegetarianism for a while and began to waste away. My doctor told me my blood type wouldn't allow for it. No matter. I was only doing it because I lived in a vegetarian household for a while and wanted to see what it was like. In the end, I see the life of an animal the same way I see the life of a plant; Alive. Thus "Free Range and Killed with Respect," has been my personal solution. --That in this reality, to live is to enter into a contract whereby life feeds life and everything must die eventually, including us.
-FL
Here's a question. . ,
Why not instead of this Frankenstein Science, just stop feeding garbage to animals, raise them kindly, and kill them with respect? This would solve the prion problem. And the super-bug problem. And the hormone laced milk problem. Among others.
After all, the lives of these animals are being taken so that we can live. Surely they deserve a bit of love. --Also, nobody needs to eat the amount of meat many people do. If our diets were regulated correctly, and if we treated our livestock with affection rather than using them with such coldness, life would be better for a whole lot of creatures as well as humanity. It is true; everything must take life in order to live, and we all must die. Why not try to infuse the process with compassion?
Of course, if you believe in a digital universe where souls do not exist, then what reason does anybody have to respect life and not adopt the behavior patterns of the psychopath?
Welcome to Mordor and the Sith's vision of Empire.
I find it strange that the very subset of the population who love such stories the most are more inclined than anybody to fall into the very paths those stories warn against.
-FL
The only reason why I know anything at all about the disease is because of the Janet Skarbek documentary. With the law on the side of the beef producers (remember the Oprah case?), you won't see too many news outlets sticking their necks out to report this. That and the CDC is doing its best to discount any cases here in the USA as "normal" CJD (as opposed to the variant type).
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What the upshot of all this is (as I understand it) is that the prion unfolds somewhat (mutates) and that is what does the damage. They aren't a virus, and they are dammed hard to destroy. And from what I remember, the mutated prions "saw" through the cells in the brain causing holes in it.
Check out the picture of a damaged brain:
http://news.bbc.co.uk/1/hi/sci/tech/572832.stm
A link to the unfolding/misfolding info:
http://www.cprmap.com/prion/prion-finding-offers-
A link to the Janet Skarbek documentary:
http://www.organicconsumers.org/madcow/sight8704.
The latest victim in the USA:
http://www.sciam.com/article.cfm?chanID=sa003&art
And a reference to the Hindu/cow link:
http://www.sustainabletable.org/blog/archives/200
I can't remember where I saw the Janet Skarbek documentary. I think it was either FreespeechTV or LinkTV.
Oh, and the word that I have to type in to prove that I'm not a script is "infected". Ironic.
John Cleese [as the bereaved son]: Um -- er, uh, excuse me but, um, are you suggesting ...*eating my mother*?
...Yeah! Not raw, cooked!
Graham Chapman [the undertaker]:
Cleese: What?!
Chapman: Er, uh, roasted, few french fries, broccoli... Horseradish sauce?
Cleese: Um, uh, well... Well, I do feel a little peckish.
"All hands, BRACE FOR IMPACT!"
Anybody else think Prion is a terrible contraction for "Priory of Scion?" Who names secret societies after cars anyway?
https://www.eff.org/https-everywhere
Further back, "In 1992 ... so called prion knock-out mice [were created]. ...
Strangely enough, mice lacking the prion gene are apparently healthy".
While other studies have found, "abnormalities in circadian rhythms and sleep" and ataxia late in life.
Proportionally, such symptoms may occur in 13 year old cattle (see halfbakery link).
So, to follow the new year's theme of predictions, I fully expect to be able to buy prion free beef by 2025.