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Scientists Produce Fearless Mice

Dotnaught writes "According to New Scientist, a Rutgers University geneticist has found that turning off a specific gene for the protein stathmin makes mice fearless. The story speculates that this research might improve treatment for phobias. It does not mention obvious military applications for the discovery. As noted in this Naval Officer's guide for managing fatigue, the use of amphetamines to stay alert, followed by sedatives to sleep, has a long tradition. Genetic treatments may offer an alternative to pharmaceuticals."

499 comments

  1. My Vision of the Future by Anonymous Coward · · Score: 5, Funny

    These mice escape and breed in the wild. Enormous of fearless mice terrorize the world's cat population. It's not going to be pretty.

    1. Re:My Vision of the Future by runciter44 · · Score: 2, Funny

      In fact this situation is possible and not funny at all.

    2. Re:My Vision of the Future by bersl2 · · Score: 4, Funny

      Here's what I was thinking:

      NIMH unavailable for comment.

    3. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      I guess to combat said enormous fearless mice someone could work on a cat with two heads (aquabats song) and that will be the end of us all...

      Science brings gifts of convenience to the modern man
      Modern man then continues, continues to expand
      But what happens when man creates something oh so wrong
      Nature bites back in a big way...good heavens what have I done!

      I kept it in a box, I watched it grow a lot
      It chewed right through the lock and ate all the new kids on the block.

      A scientist creates a beast in a secret laboratory
      Nature plots revenge, it's blood that it seeks
      That's where we begin our story!

      The cat with two heads
      Whoa, the cat with two heads...

      College brought education to this privileged man
      High school diploma a science major with a government grant
      Four years later an experiment to mutate domestic pets
      It turned into a nightmare so lock your doors and hide your hot dogs
      This cat's upset...

      Society's been so good to me, my parents paid for my college education
      Majoring in biotechnology, created a beast and now it's after me!

      (etc)

    4. Re:My Vision of the Future by ozmanjusri · · Score: 5, Funny
      In fact this situation is possible and not funny at all.
      It was the night before Christmas and a creature was stirring. It was a mouse, a grey mouse, a lean and hungry grey mouse.
      A slight breeze shuffled discarded newspapers in the grimy alley as the mouse crept a little closer to its prey. The tip of its scaly tail twitched in anticipation as it tensed its muscles for the leap.

      With saliva dripping from its fangs, the mouse covered the intervening centimetres in a huge bound, jaws fastening viciously onto its prey, a high-pitched growl issuing from deep from within its belly. Snarling, the ferocious rodent tore at the flesh of its enemy, and the rottweiler leapt to its feet with a surprised yelp.

      The mouse, every muscle shaking with anger and bloodlust, bit deeper through the rottweiler's fur, amost drawing blood, until the startled dog nipped its head off and swallowed it.
      No, you're right, it isn't funny.
      --
      "I've got more toys than Teruhisa Kitahara."
    5. Re:My Vision of the Future by GuyWithLag · · Score: 4, Funny

      In fact, I've seen a cat being chased by a mouse. Yes, a mouse, not a rat... Talk about a Bizarro-style experience ....

    6. Re:My Vision of the Future by WillerZ · · Score: 4, Informative

      Dude, that was Tom & Jerry.

      --
      I guess today is a passable day to die.
    7. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      Wait.... if the current method of inspiring soldiers to stay in line is to instill fear into them to not abandon their posts, threatening them with jail, etc....

      Wouldn't this have a rather nasty double edged sword? Soldiers who didn't fear their commanders? This might be a bad idea to impliment on a widescale.

      Kinda reminds me of the Gem hadar of DS9 lore.... (Hey, it's slashdot).
      Will we then need some kind of device to keep soldiers dependant on the military that kills them if they do not comply?

    8. Re:My Vision of the Future by hachete · · Score: 3, Funny

      lots of dead mice.

      --
      Patriotism is a virtue of the vicious
    9. Re:My Vision of the Future by RAMMS+EIN · · Score: 2, Funny

      I've seen cats being bullied by a bird. At my folks' place, they had this bird fly in one day, some yellow tropical one. Because the bird wouldn't go away, and nobody responded to the ad they put up, they decided to keep it, so they got a cage and all that.

      They also have two cats. I tend to attribute all kinds of things to cats, and one of them is that they have a sense of what they're allowed to do and what not. I guess the cats figured that this bird was part of the household, and somebody would get very pissed if they harmed the bird in any way. Or maybe they just found the bird so scary that they didn't dare to lift a paw to it.

      At any rate, we all figured that it would be good for the bird to get some exercise, so we would usually let it out of the case (somehow the bird had the decency not to shit all over the house, or try to eat everything it came across). One day, one of the cats was sleeping somewhere on the floor, and I was watching (to intervene should murder be attempted) as the bird approached the sleeping cat and pick at it with its beak. The cat stirred a bit, but otherwise paid no attention. Then the bird picked again, and again, until the cat eventually woke up, looked at the bird (who leaped back a few paces), and then decided to try sleeping again. Since that time, the bird has been positively annoying the cats, to the point that the cats wouldn't want to sleep in the room where the bird was.

      Eventually, the bird flew away, never to return.

      --
      Please correct me if I got my facts wrong.
    10. Re:My Vision of the Future by distributed · · Score: 1

      Exactly... fearlessness doesnt imply superiority.
      Think of the guy who was not afraid of sticking his finger in the power socket.
      Especially with their small brain sizes.. a single mouse can do nothing, ofcourse if we had a beowulf cluster of laser mice...

      --
      [all generalizations are untrue except this one]
    11. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      I, for one, welcome our new rodent overlords

    12. Re:My Vision of the Future by mc6809e · · Score: 1

      In fact this situation is possible and not funny at all.

      There is probably very little to worry about. Afterall, it's likely that there have already been mice born in the wild with a mutation that does the same thing. How far did their fearlessness get them?

      If mice born with a fearlessness mutation don't survive to pass it on and spread it, it's unlikely an engineered mouse would.

    13. Re:My Vision of the Future by dreamchaser · · Score: 1, Funny

      I for one...oh forget it.

    14. Re:My Vision of the Future by kryten_nl · · Score: 4, Funny

      Eventually, the bird flew away, never to return.

      That's what the cat told you, wasn't it?

      --
      For the perfect anti-Unix, write an OS that thinks it knows what you're doing better than you do and let it be wrong.
    15. Re:My Vision of the Future by wernerpm · · Score: 2, Funny

      I warned you! But did you listen to me? Oh, no, you knew it all, didn't you? Oh, it's just a harmless little mouse, isn't it? Well, it's always the same, I always...

    16. Re:My Vision of the Future by nwbvt · · Score: 1

      How? They would be unable to survive in a world in which they are constatnly surrounded with danger if they are unable to react to fear. If the mouse walked through the open forest as opposed to hiding it would be eaten within the hour. There is a reason animals evolved the ability to fear.

      --
      Mathematics is made of 50 percent formulas, 50 percent proofs, and 50 percent imagination.
    17. Re:My Vision of the Future by Anonymous Coward · · Score: 4, Funny

      Score:5, Informative

      Dude, that was Tom & Jerry.

      Speaking of bizaare experiences...

    18. Re:My Vision of the Future by Phae · · Score: 1

      My cat used to chase my neighbor's full grown dalmation around the yard. Not play chase, more like "If I catch you I'll eat you" chase.

    19. Re:My Vision of the Future by timeOday · · Score: 1

      You got it. Fearless soldiers? Uhh, maybe people have fear for a reason. You're no use to anybody as a casualty.

    20. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      I think it's great.
      Now we have cordless, fearless laser-mice.
      Who needs frickin' sharks anyway?

    21. Re:My Vision of the Future by Hercynium · · Score: 1

      You're a fellow Farker, aren't you!

      --
      I'm done with sigs. Sigs are lame.
    22. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      I don't think it's the mice that I'm worried about.

    23. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      Some scientist actually got funding to study this,
      it turns out that a suprising mouse that jumps directly into the face and attacks a cat, will have a much better chance of survival than one that just turns and runs away. (Poor Experimental Subjects!)

      The key of course is for the mouse to scare the cat, since
      cats can 'spook' easily, and then escape.

      The mouse just has to remember when to give it up,
      and run away before the cat
      calls his bluff!

    24. Re:My Vision of the Future by budgenator · · Score: 2, Funny

      We had a sulpher crested cockateel; when let out for exercise the bird would sit on the curtain rod and actually call the cat. When the cat came in the room, the bird would swoop down just above the cat's reach. Eventualy the cat grew tired of being teased and started to reduce the height of his jumps, in return the bird swooped lower untill the cat finaly nailed the bird and sent him sailing across the floor. While the cat's feet flailed to get traction, the bird was getting up and shook the daze out of his head. The cat was now starting to make some progress on the slippery floor, so the bird let out a loud hiss which caused the cat's feet to start spinning in the opposite direction.
      The whole thing seemed more like something from saturady morning cartoons, than something that would really happen. they continued to do this, but not with the same gusto as before.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
    25. Re:My Vision of the Future by greenagain · · Score: 1

      Next stop: fearless elephants.

      --
      Fuck hayrides.
    26. Re:My Vision of the Future by justin12345 · · Score: 2, Insightful

      Yeah if you want to see what a fearless soldier would look like, just watch a bunch of little kids play any FPS. They just run around aimlessly and when they find someone, they run straight at them shooting. They die a lot.

      --
      Cool art gallery, if you're into that sort of thing.
    27. Re:My Vision of the Future by budgenator · · Score: 1

      That was the first thing i thought too, the fearless mice display a real lack of self-preservation skills. Being fearless because you're invincable is one thing, being fearless because you're fearless is another is another.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
    28. Re:My Vision of the Future by clueless+idiot · · Score: 1

      No, it was Itchy and Scratchy.

    29. Re:My Vision of the Future by jasen666 · · Score: 3, Interesting

      We've got a 25 yr old Mexican Red-headed parrot that's a holy terror. He's not big, a little larger than a cockatiel, but he's a mean bastard. The thing loves my wife, gets all cudly and shit, but anyone else that comes near the cage, and he's out trying to tear you apart. Took a chunk out of the cat once, and the cat won't go near that room anymore.

    30. Re:My Vision of the Future by Scotteh · · Score: 1

      Are they fearless, or just dumb? It could be that they're more brave, but have any tests been done to make sure it's not just that they're self-protection instinct hasn't been destroyed?

    31. Re:My Vision of the Future by falzer · · Score: 1

      "Albatross chicks attacked by mice"

      BBC link

    32. Re:My Vision of the Future by HTH+NE1 · · Score: 1

      So you've seen that episode of Batman: The Animated Series too?

      --
      Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?
    33. Re:My Vision of the Future by budgenator · · Score: 1

      If you think that one person can tell 10, 50, 150 or 500 people armed with rifles, pistols, and grenades to do things that put them in harms way solely through intimidation, you would be in for a rude awakening as a military commander.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
    34. Re:My Vision of the Future by Merkuri22 · · Score: 1

      Seriously, though, fear is a defense mechanism. It evolved because creatures that run away from danger survive. If these mice escaped, they'd doubtless get eaten by something within minutes of leaving their safe, cozy cages.

      Being fearless sounds like a good thing, but it's really not. It's like pain. If I told you I could make your brain stop processing pain you'd probably rejoyce. But that's actually the disease known as leprosy. Leppers don't feel pain, so they don't recognize when they have injuries and fail to care for themselves. Lots of nasty infections (among other complications) ensue.

    35. Re:My Vision of the Future by Chosen+Reject · · Score: 1
      Right! CHARGE!!

      [30 seconds passes]

      Run AWAY! Run AWAY!!

      --
      Stop Global Warming!
      Just say no to irreversible processes!
    36. Re:My Vision of the Future by johansalk · · Score: 1

      My cat amused everyone in the park when it got chased on foot by a bird.

    37. Re:My Vision of the Future by Tongo · · Score: 1

      I'm talking out my ass here because I've never served, but I have had friends who have served.

      From what I understood, the fear and intimidation was mainly reserved for the first month or so of basic. After basic, you had been reshaped into a soldier and it was ingrained into you to obey your superiors. I could see them using this type of modification after a soldier had made it through basic training and had moved into field operations.

      Really though, I don't know how usefull it would be for the military. Being awake and alert is one thing, but being fearless is stupid. Fear is what allows you to duck when bullets fly your way. A fearless soldier is to likely to charge into a situation where keeping your head down would be a better option.

    38. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      Mmm... these scientists have just wasted the time they spent on this...

      Crowley and Robert Anton Wilson for years have been talking about imprint vulnerability and the ability to change the psychological wiring of people.

      Changing someones fear 'imprint' is just a small part of this. The fact the making someone 'imprint vulnerable' gives you access to their mental firmware through which ANY emotion etc can be changed or tinkered with.

      I bet these morons in white suits will be looking haphazardly for other genes now - instead of taking a more high level approach - one thats as old as the hills err... so to speak, since the theories have been kicking round since the 60's.

      Morons are the mothers of re-invention.

    39. Re:My Vision of the Future by bersl2 · · Score: 1

      "Hey, you got your Fark in my Slashdot!"

      "Well you got your Slashdot in my Fark!"

    40. Re:My Vision of the Future by BigCheese · · Score: 1

      Many years ago we used to have a cat who would spend much of it's day trying to figure out how to catch, kill and eat our 2 cockatiels without touching them (yes, cat logic). One day we had the birds out flying around the apartment and the cat thought it would be a good idea to sit in front of the open cage door and wait for the bird. One of the birds got spooked by something and dived toward the cage so it could hide. While the bird was in a power dive towards the cage it noticed the cat and, at the same time, the cat saw the bird zooming towards it. The cats eyes went wide with an "OH CRAP" look and the bird tried to do a quick air brake like they do in the cartoons. The bird crashed into the side of the cat and they both ran off in different directions. That cat wouldn't go near the birds for weeks after that.

      To this day it's still one of the funniest things I've ever seen.

      --
      The obscure we see eventually. The completely obvious, it seems, takes longer. - Edward R. Murrow
    41. Re:My Vision of the Future by thc69 · · Score: 1
      It chewed right through the lock and ate all the new kids on the block.
      Can it eat the Backstreet Boys and their ilk too?

      Maybe, with further genetic manipulation, it can eat 50 Cent and Eminem, and such...
      --
      Procrastination -- because good things come to those who wait.
    42. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      In the whole "informative" side of things, mice are already fearless of cats due to a parasites that cats all carry. The parasite makes the mice docile so the cat can mess with it for a while before it finishes it off.

    43. Re:My Vision of the Future by HiThere · · Score: 1

      You've got the wrong disease. Leppers only stop feeling pain in the infected PARTS of their body. There are, however, those totally without the ability to feel pain...and otherwise undamaged. They rarely live to grow up.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    44. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      That line cracked me up when I first heard the song. (Actually, it sill makes me laugh.) If you assume the song writer created said cat with two heads and you assume he thinks of crappy pop music as being in bad taste (probably true) well yeah, I think we can assume the cat will go after other boy bands. Though it is troubling that last line about "now it's after me."

      The band is Devo inspred Ska...Oingo Boingo-ish kinda thing. Good stuff.

    45. Re:My Vision of the Future by HiThere · · Score: 1

      The methods of Crowley and Wilson aren't readily convertable to a production line system...and they need the active and determined cooperation on the part of those being tinkered with. (They don't need to know exactly WHAT they're cooperating on, but they need to be cooperative, not merely submissive.)

      This is getting down to the basic layers of implementation directly, rather than indirectly and guided only by feel and experience. Don't expect the same limitations.

      OTOH, even the methods of Crowley have been known to drive folk insane...at least in the opinion of shrinks. A sharper tool is like to cut people more easily, and with less warning.

      OTTH, the army is already tinkering with the psyche of the soldiers. Currently it has soldiers who are programmed to shoot to kill, even at the cost of their own sanity. They don't usually go crazy until after their hitch is up...and at that point the army can usually deny any responsibility.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    46. Re:My Vision of the Future by Scotteh · · Score: 1

      Yeah. Leprosy is a skin disease where the skin rots or something. But yeah, the nerves die too and they can't feel anything in that area.

    47. Re:My Vision of the Future by Anonymous Coward · · Score: 0

      Dude, that was Tom & Jerry.

      Speaking of bizaare experiences...


      "Dear Penthouse forum..."

    48. Re:My Vision of the Future by edinjapan · · Score: 1

      I have 2 arrowanas and a pair of korat cats. Now arrowana are top predators and they will try to consume anything that they believe will fit into their mouths. The male was approaching 1 meter in length when the incident with the cat happened. The cat spent much of his time baiting the fish and plotting how to catch it. One day as usual he was peering into the tank from above when the fish lunged, grabbed him by the head and dragged him into the tank. Since then the cat has never looked at fish the same again, he avoids the fishtanks like they are the plague. The arrowana...He spends his time plotting how to get a delicious cat dinner.

      --
      Fish....More than just sushi
  2. Good old PCP by ReformedExCon · · Score: 5, Insightful

    Whatever happened to the good old days of pumping soldiers full of angel dust to rid them of fear?

    The non-military uses for such a treatment are pretty far-reaching. Would it be able to cure people that suffer anxiety attacks? Could children with night terrors be cured?

    If the rats don't feel fear, do they also lose understanding of danger? That would be a pretty bad mutation.

    --
    Jesus saved me from my past. He can save you as well.
    1. Re:Good old PCP by general_re · · Score: 5, Insightful
      If the rats don't feel fear, do they also lose understanding of danger? That would be a pretty bad mutation.

      My first thought also. There are some situations where fear is an entirely appropriate response - lose it, and unwarranted risks may start to become a problem.

      --
      ABSURDITY, n.: A statement or belief manifestly inconsistent with one's own opinion.
    2. Re:Good old PCP by Anonymous Coward · · Score: 1, Insightful

      > Would it be able to cure people that suffer anxiety attacks?

      Perhaps. For many people with anxiety attacks, they can be overcome by practicing whatever gives them the most panics. over and over, until it becomes re-learned that it's really a safe behaviour. If a treatment like this could be enabled temporarily, it might help.

      Then again if there's no fear, there may also be no concept of 'safe' either, so when the treatment is eased off everything may fall back to how it was beforehand.

      Much testing to be done.

    3. Re:Good old PCP by blincoln · · Score: 2, Insightful

      Whatever happened to the good old days of pumping soldiers full of angel dust to rid them of fear?

      Um, source?

      From my experience, PCP would be a terrible thing to give soldiers. You'd end up with a Jacob's Ladder scenario where they become afraid of - and attack - friends and enemies at random.

      --
      "...always new atoms but always doing the same dance, remembering what the dance was yesterday." -Richard Feynman
    4. Re:Good old PCP by ReformedExCon · · Score: 1
      --
      Jesus saved me from my past. He can save you as well.
    5. Re:Good old PCP by tabatj · · Score: 1

      Would it be able to cure people that suffer anxiety attacks? Could children with night terrors be cured?

      Actually, no. These rats were genetically modified, not given a drug. "Curing" people would involve fixing their genes before birth. Somewhat like in the movie Gattaca http://en.wikipedia.org/wiki/GATTACA

    6. Re:Good old PCP by NitsujTPU · · Score: 1

      Deaths via accidents and fires are common, and respiratory arrest can also lead to death.

