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Coffee Maybe Not a Health Drink!

perbert writes "Canadian researchers have published a study in the Journal of the American Medical Association indicating that excess coffee drinking (4+ cups a day) could lead to an increased risk of heart disease if you have the wrong gene. In light of other studies linking antioxidants in coffee to a reduction in heart disease, who is right? Or will they cancel out in a coffee death-match?"

381 comments

  1. Dose by ThenAgain · · Score: 5, Insightful

    As with anything related to toxicology, the dose is the poison.

    1. Re:Dose by AKAImBatman · · Score: 4, Insightful

      In other words, keep it to a cup or two a day and you'll be fine. You may even reap the benefits of Coffee's antioxidants.

      If anyone ever tells you to do a lot of anything, run the other way. People have died from everything from eating too much salt to drinking too much carrot juice. Keep your diet balanced and your intakes in moderation, and you'll do far better than chasing around massive doses of things that are "good" for you.

    2. Re:Dose by ergo98 · · Score: 5, Interesting

      As with anything related to toxicology, the dose is the poison.

      To a point, however that simplifies and misses the point of the article: The researchers are claiming that there are two common variants of the gene responsible for the systems that breaks down coffee, and those with one variant are made healthier by 3 cups of coffee a day, while those with the other variant (CYP1A2*1F) are detrimentally affected by the same.

      So it's the dose...and the genes that build the systems that deal with the dose.

    3. Re:Dose by ergo98 · · Score: 1

      If anyone ever tells you to do a lot of anything, run the other way. People have died from everything from eating too much salt to drinking too much carrot juice. Keep your diet balanced and your intakes in moderation, and you'll do far better than chasing around massive doses of things that are "good" for you.

      This particular study deals with genetic differences. Differences that mean that what's "a lot" for one person is "moderation" for another.

    4. Re:Dose by Alex+P+Keaton+in+da · · Score: 5, Interesting

      Also, as with anything else, direct causation is almost impossible to prove. 4+ cups of coffee leads to heart disease? I would postulate, not from scientific study but from anecdotal evidence gathered over years of stressful jobs, that the people under the most pressure and stress tend to drink the most coffee. So maybe the stress is what is causing the heart disease?
      Also, coffee is so acidic that people who work out everyday are not likely to be able to drink 4+ cups a day (again, non scientific anecdotal evidence). Coffee is currently fashionable, but when I think of a stereotypical coffee addict like myslelf, I dont think of a slim trim health nut...

      --
      And All I Ask is a Tall Ship And a Star to Steer Her By
    5. Re:Dose by gunnk · · Score: 4, Informative

      ... and even drinking to much water. That's actually been a problem for several years now at marathons, half-marathons and other road races. People tend to drink at every water station. That lowers their electrolytes to the point they require medical help. It's actually much more common now than people dehydrating during races.

      --
      Life is short: void the warranty.
    6. Re:Dose by ergo98 · · Score: 3, Interesting

      Coffee is currently fashionable, but when I think of a stereotypical coffee addict like myslelf, I dont think of a slim trim health nut...

      To really appreciate coffee saturation, get to know Canadian culture (particular Vancouver or Southern Ontario). We quaff coffee close to universally, from stressful to calm, and from unhealthy to healthy. Small towns feature half a dozen drive through coffee shops, all hosting endless lineups.

    7. Re:Dose by AKAImBatman · · Score: 3, Insightful
      I understand that. However, since it is impossible to know your gene type without doing a genetic workup (when was the last time the average person did that?), it makes more sense to just keep the amount of coffee down without necessarily eliminating it.

      According to the article, a cup a day is not a major risk. Two to three cups regularly, however, is. From the article:
      Slow metabolizers who drank two to three 250-millilitre cups of coffee each day were 36% more likely to have suffered a heart attack than single-cup drinkers.

      So if you're a Venti (20 oz/2.5 cups) Starbucks drinker, maybe you should consider cutting back to a tall (12 oz/1.5 cups). And avoid regularly making multiple trips to Starbucks. Once your doctor is able to start testing for this gene, then he can provide more precise recommendations for your genetic type.
    8. Re:Dose by Anonymous Coward · · Score: 0

      Too much coffee is bad for you?

      Majorly shock!!!!

      not...

    9. Re:Dose by mpe · · Score: 1

      People have died from everything from eating too much salt to drinking too much carrot juice. Keep your diet balanced and your intakes in moderation, and you'll do far better than chasing around massive doses of things that are "good" for you.

      One hing to remember is that "balanced diet" does not imply that every meal must be "balanced". A problem in many modern societies is that we have often trained ourselves to eat according to a clock, rather than according to what our bodies might actually need.

    10. Re:Dose by toph42 · · Score: 1

      Iocaine powder. I'd bet my life on it.

    11. Re:Dose by 0NoQuarter14 · · Score: 4, Funny

      If anyone ever tells you to do a lot of anything, run the other way.

      But don't run too far.

    12. Re:Dose by Anonymous Coward · · Score: 0

      You know, that's amazing! In a couple of minutes, you've come up with possible complications of their study.

      I'm so sure that in the 6-12 months or more in which they conducted this study that this group of professional scientists, who have experience in these kinds of studies, never once thought of the very things that occurred to you immediately...

      Yep, you sure showed them.

      Now, sarcasm aside - if something like this is obvious to you, don't you think it was obvious to, and controlled by, them?

    13. Re:Dose by gregger · · Score: 1

      Yeah, but is there amy study of coffee's LD50? Maybe that's what Starbucks is up to! ;-)

      I've found that I like drinking Yerba Mate better. It's supposed to be better for you and a study has been done about it (requires submission to their marketing machine to get the PDF - they haven't called me yet). Some of the results appear to have been lifted by one of this company's competitors. Don't buy into the "mateine vs. caffeine" BS... Mate has caffeine.

      What it doesn't have is all the other odd compounds that coffee has. I read once that the reason coffee gives you the jitters and keeps you more dependent is not solely due to the caffeine - it also involves all the other organic compounds found in your average cuppa joe.

      You can more easily experiment with a variety you can find in Trader Joe's called Guayaki. They make both bagged and loose varieties. The bagged isn't as good as the loose, but it's easier to manage. The brand I've been using lately is from Aviva.

      It's an acquired taste, and the history is unique (plus you can drink it in the traditional social way and wow your co-workers with the perephernalia). Next time you go to a Latin American grocery store (or Ashland, OR, or Santa Cruz, CA) you will see a wide variety of the South American brands... it's so common down there that some brands put pictures of missing children on the packages (like we do with milk cartons) - which is a sad, but interesting, social study.

      I've been drinking it solely for 8 years now. Does it make you more healthy? Not sure... my migraines have not gone away, but didn't get worse. I've had something similar to the stomach flu once during the past 8 years (I contend it was food related). No other sicknesses. Even when my wife is fevered and hacking up a lung next to me. Maybe there's something to it, maybe not... but I didn't like being dependent on coffee.

      TTFN

    14. Re:Dose by espressojim · · Score: 1

      Also, as with anything else, direct causation is almost impossible to prove

      Obviously, you don't work in biology.

      It's not impossible to show that an attribute (enviornmental or genetic) can affect relative risk for any phenotype (in this case, heart disease.) You need a strong understanding of statistics, a well designed study, and a large enough number of patients to see weaker effects.

      You can bolster you information by doing things like twin studies (you can negate differences in genetics, and / or differences in enviornment up to a certain time, depending on the type of twins.)

      Take some time to look at a journal or two, like Science or Nature. You might not understand all (or much) of it, but you might get an idea of the statistical work and the intense study design required to do a study correctly.

    15. Re:Dose by Anonymous Coward · · Score: 0

      Alex P Keaton - just wanted to say sorry for my other snarky reply (I'm the AC of comment http://science.slashdot.org/comments.pl?sid=179617 &cid=14876028.

      It's been a long night. I shouldn't post in that sort of mood :) Mea culpa, and my apologies for the semi-hostile reply.

    16. Re:Dose by LeonGeeste · · Score: 0

      It's not impossible to show that an attribute (enviornmental or genetic) can affect relative risk for any phenotype (in this case, heart disease.) You need a strong understanding of statistics, a well designed study, and a large enough number of patients to see weaker effects.

      True, but did they do that here? How often do they even do that? If they really controlled as well as you claim, you would not see anywhere near the number of reversals as there have been. Plus, whenever they give one of these studies, they always, always add "Oh, but there's always the possibility that this apparent health gain from coffee merely arises from other healthy activities that correlated with coffee drinking." But if you didn't find a very compelling reason to rule this out, your work never should have been published!

      And how precisely would you isolate this effect over *thirty years*? You would have to come up with, by my rought estimates, 100,000 people for a remotely useful study that could control for all the other factors and phony correlations that the GP came up with after just a few minutes of thinking. Given the self-reporting they use, the multiple alternate correlations, the number of factors that enter over 30 years, the sample size needed for controls, and the small magnitude of the supposed effect (if you cut in half the risk of heart disease, that's still only 1 in 100,000 fewer cases), it really makes me suspicious of the supposed *confidence* they claim to have in their findings.

      --
      Rank my idea: http://www.sinceslicedbread.com/node/531
    17. Re:Dose by billDCat · · Score: 1

      Statistics can show whether an effect is statistically significant or not within a stated degree of precision, but they can not actually *prove* that A causes B. Even with a well-designed study performed by a well-practiced researcher, there are always confounding factors. Over time, enough studies can be performed to test for the possible effects of those confounding factors. With a study that involves more direct measurements (eg EKG, CAT scan, etc) indeed it is easier to show causation, but with indirect measurements such as with the questionnaire used for this study, causation generally can not be proven simply through statistics. The purpose of such observational studies is more to come up with a hypothesis which can be later studied through more direct measurements rather than to prove/disprove.

    18. Re:Dose by Schraegstrichpunkt · · Score: 1

      Even without that, people have died from drinking too much water. It takes a *lot* of water, but it's not outside the range of a "See-how-much-water-you-can-drink Contest" that you might have in college.

    19. Re:Dose by severoon · · Score: 1

      Yes, if you drink 1-2 cups/day you're fine. Any more than that, and you have to start balancing off the effects with wine and beer. I myself keep things in a healthy balance by drinking about 12 cups of coffee and 10 alcoholic beverages a day.

      My doctor gives me a clean bill of health. He said, "You're healthy because your body is such a cesspool no bug can seem to survive in it." :-)

      --
      but have you considered the following argument: shut up.
    20. Re:Dose by Anonymous Coward · · Score: 0

      Recently I have developed a 'problem'. My local doc thought I had had a mild heart attack but the stress test by a specialist was clear. That doesn't put me in the clear. However, during a period of intense stress at work I was starting to have abnormal palpitations. Interestingly, when I stopped drinking coffee they went and previously I was a BIG coffee drinker. Even now about a year later I can drink as much tea or coca cola as I like but one coffee and the palpitations return especially if I am doing no physical exertion. Conclusion: coffee bad, caffeine good. I should point out I am much older than the typical slashdotter. I am in my 50s have survived numerous death marches and a recent very nasty marriage breakup but was blessed with good genes. Don't rely on good genes ... enough stress and heartache anything will break. And cut down on the coffee if it has funny effects ... yeah that means you!

    21. Re:Dose by StikyPad · · Score: 1

      Maybe, but we currently have no way to measure stress, so it's not worth worrying about, from a research perspective. You can't measure the effects of something you can't quantify. Even pain at least has qualitative modifiers, if not quantitative, i.e. sharp, dull, aching, throbbing, burning, etc. With stress, the only modifier is "a lot." "Are you under a lot of stress?" What the hell is a lot? You might as well try to measure love. (And no, those 25 cent machines from the 80s don't count).

    22. Re:Dose by zippthorne · · Score: 1

      The "study" that proves how much better the substance is was conducted by the company selling the stuff? And their principle argument seems to be that some other fellow who promotes the stuff seems to be popular?

      Dr. Mowrey is a self-proclaimed expert on herbal remedies from around the world. His work is quoted by everyone selling mate.

      emphasis mine.

      --
      Can you be Even More Awesome?!
    23. Re:Dose by Bush+Pig · · Score: 1

      Start the day with a litre of coffee ... finish it with a litre of red wine. No problem! (Well, it keeps _me_ regular.)

      --
      What a long, strange trip it's been.
    24. Re:Dose by AssFace · · Score: 1

      One of my relatives had a stroke and afterwards she is now always thirsty. At first, nobody caught on to this and she drank herself near to death, just with water - exactly as you said, she broke the balance of electrolytes in her system.
      Now it all has to be closely monitored as to how much she has had to drink, and yet she is always thirsty - must be an awful feeling.

      --

      There are some odd things afoot now, in the Villa Straylight.
    25. Re:Dose by Anonymous Coward · · Score: 0
      If anyone ever tells you to do a lot of anything, run the other way.

      What other way? With my feet flopping around? Arms straight down? What?

  2. Still waking up by PornMaster · · Score: 2, Funny

    I think I should wait until the quad venti skim latte kicks in before contemplating the coffee deathmatch.

    1. Re:Still waking up by masterzora · · Score: 3, Funny

      I'm sorry, I don't speak Starbucks.

      --
      Remember, open source is free as in speech, not free as in bear.
    2. Re:Still waking up by AKAImBatman · · Score: 1

      On the off chance you're not only trying to being funny (hey, Starbucks speak is hard to decode!), he means 4 shots of expresso in a 20 oz cup, mixed with heated, skim milk. Unfortunately, his order is incomplete. How is the Barrista supposed to know if he wants foam or no foam? :-P

    3. Re:Still waking up by LouisZepher · · Score: 1

      Fucking Starbucks. Screw the terminology, I just want a medium cup of coffee-flavoured coffee, not Advanced Coffee Substitute.

    4. Re:Still waking up by CastrTroy · · Score: 1

      I was standing in line behind a guy who ordered a quadruple venti latte. No, kidding. The Barista gave a little bit of a smirk as he handed it to him. I wonder how common something like that is?

      --

      Anthropic principle: We see the universe the way it is because if it were different we would not be here to see it.
    5. Re:Still waking up by dodobh · · Score: 1

      You spoil your coffee with milk? Loads up the quad espresso.

      --
      I can throw myself at the ground, and miss.
    6. Re:Still waking up by AKAImBatman · · Score: 1

      I just want a medium cup of coffee-flavoured coffee

      One Grande coffee (selected from the beans-of-the-day), coming right up! Would you like room in that? (i.e. space for milk and sugar) ;-)

      FYI, most of the terminology stems from specialty drinks that are more than just coffee. Plenty of people get "just coffee" at Starbucks (obstensibly because it "tastes better"), but quite a few want something other than "just coffee". For those people, they can order it just how they like it. They can chose the number of expresso shots, substitute coffee for expresso, add milk in whole or skim forms (latte), ask for flavorings both sugary and sugar free, replace milk with half-and-half (i.e. a "breve"), mix expresso with water (i.e. Americano - Though I personally find this slightly insulting to Americans; many of whom are quite well addicted to strong coffee), add "foam" to the top from steam heating, whip cream on top*, and about a bajillion other little modifications.

      Starbucks' entire business is to deliver exactly what people want, even if some of it seems a bit silly or over the top.

      * Did you know that whip cream on top of a drink will help seal the cup so that it doesn't spatter while you walk down the street or juggle various items?

    7. Re:Still waking up by CableModemSniper · · Score: 1

      I like milk in the bottom of the cup( before the coffee goes in the cup), no option like that at starbucks. Also starbucks tastes icky.

      --
      Why not fork?
    8. Re:Still waking up by LouisZepher · · Score: 1

      "...Plenty of people get "just coffee" at Starbucks (obstensibly because it "tastes better")..."

      Hardly. I've only had Starbucks coffee a few times, and each of those times it tasted horrible.

      "...Starbucks' entire business is to deliver exactly what people want, even if some of it seems a bit silly or over the top..."

      I suppose my "over the top" request for coffee that doesn't taste filthy is too silly. Also, unless I'm mistaken, doesn't "grande" mean BIG? Another thing, in what language does "venti" mean large? Last I knew it more or less mean "wind" in Latin. A windy cup of coffee? Gah.

      I'll just brew my own

    9. Re:Still waking up by andreyw · · Score: 1

      you know... liquids... the mixing thing....

    10. Re:Still waking up by CableModemSniper · · Score: 2, Insightful

      You know, hot liquids and milk, the curdling thing.

      --
      Why not fork?
    11. Re:Still waking up by AKAImBatman · · Score: 1

      I wonder how common [a quadruple venti latte] is?

      You do realize that Ventis have 3 shots in them already, right? A Grande is double shot, and a Tall is one shot. So if you hear someone order a "single shot Grande latte", it means they like warm milk with a bit o' coffee.

      Now if you want crazy, consider that I've heard people order Ventis with 6-8 shots in them! I have to wonder how close they are to getting a lethal dose of caffeine*? :-P

      * Actually, I checked. Expresso has approximately 100 mg of caffeine, so 8 shots would be 800 mg. You'd need to drink 4 of those Ventis to get close to the lowest recorded fatality from caffeine. More reasonably, you need about 16 or so 8-shot Ventis to hit the LD50 of caffeine.

    12. Re:Still waking up by Anonymous Coward · · Score: 0

      Another thing, in what language does "venti" mean large

      Well I've only set foot in a Starbucks once, for a hot chocolate, because I hate coffee, but I can answer this.

      Accordding to the babelfish, "venti" is Italian for "twenty". The g-gp poster who said "...in a 20 oz cup..." knew the code. I had to look it up.

    13. Re:Still waking up by CastrTroy · · Score: 1

      Why did his friend order a Triple Venti Latte then? Isn't the tripple a little redundant? If tall is one shot, what is the short? which is available but you have to ask for it, it's not on the menu.

      --

      Anthropic principle: We see the universe the way it is because if it were different we would not be here to see it.
  3. Paracelso once said... by Zaatxe · · Score: 4, Insightful

    "the difference between medication and poison is the dose"

    --
    So say we all
    1. Re:Paracelso once said... by Anonymous Coward · · Score: 0

      "the difference between urine and beer is nothing"

    2. Re:Paracelso once said... by thannine · · Score: 3, Funny

      Especially in the U.S.

  4. The baffled geek cries out by Bromskloss · · Score: 1

    "Coffee Maybe Not a Health Drink!" Gasp! :-)

    --
    Swedish plasma phys. PhD student; MSc EE; knows maths, programming, electronics; finance interest; seeks opportunities
    1. Re:The baffled geek cries out by qw(name) · · Score: 3, Interesting

      I see your joke but it really is pathetic how one study tells you this and another tells you something contrary. I remember when eggs were good for you and then they weren't and now they are good again. Apples were good for you ("An apple a day keeps the doctor away") and then they weren't ("The sugar in an apple can rot your teeth", my dentist told me.). Now, they are good for you again. And there are other examples out there.

      And the other thing that should not amaze me as much as it does is grammar. How about "Coffee May Not Be a Health Drink". "Coffee Maybe Not a Health Drink!" sounds like Ebonics.

    2. Re:The baffled geek cries out by Bromskloss · · Score: 1

      How about "Coffee May Not Be a Health Drink". "Coffee Maybe Not a Health Drink!" sounds like Ebonics.

      Coffee health drink mabye not, hmm?

      --
      Swedish plasma phys. PhD student; MSc EE; knows maths, programming, electronics; finance interest; seeks opportunities
    3. Re:The baffled geek cries out by qw(name) · · Score: 1

      You maybe not be up to something!

    4. Re:The baffled geek cries out by American+AC+in+Paris · · Score: 2, Insightful
      I see your joke but it really is pathetic how one study tells you this and another tells you something contrary. I remember when eggs were good for you and then they weren't and now they are good again. Apples were good for you ("An apple a day keeps the doctor away") and then they weren't ("The sugar in an apple can rot your teeth", my dentist told me.). Now, they are good for you again. And there are other examples out there.

      ...well, would you rather that scientists just sat on what they have until they're absolutely, positively sure they're right? That way we'd never need to deal with contradictory discoveries. We wouldn't know where babies come from, but at least we wouldn't need to deal with the embarassment of learning that mammalian ovaries don't work the way we always thought they did.

      Stuff is complicated. Be glad that we strive to make progress, even when it means saying, "whoops, we were wrong."

      --

      Obliteracy: Words with explosions

    5. Re:The baffled geek cries out by Digital+Vomit · · Score: 1
      And the other thing that should not amaze me as much as it does is grammar. How about "Coffee May Not Be a Health Drink". "Coffee Maybe Not a Health Drink!" sounds like Ebonics.

