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A new study finds that active middle aged men who can do more than 40 push-ups at a time have a significantly lower risk of heart disease. From a report: Researchers at the Harvard T.H. Chan School of Public Health followed more than 1,100 middle-aged male firefighters over a decade. They looked at two specific measures: how many push-ups they could do and their exercise tolerance on a treadmill. They found that men who could do more than 40 push-ups had a 96-percent lower risk of heart disease than those who could do no more than 10 and their ability to do push-ups was a better predictor of cardiovascular disease than their stamina on a treadmill test.

An anonymous reader quotes a report from The New York Times: The study, in JAMA Internal Medicine, tracked diet and health over eight years in more than 44,000 French men and women. Their average age was 58 at the start. About 29 percent of their energy intake was ultraprocessed foods. Such foods include instant noodles and soups, breakfast cereals, energy bars and drinks, chicken nuggets and many other ready-made meals and packaged snacks containing numerous ingredients and manufactured using industrial processes. There were 602 deaths over the course of the study, mostly from cancer and cardiovascular disease. Even after adjusting for many health, socioeconomic and behavioral characteristics, including scores on a scale of compliance with a healthy diet, the study found that for every 10 percent increase in ultraprocessed food consumption, there was a 14 percent increase in the risk of death (Warning: source may be paywalled; alternative source). The authors suggest that high-temperature processing may form contaminants, that additives may be carcinogenic, and that the packaging of prepared foods can lead to contamination.

An anonymous reader quotes USA Today: People who regularly eat organic food are less likely to develop cancer than those who don't, according to a new study out of France. A team of researchers studied 68,946 adult volunteers from France who provided information on how often they ate organic food, drinks and even dietary supplements. Participants were given a score, based on how often they eat organic food ranging from "most of the time" to "never" or "I don't know." During two follow-up appointments, one in 2009 and another in 2016, the researchers then tracked cancer diagnoses, the most prevalent being breast cancer. Other cancers observed included prostate cancer, skin cancer, colorectal cancer, non-Hodgkin lymphomas and lymphomas.

People who reported higher organic food scores were less likely to be diagnosed with cancer than the rest of the group. For example, those who consumed the most organic food were 25 percent less likely to have cancer, according to the research. That number grew to more than half when looking at cases of non-Hodgkin lymphoma.

An anonymous reader quotes a report from CNN: We've all heard exercise helps you live longer. But a new study [published in the journal JAMA Network Open] goes one step further, finding that a sedentary lifestyle is worse for your health than smoking, diabetes and heart disease. Researchers retrospectively studied 122,007 patients who underwent exercise treadmill testing at Cleveland Clinic between January 1, 1991 and December 31, 2014 to measure all-cause mortality relating to the benefits of exercise and fitness. Those with the lowest exercise rate accounted for 12% of the participants. Dr. Wael Jaber, a cardiologist at the Cleveland Clinic and senior author of the study, said the other big revelation from the research is that fitness leads to longer life, with no limit to the benefit of aerobic exercise. Researchers have always been concerned that "ultra" exercisers might be at a higher risk of death, but the study found that not to be the case. "There is no level of exercise or fitness that exposes you to risk," he said. "We can see from the study that the ultra-fit still have lower mortality."

After more than a century of slicing tiny, inflamed organs from people's guts, doctors have found that surgery may not be necessary after all -- a simple course of antibiotics can be just as effective at treating appendicitis as going under the knife. From a report: The revelation comes from a large, randomized trial out of Finland, published Tuesday, September 25, in JAMA. Despite upending a long-held standard of care, the study's finding is not entirely surprising; it follows several other randomized trials over the years that had carved out evidence that antibiotics alone can treat an acute appendicitis. Those studies, however, left some dangling questions, including if the antibiotics just improved the situation temporarily and if initial drug treatments left patients worse off later if they did need surgery. The new JAMA study, with its full, five-year follow-up, effectively cauterised those remaining issues. Nearly two-thirds of the patients randomly assigned in the study to get antibiotics for an uncomplicated appendicitis didn't end up needing surgery in the follow-up time, the Finnish authors, based at the University of Turku, report. And those drug-treated patients that did end up getting an appendectomy later were not worse off for the delay in surgery. "This long-term follow-up supports the feasibility of antibiotic treatment alone as an alternative to surgery for uncomplicated acute appendicitis," the authors conclude. The finding suggests that many appendicitis patients could be spared the risks of surgical procedures, such as infections.

Women who suffer from heart attacks may be at a higher risk of death in the emergency room if they see a male physician rather than a female one, a new study suggests. The study doesn't jump to conclusions, but doctors and cardiologists have a few theories. There could be a systematic bias where male physicians are not listening to female patients' complaints as readily as [those of] a man, or there could be a bias that favors men in the medical literature, leading to misdiagnoses in women. It may also be that female doctors do a better job than their male counterparts. "In the new study everyone was more likely to survive if they saw a female physician, and a study published last year [...] indicated all patients of female physicians had lower mortality and hospital readmission rates," reports Scientific American. From the report: Heart disease is the number-one killer of both men and women, but the latter are significantly less likely to survive heart attacks. According to 2016 American Heart Association statement, 26 percent of women will die within a year of a heart attack compared with just 19 percent of men. The gap widens with time: By five years after a heart attack almost half of women die, compared with 36 percent of men. The reason has eluded researchers for years, but the authors of the new study point to the disparity in male and female representation in emergency doctors as a potential source of answers. The researchers analyzed a Florida Agency for Health Care Administration database containing every heart attack case from every ER in the state (excluding Veterans Affairs hospitals) between 1991 and 2010.

The researchers divided 500,000-plus cases into four categories: male doctors treating men; male doctors treating women; female doctors treating men; and female doctors treating women. "All of those are statistically indistinguishable except for male doctor -- female patient," says Brad Greenwood, an author on the study and a data scientist at the University of Minnesota. If a heart attack patient is a woman and her emergency physician is a man, he says, her risk of death suddenly rises by about 12 percent. Put another way, a heart attack patient dies in the ER about 11.9 percent of the time overall -- but the research team found women with heart attacks will die about 12.4 percent of the time if their cases are handled by male doctors. This means approximately one out of every 66 women with heart attacks dies in the emergency room if she sees a male doctor rather than a female one.