      What about the use of PCP causes fires?

    7. Re:Good old PCP by Vintermann · · Score: 2, Interesting

      I don't think rats have very much "understanding" of danger. Why should they? They have their instincts. Well, at least until now.

      --
      xkcd is not in the sudoers file. This incident will be reported.
    8. Re:Good old PCP by ReformedExCon · · Score: 1
      --
      Jesus saved me from my past. He can save you as well.
    9. Re:Good old PCP by NitsujTPU · · Score: 1

      I tend to think of stuff like this

      Health Hazards
      PCP is addictive and its use often leads to psychological dependence, craving, and compulsive PCP-seeking behavior. Users of PCP report memory loss, difficulties with speech and learning, depression, and weight loss. These symptoms can persist up to a year after cessation of PCP use. PCP has sedative effects, and interactions with other central nervous system depressants, such as alcohol and benzodiazepines, can lead to coma or accidental overdose. Use of PCP among adolescents may interfere with hormones related to normal growth and development.

      Many PCP users are brought to emergency rooms because of PCP's unpleasant psychological effects or because of overdoses. In a hospital or detention setting, they often become violent or suicidal, and are very dangerous to themselves and to others. They should be kept in a calm setting and should not be left alone.


      As more of the hazard of using the substance, rather than the off chance that some moron might burn their house down while on it. I might burn my house down making bacon.

    10. Re:Good old PCP by pookemon · · Score: 1, Interesting

      You'd end up with a Jacob's Ladder scenario where they become afraid of - and attack - friends and enemies at random

      I can remember at least one case where that happened during Gulf war II (Operation Iraqi Freedom). IIRC a Pommy Tornado was shot down (and I think there were other cases) by US AA. Guess we know why. ;)

      --
      dnuof eruc rof aixelsid
    11. Re:Good old PCP by ReformedExCon · · Score: 1

      It's the process of dissolving the PCP into a liquid form (for injection or other use) that is a fire hazard.

      --
      Jesus saved me from my past. He can save you as well.
    12. Re:Good old PCP by unknown51a · · Score: 0

      I would dearly like to get rid of my anxiety attacks.

      But I think good old Dutch courage is all anyone needs.

      --
      I had an imaginary sig once, he said I was a loser and ran off.
    13. Re:Good old PCP by EiZei · · Score: 2, Informative

      You'd end up with a Jacob's Ladder scenario where they become afraid of - and attack - friends and enemies at random.

      Probably not unless overdosed. However PCP would still be utterly useless because it's a strong anesthetic, the soldiers would be just staring blankly and would have difficulties understanding even the most basic orders. You'd be better off giving them bottles of hard liquor.

    14. Re:Good old PCP by bmgoau · · Score: 1

      If this is done wrong, it could ahve horrible consequences in humans. Fear ranges incredibly from simple common sense and caution to the fight or flight senarious which activate a persons adreanal glands. Infact fear is a intergral part of our survival instinct, without it, we would surely self destruct.

      Im not sure about the liminations of this discovery, but if fear was removed from a human, there would be nothing except a thin layer of logic between them and the edge of a building, a knife on a desktop, or a burning fireplace.

      I cannot simply imagine living without fear, if one delves deeply enough, one realises that fear is an integral part of logic. IF touch fire THEN burn, IF burn THEN damage, DAMAGE bad. But if one has no sense of "harm" to one self, then there is a break down of logic. Its is an imperpexly complext situation, and i would be amazed to see the self destructive patter emerge in a person who has had such gene theropy.

      What do you believe would happen if a person had no fear?

      Would their survival and logic process break down?

      Would they become self destructive without realising it?

      Finally, on the issue of military use, it would seem that this development stops the production fo the protine not limits it, which would means, if used as a military application, you would have soldiers who would be unpredictable. They could possibly be self destructive, unscared of alerting enemies to their position, will not think through tactics to ensure their survival and the completeion of their obkective and finally they may not even be afraid of disobeying orders....

    15. Re:Good old PCP by blincoln · · Score: 1

      Okay, yes, it used to be used as a human anaesthetic. That's what dissociatives are generally used for in medicine =). IIRC, ketamine used to be used in the same way. Of course, now it's limited to veterinary applications because of the side effects.

      I don't see anything in there about the military giving it to soldiers to turn them into fearless berserkers, though. My (admittedly limited) experience is that it will sometimes have that effect, but can also completely incapacitate its users with fear, or by distancing them too far from reality.

      The military did experiment with BZ in Vietnam, but there's been virtually no information released on how it was used and who it was given to. Personally I wouldn't trust anyone who's hallucinating with a weapon. It's just too unpredictable of a state.

      --
      "...always new atoms but always doing the same dance, remembering what the dance was yesterday." -Richard Feynman
    16. Re:Good old PCP by T'hain+Esh+Kelch · · Score: 0

      If the rats don't feel fear, do they also lose understanding of danger? That would be a pretty bad mutation. My first thought also. There are some situations where fear is an entirely appropriate response - lose it, and unwarranted risks may start to become a problem.

      Actually fear is a different thing than being able to understand whats is dangerous and not. We know not to stand out in front of a train, but we arent scared of it. Thats two different things. And for people who doesnt understand this, go read Dragonlance: Chronicles and take note of how Tasselhoff behaves!

    17. Re:Good old PCP by Major_Small · · Score: 2, Interesting
      There are some situations where fear is an entirely appropriate response - lose it, and unwarranted risks may start to become a problem.

      Imagine the evolutionary turn that could create - it would put much more emphasis on critical thinking, and if it weren't for fear, I think we'd end up with a smarter society. What I mean is, without an emotion to guide us away from dangerous activities, we'd only have our logic and reasoning to do that.

      For example, take two mice. One is exceptionally smart, and the other is, well, not. Both of them still fear. If both of them stick to the wall of the box, they both survive another day.

      Now take away that fear. The "dumb" mouse wanders into the middle of the box and is eaten by a cat. The "smart" mouse thinks "If I leave the side of this box, I open myself to attack from predators."

      Now I know that that wouldn't happen with mice, but it could happen with some other lifeforms. The question is, without fear, would there be enough of a species that was smart enough to survive, or would it cause most specices to go extinct?

    18. Re:Good old PCP by Bastian · · Score: 1

      Speaking as someone who's had a pet rat:

      It's pretty obvious that rats can be afraid of things. Being small and incapable of speech doesn't mean that they're mindless automata.

    19. Re:Good old PCP by CableModemSniper · · Score: 1

      First Kender Post?

      --
      Why not fork?
    20. Re:Good old PCP by general_re · · Score: 2, Insightful
      Imagine the evolutionary turn that could create - it would put much more emphasis on critical thinking, and if it weren't for fear, I think we'd end up with a smarter society.

      And/or a much smaller society, as you say ;)

      The other thing that occurs to me is that I think that for many (if not most) people there are certain situations where fear of the consequences is one of the main things that keeps them (us) from behaving badly. Take away that fear, and pretty much the only thing that's left is the relatively straightforward and cold calculus of "can I get away with this?" And unfortunately, there already doesn't seem to be a shortage of people who think that yes, they are clever or careful enough to get away with some bad act - absent fear, they'd have one less restraint on their behavior.

      --
      ABSURDITY, n.: A statement or belief manifestly inconsistent with one's own opinion.
    21. Re:Good old PCP by guitaristx · · Score: 1

      I, for one, believe this to be absolute B.S. If fear of the consequences is the only thing that keeps us in line, we're all screwed. Yes, consequences of bad behavior is a deterrent, but it should be a learning mechanism, not a restraint. Our sense of morality should be the ultimate determining factor in our behavior. If not, we're nothing but rats in cages, responding to stimuli. Most of the moral decisions that I make have nothing to do with perceived consequences; I choose to act a certain way because my moral convictions dictate that I should do so.

      --
      I pity the foo that isn't metasyntactic
    22. Re:Good old PCP by romeo_in_blk_jeans · · Score: 0

      Genetic modification, right?

      I don't think this could be done to an adult human. Any program attempting to produce fearless soldiers would necessarily have to start with genetically modified babies. That leaves plenty of time to indoctrinate the subjects. Since the program would be illegal and there would be no official civilian record of any of the subjects, you could simply terminate problem subjects.

    23. Re:Good old PCP by HTH+NE1 · · Score: 5, Funny

      Users of PCP report memory loss, difficulties with speech and learning, depression, and weight loss. These symptoms can persist up to a year after cessation of PCP use. PCP has sedative effects, and interactions with other central nervous system depressants, such as alcohol and benzodiazepines, can lead to coma or accidental overdose. Use of PCP among adolescents may interfere with hormones related to normal growth and development.

      Ask your doctor if PCP is right for you.

      --
      Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?
    24. Re:Good old PCP by tabrnaker · · Score: 1
      Enlightenment coincides with the elimination of fear. Of course, it derives from the understanding and overcoming of those fears. It is quite easy and blissful to live without fear.

      However, robbing people of the opportunity to learn about self, well, it'll just lead to more 'abominations' that western medicine is responsible for.

    25. Re:Good old PCP by qeveren · · Score: 1

      My understanding is that ketamine is still used as a general anaesthetic for children, in some areas of the world, primarily because children don't seem to suffer any of the negative side effects from it that adults do. IANAD, though. :)

      --
      Don't just stand there, get that other dog!
    26. Re:Good old PCP by general_re · · Score: 1
      Most of the moral decisions that I make have nothing to do with perceived consequences; I choose to act a certain way because my moral convictions dictate that I should do so.

      That's fine, but I assume you're not about to tell me that amoral people don't exist...

      --
      ABSURDITY, n.: A statement or belief manifestly inconsistent with one's own opinion.
    27. Re:Good old PCP by qeveren · · Score: 1

      I think you're making an incorrect assumption, in that a lack of fear equals a lack of sense of harm. A fearless person is still going to jerk their hand back from a hot stove element, because it hurts like hell, not because it scares them.

      That said, I imagine the behavior of an adult human who's had their fear removed would become somewhat more reckless, since their automatic anti-recklessness alarm (fear) isn't working anymore. But I seriously doubt that they'd become self-destructive. Just because I'm not afraid of dying doesn't mean I want to die.

      --
      Don't just stand there, get that other dog!
    28. Re:Good old PCP by Archangel_Azazel · · Score: 1

      Vaild point, however, one only has to look towards those in power currently to realize that not everyone shares your positive and high moral standards.

      My 2c

      A.A

      --
      Your mind is like a parachute. It works best when it's been opened.
    29. Re:Good old PCP by Anonymous Coward · · Score: 0

      But RTA - the mice were given a bell warning, then shocked. The next day, they got the warning again. The unmodified mice ran - afraid of getting shocked again. The modified mice DID NOT REACT.

      Extrapolating into human term along the lines of the grandparent...You wade too fade out into the ocean & get sucked under, but somehow make it back into shore - then you wade in too far again & drown, not having felt the fear of the first time. Or how about...there is a screeching noise behind you; all unmodified people around you are scared & jump out of the way, but modified you stays put & you get hit by the out-of-control bus. (note: a fear reaction is more instinctual and FASTER than logic. By the time logic tells you to move, the bus has already hit you)

      Our fear is useful. It keeps us alive. In some it can be debilitating & if they can back those folks off to a NORMAL level of fear, then this would be a good thing. But any other uses are dangerously stupid.

    30. Re:Good old PCP by Anonymous Coward · · Score: 0
      I choose to act a certain way because my moral convictions dictate that I should do so.


      And if you go against your morals, that leads to what? Exactly, consequences. Everything people do is to avoid, or partake of, certain consequences. Plain and simple. Sorry to bust your bubble.
    31. Re:Good old PCP by budgenator · · Score: 1

      by knowing which protein, they can analyse it's shape, once they know the shape, they can look for simularly shaped chemical that would block the recptor sites in the brain without stimulating them. Then they would have a drug that stops or reduces fear, I think it would be very dangerous.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
    32. Re:Good old PCP by drinkypoo · · Score: 1

      They actually used methamphetamine. IIRC the germans used benzedrine, but maybe I have that backwards. AFAIK WWII was the first time they started using lots of speed to keep soldiers going, on both sides.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    33. Re:Good old PCP by coronaride · · Score: 1

      Well, I'm not going to read the mentioned book, but I call nonsense on you. You say that we know not to stand out in front of a train, but we aren't scared of it. Well, for one, it's not really standing in front of a train that we are scared of. I assume that we're talking about a moving train? We are scared of the threat, not just the result. Otherwise, activities like base jumping, skydiving, or, when you really want to get down to the base element, many other basic things that humans do for fun.

      Some people do stand in front of trains. Ever seen the movie Stand by Me? There's a whole scene where these kids stare down a train and get out of the way at the last second. Why would they do that? Deep down, an adrenaline rush builds up when your fear centre starts recognizing a potential threat. It has everything to do with fear at that point and very little to do with "being able to understand what is dangerous and not."

      --
      Those who can, do. Those who can't, go into business for themselves.
    34. Re:Good old PCP by ceoyoyo · · Score: 1

      Genes often code for proteins. If you identify the gene, then the protein, you can artificially introduce either that protein or an antagonist for it (depending on which way you want to go). Those would be the drugs you'd want to give to your anxiety patients.

    35. Re:Good old PCP by ceoyoyo · · Score: 1

      Hm... take a look at teenagers and drunk frat boys. Insufficient sense of fear, mostly through a belief in their own invincibility -- self-desctructive, check. That's why I had to pay such high car insurance premiums when I was under 25.

    36. Re:Good old PCP by not-enough-info · · Score: 1
      If the rats don't feel fear, do they also lose understanding of danger? That would be a pretty bad mutation.
      Now we just need to combine the fearless gene with limb-regenerating mice.
      --
      ---k--
      </stupid>
    37. Re:Good old PCP by Breakfast+Pants · · Score: 1

      "You'd be better off giving them bottles of hard liquor." According to the Union Captain holding the bridge in "The Good, The Bad, And The Ugly" that's exactly what you want to do.

      --

      --

      WHO ATE MY BREAKFAST PANTS?
    38. Re:Good old PCP by Anonymous Coward · · Score: 0

      I'd love to believe that, but no. The defining feature of Antisocial Personality Disorder (sociopathy or psychopathy, to use the colloquialisms) is lack of fear--we'd probably just get a sociopathic society.

    39. Re:Good old PCP by Anonymous Coward · · Score: 0

      I would bet your moral convictions are either:
      1) religious, a fear of god.
      2) social, a fear of losing social status.
      3) baseless, in which case your set of morals will not match anyone else's set, and will be chosen at random for some subset of people. Don't be suprised then that others choose a different morality.

    40. Re:Good old PCP by Anonymous Coward · · Score: 0

      Clearly youve never been involved in a pcp-fueled hardcore techno moshpit, but thats ok, society is probly a better place when only .0001% of it enjoys completely insane mayhem. :)

    41. Re:Good old PCP by carn1fex · · Score: 1

      I dunno i think 'the brass' would think this was some pretty cool shit: http://www.google.com/search?hl=en&lr=&as_qdr=all& q=pcp+stabbing

      --

      ---------

      No matter how thin you slice it, its still baloney.

    42. Re:Good old PCP by EiZei · · Score: 1

      You read the "unless overdosed" part right? ;)

    43. Re:Good old PCP by Jackmn · · Score: 1

      Morality is nothing more than instinctual response to stimuli.

      Hurting others feels wrong; it is instinctual. The same for theft or any other number of things generally considered to be wrong.

      Morality is nothing more than animalistic instinct.

    44. Re:Good old PCP by Anonymous Coward · · Score: 0

      you have part of it right, the body has regulatory mechanisms that modulate all these emotions

      once have experienced fear and the threat has passed, the a mechanism kicks in to bring you back to normal

      that's why a good scare can feel good (dependent on the fear turning out to be unfounded)

      it's the opponent process that can become addictive, not the fear/adrenlne itself

    45. Re:Good old PCP by freeweed · · Score: 1

      Oddly enough, up here in Alberta (Canada) we have public service announcements exactly like this, for crystal meth. Start out with all of the "benefits", and then the long (3/4 of the commercial) side-effect disclaimer. It's pretty creepy, and I'd say, the most effective anti-drug commercial I've ever seen.

      Then again, I never really thought my brain was an egg.

      --
      Endless arguments over trivial contradictions in books written by ignorant savages to explain thunder in the dark.
    46. Re:Good old PCP by mozkill · · Score: 1

      hey, did you notice the scene in that movie Jarhead where they are forcing soldiers to take a pill... JEEEZ... thats just the reason why I would never serve in the military since they will duck you into a no-escape situation.

      --

      -- Betting on the survival of the media industry is a serious risk. I advise investing elsewhere.
    47. Re:Good old PCP by Anonymous Coward · · Score: 0

      riiiiggghhht...

    48. Re:Good old PCP by fbartho · · Score: 1

      Dude, I don't know, I feel like a rat in a cage... I get poked prodded and cajoled to get through lower education, and then I'm still prodded, but am expected to do the same to myself to get myself through higher education, and coming out of that the rest of my life I struggle to control the most resources, the philosophy being that if I am brilliant (control the "resource" of intelligence), or I am rich (control the monetary resource), or I am a pimp ( ;) ) I can easily get enough of any other resource to satisfy my needs without a good deal of effort.

      I get fines (monetary, or in the form of loss of respect) , or broken body parts if I don't follow the rules... if I try to step out of the cage... and in the end the great big cat pounces on my ass and I am buried.

      Tell me... how can we really be different then animals responding to stimuli... just because are response patterns are more complex? just because we can supposedly fully understand the responses of a mouse, but we can't understand our own?...

      Back to my cage I go.

      --
      Gravity Sucks
    49. Re:Good old PCP by Vintermann · · Score: 1

      Sure, but what I said is that their fear is probably instinctive, not based on a rational assesment of danger. They are used to their brain stems telling them what they should be afraid of, going from that to using their tiny reserves of neocortical tissue might be a little hard.

      --
      xkcd is not in the sudoers file. This incident will be reported.
  3. Which Batman episode was that? by sTalking_Goat · · Score: 2, Interesting
    The one were Scarecrow does Batman with a gas that took away all his fear?

    That was awesome.

    --

    My days of not taking you seriously are certainly coming to a middle...

    1. Re:Which Batman episode was that? by NonSequor · · Score: 1

      Damn it, I was thinking of the same thing.

      --
      My only political goal is to see to it that no political party achieves its goals.
    2. Re:Which Batman episode was that? by shawb · · Score: 1

      Batman was around before the movie. Hence the... "Which Batman EPISODE was that" bit.

      --
      I'll never make that mistake again, reading the experts' opinions. - Feynman
    3. Re:Which Batman episode was that? by gforce811 · · Score: 1

      i dont' think batman ever got his fear taken away. he just had all his fears come to him in his head so he was scared and couldn't concentrate.

    4. Re:Which Batman episode was that? by Sparr0 · · Score: 1

      As another grandchild of the parent pointed out, Batman existed before the movies. WAY before.

    5. Re:Which Batman episode was that? by thesandtiger · · Score: 1

      That's not possible! I have a DVD here called "Batman Begins" so you see, Batman BEGINS in the movies, and then the media companies use their time machines to travel back into the past, seeding the world with evidence that Batman has existed for decades - you know, to test our faith.