      Just wait until the repeat hits with the title "Coffee Fo' Shizzle Not a Health Drink"

      --
      Modern copyright is theft of culture from everyone and it retards the progress of the useful arts and sciences.
    6. Re:The baffled geek cries out by daffer · · Score: 1

      This is a little off topic, but your comment about Ebonics struck a nerve with me. Ebonics contains rigid syntactic rules followed by all speakers, just as American English does. It is a misconception that Ebonics is "bad English". This just isn't true. On close examination Ebonics contains grammatical rules which are followed by all speakers. If you break those rules, native speakers will pick up on them. It is the same as with any dialect. Your comment illustrates a Bourgeois attitude towards segregated societies, and that offends me.

    7. Re:The baffled geek cries out by perbert · · Score: 1

      Nah, it was more of a play on words from the previous /. article that I ref'd.

      I guess it was lost on you.

    8. Re:The baffled geek cries out by LeonGeeste · · Score: 0

      The problem is not that scientists change their minds. It's that the correlation was too flimsy to justify publishing in the first place. Every time they publish something like this, they always add "but it's still not clear if this correlation between [engaging in activity thought to be unhealthy] and better heart/longevity is because of the [unhealthy activity] or because people who do that tend to also [engage in separate, healthy activity]". Um, EXCUSE ME? If you didn't find a damn good reason to rule that out, your study should not have passed peer review. Of course you shouldn't wait until all doubt is removed before publishing -- but you should also at least try to look like you did your homework the first time around.

      --
      Rank my idea: http://www.sinceslicedbread.com/node/531
    9. Re:The baffled geek cries out by Hal_Porter · · Score: 1

      Hmm, you don't like your spiritual leaders to display uncertainty and you don't like hip hop culture.

      Would you like to come in for a Free Personality Test ;-)

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
    10. Re:The baffled geek cries out by Hal_Porter · · Score: 1

      And then there's the fatal Pons & Fleischman / scientific research in $HOT_TOPIC mistake of talking to the regular press before you get peer reviewed. Either because you're afraid of getting scooped, or because you're too involved emotionally in your work to realise that it might be, to be blunt, bollocks.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
    11. Re:The baffled geek cries out by Hal_Porter · · Score: 0, Flamebait

      Don't you mean

      Yo' comment about Ebonics struck uh nerve wiff me. Ebonics be havin' rigid syntactic rules followed by all speakers, just as American English do. It iz uh misconception dat Ebonics iz "bad English". This be racist yo, a linguistic lynching.

      <snip incoherent rant about Katrina, George Bush, Enron, The war on terror, etc>

      200 years ago de white man pwned us, but thanks to Dr Farrakhan and Malcolm X we be free, but de white man pwnz our language to dis' day. White devils be dissin' Ebonics EVERYDAY, but if you be in the kno', yo kno' Ebonics be the language great black men like Tupac, Shakespeare and Beethoven rapped in. Your comment illustrates uh playa' hatah' attitude towards segregated societies, an' I'm gonna put a cap in yo pasty ass. Melanin deficient bitch.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
    12. Re:The baffled geek cries out by American+AC+in+Paris · · Score: 1
      ...and what of the scientist who, after ten years of research, has some solid leads, some strong hypotheses, but realizes that another ten-year study is in order to truly rule out some key issues? Should they not publish? If not, how do you propose they go about securing the funding they need to conduct that next round of research? "Well, I did a lot of really great science this decade, but I really need you to fund my lab for another decade before I can comfortably present any results to the scientific community. You understand, yes? I should only need three million dollars or so..."

      Should a scientist be expected to forsee problems that may crop up in year five? What if the scientist's hypothesis is wrong, but the results are still useful? What if the results are entirely inconclusive, yet the scientist has produced a wealth of sound data and reasoning that may be of use to their peers? Should they not publish their results simply to satisfy the vanity and impatience of the general public?

      We'll set aside, for the moment, the fact that scientists are human beings and need validation as much as any other person out there (how would you like to work your fingers to the bone for ten years and have absolutely nothing to show the world? Think you could muster the will to take another ten-year crack at it, knowing that you could end up in exactly the same place?) Science is, and always has been, an ongoing process, not a set of tasks. It is not the fault of the scientist that the non-scientific media seems incapable of conveying this basic truth of science.

      --

      Obliteracy: Words with explosions

    13. Re:The baffled geek cries out by LeonGeeste · · Score: 0

      If you have "some solid leads, some strong hypotheses, but realize that another ten-year study is in order to truly rule out some key issues" then your study should claim that you "found an interesting correlation", not that you "found that coffee may reduce the risk of damage to health" (or whatever the case may be). That way you can convey information which may be useful to others while not overstating your results.

      (And while we're at it, why is all this raw data the exclusive domain of a few people? If all you did was become the first person who, upon searching a database, found a cool correlation, why isn't this same data open to others? Why should we have to wait until a busy scientist gets around to checking out a few correlations before we find out about things like this?)

      You seem to have this impression that the job of a scientist is to gather data. It's not. That's the job description of a lab worker. The job of a scientist is to properly design experiments, to come up with innovative ways to rule out alternate hypotheses that a layman can come with in ten seconds, to state precisely the caveats behind the results. (A great example of this in the social sciences was an economist who investigated the impact of women having children on their future income. To control for the possibility that women who want to have children at age X also share income-enhancing or income worsening effects, she focused on a wide array of data from women who had miscarried, and therefore "were the type to have kids" but didn't.)

      It's true as you say that science is an ever-growing process, but please -- when the conclusions flip every few years, that should be taken as a signal that your conclusions have been premature and both sides need to revise estimates about how much data they need before calling something a theory. It's also correct that humans need validation, but that's precisely why we should be suspicious of anything that suggest something we want to believe. Coffee is good for you? If it's too good to be true, make damn sure it is.

      Any well-funded fool can gather data. Figuring out how to gather the right data ... that takes a scientist. Any any scientist should know how unreliable a self-reported tiny change in risk over 30 years is going to be.

      You think this is the media's fault? You don't think scientists overstate their pop-wisdon-verifying results, knowing they'll easily be misinterpreted, in order to get more attention?

      --
      Rank my idea: http://www.sinceslicedbread.com/node/531
  5. Who Cares by soapee01 · · Score: 2, Interesting

    Does anyone really drink coffee because supposed health benefits?

    I thought it was just the magic breakfast juice that helps me move, think, ...

    1. Re:Who Cares by TripMaster+Monkey · · Score: 5, Funny

      It is by coffee alone I set my mind in motion.
      It is by the juice of the java bean that thoughts acquire speed.
      The teeth acquire stains; the stains become a warning.
      It is by coffee alone I set my mind in motion.
      Apologies to Frank Herbert.
      --
      ____

      ~ |rip/\/\aster /\/\onkey

    2. Re:Who Cares by DanZ23 · · Score: 1

      Actually, I do.

      My preferred regimen is 2 cups of coffee in the morning, green or white tea in the afternoon, and a Guinness in the evening.

      Cancer is extremely prevalent in my family; I'm hoping to dodge the bullet.

    3. Re:Who Cares by phlinn · · Score: 1

      Heh... there was an online comic a while back that had something very similar to this. I wish there was an archive from badtech.com somewhere I could download. On a different note, since that spiel was only added for the movie, is Frank Herbert really responsible for it?

      --
      "Pulling together is the aim of despotism and tyranny! Free men pull in all sorts of directions" -- Havelock Vetinari
    4. Re:Who Cares by Anonymous Coward · · Score: 0

      No need to apologise to Frank. He didn't write that bit from the movie.

    5. Re:Who Cares by bla · · Score: 1
      it was goats.com's Litany of Beer. http://www.goats.com/archive/990517.html

      also, if you go to their store, you can get it on a tshirt.

    6. Re:Who Cares by Scarblac · · Score: 4, Funny

      I must drink coffee. It is the mind filler. It is the little shot that brings total caffeination. I will taste my coffee. I will allow it to pass through me. And when it has gone past I will turn the inner eye to see its path. Where the coffee has gone there will be nothing. Only I will remain. Then I must drink more coffee. It is the mind filler...

      --
      I believe posters are recognized by their sig. So I made one.
    7. Re:Who Cares by PW2 · · Score: 1

      > Does anyone really drink coffee because supposed health benefits?

      Yes; I do; I have colon issues where me being in the right place at the right time all the time is a good thing for everyone; I drink coffee in the morning because it makes my afternoons more predictable that way;

      I started out on Starbucks / etc, but finally got acclimated to the free coffee at work by adding less and less sugar;

  6. bah ... rubbish study by Anonymous Coward · · Score: 0

    I drink 8 cups a day and I ... I ... feeling ... stabbing ... chest pain ... 4y957q048ri ejifj...

    1. Re:bah ... rubbish study by Anonymous Coward · · Score: 0

      King Arthur: [about the inscription on the rock] What does it say, Brother Maynard?
      Brother Maynard: It reads, "Here may be found the last words of Joseph of Aramathia. He who is valiant and pure of spirit may find the holy grail in the Castle of Aaauuuggghhh..."
      King Arthur: What?
      Brother Maynard: "The Castle of Aaaauuuggghhhh"
      Sir Bedevere: What is that?
      Brother Maynard: He must have died while carving it.
      King Arthur: Oh come on!
      Brother Maynard: Well, that's what it says.
      King Arthur: Look, if he was dying, he wouldn't have bothered to carve 'Aaaauuuggghhhh'. He'd just say it.
      Sir Galahad: Maybe he was dictating it.
      King Arthur: Oh shut up!

  7. here we go again by dkode · · Score: 5, Interesting

    More and more often I keep hearing about things like this.

    "Doctors say more than 4 cups is bad for you!"

    then, 2 months later... "Doctors say more than 4 cups is good for you!"

    One month you hear too much fiber is bad for you, then cholesterol is good for you.

    I think as long as everyone comsumes food/drinks moderately and not go over board most people have nothing to worry about. Although, with obesity in the United States the way it is today, I would say it's already too late.

    --

    Those who trade in their freedom for security, deserve neither.
    1. Re:here we go again by hey! · · Score: 3, Insightful

      Well, I think what is missing is a technology of personal genomics.

      Salt is bad for you. Except if you don't have the gene that links salt to hypertension. In which case it isn't bad for you. If you do have that gene, then salt is very bad for you. In aggregate, given ignorance of your genes, it poses a risk.

      Experiments to date have been crude, in that they don't effectively control for genetic variation. Thus a slight bias in the genetic make-up can easily push an experiment to one or the other side of statistical significance.

      If we ever do get an efficient, fast and affordable way to do a comprehensive genetic screening, it will be of tremendous benefit to humanity. That is, after the fighting and chaos dies down, as insurance companies manage their risk to the point they become irrelevant, and families come to grips with uncomfortable holes in their pedigrees.

      --
      Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
    2. Re:here we go again by laughingcoyote · · Score: 1

      Though, I think your sig script would be worse for your health then any amount of coffee...

      --
      To fight the war on terror, stop being afraid.
    3. Re:here we go again by Anonymous Coward · · Score: 0

      Would you please stop propagating the stupid meme that obesity is somehow exclusively an American problem?

      Obesity rate triples in UK

      EU leads US for men with weight problem

    4. Re:here we go again by wcedev · · Score: 1

      The thing is that a lot of researchers need to write and defend Ph.D. thesis. The thesis should contain some degree of 'novelty'. So how many novel thing you can discover about coffee (except occasional changes in the Starbacks menu)?

    5. Re:here we go again by Anonymous Coward · · Score: 0

      while ($beer != full) {
      $beer = new Beer();
      chug($beer);


      v2.0
      while (!puking && !passedOut) {
      if (beer.isEmpty())
      beer = new Beer();
      else
      chug(beer);
      }

    6. Re:here we go again by MtViewGuy · · Score: 1

      I think as long as everyone comsumes food/drinks moderately and not go over board most people have nothing to worry about.

      That's what my doctor says, too. Indeed, eating things in moderation and getting decent exercise is key to a good, long and healthy life.

    7. Re:here we go again by supersnail · · Score: 1

      Bug fix:-
      while {
            $beer = new Beer();
            while ($beer != full) {
                    chug($beer);
          }
      } ($beer == empty);

      --
      Old COBOL programmers never die. They just code in C.
    8. Re:here we go again by GoodbyeBlueSky1 · · Score: 1

      Let's settle it once and for all...

      GoogleFight!

      There you have it. Screw the haters.

      --
      why? forty-two.
    9. Re:here we go again by EWIPlayer · · Score: 1
      while ($beer != full) {
      $beer = new Beer();
      chug($beer);
      }

      Speaking of moderation...

      :P

      --
      This sig used to be really funny...
    10. Re:here we go again by mpe · · Score: 1

      Would you please stop propagating the stupid meme that obesity is somehow exclusively an American problem?

      If would be rather ironic if "diet" food actually promoted obesity.

    11. Re:here we go again by justthinkit · · Score: 0

      Diet coke definitely promotes obesity. Emulsifiers in cola go straight to our lymph system and stay there. Since diet cola drinkers in general drink more cola than regular cola drinkers, they gain more weight (in the lymph system). As a check on this, notice that the cola drinker type has very flabby (fluid) flesh, whereas say a football linebacker is a tree trunk with pads.

      --
      I come here for the love
    12. Re:here we go again by 19thNervousBreakdown · · Score: 1

      The original version worked fine, unless you started with a full beer. If you didn't start with a full beer, you get one, then chug it, leaving you with a non-full beer and the loop continues.

      In your case, you get a new beer, and chug it until it's not full anymore, then only continue with the loop if you've managed to chug the entire beer. I suppose you could say that chug() implies an entire beer, but if that's the case, why the loop?

      Although, and maybe this is your original intent, if you can't chug an entire beer, you're probably pretty drunk, and maybe it's time to stop. If so, you've actually managed to stay on topic by modifying someone's sig to apply moderation! Well done, even if it was an accident.

      --
      <xml><I><am><so><damn>Web 2.0</damn></so></am></I></xml>
    13. Re:here we go again by Anonymous Coward · · Score: 0
      with obesity in the United States the way it is today

      The market is fixing that problem as we speak. Observe the exploding popularity of organic foods in the US. Consumers are beginning to realize that all those chemicals on the label just aren't what human beings were designed to consume.

      Just a couple of years ago, organic foods were basically non-existent in your typical mainstream supermarket. Today, I come home from Publix (a big-name supermarket here in Florida) with probably 30-50% organic. That's the market at work -- the producers, distributors, and retailers are responding to a definite change in the consumer's attitude.

    14. Re:here we go again by UnknowingFool · · Score: 1
      No, what you keep hearing is the condensed version with the important details left out in our ADHD world:

      "Coffee bad for you." is the shortened version that a study found that drinking 4 or more cups may affect blood pressue. More study is needed.
      "Coffee is good for you" is the shortened version that one or two cups was found to help lower a certain cancer risk. More study is needed.

      Both are possible correct. But getting the whole story is imporant.

      --
      Well, there's spam egg sausage and spam, that's not got much spam in it.
    15. Re:here we go again by zippthorne · · Score: 1

      no, you've missed something. in parent's version, chug() would never be called because a new beer is by definition full. Examining the beer constructor for proof is left as an exercise to the reader.

      --
      Can you be Even More Awesome?!
  8. Well, by deletedaccount · · Score: 5, Funny

    I've started injecting it, so I'm not sure how this applies to me.

    1. Re:Well, by gEvil+(beta) · · Score: 2, Funny

      Sure as hell beats the coffee enema I give myself every morning...

      --
      This guy's the limit!
    2. Re:Well, by ch-chuck · · Score: 1

      I've been taking it in tablet form for, oh, over 25 years now. Twice a day.

      --
      try { do() || do_not(); } catch (JediException err) { yoda(err); }
    3. Re:Well, by deletedaccount · · Score: 1

      At least the dark colour hides the *ahem* particles.

  9. To quote a much more sensible man than me ... by SpooForBrains · · Score: 4, Funny

    ... namely one Commander Samuel Vimes: "Coffee is merely a way of stealing time that by rights should belong to your slightly older self".

    --
    "The dew has clearly fallen with a particularly sickening thud this morning"
    1. Re:To quote a much more sensible man than me ... by JPRelph · · Score: 1

      We need a +5: Pratchett mod :-) I'm desperately trying to think of an amusing quote about Klatchian Coffee but just keep getting stuck and wanting to put in "I like the idea of democracy. You have to have someone everyone distrusts. That way, everyone's happy.".

  10. Everything in Moderation by Makarakalax · · Score: 2, Interesting

    It shouldn't be too surprising that too much of anything is bad for you. Most food stuffs have complicated chemicals in, and thus too much of any of them can give your body a hard time due to damaging reactions, or difficulty in disposal.

    However having said this, I until recently was having something like 6 cups of coffee a day. A few months ago my body started reacting really badly to even the smell of coffee, drinking a cup gives me a terrible reaction with shivering, accelerated heart rate and light-headedness for up to a few hours.

    The stuff is nasty.

    Currently I'm drinking 6 cups of tea a day instead ;)

    1. Re:Everything in Moderation by zeath · · Score: 1

      Currently I'm drinking 6 cups of tea a day instead ;)

      Good tea, I hope, such as loose stuff from Adagio. (I say this while enjoying some black apricot)

    2. Re:Everything in Moderation by qw(name) · · Score: 1

      Currently I'm drinking 6 cups of tea a day instead ;)
      That can roughly be converted to 3 cups of coffee a day. Well within the recommended daily allowance of coffee. :)
    3. Re:Everything in Moderation by rhpot1991 · · Score: 1

      What kind of conversion are you speaking of, caffeine? If that is the case then you cannot really do this conversion without knowing what kind of tea he is drinking. I also disagree with you on converting with this method as maybe he is drinking it for something other than caffeine, such as taste or just having something to drink.

    4. Re:Everything in Moderation by Anonymous Coward · · Score: 4, Informative

      Your symptoms (rapid pulse, dizziness) could be an adrenergic response to hypoglycemia.

      When this happens, do you experience difficulty concentrating? (Neuroglycopenia) And does it subsequently go away when you ingest food, especially sugar? Do you experience frequent urination during the recovery phase? If it's Hypoglycemia, it is actually very dangerous for your brain.

      Caffeine's kick comes from its ability to expedite the transport of sugar from the blood to the tissues. The occasionally dangerous side effect is that if you have a problem with your diet and/or anrednal glands, since caffeine creates this metabolic illusion of an energy boost, the combination can sometimes result in depleting the blood of sugar faster than this sugar can be replenished. Then you crash dangerously hard, experiencing what insulin-dependent diabetics refer to as a "hypo."

      When your brain detects low blood sugar, it triggers the release of adrenalin and cortisol which are stress hormones, and this causes your body to release emergency sugar from other sources, such as stored glucagon from your liver.

      So most of the unpleasant effects of hypoglycemia are actually your body's defense against it. But you are 100% right to avoid coffee if it does that to you, since this is a warning sign. Coffee does not do this to everybody.

      Whatever the problem is, things can likely be brought back into balance just by eating moderate balanced meals, and having healthy snacks between meals and before bed. If you eat a lot of sugar, take it with some protein and/or fat so that your pancreas never gets habitually braced for dealing with big jolts of sugar... because it'll get itself into a mode where it produces too much insulin at the wrong time... which can be as dangerous as the legendary diabetic insulin overdose. So ironically, too much sugar can cause hypoglycemia.

      Definitely talk to a Dietician.

      Possibly at some point in the future, you might consult an Endocrinologist if you've been bingeing on high-sugar foods, and you think you might be at risk of developing type II diabetes or something like hyperinsulinism or hypoglycemia. (The latter two may actually be somewhat common. It's the diagnosis for them which is exceedingly rare, since they are both very difficult to get clinically diagnosed. Pretty much only the textbook cases that present under ideal circumstances will ever get diagnosed.) You almost have to be pretty sick before an Endocrinologist will be able to help you.

      Good luck...

      PS:
      I personally had just one episode of "reactive hypoglycemia" involving just one strong coffee, a skipped breakfast and some physical exertion, and it felt exactly like the experiences you describe having with coffee. I did not lose consciousness, but the experience did leave me with some very subtle brain damage... (which I seem to be adapting to finally after 6 weeks.)