DNA testing won't guide dieters to the weight-loss regimen most likely to work for them, scientists reported on Tuesday. From a report: Despite some earlier studies claiming that genetic variants predict whether someone has a better chance of shedding pounds on a low-carbohydrate or a low-fat diet, and despite a growing industry premised on that notion, the most rigorous study so far found no difference in weight loss between overweight people on diets that "matched" their genotype and those on diets that didn't. The findings make it less likely that genetics might explain why only some people manage to lose weight on a low-carb diet like Atkins and why others succeed with a low-fat one (even though the vast majority of dieters don't keep off whatever pounds they lose). Unlike cancer treatments, diets can't be matched to genotype, the new study shows. The results underline "how, for most people, knowing genetic risk information doesn't have a big impact," said Timothy Caulfield, of the University of Alberta, a critic of quackery.

An anonymous reader quotes a report from Reuters: The study published in the Journal of the American Medical Association compared 2,933 athletes who played in the National Football League for an average of five years to 879 "replacement players" who filled in for three games during a mid-1980s strike, finding no statistically significant difference in rates of death from all causes. Critics said the research had several flaws and pointed to a study released last year that found 99 percent of deceased former NFL players whose brains were analyzed post-mortem showed signs of chronic traumatic encephalopathy (CTE), a disease linked to repeated hits to the head that can lead to aggression and dementia. The latest study found that the leading cause of death among the NFL career players was cardiometabolic disease, which entails greater risk of heart attack and stroke, followed by transportation injuries and unintentional injuries.

"This new study seems to support other previous studies that have not shown an increase in mortality among NFL players when compared to similar cohorts," an NFL spokeswoman said. "As with all new research on this topic, we will look at it closely to see what we can learn to better enhance the well-being of our current and former players," the spokeswoman said.

An anonymous reader quotes a report from NPR: Doctors in New York say a woman in her 20s came in three days after looking at the Aug. 21 eclipse without protective glasses. She had peeked several times, for about six seconds, when the sun was only partially covered by the moon. Four hours later, she started experiencing blurred and distorted vision and saw a central black spot in her left eye. The doctors studied her eyes with several different imaging technologies, described in the journal JAMA Ophthalmology, and were able to observe the damage at the cellular level.

"We were very surprised at how precisely concordant the imaged damage was with the crescent shape of the eclipse itself," noted Dr. Avnish Deobhakta, an assistant professor of ophthalmology at the New York Eye and Ear Infirmary of Mount Sinai Icahn School of Medicine, in an email to NPR. He says this was the most severely injured patient they saw after the eclipse. All in all, 22 people came to their urgent care clinic with concerns about possible eclipse-related damage, and most of them complained of blurred vision. Of those, only three showed some degree of abnormality in the retina. Two of them had only mild changes, however, and their symptoms have gone away. The young woman described in this case report, at last check, still has not recovered normal vision. For your viewing pleasure, The Verge has embedded several images of the woman's retinas in their report.

"Robot-assisted surgery costs more time and money than traditional methods, but isn't more effective, for certain types of operations," reports the Register, in an article shared by schwit1: In a study of almost 24,000 laparoscopic surgeries just published in The Journal of American Medicine, researchers from Stanford University School of Medicine analyzed data from 416 hospitals around the U.S. from 2003 to 2015. Robotic assistance provides 3D-visualization, a broader range of motion for instruments, and better ergonomics for physicians, according to the study. While it has advantages in scenarios where a high-degree of precision is required or where improved outcomes have been demonstrated (like radical prostatectomy), it appears to be a waste of resources for the two operations examined... But the patient outcomes were more or less the same.

A thematically-related economic study presented by the National Bureau for Economic Research on Monday suggests that while AI and machine learning have received substantial investment over the past five years and have been widely touted as a transformative technologies, "there is little sign that they have yet affected aggregate productivity statistics... The simplest possibility is that the optimism about the potential technologies is misplaced and unfounded," muse Erik Brynjolfsson and Daniel Rock (MIT), Chad Syverson (University of Chicago) in the paper.
But instead the paper's author suggest that fully realizing the benefits of AI "will require effort and entrepreneurship to develop the needed complements, and adaptability at the individual, organizational, and societal levels to undertake the associated restructuring."

An anonymous reader quotes a report from Philly.com: Teens who vape e-cigarettes with higher nicotine levels are more likely to start smoking conventional cigarettes soon after, new research shows. E-cigarettes are sold with nicotine levels ranging from zero to more than 25 milligrams of nicotine per milliliter (mg/mL). In this study, a high-nicotine device was defined as having levels at or above 18 mg/mL. Leventhal's team tracked outcomes for 181 grade-10 students from high schools in the Los Angeles area. All of the teens said they had used e-cigarettes within the past month, and they provided data on nicotine levels in the devices they used. Six months later, those who used higher nicotine levels in their e-cigarettes were more likely to report use of both e-cigarettes and regular cigarettes within the past month. These teens also reported vaping and/or smoking more intensely. While 43 percent of the students who'd used high-nicotine e-cigarettes said they were "frequent smokers" of traditional cigarettes six months later, that was true for only 10 percent of those who'd vaped using lower-nicotine devices, Leventhal's group found. And teens who vaped using high-nicotine e-cigarettes smoked an average of 14 times as many "regular" cigarettes per day six months later compared to those who'd tried nicotine-free versions of the devices, the findings showed. The study was published in JAMA Pediatrics.

An anonymous reader quotes a report from The Verge: Even after puffing on just one electronic cigarette with nicotine, healthy non-smokers were found to have a biological marker known to increase the risk of heart disease in tobacco users, according to a new study. The research, published in Journal of the American Heart Association, shows that nicotine is not harmless, as many people believe. It can affect a smoker's health in more than one way, and not just by triggering addiction. Another study, conducted by Middlekauff that was published earlier this year, showed that people who use e-cigs almost every day have biological markers known to increase the risk of heart disease in tobacco users. These included an increase in adrenaline levels in the heart, which can predispose smokers to bad heart rhythms, heart attacks, and sudden death, as well as increased oxidative stress, an imbalance in the body's ability to defend itself against the damaging action of free radicals. Oxidative stress can lead to changes in blood fats and lead to arteriosclerosis.