      --
      Since I can't tell them apart, I treat all ACs as the same person.
  4. Like Red Baron by mindflow · · Score: 5, Funny

    Now scientist need to figure out how to make theese mice pilot planes.

    1. Re:Like Red Baron by Incadenza · · Score: 4, Funny

      Have I got news for you.

  5. Won't somebody think... by Anonymous Coward · · Score: 2, Funny

    of those poor elephants! Or ladies in the kitchen standing on a high chair!

    1. Re:Won't somebody think... by moro_666 · · Score: 1

      i guess a fearless elephant whould just crush the fearless mouse that is trying to bite him, cause it has no idea what avoiding crushing is.

      however, ladies in the kitchen on chairs would be fun :)

      --

      I'd tell you the chances of this story being a dupe, but you wouldn't like it.
    2. Re:Won't somebody think... by Reziac · · Score: 1

      Once upon a time when I was a kid, I caught a garter snake, and kept it in an egg carton under the bed. Eventually it got loose, and slithered down the hall... my mom saw it and literally JUMPED onto a chair, screaming fit to raise the dead. It was exactly the same atavistic-fear reaction that monkeys do when they see a snake.

      And here you thought you'd posted a joke :)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
  6. Military applications make me shiver... by stirz · · Score: 5, Insightful

    Giving Methamphetamines to soldies to "stay alert" and to "strengthen confidence" has -sadly enough- a long tradition. As Wikipedia tells us even the Nazis spreaded the drug among their Wehrmacht. What's the point of a government saying "Stay away from drugs!" on the one hand and willingly giving it to soldiers on the other?

    Seems alright, I quit military service a long time ago...

    Regards

    Stirz

    1. Re:Military applications make me shiver... by QuantumG · · Score: 2, Insightful

      What's the point of a government saying "Stay away from drugs!"

      That's all you needed to say. There isn't two hands. Governments should butt the hell out and mind their own business.

      --
      How we know is more important than what we know.
    2. Re:Military applications make me shiver... by skinfitz · · Score: 5, Insightful

      How is this different to a Government saying "Don't kill people!" then putting guns and high explosives into the hands of soldiers?

      The only logic here is 'do what we say and don't question anything.'

    3. Re:Military applications make me shiver... by stirz · · Score: 1

      In the best case, an army is run but never has to shoot a real bullet at real people in combat. Drug application is a different story: soldiers on guard (a shift can be 24h and longer) might appreciate drug consumption if they assume it could help them performing their duty.

    4. Re:Military applications make me shiver... by Mjlner · · Score: 4, Insightful
      "As Wikipedia tells us even the Nazis spreaded the drug among their Wehrmacht."

      What do you mean, "even the Nazis"? A totalitarian government, emphasizing the military and denial of the individual, would be almost expected to do this. What is more scary, is that democracies, which we expect to respect and defend the rights of the individual, even to the point of restricting what the police and military can do, are chemically altering the bodies and minds of their soldiers.

      --
      Lemon curry???
    5. Re:Military applications make me shiver... by stirz · · Score: 1

      Sorry Mjlner, as I am not a native speaker, I've apparently not made it clearly enough: I wanted to say that even 50 years ago, there was drug (ab)use for military purposes. Hence, this "news" is not quite as new as it seems :-)

    6. Re:Military applications make me shiver... by Anonymous Coward · · Score: 0

      It also has a long association with "friendly fire" incidents.

    7. Re:Military applications make me shiver... by Anonymous Coward · · Score: 0

      In the doses prescribed by flight surgeons, it more effective and safer than caffeine.
      Do you want a pilot flying with a massive headache from caffeine or alert due to an appropriate dose of speed? Crashing due to exhaustion after a long flight, multiple mid-air refuellings, and combat has happened in the past and will happen again. Stimulants reduce the risk and just plain work. The "OMG Meths!" response is uncalled for.

    8. Re:Military applications make me shiver... by Anonymous Coward · · Score: 0

      In a military crisis situation, it's better to do drugs and have a better (still a little, but better) chance of staying alive than not to do drugs and die.

    9. Re:Military applications make me shiver... by Murphy+Murph · · Score: 1

      5mg every 2 hours not to exceed 30mg in a 24 hour period is a tiny amount of dextro-amphetamine, especially since we are talking about adults and adult body mass. This is clearly intended as an alertness aid and not an agression pill.

      I took larger doses as a child to help control my ADD, and take significantly larger doses now that I am an adult.
      5mg is almost subclinical for behavior modification.
      And did you read the disclamer pilots must sign to receive the Dexedrine?

      --
      I dub thee... Sir Phobos, Knight of Mars, Beater of Ass.
    10. Re:Military applications make me shiver... by thesandtiger · · Score: 1

      What's the point of a government saying "Stay away from drugs!" on the one hand and willingly giving it to soldiers on the other?

      Soldiers aren't civilians - different expectations, different situations.

      What's the point of a government saying "Don't kill people!" to civilians on the one hand and then training soldiers to go out and do just that? (Just using that as an example of the dichotomy - not making an editorial statement)

      --
      Since I can't tell them apart, I treat all ACs as the same person.
    11. Re:Military applications make me shiver... by Anonymous Coward · · Score: 0

      Drugs wear off, you come down, VERY DIFFERENT. Genetically modified soldiers would not be able to function in society, what do you do then. Prevent them leaving military bases. What do you do when they are too old to fight, look after them on military bases at great expense for no benefit? Euthanasia?
      I could, frightingly, imagine the Carl Rove Republicans opposing embryonic research while simultaneously breeding genetically modified soldiers.

    12. Re:Military applications make me shiver... by Rude+Turnip · · Score: 1

      True, but what you have to consider is...hold on....FFFSSSZZZT...MMMMMM, THAT'S THE STUFF!

    13. Re:Military applications make me shiver... by Anonymous Coward · · Score: 0
      What is more scary, is that democracies, which we expect to respect and defend the rights of the individual, even to the point of restricting what the police and military can do, are chemically altering the bodies and minds of their soldiers.
      Why? This is exactly what you are doing to yourself every time you have a beer, cigarette, or coffee. I found it rather nice to see a US government-linked organisation talk candidly about drugs and their uses (note I say "uses", not "abuses") without the usual "drugs are stealing your children" propaganda they usually spout... The article even suggested that soldiers should self-moderate their usage with proper medical advice.
    14. Re:Military applications make me shiver... by hey! · · Score: 1

      What is more scary, is that democracies, which we expect to respect and defend the rights of the individual, even to the point of restricting what the police and military can do, are chemically altering the bodies and minds of their soldiers.

      Because if we did that, the President might as well be a Schickelgruber. ...

      I have news for you: The President is a Schickelgruber.

      Ah, the 70s. I wish I could actually remember them.

      --
      Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
    15. Re:Military applications make me shiver... by Anonymous Coward · · Score: 0

      What's the point of a government saying "Stay away from drugs!" on the one hand and willingly giving it to soldiers on the other?

      Methamphetamines (and steroids and many other drugs commonly taken by addicts) can be legally used with a prescription in many countries. Use without a prescription is illegal. That's the difference.

    16. Re:Military applications make me shiver... by slapout · · Score: 1

      The government isn't saying "Don't kill people". It's saying "Don't kill people who aren't trying to kill you."

      --
      Coder's Stone: The programming language quick ref for iPad
    17. Re:Military applications make me shiver... by LWATCDR · · Score: 1

      Methamphetamine are also used to be used to help people loose weight. It might still be. If you think about it if you are in combat and if you fall asleep you DIE. Drugs to keep you awake are a pretty good idea. To save money planes like the B2 only have a crew of 2 one is the pilot the other is the bomber/navigator/ew operator. These planes fly some very very long missions. The old B-52s had rest bunks and a crew of 5 or 6. Not that it is the best of all possible worlds but when is combat the best of all possible worlds?

      --
      See my blog http://ilovecookes.blogspot.com/ for light hearted technical information.
    18. Re:Military applications make me shiver... by FuzzyDaddy · · Score: 1

      Morality aside, I think the military would be pragmatic enough to know that a fearless solder probably wouldn't last too long in a battle. Fear has a purpose.

      --
      It's not wasting time, I'm educating myself.
    19. Re:Military applications make me shiver... by GypC · · Score: 2, Insightful

      The purpose of amphetamines is to keep the "push" going; constantly moving forward against the enemy and keeping them off balance, unable to regroup. It's a way to win a battle and keep more of your soldiers alive. It's a standard strategy in all modern armies and would be used regardless of the availability of drugs, the drugs just help them stay awake and stay alive.

    20. Re:Military applications make me shiver... by SysKoll · · Score: 1
      The wikipedia article is bunk. Methamphetamines were not mass-manufactured in Europe at the time. And the only non-med pills on regulation list were the caffeine pills that submariners popped on long watches. Even that was rather exceptional because the reported after-effects were that the caffeinated watchmen started getting useless, effectively awake but not able to identify and report threats.

      There are extensive military archives and memoirs, and then there is Wikipedia. Guess which is more accurate?

      --

      --
      Mad science! Robots! Underwear! Cute girls! Full comic online! http://www.girlgeniusonline.com/

    21. Re:Military applications make me shiver... by Hatta · · Score: 1

      What's the point of a government saying "Stay away from drugs!" on the one hand and willingly giving it to soldiers on the other?

      This is nothing new. Soldiers have been getting drunk since time immemorial.

      --
      Give me Classic Slashdot or give me death!
    22. Re:Military applications make me shiver... by TheCaptain · · Score: 1

      Well..."drugs" is a vague term to begin with, but I'll take a stab at this one anyways.

      The government does not generally tell you to stay away from the drugs your doctor prescribes to you. (I said GENERALLY, so please calm down now...)

      I don't think soldiers today are being given meth from their friendly street drug dealer. It's likely given to them by someone who has some manner of medical training. They can explain the effects and potential side effects pretty well, and watch them to make sure it's not causing them more harm than good. Judging by the tone of some of these responses, people are trying to make it sound like uncle sam is just handing a bunch of heavily armed soldiers all the PCP and angel dust they want.

      Even beyond that, back in my parent's day, they used to PRESCRIBE methamphetamines all the time - for weightloss before the federal government put a stop to that. One of my parents actually HAD such a prescription many decades ago, and is living happy and healthy to this very day.

    23. Re:Military applications make me shiver... by justin12345 · · Score: 1

      What's the big deal? Methamphetimines are just long lasting amphetamines, and amphetamines are so safe we give them to little kids.

        </sarcasm>

      --
      Cool art gallery, if you're into that sort of thing.
    24. Re:Military applications make me shiver... by thedustbustr · · Score: 1

      which is why we are in iraq.

      more accurately, uncle sam tells us not to kill *civilians*

      --
      This sig is false.
    25. Re:Military applications make me shiver... by Frangible · · Score: 1
      Almost all sides used stimulants in combat in WW2. The Russians also used methamphetamine, and the English, Japanese, and Americans gave their troops regulard old amphetamine, the difference being the methyl group which makes methamphetamine about 50% more potent by weight. The Germans were suspected of using a method that involved the reduction of ephedrine with annhydrous ammonia, giving rise to the term "Nazi dope" which referrs to clandestine methamphetamine produced in this fashion today.

      Today, about 30 million people in the US use prescription amphetamines yearly, chiefly for ADHD treatment, and about 1 million use illegal methamphetamine. The US Air Force still uses Dexedrine (d-amphetamine) for its pilots but is considering a switch to modafinil (Provigil) as amphetamine can stimulate the amygdala and produce aggressive or fearful behavior. By stimulating the amygdala, amphetamines exaggerate the natural flight or fight response already present, so it's not a guaranteed "fearless" drug, and a sideeffect of using amphetamines in the treatment of ADHD is the anxiety it produces in some users.

      It was far from just a "Nazi" thing. And it didn't always make people fearless, either.

    26. Re:Military applications make me shiver... by tabrnaker · · Score: 1
      I see, so when you plan on killing people taking drugs is A-OK with gov't.

      Sigh, why are they killing people in the first place? Please, don't answer, no need to increase the agression and violence.

    27. Re:Military applications make me shiver... by Archangel_Azazel · · Score: 1

      "The article even suggested that soldiers should self-moderate their usage with proper medical advice."

      Which, if you ask me, is just bullshit. I've never...*EVER* seen a speed user who has used it more than a few times be able to "self-moderate". Sorry, it's like self-moderating your cigarette smoking...possible...but damn difficult.

      --
      Your mind is like a parachute. It works best when it's been opened.
    28. Re:Military applications make me shiver... by Nintendork · · Score: 1

      Creating fearless soldiers would have to be the dumbest idea ever. Just think about what happens in any FPS when you run in all gung-ho. Now imagine you don't respawn.

    29. Re:Military applications make me shiver... by gordo3000 · · Score: 1

      actually much harder. I was at a lecture in a medical school once and the the professor/MD said speed is the most addictive drug we know. It is the only one that can cause real physical addiction after only one dose. any proper medical advice would be to never take it.

      but then again, don't confuse all amphetamines with speed. speed is just one of many and lots aren't nearly as strong or addictive. It just happens speed is the most effectual.

    30. Re:Military applications make me shiver... by LWATCDR · · Score: 1

      Well ignoring the mindless troll part of it.
      If taking a drug will keep you from DIEING it is okay with the gov't.
      Lots of drugs that are illegal for recreation are legal under other situations.
      BTW lots of "missions" that involve long flights do not include killing anyone. Moving F-16s from the US to Korea would be a good example. U-2 flights to monitor cease fires can also involve very long solo missions. The USAF over the years has flown hundreds of U2 missions in support of cease fires starting back in the yearly 70s
      The need for a military is a different subject. This was on if the use of the drugs was proper.

      --
      See my blog http://ilovecookes.blogspot.com/ for light hearted technical information.
    31. Re:Military applications make me shiver... by MemoryAid · · Score: 1
      What do you mean, "even the Nazis"?

      Right. That probably should have read "As Wikipedia (the soon-to-be-discredited repository of internet knowledge) tells us, even the Nazis (who normally wouldn't do anything that may jeopardize the health of an individual) spreaded [sic] the drug among their Wehrmacht."

      I'm sure it was just a typo.

      --
      Language students: Don't try to learn English here. This ain't it.
    32. Re:Military applications make me shiver... by Varsis · · Score: 0

      There really is a large difference between Speed and medicinal amphetamines. I myself take dextroamphetamine for treatment of both adult ADD and mild narcolepsy. It's amazingly helpful, but I haven't seen the least evidence of it being addictive. After using it for six months almost constantly, I stopped taking it entirely over the summer without any negative effects (well, aside from the return of the symptoms that I was treating with it, of course).

    33. Re:Military applications make me shiver... by Dread_ed · · Score: 1

      I have seen evidence to the contrary from the likes of "Psychology Today" and other publications. Nicotine has been rated before (in one article
      I read in the 90's) as the most addictive substance, coming in even higher than injected methamphetamines.

      Of course these were the opinions of a panel of 200 of the most well known and reputable psychiatrists and psychologists in the US. Whether this strengthens the argument for this supposition or totally invalidates is left up to the indiviual.

      All I personally know is this. I know some ex-meth addicts. Hard users that would stay high for sometimes weeks at a time. They at times snorted, smoked, and shot meth.

      The one thing that they all have in common after kicking that incredibly huge albino monkey off their back? They all smoke like chimneys.

      --
      When the only tool you have is a claw hammer every problem starts to look like the back of someone's skull.
    34. Re:Military applications make me shiver... by tabrnaker · · Score: 1

      The point is, contrary to the war on drugs, the drugs themselves aren't inherently bad. Though all manufactured drugs seen to be more on the evil side, where non-processed drugs seem to be on the mild, euphoric, mind expanding love the world types. Definitely not useful in the struggle to keep the machine society alive.

  7. oh lord! by ionicplasma · · Score: 1

    They've done it now. We're soon going to have a demonic whorde of fearless mice taking down everything in their paths. Damn you, Science!

    --
    The easy part was getting the brain out, but the hard part was getting the brain out.
    1. Re:oh lord! by xanadu113 · · Score: 1

      Tweaker mice.. just what the world needs.. Do they hallucinate shadow mice?

      --
      -Myke
    2. Re:oh lord! by jouvart · · Score: 3, Funny

      See, it was all as Douglas Adams predicted. This proves that mice really are pan-dimensional super soldiers waiting to be triggered. I, for one, welcome our new fearless rodent overlords!

    3. Re:oh lord! by Anonymous Coward · · Score: 0

      and just two weeks ago there was a huge discussion defending science vs creationism...interesting

  8. There's already a fearless mouse by Anonymous Coward · · Score: 3, Funny

    Looks like Isadore Klein beat them to the punch. He created a fearless mouse in 1942. http://www.toonopedia.com/mightym.htm

  9. On-the-fly...? by Omicron32 · · Score: 1

    I thought you couldn't change someones genes 'on-the-fly' - it has to be done before they're born.

    Doesn't this mean we'd be breeding our soliders? Opening up a whole can of worms there if that's the case.

    (IANAS)

    1. Re:On-the-fly...? by Anonymous Coward · · Score: 1, Informative

      As I understand it, it would be easier to "turn the gene on" than "off", because the gene produces a protein, so you would only have to introduce that protein "manually".

      However, if you cannot remove the gene, there are other ways to prevent it from producing its protein. You can tinker with the transcription process (which parts of the ADN gets transcripted to ARN), or you can tinker with the translation part (how the ARN is used to produce proteins. That may not be easy, but certainly easier than removing a gene from the genome of a grown-up organism.

    2. Re:On-the-fly...? by walders · · Score: 1

      Your're right. These mice had their genes altered before birth, although the genes can be altered so that they are not activated or deactivated until after birth. With gene therapy, this could be used for soldiers, I guess. This is kind of changing genes on the fly. The other possibility is to produce a drug to knock down this gene or its pathway. Soldiers could then be given that drug before battle. Scary thought (for their enemies, at least).

    3. Re:On-the-fly...? by Anonymous Coward · · Score: 0

      Oops, as if my english wasn't bad enough... I meant of course DNA and RNA, instead of ADN and ARN.

    4. Re:On-the-fly...? by Anonymous Coward · · Score: 0

      Sorry, but no.

      Introducing the protein isn't changing the gene - it's changing the protein levels.

      Tinkering with the trascription or translation process of a single gene is currently not possible (kill the mechanism for one gene, and you kill it for many others, too). It would be way easier to try to remove the gene from the genome of a grown-up organism (site-specific integration into the gene concerned via viral delivery or transposon or something).

    5. Re:On-the-fly...? by Anonymous Coward · · Score: 0
      I thought you couldn't change someones genes 'on-the-fly' - it has to be done before they're born.

      Whenever I change my jeans, I start at the fly.

    6. Re:On-the-fly...? by MttJocy · · Score: 1

      Unless they come up with some developments in developing of artifical viruses desinged to replace the particular gene with the same mutation, this is how natural viruses take over a cell to produce viral agents from them

    7. Re:On-the-fly...? by raiu86 · · Score: 1

      The simplest way would be to block the receptor for the protein this gene codes, we already have many drugs that do that. They are generaly called receptor antagonists. The basic idea being, this "fear protein" must bind to some kind of receptor in other cells telling them, basically, to be afraid. If you use some drug to fill the binding site of the receptor on the other cells (that doesn't trigger the response itself) then cells can release as much of this as they want and none of the other cells will hear them. So, the scary part is, it is very possible to make a drug that turns off fear.