    5. Re:Everything in Moderation by graikor · · Score: 2, Informative

      I'm more than a little concerned, not because coffee makes me jittery (it does), but because I seem to keep caffeine in my system for a long time. If I drink a caffeinated beverage after noon, there's a good chance I may still have enough caffeine in my system to keep me awake after 2:00 a.m.

      I've known for some time that I process caffeine more slowly than many of my friends, but with the results of this new study (and a family history of heart disease), I believe I will have to seriously reduce my coffee intake.

      Bummer...

    6. Re:Everything in Moderation by Makarakalax · · Score: 1

      Thanks for this information, I'm now a little scared, but am definately going to do something about it.

  11. The coffee dilemma; a management perspective by dcavanaugh · · Score: 4, Funny

    Health hazard or health drink? What to do? The answer is simple. Find studies that support your pre-determined point of view and use those to guide the decision. I like coffee very much. Caffeine addiction is not a problem so long as I can find at least one study that proves how healthy my coffee habit is.

    Now back to our regularly scheduled programming, "TCO analysis for the enterprise"

    1. Re:The coffee dilemma; a management perspective by wrfelts · · Score: 3, Funny
      The corporate TCO Analysis goes something like this.

      The peons like coffee. We need more productivity. Coffee is a stimulant. Give them more coffee to increase productivity. Oops, now they spend too much time around the coffee pot! Buy bad coffee, they are addicted anyway. Oh no, now their health is declining and our insurance bills are going up! No problem, just make them pay most of the premiums. They won't be able to afford to quit that way...

    2. Re:The coffee dilemma; a management perspective by Anonymous Coward · · Score: 0
      dcavanaugh:
      Health hazard or health drink? What to do? The answer is simple. Find studies that support your pre-determined point of view and use those to guide the decision. I like coffee very much. Caffeine addiction is not a problem so long as I can find at least one study that proves how healthy my coffee habit is.
      wrfelts:
      The peons like coffee. We need more productivity. Coffee is a stimulant. Give them more coffee to increase productivity. Oops, now they spend too much time around the coffee pot! Buy bad coffee, they are addicted anyway. Oh no, now their health is declining and our insurance bills are going up! No problem, just make them pay most of the premiums. They won't be able to afford to quit that way...
      Mr. Bush, meet Mr. Rumsfeld.
  12. How can it be healthy? by johnfatz · · Score: 1

    Anything that stimulates you like coffee, quickens your heart beat and keeps you awake can not be healthy!

    1. Re:How can it be healthy? by Anonymous Coward · · Score: 0

      Awww, shoot, I need to give up jogging, then.

    2. Re:How can it be healthy? by smidget2k4 · · Score: 1

      There are antioxidents in coffee that are "healthy". Btw, you forgot to mention that it is also dehydrating and a diuretic. But a little stimulant never hurt anyone. Well, apparently except for the people with that gene.

  13. Hah! by Rob+T+Firefly · · Score: 1

    Take that, all you sad unhealthy coffee-addicts!

    /me tosses back the third black tea of the morning in celebration

    1. Re:Hah! by moro_666 · · Score: 1

      if you think that the caffeine contained in 3 black tea's is in anyway less harmful in your teacup then you should just check up your facts again.

      http://wilstar.com/caffeine.htm

      just as one example. read. think. you'd be better off with decaf coffee than with black tea.

      i however ignore the fact and enjoy my coffe. what's the point of having a half value long life versus a shorter at full throttle ? sure you can still see girls on the streets when i'm in the grave but you'll be getting laid at 80 as much as i do 6 feet under.

      --

      I'd tell you the chances of this story being a dupe, but you wouldn't like it.
  14. Ex Caffeine Junky by garcia · · Score: 5, Interesting

    I was basically forced to quit drinking caffeine in Decemeber. This was not something I ever expected to be able to do. The migraine lasted for about a week straight but I have been basically fine since.

    Since I was 22 I have had high blood pressure. I've spoken here about it before and complained about the high cost of Rx meds to control it and my belief that my Doctor (undercompensated by my insurance provider) is possibly pushing name-brand drugs instead of their generic counterparts to recoup some of that cost in kick-backs.

    Anyway, I was gaining on 200mg daily of various meds to control the BP. I was also gaining in daily consumption of caffeine. After switching to Diet Cherry Vanilla Dr. Pepper (aka Liquid Crack) I was heading for 5 to 6 20oz bottles a day (at work) plus 5 to 10 12oz cans every two days (at home).

    After quitting the caffeine habbit I'm on 10mg of BP meds (about $10 a month) and water.

    So, if you're looking to limit your heart disease and the high cost of protecting yourself against it with prescriptions, you might want to first take a look at your caffeine intake. It worked for me.

    1. Re:Ex Caffeine Junky by Black-Man · · Score: 1

      "my belief that my Doctor (undercompensated by my insurance provider) is possibly pushing name-brand drugs instead of their generic counterparts to recoup some of that cost in kick-backs."

      You know you can request to the Pharmacist to replace a brand name with a generic? Sheesh...

    2. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 0

      I'm in Canada, prescriptions are dirt cheap and covered by my work plan. I pay $100/year max for anything my family needs.

      I can adopt you...

    3. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 0

      You know you can request to the Pharmacist to replace a brand name with a generic? Sheesh...

      Not without my Doctor's prior and written consent. She was a royal pain in the ass about it making me believe exactly what I wrote -- but that has little to do w/the discussion.

    4. Re:Ex Caffeine Junky by Dr.+Evil · · Score: 1

      If the doctor didn't point to your caffiene intake first, switch doctors. Some are very reluctant to prescribe medication, others do it too easily. A happy medium is nice, but hard to find.

    5. Re:Ex Caffeine Junky by Epi-man · · Score: 2, Insightful

      After switching to Diet Cherry Vanilla Dr. Pepper (aka Liquid Crack) I was heading for 5 to 6 20oz bottles a day (at work) plus 5 to 10 12oz cans every two days (at home).

      Let's see here, 100 ounces at work, plus another 48 ounces at home, on average, every day. That's over 1 gallon of soda a day! How often did you have to go to the bathroom? They are working hard to get people to drink just over half a gallon of water a day, and here you are more than doubling that in soda, I take it moderation isn't (wasn't) your strong suit? Imagine if that had been the fully leaded version, you would have had over 1800 calories a day in colas alone (Dr. Pepper (my liquid crack) is 150 cal/12 ounce can, I'm fairly sure the Cherry Vanilla has even more, but can't swear to it)! That's most adults' daily allowance (at least, that's what my wife (MD) keeps telling me).

      I can relate to the compulsion to always have a drink on hand, after kidney stones at a young age, my doctor told me I basically was constantly dehydrated -> stones. Now I have my water cup at work, and drink over a gallon at work a day. Happily, it has been 4 years since my last stone, my fingers are crossed there won't be another!

    6. Re:Ex Caffeine Junky by Antimatter3009 · · Score: 2, Interesting

      I'm with you on this one. I used to have trouble sleeping and just generally felt bad a lot of the time. I would drink at least one large cup of coffee and upwards of 4 cans of soda a day (I know, a tiny amount by comparison to some people, but it was enough for me). I managed to stop my caffeine (and most of my sugar) intake for about 3 months almost completely. After that I felt much, much better. That was about a year and a half ago. Now I drink one large cup of coffee and maybe one (diet) soda a day. Sometimes I feel like that is still too much, but overall I feel a lot better. I would recommend this type of thing to anyone who feels like crap due to the caffeine and sugar. If you can just scale it back and maybe switch to a diet soda it will help a lot. There's also exercise, but I'm not going to get into that on /. :)

    7. Re:Ex Caffeine Junky by LunaticTippy · · Score: 1
      You can't replace a brand name that has no generic. Pharma companies make sure there are enough barely tweaked packaging or formulation to have some brandname only drugs in every category they can.

      A pharmacist cannot substitute an equivalent drug, only the exact same drug.

      --
      Man, you really need that seminar!
    8. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 0

      I can adopt you...

      You scare me.

    9. Re:Ex Caffeine Junky by Turn-X+Alphonse · · Score: 1

      Same story as you in ways.

      I used to get chest pains and wake up every day feeling like a truck had hit me. I quit drinking Dr Pepper and started on fruit juice. I felt ten times better and next to never get chest pains any more.

      --
      I like muppets.
    10. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 0

      Dude, maybe if you concentrated on losing weight your BP would come under control? Let me guess...

      Clerk: What will you have?
      Garcia: Two double pounders with cheese, double fries, two apple pies.
      Clerk: Anything to drink?
      Garcia: Large diet coke please.

      *doh!*

    11. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 2, Funny

      Quitters...

    12. Re:Ex Caffeine Junky by song-of-the-pogo · · Score: 1

      interesting.

      i've got a friend who's a nephrologist. he was talking about his work and the general state of kidney health in the states and told us that the leading cause of kidney disease/failure in the u.s. was high blood pressure. i said that i'd just read where office workers were drinking up to 20 cups of coffee a day, and joked that that ought to keep him in business for a long time to come. he told us that coffee/caffeine didn't actually cause high blood pressure and wasn't really a problem that way.

      i assume he was speaking of people who hadn't yet developed high bp. what i don't know and should ask is how coffee would affect someone who already has high bp. what i also don't know is how getting your caffeine from coffee as opposed to nasty diet soda (i'm guilty) differs, but i have to imagine that there may be a real difference in how those two beverages affect you and your health. perhaps it's the soda and its additional ingredients rather than just the caffeine?

      well, i'm off to my local coffee shop for a hit.

      --
      soupy twist
    13. Re:Ex Caffeine Junky by 6*7 · · Score: 1

      Get your units straight, you are only 3 orders of magnitude wrong.

      But don't feel to bad about it, even my stupid gov. doesn't know the difference between cal and kcal.

    14. Re:Ex Caffeine Junky by necro81 · · Score: 1

      For a laugh related to that subject, check out the Ill Will Press (flash-based cartoons featuring neurotic and foul-mouthed squirrels - it might make sense when you see it). Look for the one entitled "So I Said to My Doctor."

    15. Re:Ex Caffeine Junky by ursabear · · Score: 1

      Moderation is good, but sometimes our bodies force something on us.

      I had to quit caffeine all together because of atrial fibrullation. I don't miss the Diet Mountain Dew or dark roast coffee. Really I don't. I just had to put up with a few headaches the first day or so. I figured that a stroke was not worth any number of cups of coffee.

    16. Re:Ex Caffeine Junky by garcia · · Score: 1

      Dude, maybe if you concentrated on losing weight your BP would come under control? Let me guess...

      I was a Division I college athelete and had high BP. They attributed it, at the time, to my training. After I stopped competing, I still had the issues so we started on meds.

      At 183 pounds and very little body fat, I really doubt that weight was an issue.

    17. Re:Ex Caffeine Junky by edis · · Score: 1

      For me, also with BP issues, green tea (no sugar) was found to be very helpful to stimulate AND reduce pressure.

      --
      Servant of karma
    18. Re:Ex Caffeine Junky by justthinkit · · Score: 0
      After switching to Diet Cherry Vanilla Dr. Pepper (aka Liquid Crack) I was heading for 5 to 6 20oz bottles a day (at work) plus 5 to 10 12oz cans every two days (at home).

      ...100 ounces at work...48 ounces at home...over 1 gallon of soda a day! ...If that had been the fully leaded version, you would have had over 1800 calories a day in colas alone (Dr. Pepper (my liquid crack) is 150 cal/12 ounce can

      Get your units straight, you are only 3 orders of magnitude wrong. But don't feel to bad about it, even my stupid gov. doesn't know the difference between cal and kcal.

      I calculate a minimum of 100 oz at work, __30__ oz at home, divided by 150 cal per 12 oz = 1625 cal. I see no "3 orders of magnitude" error. If you are referring to the fact that all our food calories are 3 orders of mag. wrong, that is true. However in this case, the person was making an apples to apples comparison and there were no unit errors, just the 1625 vs 1800 calorie error.

      So, "anon pr*ck" (i.e. male) is consuming at least 1,625,000 real calories per day of soda and their RDA of calories is in the 2,xxx,000 range. Bottom line is the same, IF it was leaded soda then ~80% of RDA calories would be from soda.

      --
      I come here for the love
    19. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 0

      So basically you spent the day in the bathroom after drinking so much soda?

      geez man, you musta been a chatter box from all that.

    20. Re:Ex Caffeine Junky by Himring · · Score: 1

      Dude, you were consuming, conservatively (I went with your low figures), about four, 2 liter bottles of soda a day -- if we go with an average I bet you were downing 5 or 6!.... Holy geez pal! That's way much. As many posts in this thread indicate, it isn't the thing itself which causes health problems, it's the dosage. Too much of anything is a bad thing.... "All things in moderation." Now you're dealing with no soda at all. I bet I drink a can of diet coke 2 or 3 times a week. Even if I drank 3 cans a day it wouldn't be near what you were consuming.

      About 3 years ago I was fat and out of shape. I started dieting and working out. I shed 50 pounds of fat and put on 10 pounds of muscle. I started getting stronger and increased, for example, my bench press by 30% or more. I got so into it -- eating right and exercising -- that I started suffering other health problems. Basically, my joints started going out. I was up to 3 workouts a day at one point. I now realize I was, again, not moderating things well. After nearly needing a shoulder operation and working hard to do things right, I'm now down to about 3 good workouts a week and feel better than ever. I continue to eat right, but I'm not a fanatic about it.

      Again, all things in moderation....

      --
      "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
    21. Re:Ex Caffeine Junky by Anonymous Coward · · Score: 0
      But, but, but... the grandparent you are arguing about clearly said:


      Diet Cherry Vanilla Dr. Pepper


      Emphasis mine.

      N.B.: *DIET*.
    22. Re:Ex Caffeine Junky by justthinkit · · Score: 0
      Bottom line is the same, IF it was leaded soda then ~80% of RDA calories would be from soda.


      Someone else started the "IF" parade, I just rode with it.


      Hence my use of IF in my defense of "Epi-man" above.


      I need a drink...

      --
      I come here for the love
    23. Re:Ex Caffeine Junky by Epi-man · · Score: 1

      I took his every two day average to be 8 cans, in the middle of his estimate, not the minimum listed 5 cans/two days. My first reaction to the post was holy cow, this dude must be HUGE, then saw that it was the unleaded version but figured I would point out how quickly the calories add up with cola consumption (something the parents in my city don't seem to understand as I watch their 100+ pound 3-4 year olds ride around in their strollers with a bag of Cheetos and 20 oz bottle of Big Red).

    24. Re:Ex Caffeine Junky by justthinkit · · Score: 1

      I hear that. I married into 3 kids and one of the first things we did was cut out the cola and request home delivered water. Within months the oldest, probably 20+ pounds overweight, had reduced weight to normal range. Now he goes out and pogosticks 500 times in a row, just for the heck of it.

      --
      I come here for the love
  15. Everything in moderation by gasmonso · · Score: 1

    Studies about the effects of coffee have gone back and forth countless times. My guess is that so long as you don't drink 10 gallons of it everyday, you'll be fine. I hate these studies because they change every 6 months. I remember when chocolate was supposed to be bad and then they said well its actually good. I'm just waiting for that to change again.

  16. In other news by Anonymous Coward · · Score: 1, Funny

    Dr's say drinking four cups of semen a day while on Spring Break due to your being a total whore probably not good for your health either.

    Will wonders never cease!

  17. Welcome to nonlinearity and heterogeneity by G4from128k · · Score: 1

    Both studies are "right". Some coffee may be good for you, too much may be bad -- the human body is nonlinear. Some people may react well to coffee, some people react poorly -- the human gene poll is heterogeneous.

    --
    Two wrongs don't make a right, but three lefts do.
  18. the right tool for the right job by prgrmr · · Score: 1

    morning wake-up juice = coffee black

    evening night-cap = captain morgan 'n' coffee black

  19. In other news... by BecomingLumberg · · Score: 4, Funny
    In other news, drinking/eating too much of $SUBSTANCE could lead to $HEALTH.PROBLEM.

    --
    If a nation expects to be ignorant and free, in a state of civilization, it expects what never was and never will be.-TJ
  20. other news: by sabernar · · Score: 0, Offtopic

    - the sun rises in the east
    - Barry Bonds took steroids
    - Iraq is a dangerous place

  21. I keep wondering... by 1zenerdiode · · Score: 1

    When is the medical profession going to move beyond descriptive statistics to something more? In some respects, the medical profession appears to be at about the same level as the alchemists were prior to the evolution of chemistry. "If I mix this, then mix that, I get something. I don't know why."

    The studies may each be meaningful and well-designed, but to an individual trying to make good decisions, the information is basically useless, since it appears contradictory and in many cases is arbitrary and non-intuitive. "You should eat 5, not 4, pieces of celery, but only after consuming 2.5 cups of coffee *UNLESS*, of course, you have gene XYZPDQ319, in which case you should drink only 1.5 cups of coffee before urinating at sundown."

    1. Re:I keep wondering... by Makarakalax · · Score: 1

      A topic as complex and difficult to understand as biology leads to advise and information that is complex and difficult to interpret.

      Isn't that fucking obvious?

    2. Re:I keep wondering... by Anonymous Coward · · Score: 0
      A topic as complex and difficult to understand as biology leads to advise and information that is complex and difficult to interpret.

      Isn't that fucking obvious?


      What IS obvious is that medical profession do not understand adequately the topics (being complex and all), yet they pretend otherwise by not disclosing the lack of knowlege. OK?
    3. Re:I keep wondering... by 1zenerdiode · · Score: 1

      Yes, it's fscking obvious.

      But we manage complexity in other disciplines with layers of abstraction and structure. This enables (relatively) stupid people to utilize extraordinarily complex technologies in their lives. It is not necessary for me to understand semiconductor physics, branch prediction and out-of-order execution in order to type this message, yet I am using these technologies.

      As I stated in my original message, the studies may well have been properly designed, but when aggregated, the results are not meaningful. Call it a failure of the people who reported on it, but as an end user of the information, it is not useful.

      It is not possible for someone to interpret "Drink lots of coffee, but don't drink lots of coffee." This is not advice, it is a contradiction.

      Ask someone who switched to margarine in the 60's what they think about that decision now, with emerging research related to trans-fatty acids. Should we switch back to butter?

    4. Re:I keep wondering... by Makarakalax · · Score: 1

      Coffee probably has something like 40,000 different chemicals in it. You can't expect compare it with a relatively simple set of technologies like some web-browser and mouse combination.

      Anyway, if you read the studies rather than the media's interpretations of the studies you'd find none of the studies advise you on whether to drink coffee or not. They all simply discuss their finding with regards to one component of the 40,000 (or whatever) components in the coffee.

      If you don't actually read the data correctly you are destined to make bad decisions. Blaming that on people you don't even understand is stupid.

    5. Re:I keep wondering... by Makarakalax · · Score: 1

      What is obvious is you have no idea how science works at all.

      Scientists are openly aware they don't understand science. The whole point in papers/journals is to report on findings, request peer-review and discuss the findings with a goal of trying to figure out what the fuck is going on.

      OK? Moron. The less people like you in the world the faster we'd all actually make some progress.

    6. Re:I keep wondering... by Makarakalax · · Score: 1

      Having re-read your comment I have more to say I spose.

      Food and our biologies are very complex stuff, it is just stupid to assume you can draw simple and single rules about eating the stuff.

      Your example of eating 4 or 5 bits celery, etc. is exactly right. None of us have the same biology, and food is full of different chemicals. It is the best general advice science can give.

      It is not like physics where at a basic enough level everything is 100% predictable. What you are asking for is not yet possible, there's no point getting upset about it. Nor is it fair to get angry at the people who release the data, because you basically don't understand the issues under discussion.

  22. What does this mean... by dantheman82 · · Score: 5, Funny

    for the future of Java? For now, I'm drinking green tea and coding in C#.

    --
    This sig donated to Pater. Long live /.
  23. Why does by Anonymous Coward · · Score: 0

    Why does the summary give an either or proposition as an outcome. That isn't even implied and I find it curious that the submitters brain imposes such a flawed outcome.

  24. You Misunderstand by Makarakalax · · Score: 5, Insightful

    What happens is that conflicting summaries get posted around the Internet and everyone thinks scientists are just having them on.

    If you look carefully the summary for the research is saying the caffeine is bad for you, and that the study concluded this based on research into coffee consumption. The other studies that claim coffee is good for you were actually referring to other chemicals in coffee, not the caffeine, nor the entirety of the coffee.