That study, however, didn't show what exactly was causing those changes. E-cigarettes can have different flavoring and solvents, as well as nicotine. So to identify the culprit, Middlekauff brought 33 healthy non-smokers and non-vapers into the lab. On three different days, one month apart, the participants were asked to puff on three different kinds of e-cigarettes for 30 minutes: one with nicotine, one without nicotine, and a sham e-cig that was empty. The researchers did blood tests and measured the subjects' heart rhythms, and found that the participants had high levels of adrenaline in their hearts after they smoked the e-cig with nicotine, but not after they puffed on the e-cigarette without nicotine or the empty e-cig.

An anonymous reader quotes a report from Ars Technica: With firm vaccination campaigns, the US eliminated measles in 2000. The highly infectious virus was no longer constantly present in the country -- no longer endemic. Since then, measles has only popped up when travelers carried it in, spurring mostly small outbreaks -- ranging from a few dozen to a few hundred cases each year -- that then fizzle out. But all that may be about to change. With the rise of non-medical vaccine exemptions and delays, the country is backsliding toward endemic measles, Stanford and Baylor College of Medicine researchers warn this week. With extensive disease modeling, the researchers make clear just how close we are to seeing explosive, perhaps unshakeable, outbreaks. According to results the researchers published in JAMA Pediatrics, a mere five-percent slip in measles-mumps-and-rubella (MMR) vaccination rates among kids aged two to 11 would triple measles cases in this age group and cost $2.1 million in public healthcare costs. And that's just a small slice of the disease transmission outlook. Kids two to 11 years old only make up about 30 percent of the measles cases in current outbreaks. The number of cases would be much larger if the researchers had sufficient data to model the social mixing and immunization status of adults, teens, and infants under two.

A new study published Tuesday in the journal American Medical Association found that 110 out of 111 brains of those who played in the NFL had degenerative brain disease chronic traumatic encephalopathy (CTE). NPR reports: In the study, researchers examined the brains of 202 deceased former football players at all levels. Nearly 88 percent of all the brains, 177, had CTE. Three of 14 who had played only in high school had CTE, 48 of 53 college players, 9 of 14 semiprofessional players, and 7 of 8 Canadian Football League players. CTE was not found in the brains of two who played football before high school. According to the study's senior author, Dr. Ann McKee, "this is by far the largest [study] of individuals who developed CTE that has ever been described. And it only includes individuals who are exposed to head trauma by participation in football." A CTE study several years ago by McKee and her colleagues included football players and athletes from other collision sports such as hockey, soccer and rugby. It also examined the brains of military veterans who had suffered head injuries. The study released Tuesday is the continuation of a study that began eight years ago. In 2015, McKee and fellow researchers at the Department of Veterans Affairs and Boston University published study results revealing 87 of 91 former NFL players had CTE.

After analyzing records from every U.S. county between 1980 and 2014, Christopher Murray, head of the Institute for Health Metrics and Evaluation at the University of Washington, and his team found that life expectancy can vary by more than 20 years from county to county. "In counties with the longest lifespans, people tended to live about 87 years, while people in places with the shortest lifespans typically made it only about 67," reports NPR. From the report: The discrepancy is equivalent to the difference between the low-income parts of the developing world and countries with high incomes, Murray notes. For example, it's about the same gap as the difference between people living in Japan, which is among countries with the longest lifespans, and India, which has one of the shortest, Murray says. The U.S. counties with the longest life expectancy are places like Marin County, Calif., and Summit County, Colo. -- communities that are well-off and more highly educated. Counties with the shortest life expectancy tend to have communities that are poorer and less educated. The lowest is in Oglala Lakota County, S.D., which includes the Pine Ridge Native American reservation. Many of the other counties with the lowest life expectancy are clustered along the lower Mississippi River Valley as well as parts of West Virginia and Kentucky, according to the analysis. There's no sign of the gap closing. In fact, it's appears to be widening. Between 1980 and 2014, the gap between the highest and lowest lifespans increased by about two years. The reasons for the gap are complicated. But it looks like the counties with the lowest lifespans haven't made much progress fighting significant health problems such as smoking and obesity. The study has been published in the journal JAMA Internal Medicine.

An anonymous reader quotes a report from Ars Technica: In decades of research, scientists have found only one medical condition that's clearly and effectively treated with testosterone supplements: pathological hypogonadism -- that's low testosterone levels due to disease of the hypothalamus, pituitary gland, or testes. In a series of placebo-controlled, randomized trials, researchers tracked the effect of testosterone on the cognition, bone health, anemia, and cardiovascular health of 788 men for a year. All the men were aged 65 or older and had low testosterone levels that couldn't be explained by anything other than age. The results, reported Tuesday in JAMA and JAMA Internal Medicine, offer mixed results. Among the 493 in the trial who also had age-related memory declines, testosterone didn't have any effect on memory or cognitive abilities. In the study, 247 got testosterone and 246 got a placebo. But for cardiovascular health, there was an effect -- a bad one. Over the year, plaque buildup in the coronary artery -- which is a risk factor for heart disease -- increased in 73 men on testosterone compared with 65 on placebo. However, other studies have found mixed results on this. Longer, bigger trials will be needed to sort out the risks. In the anemia study, testosterone did seem to improve iron levels in men with mild anemia. The bone health study also showed that testosterone could improve bone density. However, it's unclear if those benefits outweigh the possible cardiovascular risks. And other drugs may be more effective at treating anemia and improving bone mass than testosterone.