      --
      ***Divide by cucumber error*** ***Reinstall universe and reboot***
    8. Re:On-the-fly...? by Otter · · Score: 2, Informative
      But whether you're blocking the receptor with a chemical antagonist or a biological, it's still "pharmaceutical". The submitter's notion that gene therapy is an attractive "alternative to pharmaceuticals" is simply insane.

      Incidentally, there are lab mouse strains that don't have many of the anxiety behaviors like center avoidance. The article gives the impression that the knockout animals are utterly unmouselike, which is untrue.

    9. Re:On-the-fly...? by justin12345 · · Score: 1

      To make an alteration in the evolvment of an organic life system is fatal. A coding sequence cannot be revised once it's been established.

      "Why not?"

      Because by the second day of incubation, any cells that have undergone reversion mutations give rise to revertant colonies like rats leaving a sinking ship. Then the ship sinks.

      "What about EMS recombination?"

      We've already tried it. Ethyl methane sulfonate as an alkylating agent a potent mutagen It created a virus so lethal the subject was dead before he left the table.

      "Then a repressive protein that blocks the operating cells."

      Wouldn't obstruct replication, but it does give rise to an error in replication so that the newly formed DNA strand carries the mutation and you've got a virus again. But, uh, this-- all of this is academic.

      --
      Cool art gallery, if you're into that sort of thing.
    10. Re:On-the-fly...? by budgenator · · Score: 1

      Personaly I'd rather face an enemy that was fear-less, recklessly audatious, very likely to under-estimate the threat I present, over-estimate his abilities and unable to learn from his mistakes.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
  10. i question the ethics of this by caffeinemessiah · · Score: 1, Insightful

    IMHO, there are much better ways of curing phobias than resorting to potential treatments based on genetics. It's much easier to imagine military and other subversive applications to motivate this kind of research. Imagine it billed as a "cure" to shell shock and other combat-related situations. While its definitely interesting that we now understand fear a little better, removing fear, or even tinkering with its inner workings, seems nothing short of asking for disaster. We have fear for a reason, and methink moderating it arbitrarily to within parameters that we specify will be more challenging than it is worth.

    --
    An old-timer with old-timey ideas.
    1. Re:i question the ethics of this by shawb · · Score: 1

      I assume that the gene itself won't be altered to cure phobias, but rather knowledge of the gene will help us understand the transcription process and be able to better develop drugs which regulate transcription of the gene.

      Actually, after a little basic reading it appears that Stathmin is more involved in learning the fear reactions, so regulating it wouldn't do much to correct an already existing fear. Although it is possible that fear reactions have to be consistantly relearned or reinforced, and so preventing the reconnection of the stimulus with the response may reduce the strength of a phobia. If this is true, then regulating such a protein would be very helpful in conjunction with desensitization therapy.

      --
      I'll never make that mistake again, reading the experts' opinions. - Feynman
    2. Re:i question the ethics of this by Anonymous Coward · · Score: 1, Informative

      "We have fear for a reason, and methink moderating it arbitrarily to within parameters that we specify will be more challenging than it is worth."

      What is natural is not sacred, I wish people would get it out of their head 'tinkering with mother nature' is bad for us, mother nature gave us death and bloodshed, disease and death, and very limited abilities of mind based on what we eat and our genetics to begin with. We want to shed our naturalness if medicine and agriculture proves anything, we want to transcend our natural bodies and limitations of our minds, science and technology are the coup de grace to any kind of notion that 'mother nature knows best' if it did we wouldn't need science, nor technology to begin with.

      We want to be in control of the natural forces and the forms around us to further our survival, rid our race of it's feral instincts and animal past for a more just, equitable and rational society, the fact that human beings are so weak as to use violence to solve their problems proves the point that many people who make up humanity are keeping it in a state of intellectual squalor. Natural things inside us would just as much push us towards eliminating ourselves, as it does sustain us. As always it's a double edged sword.

      We have many other emotions 'for a reason' and many of them detrimental, i.e. tendencies towards wishful thinking and superstition, tendency toward indoctrination (think propaganda and economic idealogy, in the school system, etc), tendency to not critically analyze things being said (i.e. see how easy popular opinion is swayed, think how americans respond to the word 'communism' or 'socialist' for instance, smearing entire concepts and intellectual ideas simply because they are associated with tragedy, last time I looked capitalism was just as smeared as any other idealogy with it's own failures, creation of social problems and bloodshed.

  11. Now I'm Scared.. by Plunky · · Score: 4, Funny

    Come on Mickey, are you a MAN or a MOUSE?

    AAAAAAAAAGGHHHH!

  12. In other news..... by Gunnery+Sgt.+Hartman · · Score: 4, Funny

    More mice have been committing suicide by cat.

    --
    [ ]
    1. Re:In other news..... by Ford+Prefect · · Score: 2, Interesting

      More mice have been committing suicide by cat.

      You joke, but there's already a cat parasite called toxoplasma where the complete life-cycle involves using a mouse or rat as a host, in addition to the final destination of a cat. To increase the chances of that happening, the parasite appears to mess with the rodents' brains, making them more likely to take risks and even actively search for the scent of cat urine. If that rodent gets eaten, the immature parasites can break free and make themselves at home in the cat.

      Disturbingly, this same parasite is known to infect humans as well, and there's evidence to suggest it might be altering our behaviour too...

      --
      Tedious Bloggy Stuff - hooray?
  13. Are these mice really fearless... by Mjlner · · Score: 4, Insightful

    ...or just plain stupid?

    --
    Lemon curry???
    1. Re:Are these mice really fearless... by Anonymous Coward · · Score: 0

      They're stupid anyway.

    2. Re:Are these mice really fearless... by straybullets · · Score: 1
      i don't know for sure if they are fearless, but from the article it's obvious they are deaf :

      And to test learned fear, the mice were exposed to a loud sound followed by a brief electric shock from the floor below them. A day later, normal mice froze when the sound was played again. Stathmin-lacking mice barely reacted to the sound at all

      --
      With that aggravating beauty, Lulu Walls.
    3. Re:Are these mice really fearless... by MouseR · · Score: 1

      Exactly.

      Fear is there to counterbalance stupidity. If you dope up a bunch of soldiers to make them fearless, they'll just keep ramming head-on into ambushes.

    4. Re:Are these mice really fearless... by Anonymous Coward · · Score: 0

      Fear is more applicable in a military sense to stone age warriors than to modern, highly trained soldiers. It certainly still has its uses, for example recognizing that something is wrong might be harder without fear, but surely they won't just abandon their training/conditioning...

      I'm not sure if artificially suppressing fear in soldiers would be a good thing overall, or if it's preferable to have a combination of fear and training than to rely entirely on training, but they won't just turn stupid.

  14. Apologies in advance, but... by Ars-Gonzo · · Score: 1

    I, for one, welcome our new rodent overlords.

    1. Re:Apologies in advance, but... by Mjlner · · Score: 2, Funny

      I think you meant...
      I, for one, welcome our new fearless rodent overlords. I'd like to remind them as a trusted Slashdot poster, I can be helpful in rounding up others to toil in their underground cheese caves.

      --
      Lemon curry???
  15. Don't take the piss... by szaz · · Score: 1

    Genetically engineered soliders? I think not.

  16. And the name for this new mouse is.... by Anonymous Coward · · Score: 0

    MIGHTY MOUSE !

    a new superhero is born

  17. drug abuse for fun and profit by Jeremy+Erwin · · Score: 1

    the use of amphetamines to stay alert, followed by sedatives to sleep,

    Or vice versa.

  18. Anyone see Equilibrium? by vodkamattvt · · Score: 4, Funny

    So we got fear, now there are a few more emotions to get rid of and we can make Equilibrium come true. Now that's practical applicaton of science.

    1. Re:Anyone see Equilibrium? by Rude+Turnip · · Score: 3, Funny

      /me thinks you didn't watch Equilibrium close enough...removing all those emotions was a *bad* thing, except for when Christian Bale killed all those guys that tried to take his puppy.

    2. Re:Anyone see Equilibrium? by Anonymous Coward · · Score: 0

      His puppy? I thought it was that red ribbon that made him go nuts. LOL

    3. Re:Anyone see Equilibrium? by vodkamattvt · · Score: 1

      Thats exactly the point! Having no emotions makes you into a spock like killing machine. How can this be a bad thing?!? Also it was a joke ;)

    4. Re:Anyone see Equilibrium? by not-enough-info · · Score: 1

      Ooh Ooh! I want to learn gun-fu! Pick me! Pick me!

      --
      ---k--
      </stupid>
  19. Uprise timid cubicle workers! by goobster · · Score: 1

    I'm looking for my stapler... It is a red Swingline stapler. "I'm gonna! Burn the building down!"

  20. Obligatory fearless mice joke... by KingSkippus · · Score: 5, Funny

    Three mice were sitting in a bar, each trying to impress the others with how tough they were.

    The first one said, "When I see a mousetrap, I deliberately set it off, bench press the bar fifty times, then snack on the cheese."

    The second one, not to be outdone, said, "Yeah? Well, every morning when I get out of bed, I stir in some cream and rat poison in my coffee. It gives me a good buzz that really wakes me up and gets me going."

    They both look at the third mouse who, after a few seconds, gets up and says, "I don't have time for this bullshit. I've got to go home and fuck the cat."

    1. Re:Obligatory fearless mice joke... by Jommeke · · Score: 3, Funny

      Now all we need is a fearless cat and we have Itchy and Scratchy for real.

    2. Re:Obligatory fearless mice joke... by mattspammail · · Score: 1

      (Parent) - "FINALLY! A reason to use my mouse joke!"

      --
      Now accepting PayPal donations!
    3. Re:Obligatory fearless mice joke... by Anonymous Coward · · Score: 0

      How is this funny? *boggle*

    4. Re:Obligatory fearless mice joke... by Anonymous Coward · · Score: 0

      Well, see, first you have the thought of mice, which are typically timid creatures, bragging about how brave they are, which creates an ironic juxtaposition between their expected behavior and the reported behavior in this anecdote.

      Then, you have the amusingly impossible feats that these mice are supposedly carrying out, which relates the story to the tall tales of early American folklore and evokes thoughts of modern-day "fish that got away" stories.

      Lastly, you have yet another fanciful ironic twist in that a mouse, whose species is traditionally the fatal victim of cats' predatory instincts, has the unlikely role of subjugator in a manner that demonstrates an anthropomorphic position of absolute power over his enemy.

      I hope this clears up any confusion about the methods that the parent used of invoking a humorous response in the reader. As you can see, by all objective standards, this story is indeed funny.

  21. Danger Mouse by wenchmagnet · · Score: 5, Funny

    He's The Best
    He's The Greatest
    He's The Greatest Secret Agent In The World!
    He's The Ace - He's Amazing...
    He's the Strongest... He's The Quickest.... He's The Best!

    1. Re:Danger Mouse by Anonymous Coward · · Score: 0

      Hell yeah, Danger Mouse!

  22. I hate you parental units! by mbarron · · Score: 2, Funny
    GeneEnhanced mice children grow up even faster without fear of their parents. Leaving them without a rigid sense of boundaries, invarively leading to the inhanced mice killing their parents for the inheritance.

    Till the day when they have their own children, these second generation child mice reject their parents just like the previous generation rejected their parents.
    Leaving killing the child mice as the only solution, before they become too grownup and strong to stop.

    Thus putting an end to the whole experiment, as the original generation dies when they finally turn on each other in boredom.

  23. The obvious political applications by Eternal+Vigilance · · Score: 1

    An electorate that's willing to fight for what little remains of democracy, and representatives unafraid to do what's right - and for this it cannot come too soon.



    (Please, no comments about a possible Ben/Socrates ticket.)

    1. Re:The obvious political applications by only_human · · Score: 1

      Grand Fenwick

  24. Isn't fear important? by Maavin · · Score: 1, Insightful

    I don't think that an army of fearless soldiers would be that effektive.

    Imagine hordes of these running fearless into machinegun fire... Very effective, I presume....

    Fear often prevents us from doing really stupid things. So far this worked good along evolution...

    --


    Crivens! I kicked meself in me own heid!
    1. Re:Isn't fear important? by fmwap · · Score: 1

      Imagine hordes of these running fearless into machinegun fire... Very effective, I presume....

      Operation Human Shield!

    2. Re:Isn't fear important? by TrappedByMyself · · Score: 2, Funny

      Imagine hordes of these running fearless into machinegun fire... Very effective, I presume....

      Been there, done that. We called it World War I

      --

      Help me take back Slashdot. When did 'News for Nerds' become 'FUD and Conspiracy Theories for Extremist Nutjobs'?
    3. Re:Isn't fear important? by Zentac · · Score: 1

      you where there? you must be one of te oldest slashdot readers, wow thats pretty cool, tell us about geekdom in those days

    4. Re:Isn't fear important? by Spazntwich · · Score: 1

      No, the French called it World War I.

    5. Re:Isn't fear important? by Anonymous Coward · · Score: 0
      Imagine hordes of these running fearless into machinegun fire... Very effective, I presume....

      Been there, done that. We called it World War I

      It's been done a lot more recently than that. The most recent (and extreme) example I can think of was the Iran-Iraq war in the 80s, when they actually tilted antiaircraft guns parallel to the ground to chew up hordes of charging soldiers.
    6. Re:Isn't fear important? by Anonymous Coward · · Score: 0

      that was standard practice in ww2, though the AA guns were usually used to take out armor/vehicles.

  25. Maybe they'll be something.. by QuantumG · · Score: 1
    --
    How we know is more important than what we know.
  26. Here I come to save the day! by Misanthrope · · Score: 1

    You could almost call them....Mighty mice....

    1. Re:Here I come to save the day! by Woldry · · Score: 1

      But where's Andy Kaufman when you need him?

      --
      How can a post be modded "overrated" or "underrated" when it hasn't been rated yet?
  27. since when does being alert = fearless? by artifex2004 · · Score: 4, Insightful

    The two certainly do not equate.

    1. Re:since when does being alert = fearless? by Reziac · · Score: 2, Interesting

      Indeed -- it sounds to me like what they've really discovered is the fundamental difference between predators and prey.

      Predators don't panic at every little oddity in their environment. They are much more inclined to explore new stuff than run from it, and to stop and think rather than run away screaming. They learn fear of bad things from experience, rather than just being generally afraid of everything. They can relax, because they learn that not everything in their environment is a threat.

      Conversely, prey animals can't cope with change or oddness, and tend to flee in a panic and hide in the shadows even when the "threat" is imaginary. They have difficulty learning what *really* is or isn't a threat, because they're unable to stop and examine the situation; indeed, they tend to react more strongly on repeat exposure to a fear stimulus, because now it's a fear-trigger point rather than becoming familiar. They can't relax, because omighod the bogeyman might get us at any moment. Generally not a fun existence.

      Occurs to me that panic disorder in humans is fundamentally prey-animal behaviour. Inherited panic disorder also commonly occurs in other carnivorous and omnivorous species (cats and dogs). "Abnormal" boldness in prey species is much more rare, tho has been to some degree selected for in domestic livestock, to make them steady enough for humans to deal with. (Who wants to ride a horse that takes off bucking every time it thinks it hears an odd noise??)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    2. Re:since when does being alert = fearless? by ceoyoyo · · Score: 1

      Ever snuck up on a cat? Or a bear for that matter? Predators are plenty twitchy when they're in an unexpected situation. When they're in a familiar situation where they know they're not in danger, they don't show fear, and they might investigate something unfamiliar if it's smaller than they are and appears not to be a threat, but any non-insane predators will head for the hills if they suspect they might not have the upper hand. It's just not worth the risk. Small prey just appear to be afraid more because they rarely (if ever) have the upper hand.

      Several people have shared stories about mice chasing cats, etc. Even when dealing with prey, if the prey acts in an unexpected way the predator's instinct is usually to try again with something that behaves like lunch.

    3. Re:since when does being alert = fearless? by Reziac · · Score: 1

      Diff is that when you startle a predator, sure, it usually jumps and runs -- but not very far, and it typically soon decides to come back to check out whatever startled it. Whereas a startled prey animal just bolts or hides and doesn't want to know what it was at all, nosirree, it just wants to avoid notice and evade becoming lunch.

      So you may get the occasional mouse chasing a cat, if the cat gets startled (as you say, by prey behaving in some nonstandard way), but the moment the cat realizes -- "hey! that's just a damned mouse!" -- the mouse is in deep shit.

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    4. Re:since when does being alert = fearless? by ceoyoyo · · Score: 2, Interesting

      The moment the deer realizes "hey, it's a mouse!" it won't be running so much any more either. Larger herbivores, when confronted with a predator that doesn't endanger them won't run. Llamas will even go out of their way to stomp coyotes and wolves (they hate them). Lots of farmers keep Llamas with their sheep or cattle for just that reason.

    5. Re:since when does being alert = fearless? by Reziac · · Score: 1

      Tho it takes a startled deer a lot longer to realise "Hey! it's a mouse" than it would an equally-startled coyote. That's really what this is about -- how long does it take the brain to recover from panic mode and start thinking rationally again, if it does so at all??

      And yes, there is a matter of perspective -- if it's not a significant predator to your species, why run from it?

      And sometimes there is an aggression factor even in what are nominally prey animals. I used to live next to a herd of llamas and frankly they were worthless against varmints (ran away just like the sheep did; conversely the pygmy goats would charge 'em, horns at the ready). However I've seen a horse that took malignant glee in laying for coyotes... she'd wait for 'em to get far enough from the fence that she could catch 'em before they'd reach it, and would stomp 'em good. Never killed one but not for lack of trying. And I think by now we've all seen the photos of that mule that killed a cougar!!

      --
      ~REZ~ #43301. Who'd fake being me anyway?
  28. Oh well... by Maavin · · Score: 0

    F.E.A.R isn't *that* good anyway...

    --


    Crivens! I kicked meself in me own heid!
    1. Re:Oh well... by BJH · · Score: 1

      Really? I'm liking it so far.

  29. Drug addicts are too easy to control... by Anonymous Coward · · Score: 0

    Then again if there's no fear, there may also be no concept of 'safe' either, so when the treatment is eased off everything may fall back to how it was beforehand.

    I would agree, except that, having adjusted to the "no-fear" brain chemistry, a patient would have no method of coping with their fears as normal people do, so they'd be in even more fear - of everything, rational or not - than a normal person.

    My 'type this word' for this post is "atrocity", which I think is very appropriate...

  30. fear is a good thing by circletimessquare · · Score: 5, Insightful

    people nowadays like to talk about fear in ideological and propagandistic terms, but fear keeps you alive. it keeps you from wandering into traffic or picking fights with random people. if this were ever applied to humans, you wouldn't have superhuman heroic fighters for the military, you'd have guys shooting themselves with their own guns and jumping off roofs... why not, when you're not afraid of anything, including death

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
    1. Re:fear is a good thing by Private+Taco · · Score: 2, Insightful

      Fear (in moderation), like so many things in life, is essential. Deciding which fears to heed is the tricky part.