    Also people seem to think that scientists study everything about a topic before releasing results. But that is a misunderstanding about how science works. Generally scientists focus on very small areas of large topics and then propose more sweeping conclusions. Usually the media then make even more generalised conclusions that result in complete misunderstanding in non-scientists.

    Peer review is also important, often these studies are fundamentally flawed and even though the submitted paper offers a conclusion, the scientist writing it is well aware that in science, nothing is proved by one paper. Instead wait ten years for more supporting evidence, rinse, repeat and progress.

    1. Re:You Misunderstand by flyingsquid · · Score: 1
      It's also the press. They like a good debate, or findings that supposedly overturn conventional wisdom; nothing makes a good story like conflict. The result is that you're more likely to hear a story to the effect of "New study proves all previous research dead wrong" than "New study confirms what we knew all along" and they will tend to exaggerate the extent to which a study departs from previous studies.

      Which reminds me, there was a recent study published in the Journal of the American Medical Association which said that all these conflicting health reports could stress you out and be bad for your health. But then a report in the Lancet came out proving the opposite.

    2. Re:You Misunderstand by mizhi · · Score: 1

      This is why I stopped paying attention to the media on health matters. Sure, big things I listen to (such as, there's a rash of hepatitis cases from people eating at Jon's-Not-so-Fresh sushi bar), but not about shit like how many cups of coffee I can safely consume or how many eggs I should eat a day.

      Half the time the media gets it wrong, and when you do a little digging, you find that the study they're citing covers a very small part of the problem. Like, drinking too much coffee... while pregnant... with a certain combination of genes... and wearing a pink do-rag may be bad for you. Well, the headline "Drinking too much coffee is bad for you" doesn't apply to me, a male, now does it?

      Keep this in your mind and repeat it: The media is about making money through controversy and hysteria.

      Understand that, and the scary little health articles make more sense.

      --
      Humorless sig goes here.
    3. Re:You Misunderstand by mizhi · · Score: 1

      That said, this particular article is actually not too bad... the Slashdot title and summary sucks though.

      --
      Humorless sig goes here.
    4. Re:You Misunderstand by RubberDogBone · · Score: 1

      Exactly, it's not that COFFEE was is supposed to be bad, it's caffiene. There was no discussion about whether Tea or Cola or other caffiene-containing drinks would have the same effects.

      Additional caveat: the test subjects were all Costa Rican. I have no idea what Costa Ricans call coffee but it's probably quite different (i.e. stronger brew) than the pigswill that passes for coffee in most of the western world.

      Does that make a difference? Can results based on Costa Rican coffee be applied to any other population group drinking a different sort of coffee? Again, they didn't test for that.

      But they still applied the result to the entire world. I *hate* coffee and wouldn't care if it fell off the earth and froze in space, but this study is just lousy science that leads to BS headlines.

      --
      Sig for hire.
    5. Re:You Misunderstand by bill_mcgonigle · · Score: 1

      Well put.

      Additional caveat: the test subjects were all Costa Rican. I have no idea what Costa Ricans call coffee but it's probably quite different (i.e. stronger brew) than the pigswill that passes for coffee in most of the western world.

      Costa Ricans typically drink local arabica coffee. If you buy cheap american coffee you're going to get a significant amount of robusta coffee - a different species that grows in hot climates, esp, south east asia. It is pigswill, as you mentioned.

      So, besides the bad science you mentioned, they're not controlling for the species of coffee plant (which will have a great varaiation in phytochemicals) and they're claiming that coffee == caffeine.

      If they want to study caffeine, they can do a controlled study with NoDoz or other refined caffeine, but stop throwing coffee into the study just to get headlines!

      As to your coffee aversion - there are people who actually hate coffee and people who haven't had good coffee. If you like coffee ice cream, for instance, but can't drink the stuff, there's hope yet. Swing by next time you're in New Hampshire and I'll show you what some home-roasted decaf in a vac pot can taste like. (hint: not at all like Maxwell House).

      --
      My God, it's Full of Source!
      OUTSIDE_IP=$(dig +short my.ip @outsideip.net)
  25. So it's not healthy by Opportunist · · Score: 1

    Next they're gonna tell me my 2 boxes of cigs ain't good for me either...

    Let's face it, no matter what you do, your health is not going to enjoy it. The food you eat has pesticides, fungicides, preservatives etc. in it. The air you breath is full of particulate matter and NOx. Your tap water is... no, I don't even want to know what's in there.

    Will my coffee intake make any difference is the question. THAT is isn't the healthiest thing to do is a given. The question is rather, does it matter between the other toxins and carcinogenes that you inhale, swallow and absorb with your skin?

    --
    We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    1. Re:So it's not healthy by arkane1234 · · Score: 1

      Let's face it, no matter what you do, your health is not going to enjoy it. The food you eat has pesticides, fungicides, preservatives etc. in it. The air you breath is full of particulate matter and NOx. Your tap water is... no, I don't even want to know what's in there.

      I used to think this way too, when I was younger. As I got older I realized how self-justifying that reasoning is.
      It only takes a few changes in your life (and a little bit of love for yourself) to make a big difference.
      Sure, there may be preservatives, fungicides, pesticides, in alot of food... and sure there might be particulates in the air (haven't heard about a huge nitrous oxide scare...) however with a bit of change you can avoid a large amount of the damage done by these things.

      The point is there are constant global variables in life which are controlled by the main function at initialization, and then there are the private scope variables which you alone control inside of your own instance. Alot of life depends on those variables, believe me.

      In spite of everything you hear, you really aren't doused in toxins everyday. Well... unless you live in a big city like DC/LA/NY, or London.

      --
      -- This space for lease, low setup fee, inquire within!
  26. Just about anything in excess is bad for you... by marcus+frost · · Score: 1

    If we started writing off things we consume just because in excessive amounts they can be bad for you, there really would be few things that we could say were good for us. Most people do not drink 4 cups a day. Aside from the health aspect, we cannot deny how big a role coffee has played in our lives and in society since it's creation. It helped fuel the industrial revolution, is one of the world's largest traded commodoties, and is still increasing in popularity. No matter what this study says, coffee will continue to play a singificant role in many of the world's cultures.

    --
    "I do not have as much of a fear of dying as I do of not having lived."
  27. Balance by ChaoticCoyote · · Score: 2, Insightful

    Anything to excess is likely to be harmful. The key is to find balance — moderation in all things, including moderation!

    1. Re:Balance by Chris+Burke · · Score: 1

      The key is to find balance -- moderation in all things, including moderation!

      I think moderation is the only thing I'm able to successfully moderate. :P

      --

      The enemies of Democracy are
    2. Re:Balance by Cheeze · · Score: 1

      moderation is boring. ....

      so is meta-moderation. :)

      --
      Why read the article when I can just make up a snap judgement?
  28. Really!? by Sippan · · Score: 1

    In other breaking news, smoking may cause cancer!

    --
    Frog blast the vent core.
  29. My research results by Hoi+Polloi · · Score: 2, Funny

    I am proposing that eating a Whoopie Pie a day is part of a healthy diet. Prove me wrong and give me a pie!

    --
    It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
  30. Just to point out by AlgebraicRing · · Score: 1

    Even in the summary the finding was qualified by the fact the detriment was related specifically to a single gene. The two studies do not contradict each other because one study applies to a specific gene and the other study is, I assume, more general. Note: I have no idea if either study is correct, I simply want to point out that they do not contradict each other. The story submitter was implying a contradiction where there is none.

  31. Personal record is four 10 cups pots by The+Ape+With+No+Name · · Score: 2, Funny

    In a 24 hour period. If you are not hallucinating by 11AM, it's time for another cup of coffee.

    --
    Comparing it to Windows will be a moot point, since El Dorado is going to have a 40% larger code base than XP.
  32. Studies have shown... by Anonymous Coward · · Score: 5, Funny

    "Studies have shown that research causes cancer in lab rats."

    1. Re:Studies have shown... by The_Mr_Flibble · · Score: 1

      Sex will kill you !
      Drugs will kill you !
      Marriage will kill you !
      polution will kill you !
      Life will kill you !
      Now coffee isn't looking to good
      News like this will cause you to kill you !

    2. Re:Studies have shown... by Anonymous Coward · · Score: 0

      """research causes cancer in lab rats""" ???

      Stop doing research and spare the rats.

  33. An example of interpolating narrow research by swalker42 · · Score: 2, Interesting

    I think the problem with stories like this is that broad generalizations on health are made using one narrow area of research. In this case it is discovered that 4+ cups a day may cause heart disease.
    Wait! Only if you have a certain gene that expresses itself. Or maybe it's because the gene causes a stressful life and it has nothing to do with coffee.
    Perhaps in 20 years 1 cup a day will cause colon cancer. Maybe it will help you live 20 years longer. We are far too willing to jump to holistic health decisions based on a single narrow study.
    I would hope that no one would make drastic life decisions (not that drinking/not drinking coffee should be that drastic) based on a single study.
    Cut back on fast food, drink more water, eat more fruits and vegetables. My mom was trying to tell me that 20 years ago. You feel better and your body can better handle the impurities that you put in it. Then you don't have to focus so much on the small stuff.

    --
    You keep using that word, I do not think it means what you think it means
  34. Coffee or muddy water? by UncleAlias · · Score: 1

    The linked article doesn't help much: which kind of coffee, American or European style? How much in a cup? A bit hard to tell, there.

    --

    Stéphane "Alias" Gallay
    Now, where did I put this witty quote?..

    1. Re:Coffee or muddy water? by aXis100 · · Score: 1

      Come on....everyone knows that 4 cups of coffee = 1x10-8 Libraries of congress.

  35. And the relative risks are? by harmless_mammal · · Score: 1

    And how does this increased level of risk compare to, ummm, death by car?

  36. Irish Eyes are Smiling by digitaldc · · Score: 1

    Coffee may not be a health drink, but Irish Coffee certainly is.

    --
    He who knows best knows how little he knows. - Thomas Jefferson
  37. Whew.... by sulphurlad · · Score: 1

    I miss read that for a second..... 4+ cups a day. I thought it said 4+ pots I guess I'm still safe.

  38. Totally offtopic about your signature by fistfullast33l · · Score: 5, Funny
    while ($beer != full) { $beer = new Beer(); chug($beer); }

    So here's a small problem with your signature - you run the while loop until the beer is full...but you chug the beer inside the while loop. Which means that once your beer is full...you stop drinking. Of course, this is all dependent upon the fact that chug doesn't empty the glass, which is usually what happens when you chug...so basically I think you need to check the return of chug to make sure it didn't fail. Otherwise you might have problems.

    Sorry for wasting your time.

    1. Re:Totally offtopic about your signature by Anonymous Coward · · Score: 1, Funny

      Depending on the definition, it can also be argued that:

      $beer = new Beer();

      Grabs a new glass of beer in a loop which checks if the glass of beer has been filled. If that's the case I think you could better let the while loop check if the beer_drinker_ is already full.. :D

      or something like:

      beer = beer.Beer()
      while(amount != 0):
              amount = beer.chug()

    2. Re:Totally offtopic about your signature by LunaticTippy · · Score: 2, Informative

      If chug fails you don't need another beer.

      --
      Man, you really need that seminar!
    3. Re:Totally offtopic about your signature by Placido · · Score: 2, Funny

      I think his loop is never entered if the first glass is full... OR... he ends up with a hell of a lot of half-empty beer glasses. Personally, I was thinking more along the lines of:

      $beer = new Beer();
      while ($beer != empty) {
        chug($beer);
      }

      But actually what you want is:

      while ($wallet != empty){
        $beer = new Beer(getDollar($wallet));
        while ($beer != empty) {
          chug($beer);
        }
      }

      With an optional:

      if ($upright == true){
        attemptToPull();
      }

      I guess the moral of the story is to triple check your code before posting on /.

      In re-reading this I'm coming to terms with the fact that maybe I need to GET A LIFE!

      --

      Pinky: "What are we going to do tomorrow night Brain?"
      Brain: "I would tell you Pinky but this 120 char limi
    4. Re:Totally offtopic about your signature by flooey · · Score: 4, Funny

      In re-reading this I'm coming to terms with the fact that maybe I need to GET A LIFE!

      Or a beer.

    5. Re:Totally offtopic about your signature by gfxguy · · Score: 1

      So you're saying it should be while(1)...?

      --
      Stupid sexy Flanders.
    6. Re:Totally offtopic about your signature by Anonymous Coward · · Score: 0

      Heheh, with amount I was originally referring to the amount of beer left in the glass after a chug, but your wallet idea gives it, once again, a new perspective. :D

      Living la vita loca hehe

    7. Re:Totally offtopic about your signature by PW2 · · Score: 1

      I like your code better! I think the original script calls for the person to start drinking someone else's half full beer and then he starts to buy his own until he can't keep up with the purchases. I'd rather start with my own beer like you suggest.

    8. Re:Totally offtopic about your signature by Edd · · Score: 2, Funny
      This is where Perl's syntax can make the meaning of a statement clearer, consider how much easier it is to understand the semantics of:

      drink(new Beer()) until $unconcious;

    9. Re:Totally offtopic about your signature by StarfishOne · · Score: 1

      This is Open Source with its ``free'' as in ``free speech,'' not as in ``free beer.'' ^_^

    10. Re:Totally offtopic about your signature by Kryptkrwlr_XTC · · Score: 0

      Actually, a better statement would be: while ($keg != empty) { if ($beer == empty) { $beer = new Beer(); } else { chug($beer); } return $beer; }

  39. Well according to you then... by Anonymous Coward · · Score: 0

    Geeks will live a long time due to their complete lack of their ability to get their noodle wet - which will also cause in the same symtoms you descibe.

  40. Not news. by morning · · Score: 1

    People have known for decades that coffee is not 'good' for you. Does this even deserve to be listed as news?

  41. In other news. . . by smooth+wombat · · Score: 0, Offtopic

    drinking an excess of dihydrogenmonoxide could lead to a person collapsing or in rare cases, dying. In addition, drinking an excess of flavored, carbonated beverages has been shown to cause significant weight gain in some people which can lead to other medical conditions including heart failure.

    Not to sound trite but how is this news? Every person is different and will react differently to external stimulae. In my case I can eat whatever I want in whatever amount I want and not gain a pound. However, the guy in the cube next to me probably can't do the same thing. Why? Because we're all different (in case you missed it the first time).

    If the issue revolves around whether one has a certain gene or not then this almost sounds like at birth we should be screened to see if we have this condition so we'll know not to drink so much coffee to prevent or stave off heart disease.

    Genes are what determine who we are. As of yet we don't have the means to fully change those genes to correct issues like this. We're all different (just making sure you didn't miss it the first two times) so at best we can use these studies to reinforce the old adage: everything in moderation.

    --
    We will bankrupt ourselves in the vain search for absolute security. -- Dwight D. Eisenhower
    1. Re:In other news. . . by Billosaur · · Score: 1
      Not to sound trite but how is this news? Every person is different and will react differently to external stimulae. In my case I can eat whatever I want in whatever amount I want and not gain a pound. However, the guy in the cube next to me probably can't do the same thing. Why? Because we're all different (in case you missed it the first time).

      The fact is, despite all our medical knowledge, our handle on genes and genetics, and the compendium of scientific information regardign anatomy and physiology, we don't know squat about how the human body works as an integrated system. It's like handing someone a box of parts which make up a computer and saying "...the problem is X."

      For every study you can find an opposing study. There are intellectual camps in medical science, staunchly defending their point of view. I used to get frustrated reading psychology and medical journals when I read how poorly designed a lot of these experiments are. You can prove anything you want as long as you stack the deck.

      Despite commonalities, no two people are alike. That's genetics expressing itself; we all have the same basic set of information, but mine works differently than yours. Until we have a comprehensive picture of how the whole system works and interacts with its environment, it's like replacing engine parts randomly until you get the car to run.

      --
      GetOuttaMySpace - The Anti-Social Network
  42. Size counts by nighty5 · · Score: 1

    Buuuut, coffee stunts your growth!

    Since I gave up coffee 3 months ago, my penis has enlarged by 2 inches.

    If this keeps up, I'll be bucking along with Ron Jeremy in no time!

  43. This is another reminder... by Anonymous Coward · · Score: 0

    This seems like another example of what we've been told for decades: Everything in moderation.

    Except trans fats. :)

  44. Fittingly Canadian Story by slashbob22 · · Score: 4, Interesting

    I can only laugh as I sip on my Large Double-Double[1] Coffee from Tim Hortons. Coffee can kill me, my Work may kill me, walking across the street is dangerous. On the plus side, the coffee helps me cope at work and keeps me alert as I walk across the street: reducing 2 out of 3 risks isn't too bad.

    [1] For those not in the know: double-double -- a coffee with double cream, double sugar (especially, but not exclusively, from Tim Hortons). http://en.wikipedia.org/wiki/Canadian_slang

    --
    Proof by very large bribes. QED.
    1. Re:Fittingly Canadian Story by coaxeus · · Score: 1

      I have no points today but here.. +5 insightful.

      --
      My name is coaxeus, and I approve this message. In fact, I think it is awesome.
    2. Re:Fittingly Canadian Story by whitehatlurker · · Score: 2, Insightful

      The only danger to a double-double is falling asleep in the line-ups at Timmy's, waiting to get served. None the less, I will be having my ExLarge, two cream shortly. (Hopefully before the shakes kick in.)

      --
      .. paranoid crackpot leftover from the days of Amiga.
    3. Re:Fittingly Canadian Story by zhiwenchong · · Score: 1

      This is totally off-topic:
      "If nothing else works, a total pig-headed unwillingness to look facts in the face will see us through."

      Ah yes, General Melchett from BlackAdder....

    4. Re:Fittingly Canadian Story by slashbob22 · · Score: 1

      Yes indeed Captain Darling

      --
      Proof by very large bribes. QED.
    5. Re:Fittingly Canadian Story by drew · · Score: 1

      You Crazy Canucks!!

      Everyone knows that the real double-double is possibly the finest fast-food cheeseburger that money can buy. Everything else is just a pretender to the name.

      --
      If I don't put anything here, will anyone recognize me anymore?
  45. Pshaw! by Ranger · · Score: 1

    Coffee not a health drink? Balderdash. Next they'll be telling us hard liquor, cigarettes, and lap dancers aren't healthy for us either.

    --
    "You'll get nothing, and you'll like it!"
  46. 4 out of 5 gene splicers drink Red Bull by justthinkit · · Score: 0
    One cup a day is all the body responds to anyway (less in fact). After that the dependency goes up but the benefits do not. Pretty soon you are knocking back 2+ cups a day just to feel not quite as good as when you weren't drinking. At that point it is time to knock off the stuff for a day or two, then fire up that virtuous cycle again.

    Floyd Maxwell,

    and yes I drink Maxwell House

    --
    I come here for the love
  47. What, you mean everybody's not alike? by istartedi · · Score: 1

    It never ceases to amaze me that in relatively simple systems designed by man, people recognize that different inputs will have different results for different systems. Yet, in a far more complicated system designed by Who Knows What or what knows what (depending on your beliefs) people are foolish enough to think they can reduce the determination of optimal input to a simple equation that applies to all the systems. Bolix! Until we actually understand the variations in "hardware" and "software" running on the human systems, and are able to determine the "versions" and "models" in the biological sense, 99% of all medical recommendations like this are just absolute BS. One fo the articles I read on this very study mentioned this, and I thought "well, it's about time the medical community started waking up to this issue.". To be fair, they've recognized many genetic issues for quite some time, but releasing studies with the implicit assumption that everybody can use the results is still all too common.

    --
    For all intensive purposes, "whom" is no longer a word. That begs the question, "who cares"?
  48. 100 cups by DaFallus · · Score: 2, Funny

    Bender: "You seem a tad wound up, buddy. And your face is greasy. Real greasy. You've been up all night?"

    Fry: "Of course I've been up all night! Not because of caffeine, it was insomnia. I couldn't stop thinking about coffee. I need a nap." *snores* "Coffee time!"

    --
    No one cares what your captcha was

    Houston TX, USA
  49. It's all about Moderation by thehubbell · · Score: 1

    Moderation is best for a person. This mean taking moderation in moderation and having some coffee. Because if you don't deviate from strict moderation once in a while your not taking you moderation in moderation! (I think hear this from a evening radio talk show host I just can't remember which one) www.coffeegeek.com to learn more about coffee's wonderful properties. Warning lurking in the forum could lead to a greater coffee addiction and additional cost. Slashdot regulars should avoid due to their already addictive nature.