An anonymous reader quotes a report from Ars Technica: In decades of research, scientists have found only one medical condition that's clearly and effectively treated with testosterone supplements: pathological hypogonadism -- that's low testosterone levels due to disease of the hypothalamus, pituitary gland, or testes. In a series of placebo-controlled, randomized trials, researchers tracked the effect of testosterone on the cognition, bone health, anemia, and cardiovascular health of 788 men for a year. All the men were aged 65 or older and had low testosterone levels that couldn't be explained by anything other than age. The results, reported Tuesday in JAMA and JAMA Internal Medicine, offer mixed results. Among the 493 in the trial who also had age-related memory declines, testosterone didn't have any effect on memory or cognitive abilities. In the study, 247 got testosterone and 246 got a placebo. But for cardiovascular health, there was an effect -- a bad one. Over the year, plaque buildup in the coronary artery -- which is a risk factor for heart disease -- increased in 73 men on testosterone compared with 65 on placebo. However, other studies have found mixed results on this. Longer, bigger trials will be needed to sort out the risks. In the anemia study, testosterone did seem to improve iron levels in men with mild anemia. The bone health study also showed that testosterone could improve bone density. However, it's unclear if those benefits outweigh the possible cardiovascular risks. And other drugs may be more effective at treating anemia and improving bone mass than testosterone.

An anonymous reader quotes a report from Ars Technica: In decades of research, scientists have found only one medical condition that's clearly and effectively treated with testosterone supplements: pathological hypogonadism -- that's low testosterone levels due to disease of the hypothalamus, pituitary gland, or testes. In a series of placebo-controlled, randomized trials, researchers tracked the effect of testosterone on the cognition, bone health, anemia, and cardiovascular health of 788 men for a year. All the men were aged 65 or older and had low testosterone levels that couldn't be explained by anything other than age. The results, reported Tuesday in JAMA and JAMA Internal Medicine, offer mixed results. Among the 493 in the trial who also had age-related memory declines, testosterone didn't have any effect on memory or cognitive abilities. In the study, 247 got testosterone and 246 got a placebo. But for cardiovascular health, there was an effect -- a bad one. Over the year, plaque buildup in the coronary artery -- which is a risk factor for heart disease -- increased in 73 men on testosterone compared with 65 on placebo. However, other studies have found mixed results on this. Longer, bigger trials will be needed to sort out the risks. In the anemia study, testosterone did seem to improve iron levels in men with mild anemia. The bone health study also showed that testosterone could improve bone density. However, it's unclear if those benefits outweigh the possible cardiovascular risks. And other drugs may be more effective at treating anemia and improving bone mass than testosterone.

An anonymous reader quotes a report from Ars Technica: In decades of research, scientists have found only one medical condition that's clearly and effectively treated with testosterone supplements: pathological hypogonadism -- that's low testosterone levels due to disease of the hypothalamus, pituitary gland, or testes. In a series of placebo-controlled, randomized trials, researchers tracked the effect of testosterone on the cognition, bone health, anemia, and cardiovascular health of 788 men for a year. All the men were aged 65 or older and had low testosterone levels that couldn't be explained by anything other than age. The results, reported Tuesday in JAMA and JAMA Internal Medicine, offer mixed results. Among the 493 in the trial who also had age-related memory declines, testosterone didn't have any effect on memory or cognitive abilities. In the study, 247 got testosterone and 246 got a placebo. But for cardiovascular health, there was an effect -- a bad one. Over the year, plaque buildup in the coronary artery -- which is a risk factor for heart disease -- increased in 73 men on testosterone compared with 65 on placebo. However, other studies have found mixed results on this. Longer, bigger trials will be needed to sort out the risks. In the anemia study, testosterone did seem to improve iron levels in men with mild anemia. The bone health study also showed that testosterone could improve bone density. However, it's unclear if those benefits outweigh the possible cardiovascular risks. And other drugs may be more effective at treating anemia and improving bone mass than testosterone.

An anonymous reader quotes a report from Ars Technica: In decades of research, scientists have found only one medical condition that's clearly and effectively treated with testosterone supplements: pathological hypogonadism -- that's low testosterone levels due to disease of the hypothalamus, pituitary gland, or testes. In a series of placebo-controlled, randomized trials, researchers tracked the effect of testosterone on the cognition, bone health, anemia, and cardiovascular health of 788 men for a year. All the men were aged 65 or older and had low testosterone levels that couldn't be explained by anything other than age. The results, reported Tuesday in JAMA and JAMA Internal Medicine, offer mixed results. Among the 493 in the trial who also had age-related memory declines, testosterone didn't have any effect on memory or cognitive abilities. In the study, 247 got testosterone and 246 got a placebo. But for cardiovascular health, there was an effect -- a bad one. Over the year, plaque buildup in the coronary artery -- which is a risk factor for heart disease -- increased in 73 men on testosterone compared with 65 on placebo. However, other studies have found mixed results on this. Longer, bigger trials will be needed to sort out the risks. In the anemia study, testosterone did seem to improve iron levels in men with mild anemia. The bone health study also showed that testosterone could improve bone density. However, it's unclear if those benefits outweigh the possible cardiovascular risks. And other drugs may be more effective at treating anemia and improving bone mass than testosterone.

schwit1 quotes a report from The New York Times: Social isolation is a growing epidemic (Warning: may be paywalled; alternate source) -- one that's increasingly recognized as having dire physical, mental and emotional consequences. Since the 1980s, the percentage of American adults who say they're lonely has doubled from 20 percent to 40 percent. About one-third of Americans older than 65 now live alone, and half of those over 85 do. People in poorer health -- especially those with mood disorders like anxiety and depression -- are more likely to feel lonely. Those without a college education are the least likely to have someone they can talk to about important personal matters. A wave of new research suggests social separation is bad for us. Individuals with less social connection have disrupted sleep patterns, altered immune systems, more inflammation and higher levels of stress hormones. One recent study found that isolation increases the risk of heart disease by 29 percent and stroke by 32 percent. Another analysis that pooled data from 70 studies and 3.4 million people found that socially isolated individuals had a 30 percent higher risk of dying in the next seven years, and that this effect was largest in middle age. Loneliness can accelerate cognitive decline in older adults, and isolated individuals are twice as likely to die prematurely as those with more robust social interactions. These effects start early: Socially isolated children have significantly poorer health 20 years later, even after controlling for other factors. All told, loneliness is as important a risk factor for early death as obesity and smoking.