      --
      If I could, I'd destroy you all.
    2. Re:fear is a good thing by PeDRoRist · · Score: 1

      Exactly,
      Fear is necessary as it keeps us from doing stupid things, and I feel that is even more important for soldiers. Would a fearless soldier be able to correctly evaluate a threat and deal with it without taking unnecessary risks (eg. running headfirst into a room without checking for booby traps or potential dangers first)? I doubt it.
      I think in a combat situation it's actually positive to be afraid -provided you're experienced and know yourself enough to manage it- because it makes you extra careful and thus increases your chances of surviving. Moreover fear in front of an immediate danger can give you an adrenaline boost that may very well save your life (faster running, altered perception of time, tunnel vision...)
      That's natural selection actually. Those fearless mice would probably have a lower life expectancy than their non genetically engineered counterparts, if they were to live outside a lab. I think the same goes for troopers.
      Now, if this enables soldier to know control, and actually use their fear on the battlefield to their advantage, If it can help saving (friendly or unfriendly)lives, that's good. But let's not play with fire here.
      On a somewhat related note, I've been canyoning last summer, and at some point there was an optional 10 meter dive into a very cold river. I chose to go for it, eventhough I was afraid to. I jumped but ended up with a nasty back injury -Spiderman 2 style. I wish I had listened to my fear and self-preservation instinct, because it keeps hurting today.

      --

      Anything you do can get you slashdotted, including nothing.
    3. Re:fear is a good thing by myspys · · Score: 0

      is the reason i just don't wander into traffic the fear of dying?

      i've always seen it as feeling that i want to live a bit longer

      i don't think (ha!) that i'm afraid of dying, but there are so many other things i'd like to do before dying, so therefore i don't wander into traffic

    4. Re:fear is a good thing by Kuscheltier · · Score: 2, Interesting

      While you do have a point, your assumptions aren't 100% accurate.
      I remember reading an article about a woman who was born with exactly this genetic fault. I don't remember if this research has anything to do with this specific person, or if it even worked in a similar way.
      She didn't do stupid stuff like beating people up or jumping off a roof. Keep in mind that humans don't completely rely on instincts to judge most situations. She was at least as intelligent as other people, but she totally lacked common sense and the least bit of suspiciousness. Thus she was totally dependant to her friends who had to save her from trusting the ocassional asshole who tried to abuse her behaviour.

    5. Re:fear is a good thing by UserGoogol · · Score: 5, Insightful

      I don't think so. Fear is not the source of all human behavior. Without fear, people could still say, "Well... I could jump off the roof, but then I'd probably break a few bones, and that would hurt, and I don't like being hurt." (After all, you are arguing right now that there is something inherently bad about being shot in the head, surely a fearless person might be able to see your argument.)

      Fear is merely a mental shortcut. Instead of rationally arguing that doing something will lead to an unadvantageous situation, our brains merely automatically develop fears of the situation and we avoid it quasi-instinctually.

      That said, if you were to completely remove fear without changing anything else, I do not doubt that shit would happen. Human beings are nowhere near as smart as they could be, and are probably not capable of thinking things out clearly enough. As it stands, we probably need mental crutches like fear until we are able to augment our intelligence.

      But still, we should not imply that fear and desire are the only things capable of driving people. Fear is distinct from pain, desire is distinct from happiness.

      --
      "Never attribute to malice that which can be adequately explained by stupidity." -- Hanlon's Razor
    6. Re:fear is a good thing by Cl1mh4224rd · · Score: 1
      it keeps you from wandering into traffic or picking fights with random people.
      Ok, I know this is Slashot, but I'm still surprised that people aren't even considering the application of intelligence.

      Take away someone's fear and suddenly they become a freakin' moron? Give me a break...

      A fearless, stupid person will do stupid things. A fearless, intelligent person will do great things.
      --
      People will pass up steak once a week, for crap every day.
    7. Re:fear is a good thing by Maset · · Score: 1

      Indeed. The feeling of being a Superman is what caused a lot of PCP related violence. I don't want a soldier to be completely dereft of fear: dicipline is primarily made of fear of failure and/or conforming; once this is lost then what control do the higher echelons have over the 'grunts'?

    8. Re:fear is a good thing by cerberusss · · Score: 1
      Fear... keeps you from getting laid!

      --
      8 of 13 people found this answer helpful. Did you?
    9. Re:fear is a good thing by Anonymous Coward · · Score: 0

      There are people who already have this defect and they don't jump off roofs. Maybe the suicide rate is higher than the normal population but intelligence and logic play a part in not jumping off a roof or running into traffic.

    10. Re:fear is a good thing by jellomizer · · Score: 1

      "A fearless, intelligent person will do great things."
      Not always Unless the person is an impossible 100% intelligent who first impression is always correct. Fear is part of our gut feeling, that something could be wrong, and it gives us pause to evaluate the situation. Lets say I am a scientist with no fear. I spend my entire life writing papers about every odd idea I have while maybe some of them will be good or earth shattering a lot of them will be just bad and wrong. Without fear of rejection from your community. His papers will be so random of bad and good that he would quickly loose any support and interest in his work and thus let to die.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    11. Re:fear is a good thing by Anonymous Coward · · Score: 0

      Fear is distinct from pain, desire is distinct from happiness.

      If we're talking about humans, I don't think these things are connected in ways we don't yet understand.

      "Well... I could jump off the roof, but then I'd probably break a few bones, and that would hurt, and I don't like being hurt."

      There's a peice you're missing. Fear kicks in under circumstances that rational thinking does not. Fear of heights will warn you every time you go to the roof of the building, rational thought on the other hand may not be working if you're tired or distracted.

    12. Re:fear is a good thing by GypC · · Score: 1

      Actually, according to most combat veterans, the bolder soldier is more likely to survive. Once fear starts to take over in combat it can rapidly escalate into paralyzation (and it can be contagious), allowing the enemy time to flank you or take you out with indirect fire.

    13. Re:fear is a good thing by Anonymous Coward · · Score: 0
      There's a peice you're missing. Fear kicks in under circumstances that rational thinking does not. Fear of heights will warn you every time you go to the roof of the building, rational thought on the other hand may not be working if you're tired or distracted.


      Yes. My point is that rational thinking could replace fear. It would be vastly better if human beings could just be totally rational all the time. But our brains simply aren't up to the task, and instead we fall back on hacky kludges like fear to get our thinking done.
    14. Re:fear is a good thing by Anonymous Coward · · Score: 1, Informative

      If you had read any cognitive science or behavioural psychology research, you would probably know that this is not how people generally work. Humans have a lot of difficulty making so called "rational decisions" when, for (e.g.) reasons of physiological impairment (due to their constitution or failed surgery, etc.), the parts of the brain that are most connected with emotions, like the amygdala, have lost their link to parts of the brain involved in more rational decision making. Basically, we can reason through all the pros and cons, but without emotion we have no way of evaluating what is actually more desirable.

    15. Re:fear is a good thing by nine-times · · Score: 1

      It's not intelligence. No matter how intelligent you are, you'll never find a logical reason to not-jump off a roof. The reasons will always be fear, desire, or inertia: Fear of hurting yourself or dying, desire for something that you would lose by jumping, or inertia-- an utter lack of anything pushing you toward jumping.

      Inertia, however, is going to be the least reliable. It's gone at your first bout of curiosity.

    16. Re:fear is a good thing by Dutchmaan · · Score: 1

      Ironically doesn't this sound like the beginnings of "soma" in a brave new world. Taking a substance to inhibit negative feeling... or in this case flipping a genetic switch.

      I just don't like the idea of turning off fear. Mastering fear and overcoming it with our rational thought provides humanity increased mental strength of will... Perhaps when we are ready, fear will leave on it's own, but for now I believe fear provides us with something we should be overcoming on an individual basis.

      Tampering with genetics is the slipperiest of slopes. Careful judgement must me used when deciding on when and if to use genetics as a solution to our "shortcomings" rather than a solution to our "defects"

      Granted this could be used as a solution to phobias which would fall under defects.. but how long do you believe it would take to abuse something like this. As a society, we're not ready.

    17. Re:fear is a good thing by nine-times · · Score: 1
      Without fear, people could still say, "Well... I could jump off the roof, but then I'd probably break a few bones, and that would hurt, and I don't like being hurt."...Fear is merely a mental shortcut. Instead of rationally arguing that doing something will lead to an unadvantageous situation, our brains merely automatically develop fears of the situation and we avoid it quasi-instinctually.

      So fear is the mental shortcut that tells you that jumping off a roof is bad before you've had time to think it through? That's a fine description (though I think incomplete) and is enough for me to say we should be happy to have such a wonderful thing as fear. I'm all for mental shortcuts that let me do things and react without thinking them through. Like walking. I really like the fact that I can walk without working out the math and physics involved.

      You miss, however, that there still is the issue of impetus. The part of the equation that says, "I don't like being hurt." Why not? There's something non-logical about it. It's what you like. What do we call the aversion to the anticipation of pain and/or being injured? I'd tend to call that fear.

    18. Re:fear is a good thing by Jaeph · · Score: 1

      It's not that fear is the basis of everything (though I do think it's the root of a lot more than you give credit for), but that it's hard-wired.

      Fear is rom. Rational thought is ram. Fear is fast...instinct, reaction. Rational thought is slow, complicated, takes time, and still is not always correct.

      To be honest, I suspect that removing fear from the equation would result in truly bizarre behavior.

      -Jeff

      --
      Please learn the difference between a dissenting opinion and a troll before you moderate.
    19. Re:fear is a good thing by ceoyoyo · · Score: 1

      The soldier who is alert to his fear and manages it is more likely to survive. The soldier who lets his fear get out of control, "escalate into paralyzation," isn't going to do well. But the soldier who thinks he's superman is going to get dead pretty fast. Bold and fearless are different things. Bravery isn't the absence of fear, it's doing something that needs to be done even though you're afraid.

    20. Re:fear is a good thing by Anonymous Coward · · Score: 0

      Fascinating, Dr. Crane, but the Gotham University provosts still want to fire you.

    21. Re:fear is a good thing by jbridge21 · · Score: 1

      My point is that rational thinking could replace fear.

      And on that, you are squarely wrong.

      Rational thinking merely enables you to connect your fear to an action far removed from the end result. Without the fear, you'll still be able to work through the logical sequence of steps... but then you won't be able to realize that the outcome is undesireable, as opposed to desireable.

    22. Re:fear is a good thing by UserGoogol · · Score: 1

      Although I admit that it would be "insanely difficult" for logic to replace fear, fear is not neccesary to decide what is desirable. A fearless person would still have emotions, and would be able to say, "This emotion makes me happier than that emotion, thus this consequence is preferable to that consequence."

      Furthermore, by saying that without fear people would not be able to determine whether a consequence is preferable to another implies that people always use fear to make their decisions. Although I agree with the posts which say that the human reasoning proccess is a complex thing where emotion makes its say before logic has been able to make up its mind, people are quite capable of saying, "I don't want to walk into traffic right now" even without actively feeling fear about the thing. I can think of walking into traffic, not be frightened by the idea, but still say to myself "Well, that probably wouldn't be a very good idea."

      And I should again point out that I am not talking about the specific mechanisms that the human mind uses to think. Fear might be a crucial part of the human mind, but this does not imply that fear is neccesary for thought itself. Thought can be abstracted away from whatever implementation it happens to have.

      --
      "Never attribute to malice that which can be adequately explained by stupidity." -- Hanlon's Razor
    23. Re:fear is a good thing by npsimons · · Score: 1

      Human beings are nowhere near as smart as they could be, and are probably not capable of thinking things out clearly enough. As it stands, we probably need mental crutches like fear until we are able to augment our intelligence.

      Speak for yourself! I think that if someone is so stupid that fear is the only thing keeping them from shooting his or her self in the head, they probably should be dead. Call me an elitist, I'm just sick of stupid people and think this world has far too many of them.
  31. laser mice... by NoSuchGuy · · Score: 4, Funny

    What about a laser mounted on the backs of these mice?

    Oh, never mind

    --
    Grundgesetz * 23. Mai 1949 - 30. November 2007 - http://www.vorratsdatenspeicherung.de/
  32. Face that fear! by Greatred · · Score: 1

    Bus? I don't fear no stinkin' bus!

  33. What a twist on "28 Days Later" by ConfusedGuy · · Score: 0

    What is the difference between "Rage" and "No Fear"? If you don't fear punishment or even death, what's to stop you from becoming a megalomaniacal criminal ready to kill and steal?

    I can't wait until the entire British Isle is teeming with people infected with "Fearless." And to think it's all going to start with the wrong group of animal rights activists letting these supermice out.

    1. Re:What a twist on "28 Days Later" by Vintermann · · Score: 1

      "If you don't fear punishment or even death, what's to stop you from becoming a megalomaniacal criminal ready to kill and steal?"

      Well, I don't know. If it wasn't for my fear of punishment I would be on a killing spree right now </sarcasm>

      --
      xkcd is not in the sudoers file. This incident will be reported.
    2. Re:What a twist on "28 Days Later" by ConfusedGuy · · Score: 1

      Isn't fear tied into the limits we put on greed, from material goods to our own sexual desires? If we assume that basic instinct is tied to consume and copulate, what keeps you from consuming as much as you want and copulating with whoever you want?

      Fear. Fear is tied into the same logical thought process that governs nearly every decision you make. Fear of death, fear of pain, and fear of getting kicked in the jimmies. Maybe your sarcasm is founded, but you just might be on a rape-and-pillage spree right now if it wasn't for fear of incarceration and repercussions.

    3. Re:What a twist on "28 Days Later" by Vintermann · · Score: 1

      If I believed that, I'd be a fascist. I don't mean "your statements are fascistic", just that if they were true, fascism would be a sensible course of action. Or perhaps more like Robespierre-style reign of terror.

      --
      xkcd is not in the sudoers file. This incident will be reported.
  34. Good! by Anonymous Coward · · Score: 0

    Now we are in a position to finally answer the question: If superman and mighty mouse fought, who would win?

  35. am i the only one... by doyoulikegoatseeee · · Score: 0, Flamebait

    that is outraged by this? this is stupid. i don't like to engage in slippery slope arguments but this is obscene.

  36. Editorial by dukiebbtwin · · Score: 1

    Thanks for the editorialistic introduction to my Slashdot science articles.

  37. Military applications ? by ultranova · · Score: 5, Interesting

    It does not mention obvious military applications for the discovery.

    That's because there is no military applications. You don't want the soldiers to become fearless, because if they do, they might say: "This war is wrong. I used to be too afraid to do anything about it, but now I suddenly feel fearless, and will get the heck away from here !" Basically, fearless soldiers will refuse to obey when given orders that they think are wrong, and cannot be forced to obey by fear of punishment.

    What you want is soldiers that are more afraid of their commanding officers than the enemy; that way they'll follow orders.

    --

    Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    1. Re:Military applications ? by dkf · · Score: 1
      there is [sic] no military applications.
      I agree, there are no military applications. Irrespective of what you think about current military activities.
      You don't want the soldiers to become fearless, because if they do, they might say: "This war is wrong. I used to be too afraid to do anything about it, but now I suddenly feel fearless, and will get the heck away from here !"
      To be fair, fear is also a part of what keeps soldiers from taking stupid risks in a firefight. Whatever else you say about the army, they don't want lots of casualties; saps morale of the troops themselves, and of the folks back home too. And to cap it all, it costs lots of money to replace the injured/killed person (a quick search indicates that training costs can run to $250k a head for someone who knows what they're doing, and that's only one of the costs involved with soldiering). Oh, and who knows how much the gene therapy to make them fearless would cost?

      In any case, whether or not you think wars are justified, you don't want fearless soldiers. They'd be horribly expensive.

      --
      "Little does he know, but there is no 'I' in 'Idiot'!"
    2. Re:Military applications ? by varjag · · Score: 4, Insightful

      What you want is soldiers that are more afraid of their commanding officers than the enemy; that way they'll follow orders.

      It is a bit of oversimplification. Soldiers can be motivated by things other than fear: the sense of friendship, pride, the feeling of responsibility and (misguided or not) patriotism. History is full with exapmles of people knowingly and willingly sacrificing their life for good of others, ranging from Spartans to Soviet atheists (neither of those could even hope for a decent afterlife: the void of Hades ain't much better than simple non-existance). I believe that in Iraq fights of today you could find such instances at both sides involved, too.

      That said, your general argument remains valid. Humans for high command are mostly numbers, and are operated from statistical point of view. They would hate to rely solely for underlings' loyalty.

      --
      Lisp is the Tengwar of programming languages.
    3. Re:Military applications ? by nagora · · Score: 1
      Basically, fearless soldiers will refuse to obey when given orders that they think are wrong, and cannot be forced to obey by fear of punishment.

      My impression is that the vast majority of soldiers obey orders because they have been brainwashed into wanting to obey them. You only have to listen to US Marines or watch those Iraq training videos to see that fear of punishment is way down the line of motivations: these guys actually believe the bullshit their leaders feed them.

      TWW

      --
      "Encyclopedia" is to "Wikipedia" what "Library" is to "Some people at a bus stop"
    4. Re:Military applications ? by colonslash · · Score: 1
      You don't want the soldiers to become fearless

      Besides, mice make lousy soldiers

    5. Re:Military applications ? by killjoe · · Score: 2, Insightful

      Did you see the interview with the tank drivers when they were talking about what kinds of music they were playing while on a "mission"? It was clear that whatever other motivations they had for killing enjoyment was undeniably a factor.

      I think we overlook how much fun it is to kill. It does satisfy a deep urging we have as animals. It's why people hunt, It's why children enjoy ripping legs off of grasshoppers, I knew a guy who used to buy mice and hit them with a golf club. There is a tremendous fun element in killing.

      --
      evil is as evil does
    6. Re:Military applications ? by Anonymous Coward · · Score: 0

      Fearless attack dogs could be useful though... especially with bomb belts...

    7. Re:Military applications ? by rstovall · · Score: 2, Insightful

      That's because there is no military applications. You don't want the soldiers to become fearless, because if they do, they might say: "This war is wrong. I used to be too afraid to do anything about it, but now I suddenly feel fearless, and will get the heck away from here !" Basically, fearless soldiers will refuse to obey when given orders that they think are wrong, and cannot be forced to obey by fear of punishment.

      This is so incorrect as to lead me to guess that the original poster either has not served in the armed services or had a bad experience while doing so. In a successful military, soldiers serve because they believe, not because they are forced to. This is exactly why, even in this era of recruiting problems, the US military still strongly prefers to avoid the draft. It is choice, not fear, that makes fighters effective.

      --
      Confined though we are, infinity dwells within.
    8. Re:Military applications ? by Anonymous Coward · · Score: 0

      er.... Hades wasn't so bad if you died a heroic death. http://en.wikipedia.org/wiki/Elysium

    9. Re:Military applications ? by clickety6 · · Score: 1

      It does not mention obvious military applications for the discovery.

      Bush sending the 633rd Mouse Squadron to Iraq?

      --
      ----------------------------------- My Other Sig Is Hilarious -----------------------------------
    10. Re:Military applications ? by kahei · · Score: 1


      I dunno, they're incredibly hard to hit.

      --
      Whence? Hence. Whither? Thither.
    11. Re:Military applications ? by nagora · · Score: 1
      I knew a guy who used to buy mice and hit them with a golf club.

      This story won't be good news for him!

      "Honey, there's 10,000 angry mice outside and the cat's missing. They don't seem to know the meaning of the word fear aaaaaghh..."