  50. Aspartame by AnonymousPrick · · Score: 2, Insightful
    After switching to Diet Cherry Vanilla Dr. Pepper (aka Liquid Crack) I was heading for 5 to 6 20oz bottles a day (at work) plus 5 to 10 12oz cans every two days (at home).

    Too much Aspartame gives me wicked headaches. Aspartame also breaks down into formaldehyde by your liver - how much or how long - I don't know, but that's what I've been told by a dietician - a real dietician from a hostpital. Not your typical "self educated" one who learned about diet from magazines thay, well, may not be the best source for that kind of information.

    --
    Saturday is April 1. Slashdot will be shut down. Sorry for the inconvenience.
    1. Re:Aspartame by Valdrax · · Score: 1

      So, instead people should kick the diet habit and just drink copious amounts of high fructose corn syrup?

      I kid, of course.

      --
      If it's for-profit but free, you're not the customer -- you're the product (e.g., the Slashdot Beta's "audience").
    2. Re:Aspartame by Anonymous Coward · · Score: 4, Informative

      Your dietician needs to go back to med school. Yes, aspartame breaks down to formadehyde as the tail end of the process of your small intestine converting it to methanol. Formaldehyde (from methanol) is a normal chemical to be found in your body as a normal byproduct of normal digestion.

      The amount of methanol produced by Aspartame in the body is 10% of the ingested aspartame. Assuming all the methonal is further converted to formadehyde, a normal 12 oz soft drink causes only 1/6th the amount of methonal production as an equivalent drink of Tomato Juice (which contains no Aspartame, but contains other "natural" chemicals that produce methanol).

      The actual numbers are this:

      A 12 oz diet soda contains 225 mg of Aspartame (approximately 0.05% of the drink is aspartame). That generates 22.5 mg of methanol, or about 0.005% of the drink will become methanol. We will assume all the methanol becomes formaldehyde (worst case). The LD50 of formaldehyde is 100mg/kg. For an average male of 75 kg, that would mean 7500mg. A total of 333 sodas must be drank by this average male to assure death, and they must be drank fast enough to counteract the body's natural ability to rid itself of formaldehyde.

      Of course, hyponatremia will set in, without exercise or dry heat, with drinking about 3 or more litres of fluid per hour, for serveral hours straight. 333 sodas will contain 3996 oz of liquid, or about 118 litres. Anyone attempting death through ingestion of Aspartame by soda comsumption will surely die of hyponatremia far before they have reached even small amount of their goal!

      Feel free to ask your dietician to verify this!

    3. Re:Aspartame by the+idoru · · Score: 1

      Well, using the LD-50 of a substance as a measure of how small amounts affect the body is extrapolating very far. You will often get negative effects (like headaches, as the parent noted) long before you reach the LD-50 of any substance. I'd say that's a good thing since reaching the LD-50 will--by definition--KILL half of us. And just because you can find formaldehyde in "normal" levels in the body does not mean that ingesting aspertame and raising those formaldehyde levels is an Ok thing to do. His dietician wasn't wrong in that aspartame will be broken down into formaldehyde at some point in its digestion. Whether that is what's causing his headaches is hard to tell; many big-time soda drinkers report symptoms like this that are anecdotally attributed to aspartame. No doubt injesting lots of caffeine and high fructose corn syrup also attributed.

      I'm not a dietician, but I think you'll find that most dieticians will make a concerted effort simply to get their patients to decrease their soda intake. It's just a good thing to do. Using the aspartame-formaldehyde argument is a good one. It's true that it happens, even if there's no work that I know of that definitively links aspartame to pathological formaldehyde levels.

  51. What size cup we talkin' bout here? by mottrytell · · Score: 2, Funny

    Is that 5oz, 8oz, 16oz, or the venti? I drink a lot....am I gonna die now?

    1. Re:What size cup we talkin' bout here? by Anonymous Coward · · Score: 0
      Is that 5oz, 8oz, 16oz, or the venti? I drink a lot....am I gonna die now?


      Poor Mottrytell, you're a gonner - we're gonna miss you....

  52. common sense, moderation, enjoyment by ChristTrekker · · Score: 1

    You know, it seems for every time something beneficial is found in a food, someone else discovers something else in it that causes cancer. And vice versa.

    So you know what I recommend? Use some common sense. Eat a reasonable, balanced diet. Enjoy your favorite foods, but don't overindulge - everything in moderation.

    You gotta go sometime, so you might as well eat what you enjoy eating. It appears the "experts" disagree and can't really tells us for sure one way or the other what's really good or bad for us, anyway. By the time you get done going through your tally sheet of what you can and can't have, what you should and shouldn't consume, you've probably added enough stress to your day that you'll keel over from a heart attack or develop an ulcer!

  53. hype by noopy · · Score: 2, Funny

    The hype-meter on my toolbar is pegged to the right. One questionaire, not even a clinical trial, about a substance with many, many compounds and they've got the results pegged to one allele that metabolises just one compound, caffiene, slowly. Let's put a "why do you loose sleep" on the slashdot poll. May as well conclude that slashdotters who loose sleep staying up all night do so because of cowboy neal. Well, so long as they have some odd genotype.

  54. Another slang for overconsumption (off topic) by MrNougat · · Score: 1

    When I worked at a particular car dealership, there was a Burger King half a block away. Every morning, we would send one of the parts drivers there to pick up breakfast for me and another guy.

    Burger King has the Croissan'wich and Hash Rounds. Let's say I wanted one Croissan'wich and one Hash Rounds. I would request a "One and one." (The default Croissan'wich flavor was sausage. If you wanted a different flavor, you would say "One and one, ham," for example.)

    You can do the math from there. One and two. Two and one. On particularly bold days, two and two.

    I don't think we ever got into the "threes." Thank god.

    --
    Web 2.0 == Giant Blogspam Circle Jerk
  55. please read more carefully in the future by raygundan · · Score: 5, Insightful

    Blame the media's lousy science reporting or poor reading comprehension skills, but what people see as conflicting results are often nothing of the kind, they just miss the details.

    I saw one study that said a single cup of coffee a day was good for athletic training, and another that said that the more coffee you drink, the lower the risk of heart disease.

    This study says that more than four cups of coffee a day are bad for you if you have a particular gene.

    None of these things are contradictory-- just like how a glass of wine may be beneficial, but 10 glasses may cause liver disease. Or how some types of cholesterol are good, but others are bad.

    1. Re:please read more carefully in the future by ergo98 · · Score: 1

      This study says that more than four cups of coffee a day are bad for you if you have a particular gene.

      The three Score: 5 posts right now say the same thing, which to paraphrase is "the dose is the poison, and moderation is key". The fact that they say that, and worse the fact that they're all sitting at Score: 5, is ample evidence that they have absolutely no idea what the article is about, nor do any of the moderators who handed out points to them.

    2. Re:please read more carefully in the future by raygundan · · Score: 1

      I can't tell if you're agreeing with me or disagreeing with me, since you replied to me but referenced other posts discussing moderation-- but I was not suggesting that moderation was the key. I was simply saying that what people perceieve as conflicting results are often not conflicting at all. In some of my examples, it is a question of quantity making the difference, but I did not suggest that that was the case here.

      In this particular case, it is specifically not a moderation issue, it is an issue of a particular genetic susceptibility.

    3. Re:please read more carefully in the future by ergo98 · · Score: 1

      Right, and I was agreeing to your key assertion by pointing out that, at least at the point that I submitted that reply, the highest rated point completely missed the point of the article (similar to how you were correcting yet another incorrect assumption about the article).

    4. Re:please read more carefully in the future by robbo · · Score: 1

      Not to mention that this study is about heart disease whereas other studies were about cancer. People seem to have a hard time grokking that any given food/drug/vice can be beneficial in some ways and detrimental in others.

      --
      So long, and thanks for all the Phish
    5. Re:please read more carefully in the future by rtb61 · · Score: 1
      There is of course the new way to evaluate studies, who paid for the study and who profits based upon the test results.

      A good rule of thumb, any addictive substance is not likely to be good for you, regardless of test results.

      Any addictive substance that has studies showing that it is healthy for you, is more likely to be unhealthy for you but healthy for the bank balances of the people selling it to you.

      A lot of the contradictory results out there are as a result of various marketing companies becoming involved in science and research, of the junk variety.

      --
      Chaos - everything, everywhere, everywhen
  56. When will people learn? by Anonymous Coward · · Score: 0

    Well, when will you people learn that we are being lied to by the American government? The sheep are bleating.

  57. How come is it news ? by dom1234 · · Score: 1

    I would never have expected this to surprise anyone in 2006. For those who never go out or read anything, maybe we should do some basic education :
    - MacDonald's food is bad for your health (even salads because of the dressing)
    - Coke is not healthy neither
    - Cars pollute

    Seriously, has anyone ever been taught coffee was healthy ??

  58. Two Apropos Quotes by SeanDuggan · · Score: 3, Funny
    "You know you're old when you remember when bacon, eggs, and sunshine were good for you."
    "Studies show that research causes cancer in lab rats."

    Quite honestly, all that these studies keep showing is that we still really don't understand how it all works and that, for now, you should just go ahead and eat what makes you feel healthy and good.

    --
    This sig has absolutely no significance and serves only to take up screen space and waste the time of the reader.
  59. Oh The Irony!!! by Khyber · · Score: 1

    The key is to find balance -- moderation in all things, including moderation!

    Quite ironic to find those words here on /. You've just made me shoot coffee thru my nose and all over my keyboard. Note to self: Hot Coffee and Slashdot are a near-fatal combination....

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  60. I'm ok, I drink 8+ cups a day. by olddotter · · Score: 1

    I probably really should cut back, but I really drink coffee almost exclusively during the cold months.

  61. Coffee by Himring · · Score: 4, Funny

    I quit all other drugs in my life. The only thing I have left is coffee. They can take it when they pry it from my cold (well, warmed), dead fingers. I started drinking it in college and fell in love. It's the right way to start a morning. It doesn't offend with its smell like tobacco. It doesn't impair driving like alcohol. It is the primordial source of gathering in the break room. It is the basis for the original Terry Tate, Office Linebacker skit. It gives cops something to hold along with a donut. It provided cease fires during the Civil War as the south traded tobacco for coffee with the north. It is the foundation of eclectic, bohemian establishments wherein college kids make it, and other college kids drink it (coffee shops) and also birthed some of the first public access to the Internet outside of libraries. It is a primary staple product in many South American countries. It's something that (according to my systematics professor) the English don't make very well. It revs you up before anything you need revving up for. I use it before my workout too. It is best when freshly ground and french-pressed. It has created many wonderful cups that say things on them. It gives dentists something to clean during checkups. Wtf beat it up? Study says this/study says that.

    Next: water -- a study shows too much of it can make your lungs stop producing needful oxygen....

    --
    "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
    1. Re:Coffee by Himring · · Score: 1

      Oh, and too, sometimes I feel the news articles I submit just don't meet the very high, journalistic criteria of the /. admins, and then I see this coffee blurb....

      And to think, I felt stupid for submitting the piece wherein Russian scientists are finding German tanks sunk deep into the bogs using metal detectors, the tanks having fully-functioning magnetos inside some 60 years later ... ok, well now I feel stupid again I think....

      --
      "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
    2. Re:Coffee by jimicus · · Score: 1

      It's something that (according to my systematics professor) the English don't make very well.

      Only if you drink instant which, sadly, has become ubiquitous in many offices, cheap cafes etc.

    3. Re:Coffee by bourne · · Score: 1
      It is best when freshly ground and french-pressed.
      Allow me to present another viewpoint.

      I agree it is best when freshly ground. I would expand to say that it is better than best when freshly roasted and freshly ground. A good home roaster can be purchased for $75 - $200, and an excellent one for $600-$700. I got both of mine (beginner, then a better one after I killed my first) here. That's where I get my green beans, too.

      As far as brewing goes, the french press is good. However, you should also consider the vacuum pot. An example would be the Bodum Mini-Santos which makes 25 oz (two tall mugs) of coffee. There's also a larger version. The coffee you can get out of a vacuum pot blows away any other method of brewing I've ever tried - french press, drip, drip with gold filter, percolator, boiled 8).

    4. Re:Coffee by Himring · · Score: 1

      Thanks for the tips. I might follow-up. I love coffee and all things about it.

      --
      "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
    5. Re:Coffee by Anonymous Coward · · Score: 0

      Dihydrogen Monoxide is a very seriously problem and should not be made fun of!
      MSDS

    6. Re:Coffee by beeblebrox · · Score: 1
      It is best when freshly ground and french-pressed.

      I humbly disagree. It is best when freshly ground and properly pulled.

    7. Re:Coffee by npsimons · · Score: 1

      It doesn't offend with its smell like tobacco.

      Spoken like a true coffee addict. You don't think it smells, because you are used to the smell (much like smokers). I'll grant you that freshly ground, freshly brewed coffee smells better, but it still smells. Coffee reheated (or constantly heated all day long) stinks worse than stuff that has come out of my ass. So please, for the sake of your cow-orkers and your own sense of taste and smell, at least grind your beans fresh and put on a new pot for the second half of the day.
  62. Good Reading Comprehension by Anonymous Coward · · Score: 0

    Congratulations on everyone's excellent reading comprehension. The article isn't merely stating caffeine is bad, but they actually offer an explaination as to why, and why different studies show different results.

    If you read the article, the research found that certain individuals with one of two variants of a certain gene process caffeine differently. The one group is able to better metabolize it, while the other group isn't. So people in the first group could quite easily drink 4+ cups of coffee per day with less negative effect then the second group.

    This explains why some studies show health benefits, while others don't, due to individuals processing caffeine differently.

  63. Slow poison by sita · · Score: 1

    "Coffe is a slow poison; it has to be, I have drunk eight cups a day for fifty years, and I'm still not dead." -- Voltaire

  64. The study I am waiting for. by alex_guy_CA · · Score: 1

    It's been my understanding (perhaps wrong) that the buzz you get from coffee (and tea) is supplied by your adrenal glands, and so caffeine drinking taxes your adrenals, perhaps leading to future pernicious effects. Any researches out there? Has there been a study on this, if not, would you do one?

  65. In other news.. by JavaLord · · Score: 1

    American researchers have published a study in the Journal of the American Medical Association indicating that reading studies about the health benifits of anything is useless since two months later another study will contradict the findings. The researchers came to the conclusion that people should just do whatever they think is right and let darwinism work out the rest.

    1. Re:In other news.. by Anonymous Coward · · Score: 1, Funny

      Jolt(TM) Cola has seen an unprecedented recovery from its sales low during the Dotcom burble. In a round about way, Jolt's increasing girth of influence can be attributed to reminiscent consumers who fondly remember 'the good old days.' Systems Programmer Kent Jeeley, a self proclaimed caffeine junky, states, "I used be able to go for days on nothing but Jolt Cola and Twinkies. Coding straight through for 48 hours, then crashing for 18, man, that was the life!" Jack Adhams, Program Manager to Mr. Jeeley, states "He was doing so well, eating vegetables, drinking Vitamin Water, taking the stairs. Now he just sits there, slurping twinkies, chugging Jolt, and pounding at that keyboard. He's sprawling, too, we had to order him a new chair, but boy, is he pumping out the code! I'm a bit concerned he might only last another year or two, but we can always switch him to Bawls and squeak a few more months out of him."

  66. Time for a bigger cup by Helmholtz · · Score: 4, Funny

    Since it's the number of cups that makes a difference, I guess I just need to switch to a bigger cup .....

    --
    RFC2119
    1. Re:Time for a bigger cup by morgan_greywolf · · Score: 1

      Like, say, a Grotesque Gulp, aka a 10-gallon trash can

      (Obligatory LSL reference)

    2. Re:Time for a bigger cup by serginho · · Score: 1

      For you Americans with that watery black liquid you call coffe, make it a jar.

  67. The Gene is the Poison by drooling-dog · · Score: 3, Informative
    As with anything related to toxicology, the dose is the poison.

    In this case, it may be the gene that's the poison. It appears that a gene called CYP1A2 determines how fast you metabolize caffeine, depending on which of two variants you have. People with two copies of the variant CYP1A2*1A metabolize caffeine about 4X faster than those with two copies of the other variant, CYP1A2*1F. The study found that more than 2 or 3 cups of coffee a day increases the risk of cardiovascular disease for the slow metabolizers, but may actually reduce it for those carrying CYP1A2*1A.

    That could be why studies on the health effects of coffee have been all over the map. The trick is to know your genotype with regard to CYP1A2, and of course very few of us do (or can)...

    See http://www.newscientist.com/channel/health/dn8816. html

    1. Re:The Gene is the Poison by Anonymous Coward · · Score: 0
      In this case, it may be the gene that's the poison. It appears that a gene called CYP1A2 determines how fast you metabolize caffeine, depending on which of two variants you have. People with two copies of the variant CYP1A2*1A metabolize caffeine about 4X faster than those with two copies of the other variant, CYP1A2*1F. The study found that more than 2 or 3 cups of coffee a day increases the risk of cardiovascular disease for the slow metabolizers, but may actually reduce it for those carrying CYP1A2*1A.

      That could be why studies on the health effects of coffee have been all over the map. The trick is to know your genotype with regard to CYP1A2, and of course very few of us do (or can)...


      It's actually both, since the dose determines your exposure, regardless of which phenotype you have. It still holds true that the difference between a safe drug and a poison is dose, and is why pharmaceutical companies put so much effort into making their drugs as potent as possible, which allows for a similar effect from a much smaller dose.

      Another factor relating to CYP1A2 that could be confounding some of these caffeine studies is the fact that it's inducible by some pretty common dietary constituents (such as cigarette smoke, charcoal beef, cruciferous vegetables) as well as medicines such as omeprazole, and this induction can have an effect on caffeine exposure.

    2. Re:The Gene is the Poison by RhettLivingston · · Score: 1

      It's beginning to become very obvious that we've accepted a lot of blanket restrictions because of a few people with bad genes. Medicine needs to come to a firm understanding that blanket statements based on statistical studies without an understanding of mechanism do a lot of harm and need to be stopped.

      A recent example is the large scale study of fat consumption that destroyed our supposed "knowledge" that increased fat consumption resulted in increased risk of heart disease, cancer, and other diseases. When many small scale studies indicate there is a risk and a well financed ($450 million) large scale study shows that it doesn't hold for a carefully balanced general population sample, you can bet that genes are at work. Actually, in order for it to work out mathematically, I'd bet there is a subpopulation that has a decreased disease risk with increased fat intake that hasn't been pinned down yet. In chasing this false target since the '60s, we have spent billions that could have been spent better, we have created an obesity problem because we didn't understand that a large population will increase overall intake to achieve the same amount of fat intake if you reduce the percentage of fat intake, and we've tripled the occurrence of diabetes caused by the resultant increase in carbohydrate consumption.

      Another example is salt. Yes, all of you who have avoided table salt to control your blood pressure, guess what. It has been known since the '70s that only 1 in 4 of the general American population has the gene that causes blood pressure to be very sensitive to salt intake. But since there was no easy test for it, they just threw a general rule at all of us. 3 out of 4 of those avoiding salt are doing it for no good reason. Now, that one may not have had big medical consequences, but I'd argue its a big quality of life issue as well as a stress generator in many families.

      When somebody comes up with a test to determine whether I have the bad coffee gene, I will consider whether I'd prefer to take the risk or quit. Until then, I'm enjoying my coffee.

    3. Re:The Gene is the Poison by Anonymous Coward · · Score: 0

      Hmm, sounds like a part no.

      doctor: "Sorry, looks like you have a faulty coffee gene, I can get the tech to replace it for you."
      guy: "oh, ok,..how much will that cost."

      yes, I know. Its lame.

  68. Coffee? by Anonymous Coward · · Score: 1, Funny

    Since this is a north american study, is it safe to assume that they are talking about black coloured water poured while facing a photograph of coffee beans instead of the liquid Europeans call coffee?

  69. Word of Wisdom by scottennis · · Score: 1

    Haven't the Mormons been saying this for 150 years?

  70. "Maybe" != "May be" by Ophion · · Score: 1

    "Maybe" != "May be"

  71. Air by seabreezemm · · Score: 1, Funny

    Researchers announced today that breathing air is bad for you and hence suggest that all breathing stop in order to preserve your health... The sky is falling, the sky is falling. =)

    --
    Karma: a simple way of silencing those with unpopular views regardless how correct or just that view might be.
  72. In other news.... by BkBen7 · · Score: 1

    Cancer leads to death.