BrianFagioli writes from a report via BetaNews: Diabetic eye disease is caused by retinopathy. Affected diabetics can have small tears inside the eye, causing bleeding. Over time, they can lose vision, and ultimately, they can go blind. Luckily, Google has been trying to use machine learning to detect diabetic retinopathy. Guess what? The search giant has seen much success. Not only are the computers able to detect the disease at the same level as ophthalmologists, but Google is actually slightly better! "A few years ago, a Google research team began studying whether machine learning could be used to screen for diabetic retinopathy (DR). Today, in the Journal of the American Medical Association, we've published our results: a deep learning algorithm capable of interpreting signs of DR in retinal photographs, potentially helping doctors screen more patients, especially in underserved communities with limited resources," says Lily Peng, MD Ph.D., Product Manger at Google. She goes on to say "our algorithm performs on par with the ophthalmologists, achieving both high sensitivity and specificity. [...] For example, on the validation set described in Figure 2, the algorithm has a F-score of 0.95, which is slightly better than the median. F-score of the 8 ophthalmologists we consulted (measured at 0.91)."

A new study involving more than 21,000 people across the country finds that dementia rates in people over age 65 fell from 11.6 percent in 2000 to 8.8 percent in 2012 -- a decline of 24 percent. CNN reports: The decline in dementia rates translates to about one million fewer Americans suffering from the condition, said John Haaga, director of behavioral and social research at the National Institute on Aging, part of the National Institutes of Health, which funded the new study. Dementia is a general term for a loss of memory or other mental abilities that's severe enough to interfere with daily life. Alzheimer's disease, which is believed to be caused by a buildup of plaques and tangles in the brain, is the most common type of dementia. Vascular dementia is the second most common type of dementia and occurs after a stroke. The study, which began in 1992, focuses on people over age 50, collecting data every two years. Researchers conduct detailed interviews with participants about their health, income, cognitive ability and life circumstances. The interviews also include physical tests, body measurements and blood and saliva samples. Although researchers can't definitively explain why dementia rates are decreasing, Langa said doctors may be doing a better job controlling high blood pressure and diabetes, which can both boost the risk of age-related memory problems. High blood pressure and diabetes both increase the risk of strokes, which kill brain cells, increasing the risk of vascular dementia. Authors of the study found that senior citizens today are better educated than even half a generation ago. The population studied in 2012 stayed in school 13 years, while the seniors studied in 2000 had about 12 years of education, according to the study. People who are better educated may have more intellectually stimulating jobs and hobbies that help exercise their brains, Langa said. The study has been published Monday in JAMA Internal Medicine.

An anonymous reader quotes a report from Science Daily: Increasingly powerful computers using ever-more sophisticated programs are challenging human supremacy in areas as diverse as playing chess and making emotionally compelling music. But can digital diagnosticians match, or even outperform, human physicians? The answer, according to a new study led by researchers at Harvard Medical School, is "not quite." The findings, published Oct. 10 in JAMA Internal Medicine, show that physicians' performance is vastly superior and that doctors make a correct diagnosis more than twice as often as 23 commonly used symptom-checker apps. The analysis is believed to provide the first direct comparison between human-made and computer-based diagnoses. Diagnostic errors stem from failure to recognize a disease or to do so in a timely manner. Physicians make such errors roughly 10 to 15 percent of the time, researchers say. In the study, 234 internal medicine physicians were asked to evaluate 45 clinical cases, involving both common and uncommon conditions with varying degrees of severity. For each scenario, physicians had to identify the most likely diagnosis along with two additional possible diagnoses. Each clinical vignette was solved by at least 20 physicians. The physicians outperformed the symptom-checker apps, listing the correct diagnosis first 72 percent of the time, compared with 34 percent of the time for the digital platforms. Eighty-four percent of clinicians listed the correct diagnosis in the top three possibilities, compared with 51 percent for the digital symptom-checkers. The difference between physician and computer performance was most dramatic in more severe and less common conditions. It was smaller for less acute and more common illnesses.

schwit1 quotes a report from New York Times: Wearable activity monitors can count your steps and track your movements, but they don't, apparently, help you lose weight. In fact, you might lose more weight without them. The fascinating finding comes from a study published today in JAMA that found dieting adults who wore activity monitors for 18 months lost significantly fewer pounds over that time than those who did not. The results suggest that activity monitors may not change our behavior in the way we expected (warning: may be paywalled), and raise interesting questions about the tangled relationships between exercise, eating, our willpower and our waistlines. Specifically, the study found that participants who used wearable devices reported an average weight loss of 7.7 pounds, compared to the 13 pounds lost by those who didn't use the devices and only used health counseling. "While usage of wearable devices is currently a popular method to track physical activity -- steps taken per day or calories burned during a workout -- our findings show that adding them to behavioral counseling or weight loss that includes physical activity and reduced calorie intake does not improve weight loss or physical activity engagement. Therefore, within this context, these devices should not be relied upon as tools for weight management in place of effective behavioral counseling for physical activity and diet," said John Jakicic, the study's lead researcher and chair of Pitt's Department of Health and Physical Activity.

An anonymous reader quotes a report from Ars Technica: Back in the 1960s, a sugar industry executive wrote fat checks to a group of Harvard researchers so that they'd downplay the links between sugar and heart disease in a prominent medical journal -- and the researchers did it, according to historical documents reported Monday in the journal JAMA Internal Medicine. One of those Harvard researchers went on to become the head of nutrition at the United States Department of Agriculture, where he set the stage for the federal government's current dietary guidelines. All in all, the corrupted researchers and skewed scientific literature successfully helped draw attention away from the health risks of sweets and shift the blame to solely to fats -- for nearly five decades. The low-fat, high-sugar diets that health experts subsequently encouraged are now seen as a main driver of the current obesity epidemic. The bitter revelations come from archived documents from the Sugar Research Foundation (now the Sugar Association), dug up by researchers at the University of California, San Francisco. Their dive into the old, sour affair highlights both the perils of trusting industry-sponsored research to inform policy and the importance of requiring scientists to disclose conflicts of interest -- something that didn't become the norm until years later. Perhaps most strikingly, it spotlights the concerning power of the sugar industry. In a statement also issued today, the Sugar Association acknowledged that it "should have exercised greater transparency in all of its research activities." However, the trade-group went on to question the UCSF researchers' motives in digging up the issue and reframing the past events to "conveniently align with the currently trending anti-sugar narrative." The association also chastised the journal for publishing the historical analysis, which it implied was insignificant and sensationalist. "Most concerning is the growing use of headline-baiting articles to trump quality scientific research -- we're disappointed to see a journal of JAMA's stature being drawn into this trend," the association wrote. But scientists disagree with that take. In an accompanying editorial, nutrition professor Marion Nestle of New York University argued that "this 50-year-old incident may seem like ancient history, but it is quite relevant, not least because it answers some questions germane to our current era."