      TWW

      --
      "Encyclopedia" is to "Wikipedia" what "Library" is to "Some people at a bus stop"
    12. Re:Military applications ? by amightywind · · Score: 1

      What you want is soldiers that are more afraid of their commanding officers than the enemy; that way they'll follow orders.

      Maybe Saddam thought like this. This thinking does not prevail in the western militaries that kicked his ass. The US military wants individuals who have been trained to operate in an environment that civilians consider fearful. They do so through a culture of motivation, discipline, professionalism, and peer pressure. Fear of physical retribution is not a factor. Fear of 'washing out', endangering your fellow soldiers, and not 'packing the gear to be in my beloved corps' is. You will not see genetically modified berserkers in the US military anytime soon.

      --
      an ill wind that blows no good
    13. Re:Military applications ? by Anonymous Coward · · Score: 0

      Then you have things like Blanket parties.

    14. Re:Military applications ? by Anonymous Coward · · Score: 0

      I knew a guy who used to buy mice and hit them with a golf club

      And serial killers often start out torturing animals before moving on to people. I'd watch myself (and my family) around this loser.

    15. Re:Military applications ? by ultranova · · Score: 1

      Maybe Saddam thought like this. This thinking does not prevail in the western militaries that kicked his ass.

      It is the Western economies and the resulting material and technological superiority that kicked Saddams ass.

      They do so through a culture of motivation, discipline, professionalism, and peer pressure. Fear of physical retribution is not a factor. Fear of 'washing out', endangering your fellow soldiers, and not 'packing the gear to be in my beloved corps' is.

      I never said that it was neccessarily physical punishment that the soldier needs to be afraid of to remain disciplined. It could very well be the fear of disapproval from your peer group, the fear of losing someone you care for, or the fear of losing your honor (whatever that means) that keeps you in line. Nonetheless it is fear, and making you biologically incapable of feeling fear shuts down this control/self-control mechanism.

      And of course being unable to feel fear might lead to taking stupid risks too. After all, simply because you are unable to feel fear doesn't make you unable to feel impatience or excitement. Sure, you can control those feelings to make rational decisions; but if you are disciplined enough to ignore them, then you don't need the anti-fear treatment either.

      You will not see genetically modified berserkers in the US military anytime soon.

      Yes, that was my conclusion too.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    16. Re:Military applications ? by mikeytwice · · Score: 1

      Good point, though I don't think fearless soldiers would be saying "heck."

    17. Re:Military applications ? by Frangible · · Score: 1
      There may be a military application, but I don't think any pharmaceutical to arise from this would be any better than amphetamine or methamphetamine, which have additional beneficial effects in combat, such as pain, fatigue, and appetite suppression, and somewhat greater strength and stamina. They also usually inhibit fear as well, but can sometimes exacerbate it due to how the amygdala works.

      Soldiers fight more for the man next to them than anything else, anyway.

    18. Re:Military applications ? by Shakes268 · · Score: 1

      I for one am glad they believe it...I can make this post without fear of having someone shoot me for my ideas.

    19. Re:Military applications ? by sgt_doom · · Score: 1

      I've seen utterly fearless soldiers before - and they loved fragging the officers, senior and otherwise.

    20. Re:Military applications ? by nagora · · Score: 1
      I can make this post without fear of having someone shoot me for my ideas. (I assume that you mean the marines).

      That's because you believe it too.

      TWW

      --
      "Encyclopedia" is to "Wikipedia" what "Library" is to "Some people at a bus stop"
    21. Re:Military applications ? by killjoe · · Score: 1

      How would you feel living next door to somebody who came back from Iraq and killed a few dozen people? How about a sniper who may have killed even more? Killing animals is not a sufficient factor in killing people. I pointed out the hunter example. Hunters kill animals every year but don't end up killing people. It's an acceptable way to satisfy your urge to kill and to satisfy your killing pleasure.

      --
      evil is as evil does
    22. Re:Military applications ? by Anonymous Coward · · Score: 0

      I'm all but certain that the kind of "fear" you're talking about (losing respect, causing deaths by desertion, etc.) are NOT the same kind of physical fear this is talking about.

      Moreover, the application would not be genetically modified fearless warriors, but more likely short term drugs...

      And believe it or not, the majority of soldiers in Iraq believe in the war to begin with.

    23. Re:Military applications ? by Tim+Fowler · · Score: 1

      If I feel no fear does that mean that I don't care about negative consequences? Does it mean that I don't feel the emotion of fear? Does it mean that I don't get effected by an adrenaline rush? Does it mean I don't have the instinctual reactions in response to dangerous situations (putting your arms out when you fall)?

          Is the fear that is lacking fear operating on an intellectual (this could be dangerous so I suppose I won't do it), emotional, or instinctual level? And then you could probably break down each level in to different types of responses or different aspects of the same response. I think a lot of the disagreement here is from the fact that people are talking about different things when they talk about fear and its absence. Knowledge of consequences combined with desire to avoid the bad ones, arousal in response to danger, the emotional response to that arousal, and the instincts we have to some dangerous situations are all different things.

  38. I for one... by GetHimHesDifferent · · Score: 0, Redundant

    ...welcome our new mouse overlords. :P

  39. I for one.... by rathehun · · Score: 5, Funny

    ....have a large stock of cheese, for our new....

    1. Re:I for one.... by GetHimHesDifferent · · Score: 0

      Argh, post-stealer! ;)

    2. Re:I for one.... by Solra+Bizna · · Score: 1

      I clicked Read More solely to find one of these comments or be the first (HA!) to write one.

      -:sigma.SB

      --
      WARN
      THERE IS ANOTHER SYSTEM
  40. Hmm by DominoHurley · · Score: 0

    But how will we keep the local systems in line?

  41. Why wouldn't they be fearless? by TheLoneDanger · · Score: 2, Funny

    Why the hell shouldn't they be fearless, when they are now regenerating too? Goddammit, we have to stop this madness before we are overrun by marauding fearless regenerating mice. The irony is that we need many, many more fearful, even irrationally fearful peopl to avert this impending horror. Scream with me people! "The Mice are coming! The Mice are coming!"

    --

    "But I trust in the people's capacity for reflection, rage and rebellion." -Oscar Olivera
    1. Re:Why wouldn't they be fearless? by Anonymous Coward · · Score: 0

      Thanks to us they can regenerate and be fearless.. slowly the truth is revealing:
      mice are the most intelligent species!
      The hitchhiker's guide to the galaxy is right.

    2. Re:Why wouldn't they be fearless? by thesandtiger · · Score: 1

      I'm the best there is at what I do, and what I do isn't very nice.

      I've got a healing factor that's through the roof - shoot me full of lead, and I'm back on my feet and tearing you a new one before the echo of the gunshots fades.

      I've got an unbreakable adamantium skeleton, claws equipped with diamond coating that'll just tear through anything, and now the boys with the high foreheads just went and made me fearless.

      Oh, I'm the best there is at what I do, bub.

      I am... THE MOUSEVERINE! *SKNIT*

      --
      Since I can't tell them apart, I treat all ACs as the same person.
    3. Re:Why wouldn't they be fearless? by mink · · Score: 1

      I think Mouverene sounds more appropriate.
      When did he get a bling coating?

      --
      Well I've wrestled with reality for thirty five years doctor, and I'm happy to say I finally won out over it.
    4. Re:Why wouldn't they be fearless? by thesandtiger · · Score: 1

      When did he get a bling coating?

      He didn't - I just made that part up to avoid copyright issues.

      --
      Since I can't tell them apart, I treat all ACs as the same person.
    5. Re:Why wouldn't they be fearless? by Anonymous Coward · · Score: 0

      Yes, that goes really well with your signature!

  42. Side effects by CrimsonScythe · · Score: 0

    Not all was good; the potential drug seemed to have some side effects.

    Although the mice became fearless, their mobility was reduced due to the vast increase in the size of their testicles, which also seemed to have taken on a shiny metallic tinge. The researchers were also sceptical about the military application for covert operations based on the loud clanking noise that resulted when the mice moved.

    --
    The view was horrible and the smell was even worse; Julie severely regretted becoming a proctologist.
  43. oh no! by ShaunC1000 · · Score: 1

    Now these mice will set traps for humans!

  44. A fearless soldier is a crap soldier by Julian+Morrison · · Score: 4, Funny

    "Hey check this out, I'm not in the least afraid anymore. Hmm, I wonder what it feels like to plough an airplane into the ground on full afterburner. Whee, fast! Hello mr cornfield. Ooh, a scarecrow. My, that ground sure is big."

    1. Re:A fearless soldier is a crap soldier by ben3 · · Score: 1

      Not having fear doesn't mean you turn into a kamikaze dick. You'll still understand the concept of danger and whilst you may not fear getting hurt or even being killed, you'll understand the consequences of both and try and avoid it. The main advantage of not having fear is that it doesn't factor in your decisions and under enemy fire, which may be a very good thing.

    2. Re:A fearless soldier is a crap soldier by Julian+Morrison · · Score: 1

      It depends how much fear is removed. Consequences themselves are conceptual fear, the abstract avoidance of an unwanted outcome. Erase all fear, and judgement between outcomes is bounded by present whim. You might decide you want to follow orders. You might decide that orders are boring, and go sight-seeing. You might get curious what your entrails look like, and disembowel yourself (or someone else). Basically you'd be unpredictable, uncivilized and ruthlessly selfish.

      The inability to sensate any fear is quite a different thing from the trained skill of putting it aside in emergencies.

    3. Re:A fearless soldier is a crap soldier by MttJocy · · Score: 1

      I am of the thought that doing this will remove fear at the genetic level, effectivly removing the instinct not so much the ability to make a rational decision, if you lacked the instinct to detect hunger but were raised to eat 3 square meals a day you would learn to cope with the condition using a learned responce, a factor of higher intelligence. Of course this is not as effective as having the real instict. Taking a view on a more realistic level which does exist people like myself and others with Autism/Aspergers Syndrome have a lack of the genetic pre defined instictive interpretations of reading emotion etc, however we learn to attempt to use rational thought to gain understanding of such things, not as good as having the instinctive method, having said that with emotion it is another story, applying logic and reasoning to emotional behaviours does not really work as emotion is by nature irrational.

    4. Re:A fearless soldier is a crap soldier by GypC · · Score: 1

      I disagree. The Buddha, for example, had no fear, yet he didn't act stupidly or psychotically. There are higher emotions to regulate behavior, the chief one being love.

    5. Re:A fearless soldier is a crap soldier by Anonymous Coward · · Score: 0

      Buddha overcame fear. He wasn't genetically lacking the ability to fear. Big difference.

    6. Re:A fearless soldier is a crap soldier by GypC · · Score: 1

      No fear either way. What's the big difference?

    7. Re:A fearless soldier is a crap soldier by Anonymous Coward · · Score: 0

      Two men are on an island.

      One woke up there, with no memory of how he got there.
      One swam there, and knows there are sharks in the water.
      Both are intensely curious about the world.

      Which one do you think will stay on the island and contemplate his own reality?

      There is a big difference between not knowing fear, and not feeling fear.

      The waker will be eaten by sharks, and the swimmer will think he stupid and deserved it.

    8. Re:A fearless soldier is a crap soldier by Dirtside · · Score: 1
      My, that ground sure is big.
      I wonder if it will be my friend?

      --
      "Destroy science and religion. Science would re-emerge exactly the same; but not religion." - Penn Jillette, paraphrased
  45. Fearless until... by Slashcrunch · · Score: 1

    Fearless until you throw the boy mice in a room full of SEXY! lady mice. Then they get all cowardly again, back to running on the treadmill.

  46. so ...War on Terror vs War on Drugs by fantomas · · Score: 1

    hmmm, complex, do we now get to see George Bush and Tony Blair tell us drugs are ok as long as you're one of the good guys? Maybe the crackheads who live down the road from me in that smashed up house are actually ultra elite commandos keeping me safe from the Axis of Evil Unknown But They Are Really There Terrorists which are all around us these days? maybe they're a bit like the the rangers in Lord of the Rings, I think they are outcasts but actually their curious ways and p*ssing in our hedge is just a cover while they protect us innocent little people from the evil threat which will surely destroy civilisation if it wasn't for them?

  47. 100mg of diphenhydramine... by drewxhawaii · · Score: 1

    ...isn't enough to knock most people out, especially in 15 minutes.

    1. Re:100mg of diphenhydramine... by Anonymous Coward · · Score: 0

      I took 1000 mg of dihydrogenoxide an hour ago and I haven't noticed any effect yet.

  48. USB by linumax · · Score: 4, Funny

    Does this have any impact on USB mice?

    1. Re:USB by lw54 · · Score: 1, Funny

      Wise men talk because they have something to say; fools, because they have to say something. -- Plato

    2. Re:USB by Anonymous Coward · · Score: 0

      Those USB mice are already serial killers

    3. Re:USB by Anonymous Coward · · Score: 0

      i thought it was cute.

  49. wrong by circletimessquare · · Score: 1

    fear is biological, not ideological

    fear is about avoiding predators, not what kind of partisan brainwashed victim you are, either from the right or the left

    but don't let me stating the obvious stop you from spewing more of your braindead propaganda against more of their braindead propaganda

    right or left, i'm so sick of partisans

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
    1. Re:wrong by Hex4def6 · · Score: 1

      fear is biological, not ideological

      fear is about avoiding predators, not what kind of partisan brainwashed victim you are, either from the right or the left

      but don't let me stating the obvious stop you from spewing more of your braindead propaganda against more of their braindead propaganda

      right or left, i'm so sick of partisans


      What?

      Also: Note that your post consisted of one bullshit statement and three lines of drooling idiot. Bad ratio.

    2. Re:wrong by kahei · · Score: 1

      Now, to be fair, you're not really 'stating the obvious' so much as 'ranting about something that has freaked you out for some strange reason internal to yourself', are you?

      --
      Whence? Hence. Whither? Thither.
    3. Re:wrong by Dogtanian · · Score: 1

      fear is biological, not ideological. fear is about avoiding predators

      You're pretty damn confident in asserting an overly simplistic and incomplete idea. People have fear about lots of things; social rejection is one, because if your life depends on being a part of a social group and you're cast out, you may starve to death, etc. etc. One could argue that predators (i.e. defence from) might enter into that equation, but there are other factors, such as the ability to get your own food, be protected from the elements, etc. that also enter into it.

      not what kind of partisan brainwashed victim you are, either from the right or the left. but don't let me stating the obvious stop you from spewing more of your braindead propaganda against more of their braindead propaganda

      Where the hell did you get that one from? I didn't see him/her taking sides; on the contrary, it looked healthily sceptical of those on any particular side. Your knee jerked and the guy hadn't even touched it.

      --
      "Slashdot - News and Chat Sites Deviant". (Click "homepage" link above for details).
    4. Re:wrong by Anonymous Coward · · Score: 0

      shut up you fucking faggot tardo

  50. one protein for fear, huh? by FlippyTheSkillsaw · · Score: 1

    Yeah, that sounds reasonable.

    Biological systems tend to reuse proteins for a lot of things, and when you're dealing with something as complicated as fear, you're certainly going to have some crossover.

    For example, imagine that this protein is involved in memory. Turn off the protein and you are unable to remember things for more than 5 minutes. This is going to manifest itself as fear would, in that you won't have any inhibition due to past experience, which would be similar to being fearless. Fearless like a goldfish.

    Then you get into the whole cortex thing(i.e. not in mice, but in humans). Having a cortex almost certainly moves the center of the brain which handles fear around in space.

  51. No, it doesn't cause fearlessness. by Anonymous Coward · · Score: 0

    This is the stuff media latch on. You know in the 1960s this guy Delgados discovered the TAMING CENTRE OF THE BRAIN? Oh yea what it did was it made animals dizzy. Cause you see, dizzy animals tend to sit down all confused, and therefore appear tame.

    There was also a discover of a very special part of the brain. If you destroyed it (now known as the prefrontal cortex), people would become completely docile. Oh right, that was the LOBOTOMY. Anyone remember those good old days?

    Anyone with half a clue will tell you that the amygdala does not "control" fear. It's idiotic to ever believe there is some type of "center" for ANY complex process. The visual cortex at the back of your brain, the one you learned about in highschool? The only thing it looks at is contrasting edges, and thats about it. It is not the visual center. Don't get me wrong, the amygdala is crucial for fear. But if you're afraid of snakes, and someone took out your eyes, and there was a snake in front of you, you wouldn't be afraid either. Aha, the visual system must be involved in phobias! *snort*

    Occam's Razor/Morgan's Cannon: The simplest explanation is the most plausible.

    Phobias are complex cognitive processes. A "fear response" in a mouse is most simply reduced anxiety or increased stress, very basic physiological processes.

    This is a protein modification. But there is an easily accessible drug that also reduces "fear". It's called alcohol (alcohol-fed mice also display lowered stress in novel situations, and are more likely to take risks). But we all know what alcohol really does right? It makes you stupid. Stupid people don't learn not to touch a hot stove after burning themselves. Stupid people have no fear. /has no Slashdot account because he rarely visits it //doing spatial learning research with Fragile-X gene knockout mice, so has somewhat of a clue what he's rambling about

  52. Are you a Russian general? by Anonymous Coward · · Score: 0

    Uncle Joe is that you?

  53. Earwigs! by Eightyford · · Score: 1

    Can't wait till I can get rid of my fear/disgust of earwigs! Those fuckers are nasty!

  54. No Fear = Terrorists Lose ! by Chaffar · · Score: 1
    Since The Terrorists' (tm) goal is to create fear, this new drug will allow us to finally defeat the evil-doers!

    If we are immune to fear, then there is nothing they can do to scare us.

    For those still unconvinced, the drug should be taken in combination with this other new drug, one that suppresses critical thinking, another totally unnecessary brain function.

    Yours Truly,

    Your Government

  55. Something similar with a vaccination side effect by Mostly+a+lurker · · Score: 1

    About forty years ago, a neighbour's child was damaged by a rare adverse reaction to a vaccination (cannot remember which one). One of the most striking affects was that the child became completely without fear of anything. By this, I do not mean antisocial in any way. He was a really nice kid but had lost the capacity to feel fear. The consensus was that this was very dangerous.

  56. ... it's the mouse that roared by WiseOwl2001 · · Score: 1

    'nuff said.

  57. Obligatory Star Wars quote by Zog+The+Undeniable · · Score: 1

    Fear is the path to the Dark Side! Fear leads to anger. Anger leads to hate. Hate leads to suffering...

    --
    When I am king, you will be first against the wall.
  58. If the fearless-gene was beneficial for the mice by gomel · · Score: 2, Insightful

    this mutation would have dominated the species milions of years ago.

    In a world of cats, fear is the superior evolutionary trait.

    --
    Fight Frist Psoting!
    Browse Slashdot with 'Newest First'!
  59. Something backwards here... by Anonymous Coward · · Score: 0

    Shouldn't they really be working on making the elephants fearless?

  60. Well, nothing new by cciRRus · · Score: 1

    Fearless mice? Well, that's nothing new. They have been around since 1995!

    Pinky: Gee, Brain, what are we going to do tonight?
    Brain: The same thing we do every night, Pinky. Try to take over the world!


    --
    w00t
  61. DNA exchange.... by Anonymous Coward · · Score: 1, Funny

    It was merely a DNA exchange with the fearless rats in the White House.