    --
    I'm a Book
    On the Bookshelf
    1. Re:In other news.... by psykocrime · · Score: 1

      Cancer leads to death.

      So does breathing if you do it long enough.

      --
      // TODO: Insert Cool Sig
  73. best not to have any coffee by Anonymous Coward · · Score: 3, Insightful

    As with all addictive substances, it's best not to become addicted.

    Two cups a day means you are addicted. If you "need" a cup a day, you are addicted.

    1. Re:best not to have any coffee by KDan · · Score: 2, Interesting

      Tip for breaking the vicious cycle: I've stopped drinking coffee twice... once cold turkey, once progressively after getting back into it through the devious paths of coca-cola and green tea (I didn't realise green tea had caffeine).

      I found that breaking off progressively was *much* easier than all-of-a-sudden. You don't get all the psychological trip where your brain tries to convince you that you *must* have a cup otherwise something bad will happen (eg. you won't be sharp enough to do your job, etc). Breaking off cold turkey was a nightmare for a whole week, then progressively got better. Breaking off progressively (cutting my consumption by half every week, until I was having half a cup of espresso every other day, and then nothing at all) worked a LOT better, very smoothly. I don't even recall having any coffee cravings when I did that.

      Daniel

      --
      Carpe Diem
    2. Re:best not to have any coffee by TheCarp · · Score: 1

      I went through massive caffine withdrawls in High School once. It was horrid. After that I developed a different way of working with caffine.

      Still to this day, I tend to like alot during the work day... but if I continue caffine past the end of the work day, its horrid for my sleep. (instead of awake to asleep in 5 minutes, it can take 2 hours, if i have even 1 cup of coffee within 5 hours or so of sleep)

      Anyway, I tend to drink alot, until I hit the very first morning headache before my coffee... then I go cold turkey for at least a week. (unless i have a deadline or other reason to need to dip a little further into the addictive cycle, but I never let that last more than an extra day or two)

      Its workign so far. Lately I have found half-caf to be key. I like to drink so much coffee that if I drink it full strength, then I am so buzzed by about 1 pm that I can't focus on anything, I am just jumpy and excited.

      I dunno... its what works for me. I do have to wonder, how much of these heart effects were "coffee" specifically, and how many were just caffiene? Admittedly, for the average person, coffee is the most caffinated drink that they encounter, and most regularly, so even if it is caffine solely causing these effects, its still coffee doing it most of the time... but... it does beg the question, doesn't it?

      -Steve

      --
      "I opened my eyes, and everything went dark again"
    3. Re:best not to have any coffee by flyingsquid · · Score: 4, Interesting
      As with all addictive substances, it's best not to become addicted. Two cups a day means you are addicted. If you "need" a cup a day, you are addicted.

      It's not like it's freakin' heroin or something. First of all, you're probably better off being a "hard-core" coffee addict than a casual user of cocaine or heroin. Second, last time I checked there weren't any twelve-step programs for coffee drinkers, or patches to help them quit. That suggests that either people don't have a problem with being regular coffee drinkers, and/or they don't have much of a problem quitting if it's making them irritable, sleepless or whatever.

      The whole "addiction" thing is just a little out of hand. When I'm working out in the desert I may drink two liters of water a day, and damn sure I feel a "need" for water when its 90 degrees. So I'm a water addict? To be an addiction, I think it has to (a) be seriously detrimental to your well-being, and (b) you have to have serious trouble quitting. Coffee doesn't meet either of those criteria.

    4. Re:best not to have any coffee by Anonymous Coward · · Score: 0

      I fully agree regarding addictive substances, I used to drink four glasses of water a day before a friend spoke to me about my addiction. Cold turkey wasn't an option as the withdrawl was simply too painful, but I've since cut back to two glasses a day.

      On a serious note, I think it is important to consider the harm involved as opposed to simply the addiction. If coffee has positive health benefits then you have to weigh that with the disadvantage of not being able to function without it.

    5. Re:best not to have any coffee by Hatta · · Score: 3, Interesting

      It's not like it's freakin' heroin or something. First of all, you're probably better off being a "hard-core" coffee addict than a casual user of cocaine or heroin.

      Actually, if you're sure of the purity and dose of your heroin it's very physiologically benign. It's just an opiates, and pain patients use opiates their entire lives. If heroin were legal it would be cheap enough that addicts wouldn't have to steal to get it, and wouldn't be stigmatized by being an addict. Because of tolerance the actual deleterious effects of being opiated go away. They could live entirely normal lives.

      --
      Give me Classic Slashdot or give me death!
    6. Re:best not to have any coffee by justthinkit · · Score: 0
      I didn't realise green tea had caffeine

      Worse than that, tea in general has high concentrations of fluoride. http://www.just-think-it.com/f-facts.htm

      --
      I come here for the love
    7. Re:best not to have any coffee by Omestes · · Score: 1

      I went through a severe caffeine withdrawl in college once, it was probably the first time since I was 9 that I went 12 hours without any caffeine. My solution was tylenol, and a quick run to the local coffee shop for a double espresso, and a bag of freshground.

      After that, the solution was to always keep some coffee (or if worst comes to worse, pop) ready at hand. Seems to have worked, never got the lethargy or headache again.

      But then again, I doubt I'm at risk, or carry this gene, I'm pretty far from a "slow metabolizer", I can eat like a pig, and never gain a pound, and get plenty of exercize.

      This is one of those damn fad things. Dietary issues are full of them. I'll wait a year or ten before taking EITHER study seriously, since they will surely flip-flop 6 million times before anyone thinks they know anything. And I take genetic findings with a big grain of salt, since people have claimed to have found a "gene" for everything now. Also, there are many factors, as someone else has stated, that could play into this.

      Besides, something has to kill me. I enjoy drinking coffee, and if it turns out to be the death of me, sobeit. Its all about quality of life, not quantity.

      --
      A patriot must always be ready to defend his country against his government. -edward abbey
    8. Re:best not to have any coffee by Omestes · · Score: 0, Flamebait

      Err...

      and pain patients use opiates their entire lives.

      Yes, because they are in chronic pain, pain which hurts their livelyhood, and quality of life. Your average junky is just a tool who is to weak to live life as it is. And being that opiates are severely addictive, they probably won't quit the smack to see that life is actually quite a nice place. And because the fact that it is addictive their quality of life will still suffer. Opiates to build tolerance on their own, so said legal junky will still need more and more.

      and wouldn't be stigmatized by being an addict.

      Sure, like alcoholics aren't? Good example there, alcohol = legal drug, and a large portion of the population is directly harmed by it. Be it through drunk drivers, domestic abuse, or just the general unpleasantness that exists in being around them. Stigma exists for a reason, not because it is illegal.

      They could live entirely normal lives.

      Ignoring a fact that they are incapible of actually living a normal life. I live a normal life, I can tolerate the world without mainlining my pleasure centers to oblivion. I guess normal in the sense of that famous rat with a wire to its pleasure centers that starved to death.

      Why did I respond? I already regret this.

      --
      A patriot must always be ready to defend his country against his government. -edward abbey
    9. Re:best not to have any coffee by miskatonic+alumnus · · Score: 1

      Your average junky is just a tool who is to weak to live life as it is.

      Your average dancer, sports fan, extreme athlete, poker player, movie afficionado, stamp collector is to weak to live life as it is. Who are you to condemn someone's choice of escapism?

    10. Re:best not to have any coffee by Hatta · · Score: 4, Insightful

      Open your mind, most junkies are just normal people who made some bad choices. Given that we can't stop them from using, we may as well try to minimize the damage those choices inflict.

      Opiates to build tolerance on their own, so said legal junky will still need more and more.

      People on heroin maintenance programs tend to acclimate to a dosing schedule that keeps them functional. They're so tolerant that they literally can't get enough to get high, so it's barely worth considering them intoxicated.

      Sure, like alcoholics aren't? Good example there, alcohol = legal drug, and a large portion of the population is directly harmed by it. Be it through drunk drivers, domestic abuse, or just the general unpleasantness that exists in being around them

      So your solution is to prohibit alcohol? Look how well that worked... Besides, the comparison between alcohol and heroin is very tenuous. The violence caused by alcohol is pharmacological, the violence caused by heroin is sociological.

      Ignoring a fact that they are incapible of actually living a normal life.

      That's just ignorant prejudice. Heroin maintenance works.

      If you hate heroin addicts so much, why not advocate legalization so it will be easier for the bastards to get what's coming to them?

      --
      Give me Classic Slashdot or give me death!
    11. Re:best not to have any coffee by Omestes · · Score: 1

      I think there is a large difference between dancing, movies, or stamp collecting, and purposely messing with addictive substances which alters your brain chemistry. If I quit stamp collecting, there is no physical withdrawls, now is there? Sure, I might miss it, but it won't lay me out. I don't physically NEED to collect stamps, nor is it altering my brain chemistry.

      If you made the claim for pot, I wouldn't argue, since it is non-addictive, and has life-effects no worse than alcohol. But heroin remains the most addictive drug around (besides perhaps methamphetimines), and it can still (no matter how pure) lead to a social burden.

      --
      A patriot must always be ready to defend his country against his government. -edward abbey
    12. Re:best not to have any coffee by vandon · · Score: 1

      This proves that coffee is good.

    13. Re:best not to have any coffee by kaniaro · · Score: 2, Funny
      Maybe not an addiction, but definately bad for sotware development. According to the APA:
      "Bill Gates has been quoted saying that his programmers can program for 72 hours straight," Stickgold says. "And I say-yeah, but their product is Windows."
    14. Re:best not to have any coffee by miskatonic+alumnus · · Score: 1

      If I quit stamp collecting, there is no physical withdrawls, now is there?

      So, don't quit using the drugs.

      I don't physically NEED to collect stamps, nor is it altering my brain chemistry.

      Altering brain chemistry isn't necessarily a bad thing. In fact, it happens all the time. The reason psyhotropic drugs have an effect on the brain is that our brain naturally operates on psychotropic drugs (albeit different ones). Going without sleep or taking OTC pills or even eating certain foods alter brain chemistry.

      But heroin remains the most addictive drug around (besides perhaps methamphetimines), and it can still (no matter how pure) lead to a social burden.

      I believe that barbiturates are actually the most addictive drug, and the most difficult to kick --- you actually need medical assistance doing it, or you'll die. Anyway, many people have fed an opiate (morphine) addiction and led relatively normal lives. Besides, the social burden of heroin addicts pales in comparison with the legions of unemployed and underemployed citizens.

    15. Re:best not to have any coffee by Jaknet · · Score: 1

      Not too sure, but I believe you will find the out of all of them it's Tobacco that is actually the most addictive.

      But then whatever survey you use to compare these, it's all just statistics.

    16. Re:best not to have any coffee by raoul666 · · Score: 2, Interesting

      So your solution is to prohibit alcohol? Look how well that worked... Besides, the comparison between alcohol and heroin is very tenuous. The violence caused by alcohol is pharmacological, the violence caused by heroin is sociological.

      Overall I agree with you, but I just thougth I'd mention that some studies suggest that the link between alcohol and aggression is sociological as well - in a study I read, people who believed they consumed alcohol, whether they had or not, were more aggressive than people who didn't think they had consumed alcohol, whether they had or not.

      --
      When cryptography is outlawed, bayl bhgynjf jvyy unir cevinpl
    17. Re:best not to have any coffee by Omestes · · Score: 1

      First, I never did a 1:1 equation of alcohol to heroin, I was just saying that legal does not = good, and that stigma does exist for a reason other than legality. Stigma exists because of the effects of addiction, legal or non.

      Sure, maintenance works. Never denied that, being that it wasn't the topic at hand. And successful mainenance would have the goal, one would think, of cutting the habit. Otherwise it seems rather pointless, even by your own logic, since there isn't even a high involved.

      My solution isn't to prohibit alcohol, since that isn't the topic, and I never made any noise towards that end. Again, alcohol was an example of something completely different.

      I really don't hate heroin addicts, I've know too many of them (and addicts of other 'hard' drugs) to hate them, pity them would be a better choice of words.

      Whats coming to them is completely by their own hands, and the job of a responsible and intelligent citizen would be then to help them. Helping them would include your beloved maintenance, with intent to cut the addiction, not to prolong it indefinatly.

      And the public goal should be education to keep people away from it.

      Now, as an aside (to this aside) how the hell did I get modded as flamebait? Appearently thinking that drugs are not acceptable towards quality of life is not popular to /. mods. Explains a lot of odd /. behavior, I guess.

      --
      A patriot must always be ready to defend his country against his government. -edward abbey
    18. Re:best not to have any coffee by Omestes · · Score: 1

      Self improvement is wrong, I agree. If you cannot live happily in the real world, by all means reach for the needle instead of learning to cope. Sure. I think we should also hand out handguns to people with chronic depression.

      The thing, in the end, has nothing to do with the indvidual, it has to do with the price to society. People on junk generally do not have the rather hefty means to feed their monkey. And purity has little to due with this, nor does legality. When it comes to pressing the pleasure-center button, it can tend to become more desirable than gainful and legal employment. Thus, these people end up on the public dole, or doing shortcut means for drug use. Thus it becomes a public matter to regulate.

      Yes, to the food/activity argument, things change brain chemistry. You reading my post will, looking at the sunset, having a child born, falling in love, eating a good taco, all these do too. But not in a serious way that affects your behavior, or society at large in a deleterious way. I like cocoa, it influences the opiate content of my brain in a way much like heroin (opiates), but to a much lesser extent, with no long term addiction, or problems. You name a food that will get me addicted for a long-term, and harm my ability to participate in society.

      Yes, some junkies have legally interacted in society. But a far larger portion have not. Having unprotected sex with someone with HIV/AIDS is not 100% infectious, but is it a good idea? Nothing is 100%, does that make everything okay?

      And for a philosophical question (which is where I'm really going from, in the beginning), how is being attatched to anything (especially artificial) things a good or desirable thing? And how can I, in good faith, stand by and watch it happen?

      Where I grew up methamphetamines were, and are, the big thing. I've seen it kill, and mess up many a promising life by getting there early in life. It is insideous. Sure, a case can be made for functioning tweakers, a small minority, but a majority of them don't stay functional very long, it is unstable. And a when they cease to be functional it becomes our problem, our being all of us.

      All junkies need help, be it alcohol, heroin, amphetamines, or OTC pills. Granted I don't think the draconian "war-on-drugs" is a viable answer, but neither is legalization. There is middle ground. Treatment, education, and changing social influence. Much harder.

      --
      A patriot must always be ready to defend his country against his government. -edward abbey
    19. Re:best not to have any coffee by evoltap · · Score: 1

      Stupid comparison, water and coffee. The human body is mostly water and will die without it. So of course you can't be addicted to water. Coffee on the other hand is a stimulant and has psychological effects, often mood lifting. People don't have coffee every morning and at 11 because their bodies require it for survival, they do it because they WANT it, it gives them pleasure. I think something that one wants but does not NEED, and consumes habitually, defines addiction. That dosn't mean it's BAD just because it's an addiction. Everybody has some....TV, chocolate, weed, tea, etc.

      The parent and others i've met seem to cringe at the word addiction and point fingers at "junkies" and such not realizing that to be human is to have some addictions. Acknowledging it and noticing how they affect me is what i do.

    20. Re:best not to have any coffee by Cobralisk · · Score: 1

      Its possible that you're using a different meaning of addiction than the commonly held connotation. I believe that the term addiction is as you defined it, with the added constraint that consumption causes negative side-effects which are ignored by the user in favor of continued use. An example of this would be an alcoholic who loses his job because he was unable to perform his work function while under the influence, but continues to drink anyway and continues to suffer negative consequences. It comes down to priorities, and whether harm in the eyes of the individual occurs. If the above mentioned alcoholic was not fond of his job and did not need it financially, addiction might still be an open case. In my understanding, what you defined is closer to misuse or abuse in the scale of use, misuse, abuse, addiction. Addiction could also be defined as mislabling mentally something you WANT as something you NEED.

      --
      Waiting for ad.doubleclick.net...
    21. Re:best not to have any coffee by Bush+Pig · · Score: 1

      Love your sig.

      --
      What a long, strange trip it's been.
    22. Re:best not to have any coffee by Bush+Pig · · Score: 1

      What's wrong with flouride?

      People of my parents' generation (70+) have false teeth. People of my generation (50+) generally have most of their own teeth, but they're mostly bog with a thin external shell of enamel (or a crown). People of my childrens' generation (20-30) have perfect teeth - no fillings, no crowns, no problems.

      Guess which generation grew up with flouridated water.

      --
      What a long, strange trip it's been.
    23. Re:best not to have any coffee by Bush+Pig · · Score: 1

      > I don't physically NEED to collect stamps, nor is it altering my brain chemistry.

      Are you sure? I think you're protesting too much. I don't NEED alcohol - oh wait, maybe I do.

      I wonder if there's a twelve step program for stamp collectors ...

      --
      What a long, strange trip it's been.
    24. Re:best not to have any coffee by Anonymous Coward · · Score: 0

      Heroin maintenance doesn't work. Sorry, been there, had many friends on methadone and the big picture is that it doesn't help them. At all.

      It comes down to choices we make.

    25. Re:best not to have any coffee by Hatta · · Score: 1

      But heroin remains the most addictive drug around (besides perhaps methamphetimines)

      It's pretty well established that nicotine is more addictive than heroin.

      and it can still (no matter how pure) lead to a social burden.

      Yes, and prohibition only exacerbates the problems.

      --
      Give me Classic Slashdot or give me death!
    26. Re:best not to have any coffee by justthinkit · · Score: 0
      What's wrong with flouride?

      I guess it is time for you to find out, beginning with the spelling.

      People of my parents' generation (70+) have false teeth. People of my generation (50+) generally have most of their own teeth, but they're mostly bog with a thin external shell of enamel (or a crown). People of my childrens' generation (20-30) have perfect teeth - no fillings, no crowns, no problems. Guess which generation grew up with flouridated water.

      Wow, I guess scientists could learn from your methodology then.

      Seriously, I'll just say (1) I'm a chemical engineer with 10 years of chemistry courses that all say the same thing -- briefly that Fluoride is more toxic than lead and almost as toxic as arsenic, (2) fluorine is the most reactive element known to man, (3) the average dental program has zero or one chemistry course in it, whereas I took about a dozen higher ed. chem. courses, (4) everyone can research the issue for themselves, (5) click this http://www.just-think-it.com/the-f-db.htm to find out if your water supply is poisoned.

      --
      I come here for the love
    27. Re:best not to have any coffee by Anonymous Coward · · Score: 0

      Two cups a day doesn't mean you're addicted. I drink ~2 cups a day on average - 0-4 on any given day, but usually 2 - and occasionally go 1-2 weeks at a time without any coffee without having a craving or negative effect.

    28. Re:best not to have any coffee by Omestes · · Score: 1

      This argument is kind of pointless, I doubt either of us will budge, though you did give me something to think about.

      I could see a shift to mild-acceptance, so the money used to incarcerate, and hunt street-level junkies could be saved, and put towards rehab, clean needles, and trying to get the high-level sources of heroin. Much like much of Europe. But the goal should always be to keep as many people off of it, as possible, and to try to cut the strings of addiction in existant users.

      In the end, and "get'em" attitude will fail, since junkies (and I do know this, emotional arguements aside) are people too, wretched perhaps, but the goal of any sane society is to raise everyone to an acceptable level, we can argue the methodology of this, but I have a feeling that we would disagree, perhaps vehemently.

      --
      A patriot must always be ready to defend his country against his government. -edward abbey
    29. Re:best not to have any coffee by Anonymous Coward · · Score: 0
    30. Re:best not to have any coffee by marcello_dl · · Score: 1

      Wow, I guess scientists could learn from your methodology then.

      Well to help future scientist: I am 30 and lots of fillings, ditto my sis, and we got fluorine all the way. Bro in law, same age, drinks lotsa coke (which we don't), raised in germany with no fluorine, perfect teeth.

      Seriously, I'll just say (1) I'm a chemical engineer with 10 years of chemistry courses that all say the same thing -- briefly that Fluoride is more toxic than lead and almost as toxic as arsenic, (2) fluorine is the most reactive element known to man, (3) the average dental program has zero or one chemistry course in it, whereas I took about a dozen higher ed. chem. courses, (4) everyone can research the issue for themselves, (5) click this http://www.just-think-it.com/the-f-db.htm [just-think-it.com] to find out if your water supply is poisoned.

      Gee...