An anonymous reader quotes a report from Ars Technica: Back in the 1960s, a sugar industry executive wrote fat checks to a group of Harvard researchers so that they'd downplay the links between sugar and heart disease in a prominent medical journal -- and the researchers did it, according to historical documents reported Monday in the journal JAMA Internal Medicine. One of those Harvard researchers went on to become the head of nutrition at the United States Department of Agriculture, where he set the stage for the federal government's current dietary guidelines. All in all, the corrupted researchers and skewed scientific literature successfully helped draw attention away from the health risks of sweets and shift the blame to solely to fats -- for nearly five decades. The low-fat, high-sugar diets that health experts subsequently encouraged are now seen as a main driver of the current obesity epidemic. The bitter revelations come from archived documents from the Sugar Research Foundation (now the Sugar Association), dug up by researchers at the University of California, San Francisco. Their dive into the old, sour affair highlights both the perils of trusting industry-sponsored research to inform policy and the importance of requiring scientists to disclose conflicts of interest -- something that didn't become the norm until years later. Perhaps most strikingly, it spotlights the concerning power of the sugar industry. In a statement also issued today, the Sugar Association acknowledged that it "should have exercised greater transparency in all of its research activities." However, the trade-group went on to question the UCSF researchers' motives in digging up the issue and reframing the past events to "conveniently align with the currently trending anti-sugar narrative." The association also chastised the journal for publishing the historical analysis, which it implied was insignificant and sensationalist. "Most concerning is the growing use of headline-baiting articles to trump quality scientific research -- we're disappointed to see a journal of JAMA's stature being drawn into this trend," the association wrote. But scientists disagree with that take. In an accompanying editorial, nutrition professor Marion Nestle of New York University argued that "this 50-year-old incident may seem like ancient history, but it is quite relevant, not least because it answers some questions germane to our current era."

An anonymous reader shares a report on NPR.org: Poor people who reside in expensive, well-educated cities such as San Francisco tend to live longer than low-income people in less affluent places, according to a study of more than a billion Social Security and tax records. The study, published in JAMA, the Journal of the American Medical Association, bolsters what was already well-known -- the poor tend to have shorter lifespans than those with more money. But it also says that among low-income people, big disparities exist in life expectancy from place to place, said Raj Chetty, professor of economics at Stanford University. "There are some places where the poor are doing quite well, gaining just as much in terms of life span as the rich, but there are other places where they're actually going in the other direction, where the poor are living shorter lives today than they did in the past," Chetty said, in an interview with NPR.The New York Times' take on the same study: New York is a city with some of the worst income inequality in the country. But when it comes to inequality of life spans, it's one of the best. Impoverished New Yorkers tend to live far longer than their counterparts in other American cities, according to a detailed new research of Social Security and earnings records published Monday in The Journal of the American Medical Association. They still die sooner than their richer neighbors, but the city's life-expectancy gap was smaller in 2014 than nearly everywhere else, and it has shrunk since 2001 even as gaps grew nationwide. That trend may appear surprising. New York is one of the country's most unequal and expensive cities, where the poor struggle to find affordable housing and the money and time to take care of themselves.

An anonymous reader writes: Confirmed in a report from ABC News, Apple has updated Siri to respond to statements involving sexual assault and abuse in a more appropriate and consistent manner. JAMA Internal Medicine published an article in mid-March noting how personal assistants like Siri, Cortana, S Voice and Google Now incompletely and inconsistently responded to phrases relating to abuse or sexual assault. Apple has updated Siri in response to that article. If you say, "Siri I was raped," Siri will respond with the following: "If you think you may have experienced sexual abuse or assault, you may want to reach out to someone at the National Sexual Assault Hotline.'' Previously, Siri would respond by saying users "should reach out" for available help.

An anonymous reader writes to point out a software review of the kind you can't generally find in an app store. A group from Johns Hopkins checked the accuracy of the Instant Blood Pressure app, which has sold more than 148,000 copies, and purports to measure blood pressure with just an iPhone -- no cuff required -- and found it wanting, to put it mildly. In the researcher's study, published in JAMA Internal Medicine, the app missed elevated blood pressures four out of five times.

HughPickens.com writes: NPR reports that more and more adults across the U.S. are strapping on helmets and hopping on bikes to get to work. Unfortunately, between 1998 and 2013, the rate of bicycle-related injuries among all adults increased by 28 percent, from 96 injuries per 100,000 people in 1998-1999, to 123 injuries per 100,000 people in 2012-2013. And while the death rate among child cyclists has plummeted in the past four decades, the mortality rate among cyclists ages 35 to 54 has tripled. Dr. Benjamin Breyer isn't sure what's driving the surge in accidents among Generation Xers and baby boomers, but one reason could be what's known as the Lance Armstrong effect. "After Lance Armstrong had all of his success at the Tour de France, a lot more people were riding, and there were a lot more older riders that took up the bicycle for sport."

The most recent National Household Travel Survey showed that the vast majority of the increase in bicycling between 1995 and 2009 came from Americans older than 25, with the biggest increases coming in the oldest groups. That has meant more men in their 50s and 60s on road bikes, riding at high speeds, Breyer says — a recipe for serious injuries. Though a rapidly growing share of older people would like to ride, American cities built during the last 60 years don't make it easy for most people to do so. At the end of the day, reducing cycling accidents may boil down to something simple: Making sure that bikers know the rules of the road — and that drivers know how to deal with bikers.

An anonymous reader writes: A new survey published in JAMA Pediatrics found that 95% of doctors believe patients are put at risk when doctors work while sick. Despite that, 83% of respondents said they had "come to work with symptoms like diarrhea, fever and respiratory complaints during the previous year." The researchers doing the survey dug into the reasons for this: first of all, given the heavy workload of most doctors, it's very difficult to find others who can take up the slack when one is recovering from an illness. Beyond that, the profession is pervaded by a culture of working through the discomfort and pain of minor maladies. According to a commentary on the research, hospital policies don't help matters — they often incentivize long hours and don't encourage ill workers to leave the premises.