    Nothing to see here, move along...

  62. Datura by PeDRoRist · · Score: 1

    Reminds me of Datura. Not the chamanic herbal drug with days lasting effects, the imaginary US army nerve gas in Coin Locker Babies (great book from Ryû Murakami)

    In the book, whoever is exposed to the gas enters an hyper-agressive state, and starts attacking anyone they see, until they eventually die.
    But actually, real life datura has somewhat related effects. If you drink it (with tea), or smoke it (even worse), it'll make you lose any sense of fear, and you might very well kill yourself without even trying (or at least hurt yourself bad and without even noticing it). That's why it's recommended to have someone look after you if you are to trip under datura (someone really patient, with lots of time and little need for sleep as datura's effects last anywhere from 12 to 48 hours IIRC).

    --

    Anything you do can get you slashdotted, including nothing.
  63. Confused? by Anonymous Coward · · Score: 0

    You're thinking of the Cowardly Lion in The Wizard of Oz.

    Don't remember where Batman fitted in though... ;)

  64. Ignatz? by flyingsquid · · Score: 1
    Reminds me of Krazy Kat- early 20th century comic strip and one of the all-time classic comic strips. Mouse, cat, dog- standard comic setup.

    Except, Krazy is deeply in love with Ignatz Mouse. Ignatz, meanwhile, finds his primary purpose in life is to throw bricks at Krazy's head. Krazy Kat interprets the hurling of said bricks as thoughtful tokens of Ignatz's affections. The dog loves Krazy, and so spends his time trying to put Ignatz in jail.

  65. so what is the next step by Anonymous Coward · · Score: 0

    Way to go Rutgers - thank God their researchers don't suck as much as the football team.

    1) Fearless mice (meeces as Jinx said)
    2) ????????
    3) PROFIT.

    RU class of '99

  66. No, fearless mice get eaten. by kale77in · · Score: 2, Insightful

    If you put a fearless mouse in the wild, it will die like anything else that lacks a healthy sense of which dangers are worth avoiding.

  67. Fearless doesn't mean insane by microbox · · Score: 2, Insightful

    Fear is an emotion that rules our lives from moment to moment. Losing fear doesn't mean losing sanity, actually is usually means the opposite.

    --

    Like all pain, suffering is a signal that something isn't right
  68. Obligatory SW comment by wizardguy · · Score: 2, Interesting

    No more Sith Lords since we know it is fear which leads to the Dark Side.

  69. Re:Something similar with a vaccination side effec by Digital+Pizza · · Score: 1

    And so, what happened to him? Don't leave us hanging.

    --
    We apologize for the inconvenience.
  70. As a weapon by TummyX · · Score: 0, Redundant

    If you could weaponise it, you could confuse the enemy ... or create an army of suicide bombers.

  71. Can they do the opposite as well? by surfcow · · Score: 2, Interesting

    Ok, so they found a clever way to turn down fear.

    I wonder if they can use this knowledge to do the opposite: turn fear way up? How might that be used & abused? Say around election time?

    The idea is ... scary.

    1. Re:Can they do the opposite as well? by Moderator · · Score: 0

      I wonder if they can use this knowledge to do the opposite: turn fear way up? How might that be used & abused? Say around election time?

      The idea is ... scary.


      Sure. Just develop a way to alter the DNA of already living specimens, make it such that it only works around election time, make it only instill fear into one's political judgement, and oh yeah, find a way to apply it to large populations without their knowledge. That's about as plausible as witchcraft.

      Relax. Current politicians (at least here in the US) have almost perfected the technique of instilling fear into the masses. For the right wing, it's an applied fear of being attacked by terrorism. For the left, politicians use a fear of losing individual rights. And for all, a fear of change, for both Democrats and Republicans are evil in that they are really two extremes of a one party system determined to keep itself in control by crushing third parties when they make the points mentioned above.

      --
      The World is Yours.
    2. Re:Can they do the opposite as well? by jmichaelg · · Score: 1
      Making Mice Meek. Scroll to the bottom of the page for the article on Elizabeth Simpson's research.

      P.S. Your paranoia is showing. No worries though, there's a gene for that too.

    3. Re:Can they do the opposite as well? by mink · · Score: 1

      In Ohio, after the 2004 election, someone actually said he lost an election because of witchcraft. He blames some woman for putting a hex on him and thats why he lost. He actually challenged the election results with that as his reason. Sadly the paper I read the news story in does not have it's archives up on-line for some reason (they have a section for the link but it is not active).

      --
      Well I've wrestled with reality for thirty five years doctor, and I'm happy to say I finally won out over it.
  72. I for one by squoozer · · Score: 1, Redundant

    bow down to our fearless mice overloads (and may I strongly suggest you do the same).

    --
    I used to have a better sig but it broke.
  73. Quite the Weapon by Anonymous Coward · · Score: 0

    I can see it now. A woman goes to have an abortion, the doctors keep the fetus.

    The process is performed on the youngest of a strata, and the strongest live. These become wards of the state, and are given an Episode 2 cloned experience, teaching them all about tactics and weaponry, playing immersive vr for their childhood. Sounds great, huh? Who would complain. But the net effect is a Fearless, well honed assault team. Quite the weapon.

  74. This isn't new! by Anonymous Coward · · Score: 0

    He's the greatest
    He's fantastic
    Where ever there is danger, he'll be there.

    He's the ace,
    He's amazin.
    He's the strongest, he's the quickest, he's the best.
    Dangermouse, Dangermouse, Dangermouse

    Ah, kids' TV at its finest.

  75. Re:If the fearless-gene was beneficial for the mic by Anonymous Coward · · Score: 1, Funny

    But you don't understand: GOD made mice with the fear gene 6000 years ago. Now these evil scientists are tinkering with GOD's intelligent design and they will unleash DAEMONS. :-/

  76. Incorrect by NidStyles · · Score: 0

    Being a military person myself, what you want is confidence, and intelligence. In the Army they want people that can work effectively as an individual and in a team. Fear is there, but you are drilled and trained with such repetition to be able to operate with the fear, because it's so ingrained into what you are supposed to do. The biggest flaw in any soldier is being indecisive. That will get you killed faster than a bad choice. Fear is something that drives you to learn from your mistakes, and make sure you can make a choice, and hopefully the right one.

    --
    Yes, I said it.
  77. Fear is the mind killer by BlueHands · · Score: 1

    Is surprises me that this has been mentioned a couple of times already, that people truly think there is no military application.

    First, we are going to set aside the fact that as other have pointed out lack of fear does NOT mean your stupid. This may be gene therapy now but it will lead to drugs that help manage fear and that is where you would get payoff even if being totally fearless was bad in a combat situation.

    When fear gets to strong, it gets in the way of making rational choices. So while you might not want a totally fearless solider all the time, there are plenty of times when being able to control the level of fear would be vastly useful.

    --
    I mod everyone down who says "I'll get modded down for this." I hate to disappoint.
  78. new perspective by ]ix[ · · Score: 1

    It certainly puts the old proverb of mouse and men in a new perspective.

    The scientist where probably called scared mice by their bullies at school you know.

    --
    This is my sig, show me yours
  79. Re:Something similar with a vaccination side effec by Mostly+a+lurker · · Score: 1
    And so, what happened to him?

    I last saw him about 20 years ago. He was in his early 20s. His life at the time was unexceptional. He had a low paying job and a nice girlfriend. The "no fear" side effect was still there.

    Apparently, in spite of having no fear of anything, he had a sense of self preservation. He never (that I know of) did anything to threaten his continued existence.

  80. Fear is like salt in the food by Steeltoe · · Score: 1

    Fear in life is like salt in the food.

    Too much and it will make the food inedible.
    Too little will make the food bland and tasteless.

    The trick is not to be paralyzed from fear, but use it for good. To stay alive and avoid situations which are clearly not in the best interest of the people involved, securing your child, etc.

    There is nothing wrong with fear, on the contrary, if you feel fear, then you're still alive. How about that!

    1. Re:Fear is like salt in the food by Garak · · Score: 1

      I think its more the other way around....

      Too much and it make life bland and tasteless.
      Too little will make you die.

      --
      God, root, what is the difference?
    2. Re:Fear is like salt in the food by Gulthek · · Score: 1

      Bad analogy. I like saltless food.

    3. Re:Fear is like salt in the food by Chris+Mattern · · Score: 1

      > Bad analogy. I like saltless food.

      No, you don't. If you truly did, you'd be dead, because the human body can't function without a minimum intake of salt. Unless you eat a very unusual diet, you'll find that a great deal of what you eat has salt in it. What you like is not adding *additional* salt to your food (as most people do, including myself (and I know I probably shouldn't)).

      Chris Mattern

  81. Huh? by Conanymous+Award · · Score: 1

    Didn't Apple already develop things like this?

    "They're laboratory mice, their fears have been sliced..."

  82. utterly wrong by circletimessquare · · Score: 1

    because fear is intelligent

    i'm not talking about the propagandistic, politicized fear

    i'm talking about the simple basic fear of predators and death: it keeps you alive

    it IS intelligence

    so for you to talk about a "fearless, intelligent person" is like talking about a "wet, dry person"

    a fearless intelligent person is a contradiction, an impossibility

    you're just not being intellectually honest about what fear really is when you talk about it

    you're probably thinking about fear in the propagandistic, politicized ways people always talk about it nowadays, but that kind of fear is a derivative meaning of what fear really is

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
    1. Re:utterly wrong by GypC · · Score: 1
      Fear is animalistic. It's a throwback emotion that the lower species depend on for survival. In humans it's destructive and counter-productive.

      I don't avoid burning myself because I'm afraid of fire...

    2. Re:utterly wrong by TrekkieGod · · Score: 1
      I don't avoid burning myself because I'm afraid of fire...

      Yes, you do. You don't run away at the sight of fire (that's animalistic fear), but you don't put your hand in the middle of a fire because you're afraid of the pain, and depending on severety, you're afraid of living the rest of your life with a deformed hand, or one that has lost some functionality.

      Intelligence changes the nature of fear and allows you to do evaluate the danger and be fearful of the right things. So, you know that as long as you don't go putting your hand in the fire, and you are careful, you minimize the chances of getting burned, while animals minimize the chances of getting burned by just running the hell away from it (well, I had a dog once that was fascinated by a candle and decided it just *had* to smell that bright red wavy thing on top of the white stick, but that's besides the point).

      I think a complete lack of fear would completely change the way people make "rational" decisions. Save for retirement? I'll be old, I won't be able to enjoy my money. I don't fear death...once I retire and don't have any money, I'll just kill myself. It's not like it'll get any better anyway, I'll just get physically weaker and have all sorts of health problems.

      --

      Warning: Opinions known to be heavily biased.

    3. Re:utterly wrong by ceoyoyo · · Score: 1

      We have more in common with those "lower species" than we'd like to admit. Depending on your reasoning ability is all well and good, but what happens in situations where you don't have time for that? Admittedly the average sheltered city dweller isn't put in such situations as often as they might be, but it still happens.

      Soldiers were mentioned -- if you hear a loud noise (artillery explosion, bullet smacking into the tree next to your head) what happens? You move, dive for cover. Instinct. Without that instinct, you stand around "hm, that sounded like a bullet smacking into the tree next to my head. What shall I do? Well, Aristotle would say..." and by the time you go to "sounded like" the next bullet would have killed you.

      A little closer to home, you stumble on the top step of a staircase. Instinct throws out your arms and by doing so you grab the handrail and are safe. Without that instinct? You're a pile of broken bones at the bottom of the stairs before you get past "hm" again.

      Those are examples of instincts that still serve us very well. Fear is an instinct, and also a response to learned situations. By removing (normal) fear you may not compromise the instincts in my two examples, but chances are you'll do something undesireable. We have instinctual and learned fears for a reason.

  83. Scientists torture fearless mice by Anonymous Coward · · Score: 0

    >to test learned fear, the mice were exposed to a loud sound >followed by an electric shock from the floor >below them. A day later, normal mice froze when the sound was >played again. Stathmin-lacking mice barely >reacted to the sound at all.

    And so the new rodent species will be named in taxonomy as
    Mus Musculus Abugraibus Gitmoensis

  84. These already exist by Karem+Lore · · Score: 5, Funny

    They are called lemmings...

    --
    When all is said and done, nothing changes...
    1. Re:These already exist by PitaBred · · Score: 2, Informative

      Totally off topic, but that stuff about lemmings is completely wrong ;)

  85. Nuremberg Process by Anonymous Coward · · Score: 0

    Oh my, oh my, and here I was thinking, that since the Nuremberg process "Do it, don't question" was not a defense at all. And every year I am reminded that nobody learnt from it.

  86. That's absurd... by Cl1mh4224rd · · Score: 1
    because fear is intelligent
    All dogs are mammals, but not all mammals are dogs. Do well to remember that.

    Intelligence is not fear.

    You don't need to be afraid of moving traffic to know that dodging cars doing 60mph is a really, fucking bad idea...
    --
    People will pass up steak once a week, for crap every day.
    1. Re:That's absurd... by HarvardAce · · Score: 1
      You don't need to be afraid of moving traffic to know that dodging cars doing 60mph is a really, fucking bad idea...

      So you would recommend letting them hit you intead of dodging them?

      --
      Note to self: Stop putting jokes in my insightful comments so I can get something other than +1 Funny!
    2. Re:That's absurd... by Cl1mh4224rd · · Score: 1
      So you would recommend letting them hit you intead of dodging them?
      Bah. I knew that would bite me in the ass. :p
      --
      People will pass up steak once a week, for crap every day.
  87. ...or as Gentoo-oriented Brain would say... by mrv00t · · Score: 0

    Brain: The same thing we do every night, Pinky. Try to emerge the world!

    1. Re:...or as Gentoo-oriented Brain would say... by cciRRus · · Score: 0, Offtopic

      This is rather funny. I'm surprised that you're modding down. :-(

      --
      w00t
  88. Re:If the fearless-gene was beneficial for the mic by rk87 · · Score: 1

    Unleash Daemons? I'm sorry, but I've already got plenty of those running on my Linux box, and they're not killing me or anything ...

    --
    I'M NOT ANGRY!
  89. Cat chased by mouse by jurt1235 · · Score: 1

    If the mouse is daring enough, some cats do not know what to do with it. It has to do with the way they are programmed to hunt. The same pretty much goes for wolves too: If the prey faces them, they will be put off for a moment trying to decide what to do. Once the prey starts running, they act again as they are programmed too: Follow it and kill it.

    --

    My wife's sketchblog Blob[p]: Gastrono-me
  90. The perfect mouse by DrMrLordX · · Score: 2, Funny

    I'd love a mouse like this! I'd name him Johan, and let him loose in cages of other mice just to see how long it would be before they all died. Except Johan, of course.

    In the end, Johan would only kill me, though. I guess that was part of the plan from the start.

  91. Re:If the fearless-gene was beneficial for the mic by Gridpoet · · Score: 1

    But you don't understand: mice RANDOMLY formed from some green goo with the fear gene 600000000 years ago. Now these PREISTS^H^H^H^H^H^H^H scientists are tinkering with DARWINS design and they will unleash a PATENT. :-/

    --

    -=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-
    This is MY galaxy...go find your OWN!

  92. The appropriate techical term is "berserker" by smchris · · Score: 2, Insightful

    This seems like a profoundly unwise idea. And unless they can reactivate the gene at decommissioning, troops who survive their fearlessness better report to the Soylent Green Division for final debriefing. (And why wouldn't they? They're fearless.)

  93. Are you a man or a mouse? by digitaldc · · Score: 1

    A mouse!

    --
    He who knows best knows how little he knows. - Thomas Jefferson
  94. One word... by krunchyfrog · · Score: 0

    ph33r

    --
    printf($randomline(sigs.txt) \n "-- "$randomline(authors.txt));
    -- myself
  95. Re:If the fearless-gene was beneficial for the mic by Agret · · Score: 1

    Ah so you've seen DOOM The Movie too. I feel for you man.

    --
    Have you metaroderated recently?
  96. I have experience with mouse by Anonymous Coward · · Score: 0

    caught one this morning in a glue trap (next time I'll use one of those swifter methods involving a spring trap). I took precautions and distance to avoid getting a bite from that thing. It was scared as could be and bit the lid of a can I used to carry it to the garbage can. The problem it seems is that if that mouse was fearless (or for that matter a human would be temporarily so for military purpose) it wouldn't bite or fight back. It would happily just go along with whatever happens to them. I'm sorry to say but fear is part of our fight or flight mecanism and without it we'd be darwin award nominees withing far too little time.

  97. Roy Batty by cocoamix · · Score: 1

    In the sequel novel to "DO Androids Dream of Electric Sheep" it was explained that the original Roy Batty on whom the replicant was based had a genetic mutation that prevented him from experiencing fear, thus making him an excellent soldier and assassin. Even though it was a pretty lousy book, I doubt I'm the only /.er that's read it.

  98. Anyone remember by drkfiber · · Score: 1

    What happened in the movie Jacob's ladder?...

  99. They should make sure... by Anonymous Coward · · Score: 0

    ...that it's actually a mouse, and not a baby kangaroo. It's less painful that way.

  100. Mighty Mouse! by manojar · · Score: 1

    That gives a new meaning to the phrase "meek as a mouse"

  101. Slashback.. by Anonymous Coward · · Score: 0
    I can foresee the next Slashback:
    Combining several previous researchs, a new FEARLESS, SELF-REGENERATING, ERGONOMIC, SMART MOUSE has escaped into the wild. The results are unpredictable. Expect the unexpectable.
    1. Re:Slashback.. by Cat_Byte · · Score: 1

      Combining several previous researchs, a new FEARLESS, SELF-REGENERATING, ERGONOMIC, SMART MOUSE has escaped into the wild. The results are unpredictable. Expect the unexpectable.

      With lasers on their friggin heads.

      --
      Two roads diverged in a wood, and I - I took the one the bus load of girls just went down.
    2. Re:Slashback.. by HTH+NE1 · · Score: 1

      "Combining several previous researchs, a new FEARLESS, SELF-REGENERATING, ERGONOMIC, SMART MOUSE has escaped into the wild. The results are unpredictable. Expect the unexpectable.

      With lasers on their friggin heads."

      I'd think the lasers would be where their balls should be.

      --
      Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?
  102. alcohol by urbster1 · · Score: 0

    Alcohol makes you fearless, too, but it also makes you make a complete ass of yourself.

  103. Wee Sleeket... by tiluki · · Score: 1

    Wee, sleeket, stalwart, non-tim'rous beastie,

    O, what panic's in my breastie!

    Thou need na start tward me sae hasty,

    Wi' bickering brattle!

    I wadna be laith to rin fae thee,

    Wi' yer murd'ring pattle!

    After the bard - http://www.electricscotland.com/burns/mouse.html

  104. I doubt it by Joe+Tie. · · Score: 2, Insightful

    "Genetic treatments may offer an alternative to pharmaceuticals." So a company has two options. Either a (theoretically and best case) one time genetic therapy which will raise the wrath of a public who leaned everything they know about science from bad movies. Or slightly less effective pills targeting the same mechanism, but which can be sold again and again to a person throughout their lives. I think the whole customer for life deal has a bit more appeal.