      --
      ---- MISSING MISCELLANEOUS DATA SEGMENT --- [sigdash] trolololol
  74. Forget deathmatch: Google Fight by Gulthek · · Score: 1

    A Google fight between 'coffee heart disease' and 'coffee antioxidants' makes it clear that this no contest.

    Coffee heart disease: 8,860,000 results
    Coffee antioxidants: 1,500,000 results

    Now should I feel like Fry when they discovered what Slurm really was?

    "Ewww!" (sip)

  75. Meh. by failure-man · · Score: 1

    As a graduate assistant in engineering it really is either coffee or cigarettes. They can't seem to decide whether coffee is mostly harmless or slightly helpful, but nobody's gonna argue that cigarettes aren't bad for you.
     
    I'll take the lesser evil/not-evil.

  76. Not just dose. by slughead · · Score: 2, Insightful

    As with anything related to toxicology, the dose is the poison.

    Not to mention the person's physiology. There's a reason they call the lethal dose of something the "LD50", and that's because that's the dose at which 50% of the animals they injected the substance into died. (they measure it in milligrams of drug per kiligram of animal, in case you're wondering).

    Some people are immune to AIDS, some people are allergic to peanut butter, in some people Ibuprophen works for headaches, in others Asprin or Tylenol works. Sometimes people are just plain different.

    There was an article in The Economist (print edition, so I wont bother linking) about how doing DNA tests on people and finding out how they would react to drugs would save a lot of time and possibly lives. The reason we don't is because it's expensive and people (all of a sudden, and seemingly on this issue alone) are concerned about privacy.

    There was a reason 1 out of every 100,000 people who took Vioxx died, and it's not because Merck was "evil," it's because they simply couldn't account for all the different physiologies out there. Don't worry though, the law suits will certainly ensure higher prescription drug prices in the future, all due to ignorance and jerks like James Sokolove. :)

    1. Re:Not just dose. by badmammajamma · · Score: 1

      Actually, it is believed that Merck knew about the death problem and ignored it. I don't know if it's true or not but the drug companies are evil so it wouldn't surprise me. Also, the real reason drugs cost so much is that drug companies spend over 60% of their income on marketing (which includes those little doctor boondoggles) and lobbying. Drugs should require very little marketing. I don't need to see the shit on t.v. since I can't just go get it from the drugstore.

      --
      Any man who afflicts the human race with ideas must be prepared to see them misunderstood. -- H. L. Mencken
    2. Re:Not just dose. by mpe · · Score: 1

      There's a reason they call the lethal dose of something the "LD50", and that's because that's the dose at which 50% of the animals they injected the substance into died. (they measure it in milligrams of drug per kiligram of animal, in case you're wondering).

      Not only can the level of toxicity vary between species but also lab animals tend to be carefully bred to mimimise genetic variation. Thus all you may actually be finding out is that a certain dosage is likely to kill half of a certain strain of rodents. The figure may not even hold for the same species...

    3. Re:Not just dose. by slughead · · Score: 1

      Also, the real reason drugs cost so much is that drug companies spend over 60% of their income on marketing (which includes those little doctor boondoggles) and lobbying.

      Actually it's more like 30%, and it more than likely has little to do with the price of drugs.

      The price of drugs has a direct corrilary to how much they're able to charge for them. Some drugs take years on the market to pay for themselves--especially those speciality drugs that cost $10,000 a dose and are only given once when you're about to die. Drugs like these don't get advertised because they don't need to be, the cost is coming from R&D directly, and something new may come along, making the drug obsolete and a "dead end".

      It takes 30% of the drug companies' incomes to convince you that taking celebrex (a "blockbuster drug") is better than asprin, though it has little advantage. Does it pay for itself? Hell yes. Celebrex paid for its own development plus the development of probably 6 or 8 other drugs, and MARKETING is what sold it. Celebrex itself was practially worthless, I was even on it for a while until my sample box ran out and I told my doc "this **** is totally ineffective, even when snorted." He then gave me over-the-counter "Wobenzeim" and my symptoms were totally gone in 5 days. Studies show only 18% of people have positive results better than placebo.

    4. Re:Not just dose. by badmammajamma · · Score: 1

      Let me put it this way...they spend three times as much on marketing as they do R&D.

      --
      Any man who afflicts the human race with ideas must be prepared to see them misunderstood. -- H. L. Mencken
  77. What is it, really? by spect3r · · Score: 1

    I hear news about coffee every month. We're obsessed with knowing whether or not it is good or bad for you, and people wasting their time figuring out "It may increase your chance of heart disease" and "It may help the war on Alzheimers" seem to be have been on a one lined broken record for the past 5 years. If the obvious health affect, ill or not, aren't apparently evident (I.E. smoking); then relax, and tell the people that "anything in excess of 4 per day might be harmful to your death". Yes, the rule of 4 keep me alive!

    --
    The beatings will continue until Morale Improves!
  78. Genes by aeric67 · · Score: 1, Funny

    These damn genes. I should have gone with the +3 resistance to coffee-induced hypertension and taken the hit on flawed cholesterol transport... Reroll?

  79. HA! Take that, you caffeine-addicted wankers! by wheany · · Score: 3, Funny

    I really don't get geeks' caffeine worship. Some seem to think that it's somehow a good thing to not be able to wake up properly before drinking half a pot of coffee.

    Oh, and all you self-righteous green tea drinking hippies are no better.

    1. Re:HA! Take that, you caffeine-addicted wankers! by arkane1234 · · Score: 0, Flamebait

      And those smug, self important asshats who think they're somehow better than everyone else...
      I hate them...

      --
      -- This space for lease, low setup fee, inquire within!
    2. Re:HA! Take that, you caffeine-addicted wankers! by wheany · · Score: 1

      Zing! You sure showed me!

    3. Re:HA! Take that, you caffeine-addicted wankers! by Creepy · · Score: 2, Funny

      I can think of a several good reasons to worship caffeine

      1) it doesn't impair your ability to work, which isn't true for most other substances
      2) it's often free at workplaces and available at schools (usually in soda form for the latter)
      3) it's better than being SMITTEN by the CAFFEINE GOD, you self-righteous caffeine-free prick.

      ok, 3 was really to poke fun at you ;)

    4. Re:HA! Take that, you caffeine-addicted wankers! by wheany · · Score: 1

      Where the hell did I say that I'm caffeine free? I drink coffee several times a week. That doesn't mean I think that caffeine addiction is somehow admirable or cool.

  80. I prefer chemical warfare by csoto · · Score: 1

    This is why I have coffee after a night of liquor. Let them duke it out for control of my heart.

    --
    There exists no way of exchanging information without making judgments. --Bene Gesserit Axiom
  81. In other news... by danpsmith · · Score: 1

    cigarettes not really a good weight loss tactic.

    --
    Judges and senates have been bought for gold; Esteem and love were never to be sold.
  82. You can take my coffee ... by j_cavera · · Score: 1

    ... when you pry it out of my cold, dead (yet still shaking) hand!

    --
    #include "humorous_pop_culture_reference.h"
  83. "Contradictions" in science by raygundan · · Score: 1

    It's only pathetic that people can't understand the difference between "An apple is good for your diet" and "An apple is bad for your teeth."

    Both can be true at the same time. No contradiction, just lousy reporting or lousy reading comprehension.

    Perhaps instead of throwing your hands up and whining about science contradicting itself, you could instead make the logical conclusion from those two statements that you should eat an apple now and then and brush your teeth afterward.

    1. Re:"Contradictions" in science by ultranova · · Score: 1

      you should eat an apple now and then and brush your teeth afterward.

      Not a good idea. The sugar and acid in the apple soften your teeth, making them less able to defend against the mechanical stress caused by brushing. Just eat Xylitol bubblegum afterwards, that'll kill the nasty bacterians dead.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    2. Re:"Contradictions" in science by raygundan · · Score: 1

      Fair enough, and just another example of one of those things people might see as a "contradiction."

      Brushing my teeth is good! Wait, now it's bad after eating apples! Science can never make up it's mind!!

      (Assuming this info is true) You should eat the occasional apple, chew xylitol gum afterwards, and continue brushing your teeth the rest of the time.

      Incorrect conclusions: "I should stop eating apples!" "I should stop brushing my teeth!" "I should eat 100 apples every day because they're healthy!" "I should chew Xylitol gum every waking moment!" "I should quit listening to scientists!"

  84. Shweet. by raygundan · · Score: 1

    Just making sure. Intent in internet posts can be notoriously hard to decipher sometimes.

    Science must be even harder to decipher, given the difficulty people seem to be having.

  85. Know your genes Or... by Luyseyal · · Score: 1

    Know your genes OR switch to decaf! :) Yeah, I'm aware of that recent study that says decaf may be bad for you. However, it didn't study the various kinds of decaf and I seriously doubt water-filtered Arabica decaf is very much different from run-of-the-mill Arabica coffee.

    Cheers,
    -l

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    1. Re:Know your genes Or... by bware · · Score: 1

      Except for that caffeine part.

    2. Re:Know your genes Or... by Carewolf · · Score: 1

      Most decaffs like instant coffee is not meant for coffee affectionaries. They are more or less all crap, undrinkable without adding sugar and milk.

    3. Re:Know your genes Or... by Luyseyal · · Score: 1

      Right, which is why I don't recommend most decafs. :) If you genuinely love coffee, you drink decaf. Everyone else is just a caffeine whore!

      OK OK I'm exaggerating. The nice thing about the quality decaf that I buy is that I get to drink a pot every day. If I was drinking that much caffeinated, I'd never get proper sleep and experience various health problems. I got sick of the insomnia so I quit about three years ago.

      On Fridays, sometimes I'll mix in a little caffeinated from upstairs to get a little buzz.

      -l

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  86. No free lunch by HardFocus · · Score: 1

    Alas, there are not enough antioxidants in coffee to offset even a fraction of the highly free-radical sugar that most people put in their coffee, never mind the rest of their diet.

    Anyway, the gene in question is linked to caffeine metabolism not to coffee metabolism. But the "questionnaire revealed that quaffing coffee boosted the risk of a heart attack in those who had genes making them slow metabolizers."

    So tell me.... were those coffee drinkers putting sugar in their coffee? Were they fat? In the absence of obesity, what was their daily carbohydrate intake?

    My reasoning is sugar raises your insulin which has a stronger link to heart disease than either coffee or caffeine ever did. Other studies have linked high blood pressure to heart disease.

    Other studies link caffeine to high blood pressure. But from what I can tell those studies only studied people with high blood pressure to start with. I have never seen a study that shows that, in the absences of high blood pressure, that caffeine raise it to "abnormal" levels.

    Incidentally I used to have high cholesterol and high blood pressure. Now both are normal. I'm 50, my BP is 120/70 and I still drink 8 mugs (that's 16 cups) of coffee a day.

    I'm not saying coffee is good for you.... just that the genetic link to heart disease should basically be ignored.

  87. Next on slashdot... by TangoCharlie · · Score: 1

    Red wine not good for you!
    Beer not good for you!
    Watching porn good for you!
    Watching porn makes you blind!
    Watching porn doesn't make you blind!
    Cocaine is good for you!
    Cocaine is not good for you!
    Red wine IS good for you!

    Take your pick.

    Mine's a strong black coffee.

    --
    return 0; }
  88. This study once said.... (and it disagrees) by raygundan · · Score: 2, Informative

    It's not the dose that matters here, it's whether or not you have a particular gene that slows the metabolism of caffeine.

    For folks with the gene, even two cups was harmful. For those without, the more the merrier. Please read more carefully.

  89. I don't like coffee by DrewCapu · · Score: 1

    I'd much rather have a cupful of liquid that is almost, but not quite, entirely unlike tea.

  90. No. by raygundan · · Score: 1

    In other words, keep it to a cup or two a day and you'll be fine.

    According to the study, two cups a day raised the risk of heart disease by 36% over one cup in people with the gene. The article does not say how much a single cup raises your risk.

    It's not the !@#!@#!! dose in this case, as so many people are wrongly pointing out, it's whether or not you carry a particular gene. Without the genes, coffee reduces your risk of heart attack.

    1. Re:No. by mpe · · Score: 1

      According to the study, two cups a day raised the risk of heart disease by 36% over one cup in people with the gene. The article does not say how much a single cup raises your risk.

      "Cup" is a variable quantity as is ammount of coffee people put into their cup.

    2. Re:No. by Descalzo · · Score: 1

      In the context of a scientific study, a "cup" of coffee would be 8 fl. oz.

      --
      I cried real tears when Li Mu Bai died.
    3. Re:No. by Hal_Porter · · Score: 2, Funny

      A US cup is 236 ml

      Or it's 48 US teaspoons

      or half a US pint, or 41.6% of a uk pint

      If the cup were full of tea made out of antimatter and it combined with a cup of normal matter it would produce a blast of about

      10.6 megatons

      So 22g of antimatter+22g of normal matter=1 megaton. This is a very useful thing to know

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
  91. Uhh.. by Anonymous Coward · · Score: 0

    Extra! Extra! Bacon is not a healthfood! Shockwaves sent across scientific community

  92. coffee has to be good for you by confused+one · · Score: 1
    If I don't drink it, I get all shaky and have a headache. I drink the coffee and feel better! Empirical evidence that coffee must be good for you.

    I remember mumbling something, just this morning, like "you'll get my coffee cup when you pry it out of my cold dead hands." Never mind, just the ramblings of a coffee addict.

  93. EEEAAARRRrrrrgGGggghhhhh by raygundan · · Score: 1

    Pardon my exasperated screaming-- people seem to be totally misreading this study.

    This study is not showing that moderation is key, it is showing that the genes you carry are key. Previous results that as many as four cups of coffee a day reduce risk of heart attack still stand for folks not carrying two copies of the slow-caffeine-metabolism gene.

  94. Caffeine as a meditation aid by kwahoo · · Score: 2, Interesting

    I like to have a dose of espresso before meditating. It makes it more challenging. /K

  95. Warning: This May Be Harmful To Your Health by ackthpt · · Score: 5, Funny
    "Coffee Maybe Not a Health Drink!" Gasp! :-)

    From a life-long geek's perspective:

    • I've sat for hours, for years in front of 25" colour TVs before they reduced radiation emissions.
    • I've eaten countless bags of crisps flavoured with chemicals for visual and taste enhancements and dusted with MSG
    • I've eaten countless pounds of fried foods
    • I've made my share of /. typos (inadvertent and purposful)
    • I've raced on a bicycle over 60 MPH downhill
    • I've been hit with kilovolt shocks
    • I attended dozens of indoors Hamfests, choked with the smog of hundreds of cigarettes, plus a few pipes and cigars.
    • I've been run over by a car
    • I've drunk a Mickey's Bigmouth
    • I flew on a jet that bounced on the runway at Baltimore
    • I fell out of a raft in the middle of Lost Paddle class V rapids in the Upper Gauley river of West Virginia
    • I've collided with my brother's sled on an icy hill in Michigan, nearly fracturing my skull.
    • I've been in 3 auto accidents
    • I've lept off a 40 foot cliff into a flooded quarry
      • I'm not done yet.

        Regarding health, it will be bad for someone's if I don't get my coffee.

    --

    A feeling of having made the same mistake before: Deja Foobar
    1. Re:Warning: This May Be Harmful To Your Health by BeanBunny · · Score: 1
      Hmmm... Remind me not to stand next to you.

      ;)

  96. over hydration by Tmack · · Score: 1
    That's actually been a problem for several years now at marathons, half-marathons and other road races.

    Add in triathlons, bike races, etc... its to the point where the sports supplements companies have started making stuff specifically to combat it. The last Tri I was at one of the free-bes in the grab bags were electrolyte pills. Basically capsules of salts and such to keep you from bonking from losing electrolytes through sweat or diluting them too much by drinking alot of water.

    tm

    --
    Support TBI Research: http://www.raisinhope.org
  97. The balance in this study by raygundan · · Score: 1

    Is not how much coffee you have, but rather balancing whether or not you have the gene that makes coffee bad for you.

    I don't believe "being born with a slow caffeine-metabolism gene" is something you can do in moderation. For everyone else, as many as four cups a day is still good for your heart attack risk.

  98. Re:This study once said.... (and it disagrees) by gfxguy · · Score: 1

    It's like that with everything, though, and people need to be more attuned with their bodies... remember when low-carb diets were all the craze? You know what? It worked really well for me... some people respond better to losing weight by cutting fat, some people respond better by cutting carbs. But more than weight, it had a lot of other positive effects for me. I won't go into detail because it's OT.

    I was continously diagnosed with high blood pressure by my doctor. After I stopped drinking regular coffee, my blood pressure dropped into the normal range... but there's more, it's more than just caffeine - because when I stopped drinking de-calf, too, my allergies to pollen went away. And when I thought back, they started while I was in college... right around the time I started drinking coffee.

    Some people should be eating more vegetables, some people less... everyone is different.

    --
    Stupid sexy Flanders.
  99. One substitute. by Piranhaa · · Score: 1

    Green Tea

    1. Re:One substitute. by klang · · Score: 1

      Oolong, maybe...

  100. Well, I guess you're right! by ursabear · · Score: 1

    CAFFEINE SEZ:ARE YOU REALLY REALLY REALLY REALLY REALLY SURE THAT COFFEE CAN BE BAD FOR US BECAUSE YOU KNOW THAT IT HAS SUCH WONDERFUL BENEFITS LIKE MAKING SURE YOUR BRAIN IS OPERATING AT OPTIMUM WARP AND CAN EVEN KEEP YOU AWAKE LONG ENOUGH TO SIT THROUGH YET ANOTHER MEETING WITH PEOPLE THAT WANT TO ARGUE ABOUT NITS BUT REALLY IT ISN'T THE CAFFEINE IT IS ALL ABOUT THAT WONDERFUL BREWED-IN-THE-SAME-POT-FOR-10-YEARS-WITHOUT-CLEANI NG TASTE BUT REALLY YOU CAN SOMETIMES STICK A FORK IN IT AND THE FORK WILL STAND UP.

    But seriously folks... so many things we consume are not good for us. Some coffee additives add loads of cholesterol, and others add chemicals that we don't fully understand.

    However , coffee is a social drink that doesn't cause accidents, and is great when you're cold or when your throat has dust bunnies first thing in the morning. If nothing else, life is what we make of it - and the social interaction that often surrounds coffee is generally a very good thing. I sincerely hope that conclusive studies don't find major issues with coffee - it adds to the experience of life these days.

    Besides, Tim Horton's/Starbucks are great places to meet folks! (In other news Starbucks and Tim Horton's merge into Timbucks...)

  101. Holy Jumpin' Jesus! by Anonymous Coward · · Score: 0

    Will you just SHUT THE F**K UP and GO AWAY!?! You give us almost an entire week of freedom from your stupidity only to come back with some stupid post that isn't even all that funny! Yet, your fanboys mod you up while a similar post gets hit with an "overrated", probably by the same, idiot fanboy who modded you "funny".

    Idiot. I'm shocked that you didn't get your beloved, egocentric, "hey, everyone, look at me" first post.

  102. Wwhhaattt heeaaalllthh iiissueeess??? by Anonymous Coward · · Score: 0

    II dddddrriiinnk 44 ppppppootttss aa ddayyy. III haaaaavvee nnnnnneevverr bbbbbeeeeeennn hheeaallllthiiieerrrr. I jjjjussssst wwiisssshh ttttthhhhheeeeessee ccoonnssttttaanttt eeaarrthqquuuaaaakees wwwwouuldd sttopp!!

  103. Why do you drink it? by jago25_98 · · Score: 1

    1) Everyone is different

    2) Why are you drinking it?

    It compounds the effects of smoking. Are you drinking it because you life sucks and it helps you forget you got the late morning and aftertoon to go yet?

  104. The best way to moderate intake... by Dixie_Flatline · · Score: 1

    ...is to become a snob. Because you can't permit yourself to drink the brown water that they serve in the lunchroom, or the over-roasted, over-heated stuff at Starbuck's, you're forced to find a nice small espresso shop, or buy a machine for home.

    Drink less of the crap and more of the good stuff, and not only will your intake drop as you savour your shot of espresso or your well-made cappucino (BTW, if it comes in something the size of a bowl, it's wrong. A good cappucino is smaller than a regular cup of coffee) but you'll feel good about drinking less.

    Besides, part of being a geek is analysing things to death and a streak of rampant snobbery. It's why I used to run Linux, and why I run OS X now. I drink my coffee black, and Tim Horton's can pour their drek down the sink!