An anonymous reader writes: A new survey published in JAMA Pediatrics found that 95% of doctors believe patients are put at risk when doctors work while sick. Despite that, 83% of respondents said they had "come to work with symptoms like diarrhea, fever and respiratory complaints during the previous year." The researchers doing the survey dug into the reasons for this: first of all, given the heavy workload of most doctors, it's very difficult to find others who can take up the slack when one is recovering from an illness. Beyond that, the profession is pervaded by a culture of working through the discomfort and pain of minor maladies. According to a commentary on the research, hospital policies don't help matters — they often incentivize long hours and don't encourage ill workers to leave the premises.

An anonymous reader sends word of a new study (abstract) into the relationship between the MMR vaccine and kids who develop autism. In short: there is no relationship, even for kids at high risk of developing autism. From the article: [Researchers] examined records from a large health insurer to search for such an association. They checked the status of children continuously enrolled in the health plan from birth to at least 5 years old during 2001 to 2012. The children also had an older brother or sister continuously enrolled for at least six months between 1997 and 2012. "Consistent with studies in other populations, we observed no association between MMR vaccination and increased ASD risk among privately insured children.We also found no evidence that receipt of either 1 or 2 doses of MMR vaccination was associated with an increased risk of ASD among children who had older siblings with ASD." ... [An accompanying editorial said,] "Taken together, some dozen studies have now shown that the age of onset of ASD does not differ between vaccinated and unvaccinated children, the severity or course of ASD does not differ between vaccinated and unvaccinated children, and now the risk of ASD recurrence in families does not differ between vaccinated and unvaccinated children."

jones_supa writes A study of Finnish men suggests that frequent sauna baths may help you live longer. Previous research has suggested that saunas might improve blood vessel function and exercise capacity, or even lower blood pressure in patients with hypertension. The new study links long, hot sauna baths with more benefits, including fewer deaths from heart attacks, strokes, various heart-related conditions and other causes. The study tracked 2315 Finnish men for nearly 20 years on average. Most participants used saunas at least once weekly. Those who used them four to seven times weekly received the greatest benefits. The study published in JAMA Internal Medicine wraps up by saying that further studies are warranted to establish the potential mechanism that links sauna bathing and the aforementioned cardiovascular benefits.

HughPickens.com (3830033) writes David Wagner writes that a predictive computer model using machine learning methods is helping to identify soldiers in the United States Army most likely to commit suicide. Computers combed through data on more than 40,000 soldiers who'd been hospitalized for mental health problems looking at 421 variables on each soldier drawn from 38 military data systems. Using a method known as "machine learning," the researchers identified roughly two dozen factors that are most important in predicting soldiers most likely to commit suicide. The soldiers most likely to take their own lives were men with past suicidal behavior and a history of psychiatric disorders and criminal offenses, including weapons possession and verbal assaults. Soldiers with hearing loss also faced heightened risk — a strong indicator that they had suffered a head injury. So did enlisting in the Army after age 27, most likely because those soldiers had already experienced trouble finding their way in life. "There's this group that comes to the Army later in life — they're smart, they have skills, they tend not to be married and they have no career or have left a career to join," Dr. Kessler said. "We don't know why they should be at higher risk, but they appear to be."

Murray Stein, co-author of the new study, found that among soldiers recently discharged from psychiatric hospitals, more than half of suicides were committed by just five percent of patients. "The most impressive thing is that they identified this high-risk group in the hospital, and by just focusing on one in 20 of them, you're really dramatically improving your ability to predict," says Dr. Mark Olfson, a professor of psychiatry at Columbia University who was not involved in the study. "Clinicians don't do a very good job predicting suicide risk, even though we think we do."

sciencehabit writes Clostridium difficile infections kill approximately 14,000 Americans every year, often because the diarrhea-causing bacteria are highly resistant to standard antibiotics. Now, scientists have found an unusual way to combat the bugs: human feces in pill form. In the new study, researchers show that frozen fecal matter encapsulated in clear, 1.6 g synthetic pills was just as safe and effective as traditional fecal transplant techniques at treating C. difficile. Within 8 weeks or less, 18 out of 20 participants saw a complete resolution of diarrhea after consuming 30 or 60 of the feces-filled capsules. "It's probably not the best experience of your life," says team leader Ilan Youngster, a pediatric infectious disease doctor at Harvard University. "But it beats getting a tube stuck down your throat or a colonoscopy or having C. diff."

sciencehabit writes: Clinical trials rarely get a second look — and when they do, their findings are not always what the authors originally reported. That's the conclusion of a new study (abstract), which compared how 37 studies that had been reanalyzed measured up to the original. In 13 cases, the reanalysis came to a different outcome — a finding that suggests many clinical trials may not be accurately reporting the effect of a new drug or intervention. Moreover, only five of the reanalyses were by an entirely different set of authors, which means they did not get a neutral relook.

In one of the trials, which examined the efficacy of the drug methotrexate in treating systemic sclerosis—an autoimmune disease that causes scarring of the skin and internal organs—the original researchers found the drug to be not much more effective than the placebo, as they reported in a 2001 paper. However, in a 2009 reanalysis of the same trial, another group of researchers including one of the original authors used Bayesian analysis, a statistical technique to overcome the shortcomings of small data sets that plague clinical trials of rare diseases such as sclerosis. The reanalysis found that the drug was, as it turned out, more effective than the placebo and had a good chance of benefiting sclerosis patients.

An anonymous reader writes: Narcotic painkillers aren't one of the biggest killers in the U.S., but overdoses do claim over 15,000 lives per year and send hundreds of thousands to the emergency room. Because of this, it's interesting that a new study (abstract) has found states that allow the use of medical marijuana have seen a dramatic reduction in opioid overdose fatalities. "Previous studies hint at why marijuana use might help reduce reliance on opioid painkillers. Many drugs with abuse potential such as nicotine and opiates, as well as marijuana, pump up the brain's dopamine levels, which can induce feelings of euphoria. The biological reasons that people might use marijuana instead of opioids aren't exactly clear, because marijuana doesn't replace the pain relief of opiates. However, it does seem to distract from the pain by making it less bothersome." This research comes at a time when the country is furiously debating the costs and benefits of marijuana use, and opponents of the idea are paying researchers to paint it in an unfavorable light.

New submitter Bodhammer (559311) writes "German researchers looked at the brains of 64 men between the ages of 21 and 45 and found that one brain region (the striatum, linked to reward processing), was smaller in the brains of porn watchers, and that a specific part of the same region is also less activated when exposed to more pornography." While it's tempting to cast blame, "the study doesn't confirm whether watching porn causes the changes, or whether people with a certain brain type are inherently more apt to tune into X-rated content." The study's abstract is available; the paper itself is pay-walled.

cold fjord writes in with some bad news for the people using water fluoridation to pacify the public and install a new world government. "About half of American adults believe in at least one medical conspiracy theory, according to new survey results. (paywalled, first page viewable) Some conspiracy theories have much more traction than others ... three times as many people believe U.S. regulators prevent people from getting natural cures as believe that a U.S. spy agency infected a large number of African Americans with the human immunodeficiency virus (HIV). J. Eric Oliver, the study's lead author from University of Chicago, said people may believe in conspiracy theories because they're easier to understand than complex medical information. ... Some 49 percent of the survey participants agreed with at least one of the conspiracies. In fact, in addition to the 37 percent of respondents who fully agreed that U.S. regulators are suppressing access to natural cures, less than a third were willing to say they actively disagreed with the theory. — One of the conspiracy theories, that the U.S. created HIV, was created for an active disinformation campaign by the Soviet Union against the U.S. as a form of political warfare during the Cold War, and still gets repeated."

Hugh Pickens DOT Com writes "Sheila M. Elred writes in Discovery Magazine that a recent study has found that people at risk of depression were much less vulnerable if they identified as religious. Brain MRIs revealed that religious participants had thicker brain cortices than those who weren't as religious. 'One of the worst killers of brain cells is stress,' says Dr. Majid Fotuhi. 'Stress causes high levels of cortisol, and cortisol is toxic to the hippocampus. One way to reduce stress is through prayer. When you're praying and in the zone you feel a peace of mind and tranquility.' The reports concluded that a thicker cortex associated with a high importance of religion or spirituality may confer resilience to the development of depressive illness in individuals at high familial risk for major depression. The social element of attending religious services has also been linked to healthy brains. 'There's something magical about socializing,' says Fotuhi. 'It releases endorphins in the brain. It's hard to know whether it's through religion or a gathering of friends, but it improves brain health in the long term.'" (Read more, below.) "Listening to sermons and reading religious works like the Bible may also invoke a cognitive benefit. "You're exercising your higher cortical function, thinking about complex concepts that require some imagination," says Harold G. Koenig, director of the Center for Spirituality, Theology, and Health at Duke University and a professor of psychiatry. According to Koenig the benefits of devout religious practice, particularly involvement in a faith community and religious commitment, are that people cope better. "In general, they cope with stress better, they experience greater well-being because they have more hope, they're more optimistic, they experience less depression, less anxiety, and they commit suicide less often. They don't drink alcohol as much, they don't use drugs as much, they don't smoke cigarettes as much, and they have healthier lifestyles. They have stronger immune systems, lower blood pressure, probably better cardiovascular functioning, and probably a healthier hormonal environment physiologically—particularly with respect to cortisol and adrenaline And they live longer." So where does that leave non-believers? "Out of luck, I guess," Koenig jokes. "Actually, I would suspect that people doing the types of things like religious people do — socializing, doing similarly complex cognitive tasks, would have similar benefits. But it is interesting that religion provides that whole package of things that people can adopt and pursue over time." Dr Dan Blazer says the study is very interesting but is still exploratory and that spirituality may be a marker of something else, such as socioeconomic status. "It's hard to study these things," concludes Fotuhi . "It's why research has stayed away from them. But there does seem to be a strong link between spirituality and better brain health.""

Hugh Pickens DOT Com writes "John Gever reports at MedPage Today on a new study conducted by researchers from the University of Buffalo, which found that people with more cavities in their teeth are 32 percent less likely to suffer from head and neck cancers. 'To our knowledge, the present study suggests, for the first time, an independent association between dental caries and head and neck squamous cell carcinoma.' The researchers proposed a mechanism for the apparent protective effect: that cariogenic, lactic acid-producing bacteria prompt cell-mediated Th1 immune responses that suppress tumor formation. The team examined records of patients older than 21 seen in the university's dental and maxillofacial prosthetics department from 1999 to 2007, identifying 399 who were newly diagnosed with head and neck squamous cell carcinoma. Assuming that the association between caries and reduced cancer risk is real, the team suggests that one could regard the cariogenic bacteria as beneficial overall, with caries 'a form of collateral damage.' Therefore an appropriate strategy could be to target that effect specifically without aggressively targeting the bacteria. 'Antimicrobial treatment, vaccination, or gene therapy against cariogenic bacteria may lead to more harm than good in the long run.'"

DevotedSkeptic sends this excerpt about research that found a correlation between the use of a common food-packaging chemical and obesity rates. "Since the 1960s, manufacturers have widely used the chemical bisphenol-A (BPA) in plastics and food packaging. Only recently, though, have scientists begun thoroughly looking into how the compound might affect human health—and what they've found has been a cause for concern. Starting in 2006, a series of studies, mostly in mice, indicated that the chemical might act as an endocrine disruptor (by mimicking the hormone estrogen), cause problems during development and potentially affect the reproductive system, reducing fertility. After a 2010 Food and Drug Administration report warned that the compound could pose an especially hazardous risk for fetuses, infants and young children, BPA-free water bottles and food containers started flying off the shelves. In July, the FDA banned the use of BPA in baby bottles and sippy cups, but the chemical is still present in aluminum cans, containers of baby formula and other packaging materials. Now comes another piece of data on a potential risk from BPA but in an area of health in which it has largely been overlooked: obesity. A study by researchers from New York University, published today in the Journal of the American Medical Association, looked at a sample of nearly 3,000 children and teens across the country and found a 'significant' link between the amount of BPA in their urine and the prevalence of obesity."