  105. uh by Anonymous Coward · · Score: 0

    What are you, 6?

    "coffee maybe not" ....

  106. key piece of the puzzle is missing... filtered? by Creepy · · Score: 2, Interesting

    I don't mean to discount their identification of a genetic link (which I think is valid), and I have no idea how Costa Ricans drink their coffee, but previous research has identified a risk in unfiltered coffee like that through a percolator or French press (or Turkish, Espresso machine, etc) vs filtered coffee. Since terpenes (oils) in unfiltered coffee are suspected raising cholesterol, it is possible that elevated cholesterol levels from drinking unfiltered coffee may also play a role here.

        In any case, having that gene and drinking a lot of unfiltered coffee would put a person most at risk, I would think.

  107. Obsessive much? by Anonymous Coward · · Score: 0

    As you said, TMM's been away for a week, and the moment he posts again, you leap all over him, frothing at the mouth.

    You must really have a hard-on for the Monkey. That week he was away must have been simply devestating for you.

    1. Re:Obsessive much? by Anonymous Coward · · Score: 0

      TMM, you homo, how many times do I have to say, DON'T defend yourself as AC pretending you are not you. It is totally obvious, and you're not fooling anyone, just showing once again how incredibly pathetic you are.

    2. Re:Obsessive much? by Anonymous Coward · · Score: 0

      Let me give you a hint, Rhombus. That AC you were replying to? That's actually none other than Zonk.

      ^_~

    3. Re:Obsessive much? by MyLongNickName · · Score: 1

      This is getting sad. TMM has resorted to hacking folks accounts to post pro-TMM material ;)

      --
      See my journal for slashdot ID's by year. Mine created in 2005. http://slashdot.org/journal/289875/slashdot-ids-by-year
    4. Re:Obsessive much? by Anonymous Coward · · Score: 0

      Y'see, I'm really PROJECTING. Yeah, PROJECTING. That's what my therapist said. See, I REALLY, REALLY want to suck cock, but have issues with that. Anyone who REALLY DOES suck cock, like TMM, is likely to draw a reaction from me. Like, I'm PROJECTING my hatred for homos by getting all steamed by TMM and his flaming ways. I mean, the way he puts himself in front of thousands of smelly male geeks and makes them WANT him... well, it pisses me off, and I wish I was as comfortable being a homo as TMM is. That's the real issue. It's all my bad.

  108. Who funded the study? by deviantphil · · Score: 5, Insightful

    A lot of who is right depends on who funded each study and what they set out to prove (or disprove) in their study.

    1. Re:Who funded the study? by bunco · · Score: 1

      PepsiCo? Get all those coffee addicts freaked out. When they start itching, they'll surely turn to cola.

  109. Coffee can be both good and bad by CodeBuster · · Score: 1

    In light of other studies linking antioxidants in coffee to a reduction in heart disease, who is right?

    Perhaps they are both right. I remember reading in one study that coffee contains hundreds of different chemicals and compounds and that there is no data regarding the possible long term effects of many of these chemicals. It is quite possible that coffee contains both good and bad things, but either way I will not stop drinking my coffee just because of reports like this, although I do drink fewer than 4 cups per day already anyway.

  110. Abuse kills by LinuxRulz · · Score: 1

    Won't people understand this! Coffee may be good, like plenty of other things. But anything can be bad if you abuse. It's a matter of balance. Stop believing that something is bad for your health because if you take too much it has nasty consequences. Taking too much coffee is unhealthy, as can be taking too much water, so I don't believe we should take too seriously that article.

  111. Just a thought by Descalzo · · Score: 1
    At one point, you DID quit cold turkey. The second you finished your last cup, you suddenly went from drinking coffee to not drinking coffee anymore.

    I know what you mean, but this is just a thought.

    --
    I cried real tears when Li Mu Bai died.
  112. Caffeine... not a drug. by Anonymous Coward · · Score: 1, Funny

    Caffeine is not a drug. It is an essential nutrient, necessary for proper brain function in humans.

  113. The STRESS of not knowing what to eat by JohnnyGTO · · Score: 2, Funny

    is going to kill us!!

    --
    Si vis pacem, para bellum! For evil to succeed good men need only do nothing!
  114. As a self-appointed coffee expert... by llthomps · · Score: 1

    Coffee lovers have been trying to extoll the virtues of coffee for decades. In the 192x book "All About Coffee" (still considered the foremost book on the coffee trade), an entire chapter is devoted to the medical benefits of coffee, including quotes from doctors saying things like, "There is strong medical evidence suggesting that a cup of coffee a day is not only harmless, but a benefit to the fortitude and energy of the individual." This continues modernly, as many of you have noted above, with studies about the heart & the brain & worker productivity. Recently, I read an article claiming coffee drinkers were less likely to committ suicide - which is awesome, because I don't want to committ suicide.

    On the other side are the green tea drinking, yoga people who think coffee ruins your nervous system, and vehemently attack it because they assume we are ignorant of what they think.

    And let's face the facts - who cares? Life isn't living without coffee. If I found out that cofee was going to make me shit out my kidneys in 45 years - I'd probably drink more water and hope for the best.

  115. Addiction by just_forget_it · · Score: 1

    Coffee and caffeine addiction can be a problem for people that have addictive personalities. I, for example, have been drinking coffee for 5 years (I'm 23, started at around 18). I drink maybe 3-4 cups a week. I can get through a day without drinking it and be fine. In fact, some days I have found a liter of water to be much more rejuvenating than coffee. My favorite drink at Starbucks though is a venti Chai with 3 espresso shots, but I usually burn out on caffeine afterwards and don't drink any more for a while. I believe that it is healthy for most people, but can be harmful in excess. Of course celery is good for you too, but if you eat 100 lbs of it, you're going to gain 100 lbs.

  116. Potatoes or Water pick your poison by bombadillo · · Score: 1

    excess coffee drinking (4+ cups a day) could lead to an increased risk of heart disease if you have the wrong gene.

    In related news. If you eat over 8 potatoes in a day or drink large amounts of water you will die.



    It's all about moderation folks.

  117. It takes way less than one cup of coffee by justthinkit · · Score: 0

    to wreck a keyboard, even the great IBM original. This was the only IBM keyboard I've ever seen fail too.

    --
    I come here for the love
  118. In other news... by UNOStudent · · Score: 1

    ...eating 15 pounds of carrots daily may also be harmful to your health.

  119. Genesis by ryokuin · · Score: 1

    I'm feeling so confused today
    they've gone and changed the rules again
    cos in my life I'm trying hard
    to do it all so I can remain
    healthy and sane

    I'll live forever, always one more tomorrow
    living forever, always one more tomorrow

    I heard it on the radio
    too much of what they said wasn't so
    and now we've got to do those things
    that they thought before were so wrong
    to be healthy and strong

    and live forever, always one more tomorrow
    living forever, always one more tomorrow

    I know we don't need you
    I know we don't believe you
    you don't really have the answers
    you think you know better
    you think it really matters
    you just want to rule over everybody's lives

    I think I'll change my life today
    gone are the times of taking care
    and I really don't need a reason why
    all I need is all in a day
    survive in a way

    or just till tomorrow, there's always one more tomorrow
    living forever, do you really want to live forever

  120. Not bad... here is another version by SylvesterTheCat · · Score: 1

    I like this one better...

    It is by coffee alone I set my mind in motion,
    It is by the beans of java that thoughts acquire speed,
    The hands acquire trembling, the trembling becomes a warning.
    It is by coffee alone I set my mind in motion.

  121. Q: who is right? A: it depends on you. by gordguide · · Score: 2, Informative

    Q: " ... In light of other studies linking antioxidants in coffee to a reduction in heart disease, who is right? ..."

    A: Since it's the presence of a gene that matters which is right, Check family history:
    Look for heart disease or diabetes (essentially, the same thing as far as your likelihood of heart disease goes). If found, avoid coffee.
    Check family history again, look for average age at death. If less than 60 for males, assume heart attack, avoid coffee.
    For females, ignore childbearing age, look for deaths aged 40~60. If found, assume heart disease, avoid coffee.

    If most of your ancestors and siblings seem to live past 70, assume decent heart, drink coffee.
    If most live past 80, you may safely ignore cause of death, even if from heart attack, because they didn't "really" die of a heart attack, they died because they were healthy and got old, like all healthy people do and everyone dies of something. Drink coffee.

  122. Study confirms that... by JetScootr · · Score: 1

    Laboratory researchers cause cancer in lab rats...

    --
    Pavlov wouldn't be so famous if he'd used a can opener instead of a bell.
  123. I have an axiom by Swisssushi · · Score: 1

    Life results in Death.

    Given that, eat well, drink well, be kind, and you'll die when it's time.

    --
    Swisssushi - When the going gets tough, get some tenderizer
  124. re: Stimulants by Wizardry+Dragon · · Score: 1

    I Am Not a Doctor, but any high dosage of stimulants (and coffee is a stmiulant - specifically, caffiene is) runs the risk of nervous system failures - the brain can only take -so- much activity. The heart can only pump so fast, as well.

    ~ Wizardry Dragon

  125. Conflicting "Science" nothing more than agendas by HighOrbit · · Score: 1

    All that the "lastest studies" do is reduce public confidence in science. A long time ago, I tuned out all the "latest studies" on food as a bunch of fraudulant BS foisted upon the public by "scientists" looking to feather their nests with research grants or lawyers looking for an ambulance to chase. Check out the following link. "According to the latest study" campaign. I just follow two maximums that have been know for hundreds (if not thousands) of years and that did not require multi-million dollar research programs to figure out : 1) All things in moderation and 2) eat a balanced diet.

  126. Drinking Dog Urine Lowers Heart-Attack Risk by Anonymous Coward · · Score: 0

    From The Onion
    ^^^^^^^^^^^^^^^^^
    Drinking Dog Urine Lowers Heart-Attack Risk, Say Snickering Researchers
    July 28, 1999 | Issue 3526

    BALTIMORE--A team of researchers at Johns Hopkins University have found a link between the consumption of dog urine and the decreased likelihood of heart attacks, team leaders announced Tuesday in cracking, uneven voices.

    http://www.theonion.com/content/node/29429/print/

  127. Funny... by Anonymous Coward · · Score: 0

    What's really funny is when people like TMM (and Rhombus, apparently) think that all of TMM's detractors are only one person. I particularly enjoyed how you continued what I had started. Oh, but that's right! As far as they're concerned, we're the same person! I forgot.

    Let them think that we're the same person. It only proves how delusional TMM is about his self-importance.

    1. Re:Funny... by Anonymous Coward · · Score: 0

      Actually, TMM and Rhombus are the same person. TMM started the new account because he got tired of the well-earned -1 starting score he has with Rhombus and became a dues paying karma-whore. Notice how they share so much animosity towards Zonk...

      (-)_(-)

  128. 12-step program? by AgentPhunk · · Score: 1

    there weren't any twelve-step programs for coffee drinkers

    I'm on the 6-step program.

    Its every OTHER day at time.

  129. Wrong information on article or on local news by javcrapa · · Score: 0, Offtopic

    This study was made her in Costa Rica, in the local news it was reported to be applied to 4000 people, not 2000 as the nature article states.

    For the lucky ones who speak spanish:

    http://www.nacion.com/ln_ee/2006/marzo/08/aldea1.h tml

    ------------------
    El café aumenta riesgo de infarto cardíaco en algunos
    El peligro es para quienes metabolizan la cafeína de forma más lenta
    La investigación se desarrolló en 4.000 pacientes costarricenses

    Debbie Ponchner
    dponchner@nacion.com

    Tomar café en grandes cantidades -más de cuatro tazas al día- puede aumentar hasta en 64% su riesgo de sufrir un infarto cardíaco, pero solo si usted es uno de los individuos cuya genética dicta un mecanismo lento de absorción de la cafeína.

    En cambio, quienes metabolizan la cafeína de forma rápida no aumentan, con cada taza de café que disfrutan, su riesgo de padecer enfermedad coronaria.

    Además:
    # El corazón de 4.000 ticos 'bajo la lupa'

    Esta relación entre la cafeína, la genética de la persona y la enfermedad coronaria fue demostrada en un estudio en el que participaron poco más de 4.000 costarricenses, todos habitantes de la Gran Área Metropolitana.

    Bajo la dirección de investigadores de la Universidad de Costa Rica, la Universidad de Toronto y la Universidad de Harvard el estudio confirma observaciones hechas antes de que existe una relación entre el consumo de café y el padecimiento de infartos. Sin embargo, demuestra que solo es cierto para personas con una genética específica.

    El estudio lo da a conocer hoy la revista Journal of the American Medical Association y fue desarrollado por la costarricense Hannia Campos en colaboración con Ahmed El-Sohemy, Marilyn Cornelis y Edmond Kabagambe.

    Un gen. Todo se debe al gen CYP1A2, encargado de llevar a cabo el metabolismo de la cafeína en el hígado de la persona, explicó Hannia Campos en una entrevista telefónica desde su oficina en la Escuela de Salud Pública de Harvard, en Massachusetts.

    Popular bebida

    El café es una buena fuente de cafeína, el estimulante más consumido en el mundo

    Existen dos alelos o formas de "escribir" ese gen. Ambas son correctas y se distinguen una de otra en tan solo un aminoácido en la cadena de ADN que lo compone.

    Esa minúscula diferencia hace que algunas personas hereden la versión del gen que realiza un metabolismo lento de la cafeína, mientras que otras obtienen la que realiza el metabolismo rápido.

    Quienes tienen la versión lenta, no logran eliminar la cafeína del todo de su cuerpo.

    Al cabo del tiempo, esa acumulación de cafeína puede llevar a un aumento en la presión sanguínea y otras condiciones involucradas en un posible infarto, explicó Campos, quien también es investigadora del Centro Centroamericano de Población de la Universidad de Costa Rica (UCR).

    El estudio. Teniendo en consideración la existencia de este gen involucrado en el metabolismo de la cafeína, Hannia Campos y Ahmed El-Sohemy diseñaron un estudio que evaluara el efecto del consumo de café, el gen y el riesgo de sufrir un infarto.

    Tomaron a 4.000 costarricenses. La mitad de ellos sufrieron un ataque del corazón entre 1994 y 2004, la otra mitad son individuos, de edad similar a cada uno de los pacientes, pero que no han tenido infartos.

    A todos los participantes en el estudio se les realizó entrevistas sobre su alimentación y estilo de vida; además se les tomó muestras de sangre y la medición de la proporción de grasa en el cuerpo.

    Primero determinaron cuál alelo tenía cada persona.

    En la población estudiada, el 55% tenía el alelo

  130. And caffeine also has good benefits by Calyth · · Score: 2, Informative

    In another study, they said that caffeine can help Ashkenazi women to reduce their risk of getting breast cancer. However, the most effective dosage exceeds 4 cups.
    Just like anything that a human can ingest, moderation is the key. Try drinking gallons of water in a short period and see whether that would kill you.

  131. Research brought to you by the same country... by atomic_toaster · · Score: 1

    ...that is opening up a Tim Horton's in Kandahar. Canadian soldiers aren't over there to help keep the peace, they're slowly trying kill genetically-succeptable Afghanis with a coffee overdose!

    Okay, that's a stretch, even for me. But honestly, what with the relationship between Canadians and the almighty Timmy's, it probably puts the soldiers more at risk than the average Afghani.

  132. I'VE HEARD A RUMOR! by dizzy+tunez · · Score: 1

    Hit the alarm! Drinking to much coffee will kill you.
    At age 80+, that is.

    --
    "If you loved me, you`d all kill yourselves today"
    Spider Jerusalem
  133. Article Title by Anonymous Coward · · Score: 0

    Maybe Not Good English

  134. Foolish consumers by thoughtlover · · Score: 1

    "People carrying a common variation in a certain gene could be worsening their risk of a heart attack simply by drinking several cups of coffee per day."

      How typical of an article to stir this much emotion based off so little science. The key words being "could be" are an immediate sign of 'alarmist science-journalism.' Since massive trials have not been conducted to address how much coffee affects different gene types, how can any person be sure if they are susceptible?

      Simple. Don't be the average American. Take small steps.

      If a study claims that a person may benefit from something, don't overdo it. Feel _how_ your body reacts to certain 'doses' of anything you may do or consume (exercise included.) If you feel bad after eating or drinking something, consume less or stop consuming it entirely. If not, keep doing/consuming it until you feel bad.

    On a side note, I used to smoke cigarettes. I knew it was bad, but I didn't 'feel' what they were doing until sometime last year. I'm happy to say I was able to stop entirely, but I realize that coffee may be like cigarettes to others --it's hard to stop consuming something despite how you feel afterwards.

    --
    No sig for you! Come back one year!
  135. Really? by Anonymous Coward · · Score: 0

    Oh, fuck off! It is, it isn't, it is, it isn't, oh, hang on a sec, it is. Is it?

  136. I NEED my Slashdot Fix!!! by Anonymous Coward · · Score: 0

    'Hi. I'm Anonymous Coward, and I'm a slashaholic.'

    everyone: "Hi A.C.!"

  137. Wrong Gene? by Tablizer · · Score: 1

    could lead to an increased risk ...if you have the wrong gene.

    That is true of just about anything. If you have a gene that shuts down brain development at the fetal stage you are also at risk. Some of you were born with the gene to mod me down. Nasty gene that one is :-)

  138. HERESY!!! by edwartica · · Score: 1

    How dare they discredit the secret bean!!!!

    1. Re:HERESY!!! by edwartica · · Score: 1

      err, sacred. sacred bean. sacred bean. I spend a lot of time in coffeehouses.

  139. Life without coffee ain't worth it! by Anonymous Coward · · Score: 0

    Life just isn't that good. Most of us are probably better off kicking the bucket a little earlier, anyways! It'll save SSI some money :-)

  140. Re: by Thomas+Shaddack · · Score: 1
    Whats coming to them is completely by their own hands, and the job of a responsible and intelligent citizen would be then to help them. Helping them would include your beloved maintenance, with intent to cut the addiction, not to prolong it indefinatly.

    Some people have naturally too low production of endorphins. Such people tend to live in permanent subconscious level of pain, which a proper dose of opiates can make go away and make them feel genuinely better. That is likely to be a major predisposition for addiction to opiates.

    Overstigmatization of addiction causes serious problems for people with chronic pain. Due to fear of people feeling better than somebody thinks they should, doctors are limited in prescribing even non-opiate painkillers, so people unnecessarily suffer. Maybe it makes somebody powerful feel better, I don't know.

  141. Re: by Omestes · · Score: 1

    Some people, not a majority, and perhaps not a signifigant portion.

    Let them get a diagnosis, and get something that does not have serious social consequences. A minority of people is not an excuse for street drugs, since a majority of people who get hooked have no reason too, and only cause problems for society.

    To draw an example, I know a signifigant amount of people who smoke pot, and only a single one of them smoked it for pain (post-polio), while the rest were purely recreational. Heroin, I'm sure is the same. Its about the hit to the pleasure-center, and not a medical disorder. For the minority with the disorder, I would endorse methadone, or more probably some more standard pain-killer with less addictive consequences.

    Please don't assume that I am against the minority with a pain condition that can be medically verified. Let the opiates flow to them in a pure, and well controlled stream.

    --
    A patriot must always be ready to defend his country against his government. -edward abbey
  142. It is a trick by ebvwfbw · · Score: 1

    Eat healthy, excersize, do everything right and I can assure you - you will die one day anyway. Nobody gets out of life alive.

  143. Water Addict by QMO · · Score: 1

    "So I'm a water addict?"

    Yes.
    "They" say that you can beat any addiction in two weeks, if you quit cold turkey.
    Come on! You can do it!

    --
    Exam 4/C again. Maybe I'll do better this time.
  144. Caffine by Jamesthe4th · · Score: 1

    Personally I am a severe insomniac. One cup off coffee can screw up my entire night.

  145. Starbucks agrees with this by Anonymous Coward · · Score: 0

    Coffee is just like water. It is essential to life.

  146. Starbucks agrees with this by Anonymous Coward · · Score: 0

    Coffee is a health drink. Trust us. We don't think there are health risks, and we believe that a lifetime commitment to drinking coffee is a wise and healthy choice.

  147. 16oz cofee w/6 sugars&2creamers 6times a day + by Anonymous Coward · · Score: 0

    and 4 cokes and a pack of cigs.I couldnt calculate the movements of a 3,4,5.6,7 body system in 4d in my head without them.LG