    --
    Everything will be taken away from you.
  105. And examples from the story bear that out by ianscot · · Score: 1
    Criminy yes, what a completely absurd assumption. Let's take a look at the evolutionary advantages conferred on these lab mice by their alteration:
    In the experiments, the stathmin-lacking mice wandered out into the centre of an open box, in defiance of the normal mouse instinct to hide along the box's walls to avoid potential predators.

    ...the mice were exposed to a loud sound followed by a brief electric shock from the floor below them. A day later, normal mice froze when the sound was played again. Stathmin-lacking mice barely reacted to the sound at all.

    So they don't avoid predators, and they don't learn from their mistakes. These do not sound like hyperalert mouse "soldiers" whose qualities one would expect to win a war with owls and cats.

    The original article, and the researchers quoted in it, talk about potential applications for anxiety disorders. Sounds a lot more reasonable, trying to help people for whom fear is debilitating.

    (Our /. poster would probably be among those who think evolution naturally results in more and more extreme traits over time: bigger brains, faster rabbits, stronger people. Fearless, fast-running rabbits run into a clearing and get eaten.)

    --
    "Fundamentalism" isn't about divine morality. It's about human authority.
    1. Re:And examples from the story bear that out by catalyst · · Score: 1

      So they don't avoid predators, and they don't learn from their mistakes. These do not sound like hyperalert mouse "soldiers" whose qualities one would expect to win a war with owls and cats.

      Indeed, but that's only because the mice lack the drive to kill something and protect something else. You make the faulty assumption that the mice must go from irrational fear to irrational exuberance; we spend so much energy drilling and training our soldiers exactly because we want them to replace their personal emotions with "pragmatism" (albeit someone else's arbitrary conception of that).

      Our /. poster would probably be among those who think evolution naturally results in more and more extreme traits over time: bigger brains, faster rabbits, stronger people. Fearless, fast-running rabbits run into a clearing and get eaten

      Yes, and that's precisely the difference between war and genetic selection. It is the role of a good soldier to sacrifice their genes and those of any family members in the vacinity for the socially dominant. In a sense this promotes those evolutionary traits that make one a senator[1], but that is not the same thing as promoting the traits that make one a soldier.

      I am quite sure this drug will be on the battlefield in a year or 2. To my mind, the more interesting question is whether things such as this and the new sorts of sleep-replacement drugs will cause a rethink of our drug policy. Suddenly the old categories of Medicine and Street Drugs that the FDA sees look outdated; surely people have a right to something so mindbogglingly useful just because?

      [1] Which is why social dominance nearly always brings breeding rights both in nature and in Potomac whorehouses

  106. Wait a second... by McD · · Score: 3, Funny

    ...a Rutgers University geneticist...

    Rutgers? Didn't we read about them loosing three plague mice into the wild a few months back?

    I don't know what these Rutgers scientists are up to, but I think we can all agree that "Fearless Wild Plague Rodents" would be an excellent name for a rock and roll band.

    --
    "Given the pace of technology, I propose we leave math to the machines and go play outside." -- Calvin
  107. What military applications? by nwbvt · · Score: 1
    This article wasn't about methamphetamines, it was about a new treatment that made mice "fearless". What exactly are the great "military applications" that you and the submitter are worrying about?

    Obviously it can't involve using the treatment on our own soldiers as that would be incredibly counterproductive. You want your soldiers to have a quick and instinctive reaction to things that could harm them in the battlefield, not a slow one. Assuming you are able to control it, fear is your friend in situations where your life is in danger (and if you can't control it, I don't think a job as a soldier was a good career choice in the first place).

    Would it involve somehow feeding this drug to enemy soldiers? That would make them more likely to become suicide bombers and take out your own soldiers.

    The only thing I can think of would be to reverse this process and make enemy soldiers more afraid and thus easier to force into a surrender (notice I could be making a joke about the French here but I am controlling myself). But if you have enough access to the enemies to sneak the drug into their system, why not just kill or capture them outright?

    --
    Mathematics is made of 50 percent formulas, 50 percent proofs, and 50 percent imagination.
    1. Re:What military applications? by budgenator · · Score: 1

      We have or had a chemical agent called BZ which if memory serves me correctly was chemicaly related to LSD, and caused hallucinations and almost universaly caused "bad trips". Our stocks were trivial amounts and only used in tests to devise defensive measures. That was the thing that bothered me about Iraq and WMD, with all of that chemical defense equipment, there should have been a little bit of everything for testing purposes. Telling and showing the inspectors 100gm of sarin and a couple liters of cyanogen-cyanide gas would have made things more believable.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
  108. Related News by vjmurphy · · Score: 1

    In a related development, the Guardians of the Universe have announced that they've solved the problem of finding suitable Green Lantern candidates.

    Daredevil's press representative, though, had no comment.

    --
    Vincent J. Murphy
    Spandex Justice
  109. Think about it... by Chewbacon · · Score: 1

    Are we genetically enhanced mice or MEN?!

    --
    Chewbacon
    The Bible is like Wikipedia: written by a bunch of people and verifiable by questionable sources.
  110. Mighty Mouse by Anonymous Coward · · Score: 0

    Here I come to save the day!

  111. Fearless? by SeanDuggan · · Score: 1
    Didn't I see this in some book? (And my apologies if I didn't manage to properly sanitize the link... not experienced in linking Amazon) Anyhow, one of the bits in the Fearless series (and I think it was in the 22nd one) involved the scientists demonstrating the "fearless gene" (yeah... the science in the book is a bit iffy) by injecting a mouse and showing that he showed no fear when the cat behind the glass partition tried to pounce him, but rather reacted by trying to attack the cat. One of the more amusing bits of the book was were the main villain, after the potential subject left, lifted the glass partition and watched the mouse get easily devoured by the cat as he lacked the proper fear to run.

    Amusing series in a lot of ways although, as aforementionned, the science is not top-rate.

    --
    This sig has absolutely no significance and serves only to take up screen space and waste the time of the reader.
  112. Settles the age-old question by coinreturn · · Score: 1

    Regarding the age-old question: Are you a mouse or a man? You now want to be a mouse - they are fearless.

  113. CATS?!? by christian.elliott · · Score: 0

    Will someone please think of the Elephants?!

  114. OblQuote by BWGames · · Score: 0, Redundant

    Unless I've missed something, no one has said this yet... I for one welcome our mice overlords!

  115. I raised mice like this... by psyon1 · · Score: 1

    When I was a teen, I had a ball python. I bred mice to keep a steady food supply. The snake had graduated from eating pinkies, and was just starting on the small babies who would now run around. I put one in... later, so did my brother. The next morning I woke up to find my snake dead, with its eyes eaten out, and most of the scales on its head gone. I must have had some fearless mice.

    I have heard since then (from a few different sources), that when mice are bred for food, they become more agressive for some reason. I was never told exactly why, but just that alot of people had noticed the pattern.

  116. Re: Fearless mouse - powered by beer by Getzen · · Score: 3, Funny
    Reminds of that Guinness rhyme (feel free to substitute your favorite brew):

    Some Guinness was spilt on the bar-room floor
    Just around closing one night,
    And a wee little mousie crept out of his hole
    And into the pale moonlight.
    He lapped up all of that dark frothy brew
    And back on his haunches he sat,
    And all the night long you could hear that mouse roar,
    "Bring on that god-damned cat!"

    Getzen

  117. Does anyone else see a Stephen King book in this? by imablonde · · Score: 1

    Does anyone else see a Stephen King book in this? I suppose if he's too busy I could use his standard formula and make his book for him, for a small fee. Hmm, who do we put in the movie?

    --
    Have you heard about the Hooters application process? They hand the girls a bra and say "Fill this out."
  118. Parasites by Detritus · · Score: 1

    I've read several stories about parasites that affect the behavior of their host. The host's behavior is changed in a way that increases the likelihood that it will be eaten by a predator, perpetuating the life-cycle of the parasite. Dicrocoelium dendriticum causes ants to climb to the tops of blades of grass, waiting to be eaten by the next convenient herbivore.

    --
    Mea navis aericumbens anguillis abundat
  119. Funny, did you read the article? it reads by MrJerryNormandinSir · · Score: 1

    like the mouse is retarded! Not Courageous? So... If you are stupid and don't learn you are brave? NO. How the heck do they dieerentiate between brave and retarded.

    I'd say they made the mouse retarded, not brave!

  120. Maybe, maybe not, but nothing in it for the Army by Pierric · · Score: 1

    I agree with that. Or, if they do keep their instincts, and become super warrior mice, then the application to the military doesn't hold either. Because of do you maintain order in an Army if the soldier has totally no fear of the consequences of not obeying ?

  121. Conversaiton between two of the mice: by abramovs · · Score: 1

    Mouse 1: "Brain, what are going to do tonight?"

    Mouse 2: "Try and take over the world!"

  122. Turning off Fear? by ReadParse · · Score: 1

    I don't think turning off fear in general is ever a good idea. I find it hard to believe this could ever be used to treat human phobias, since those are isolated fears of things that are often irrational. But most fears that we have every day are completely rational and actually critical to survival. The fear of falling down the stairs, for example. And the fear of a crash on the interstate, which causes us to look before we do it.

    RP

  123. Fearless mice? by abburdlen · · Score: 1
    big deal, Toxoplasma gondii has been making fearless mice for a long time.
    Toxoplasma gondii, causes rats to lose their typical fear and avoidance behavior. It also makes them act hyperactive, which makes it more likely that they'll attract a passing cat's attention.
  124. Not at all by Dr.Syshalt · · Score: 1

    Rational thinking is by order of magnitudes slower than emotional thinking. Even more, the whole process of thinking is based on emotions - read the paper on emotional decisions. In a nutshell, we make emotional decisions first and *then* we rationalize them. If you remove the fear from the sets of emotions, you will seriously change the way the given person thinks. Getting rid of a fear is a bad, *bad* thing.

  125. are you pondering what I'm pondering? by hobo+sapiens · · Score: 1

    Yes, but where are we going to get 40 gallons of cheez-whiz, a ladder, and 1500 gypsy moths?!?

    --
    blah blah blah
  126. Someone had to say it... by Kahless2k · · Score: 1

    I for one hail our new rodent overloards! Someone needs to get rid of the old ones though..

  127. Just two points... by DarthVain · · Score: 1

    #1) Fear is good, its a natural and it keeps people alive. You don't want soldiers that will run in the face of battle, but you certainly don't want sucidle morons either (I wouldn't want him protecting my ass anyway). As for pilots, do you really want to put someone with no fear at the wheel of a 30-100 Million dollar machine? Controling fear is good, having none is bad.

    #2) I fail to see the connection with soldiers taking drugs to stay awake or fall asleep as to do with fear. Unless they have a fear of sleeping, or staying awake (how messed up would that phobia be!?)

  128. I'm not so sure by hey! · · Score: 2, Insightful

    We're a big bag of complex chemical equillibria and messy neural wiring. We give names like "love" and "fear" to aspects of the subjective experience of existing this way, but they're seldom precise enough to be something you can switch on and off. You're bound to get either more than you intend or less than you intend, or both.

    Fear would seem to be a good candidate for a neurobiologically switchable emotion, but even fear is more complex than it seems at first glance.

    I saw a photo in some book I read on the psychology of emotions that showed a truck tipping over. The truck was loaded with maybe thirty soccer fans returning from a game, and all that rowdy weight caused the thing to overbalance. The photo was taken just as the truck was approaching 45 degrees, and the people on the top were leaping to safety. What was interesting about the photo was the peoples' faces. The people leaping to safety had no look of fear or emotion at all -- just intense concentration. The driver, however is obviously terrified.

    The point is that there is arousal in response to danger, and there is fear. Arousal in the presence of danger is not fear: fear is specifically an emotional reaction to helplessness in the presence of danger. It's evolution's way of say, "If you're going to do nothing about this situation, then you'd better do it really, really unobtrusively."

    There is already a method for controlling and eliminating fear in a soldier. It's called "training". You ingrain the right response in a danger situation into him so he can act automatically. He may be afraid before hand and traumatized afterward, but you want him aroused and as close to fearless as possible at the moment of truth.

    Because of the imprecision of language, I suspect a pill that turns off "fear" would actually make a soldier's training less effective. The physiological and emotional response to danger which is not fear, or at least not exactly fear, curiously doesn't have a distinct name. Clearly this unnamed state is a kind of emotional state -- one in which reactions are automatic and information is extensively filtered down to that which is paradigmatically most useful for survival. Perhaps "fear" is a reasonable umbrella term for all kinds of arousal reactions to danger, but we have to distinguish between being "frightened" or "scared" on one hand and being "terrified" or "petrified".

    But whatever the word is, I expect the condition of reacting to danger is on the whole more beneficial to the warrior than it is detrimental to a warrior. And, as you say, if the soldier does not react in an emotional way to danger, then the way he does react is probably unpredictable. An ideal pill from a military standpoint would narrowly block the "petrification" reflex, without altering any of the other subjective aspects of fear.

    --
    Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
  129. Interestingly however, rats are parttime predators by gd23ka · · Score: 3, Informative

    ... and for that extra helping of protein hunt for insects and in the case of rats even small birds and other mice. Both rats and mice also eat unhatched eggs. They don't have fangs like dogs and cats, but anybody ever bitten by a rat will tell you they have razor sharp incisors and a powerful jaw and the bite hurts plenty.

    However... to set the record straight, like most other mammals a rat will
    only attack a human when cornered or provoked. I suggest you do not pickup
    or otherwise try to pet the rat you find out in the streets but they are
    actually some of the cutest mammals in existance and they
    make excellent pets.

    See the pages of the Rat & Mice Club of America http://www.rmca.org/ if you're interested.

  130. Islam by botmfeedr · · Score: 0

    Praise be to allah! Who needs science to get rid of fear when religion can do it much easier!

  131. Re:If the fearless-gene was beneficial for the mic by Wordsmith · · Score: 2, Insightful

    Not necessarily. Darwinian evolution doesn't necessarily dictate that the best mutation wins out. It generally suggests that the mutation best adapted to the species' circumstances will survive, but really, anything that works well enough to allow further breeding will still continue to exist. That's why we have all sorts of absurd animals in nature right alongside the magnificent ones, and why in our own species various forms of genetic disease and handicap continue (although for the latter, our own social evolution and co-dependency has something to do with it too).

  132. One of the mice by Ranger · · Score: 1

    was heard to utter "Andale! Andale! Ariba! Ariba! Eh-hah!" then zipped into the next room, followed by a loud crash and a voice yelling "Sufferin succoutash!"

    --
    "You'll get nothing, and you'll like it!"
  133. Vikings ate mushrooms, this is old science :) by dindi · · Score: 1

    Vikings used to eat amanita muscaria before going to battle. It gave them spiritual courage, fearlessness and anger. Not to be mistaken by magic mushrooms (psylocibe content).

    It is a strong psychedelic in bigger quantities and you can actually get it online as it is considered legal and grows all over the norht hemisphere.

    Disclaimer:
    No I am not a biologist, not a Viking nor am I any kind of substance abuser. And don't run and pick some now (just by googling for a pic), they look very similar to other shrooms that will make you drop dead in an instant.

    1. Re:Vikings ate mushrooms, this is old science :) by micromuncher · · Score: 1

      Its so true! Bjorne could keep fighting with an arm off!

      Selective breeding is wonderful. It explains George Bush and mulletheads.

      --
      /\/\icro/\/\uncher
  134. not just the military by plopez · · Score: 1

    All sides used some form of speed during WWII, not just for soldiers but also for cicilian denfense workers working long shifts. In fact in the US if you were working long hours in the oil fields or mine and refinerys you often could get a Rx from the company doctor for amphetmines. That finally got phased out, but I think that is where the meth epidemic started. People could no longer get a legal source and so this created a market for bath tub crank.

    --
    putting the 'B' in LGBTQ+
  135. Beer by nortcele · · Score: 1
    I've seen beer create fearless men with the same disregard for their own safety... walk out in front of a bus while a normal man would be fearful.

    This removed "fearless" gene might instead be an I.Q. gene.

  136. Dude by Anonymous Coward · · Score: 0

    Dude, if you don't know the difference between doing drugs and killing people, I want what your smoking!

    Hmmm. Then again, maybe not.

  137. Because it makes them rip their shirts off? by Medievalist · · Score: 1


    I guess they would lose all fear of sunburn... the great of scourge of Viking warriors.

  138. I take my cue from the Bene Gesserit by greg_barton · · Score: 1

    The Litany against Fear is a pretty good guide: Fear is the mind-killer. Fear wipes the mind of rational thought. "Sometimes," you might say, "this is a good thing. Sometimes you need to act quickly." But I ask you, in our day and age, how often do those times come up, and how often is wiping your mind of rational thought useful? I'd argue that the drastic measures fear employs are rarely needed. And, if fear were eliminated, would be needed even less.

    Besides, you can train yourself to act decisively without fear and with all of your mental facilities intact. Various martial arts do this well, as do other disciplines that teach self awareness. All it takes is mindfullness and awareness of one's surroundings.

    1. Re:I take my cue from the Bene Gesserit by Reziac · · Score: 1

      This awareness, thus ability to react instantly yet rationally, is the diametric opposite of the unreasoning fear that mice and other prey animals live with all the time. See above where I talk about this as predator behaviour vs prey behaviour.

      Ask yourself which type gets eaten more often, and therefore whether fear or rationality has better survival value :)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    2. Re:I take my cue from the Bene Gesserit by greg_barton · · Score: 1

      Ask yourself which type gets eaten more often, and therefore whether fear or rationality has better survival value :)

      I would say that fearful mice get eaten more often than non-fearful humans. Is that an apples and oranges comparison? Of course. Survivability is situational. What works for mice in a predator/prey situation probably won't work for humans in a civil society. Why should we hold on to the emotional reactions we inherited from our meek ancestors? Undoubtedly they served us well then. Do they now? I would argue, on the average, no.

      And, in answer to your question, rationality does have a better survival value for humans, at least in societies I would like to live in.

    3. Re:I take my cue from the Bene Gesserit by Reziac · · Score: 1

      Actually, it's not entirely apples and oranges. Watch an unusually-fearful kid on the playground -- ALL the other kids pick on him. A dog pack will torment and eventually kill an abnormally-fearful member. Same with chickens (one that panics when pecked will eventually get ganged up on, killed, and eaten by the other chickens. Contrary to popular belief, chickens are more predatory than not; their natural diet includes mice, snakes, and anything else they can catch.)

      As to evolutionary survival value -- if you're a monkey living in a panther-infested jungle, then the whole troupe fleeing in panic may save the majority, but one monkey still gets caught and eaten by the hungry cat (likely the one that was most panicked and therefore thought the least about its escape route). If the troupe holds its ground (staying rationally out of reach; that is, in control of their fear) and throws rocks at the cat's head, chances are it'll look for an easier meal elsewhere.

      As someone once pointed out, intelligence gets selected for by the dumb (here defined as panic-prone) individuals being eaten out of the gene pool.

      Maybe we need a new big predator :)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    4. Re:I take my cue from the Bene Gesserit by greg_barton · · Score: 1

      Maybe we need a new big predator :)

      The chosen "big predator" at the moment seems to be international terrorism. Sex offenders and liberals seem to be competing for second place...

    5. Re:I take my cue from the Bene Gesserit by Reziac · · Score: 1

      Terrorists, sex offenders, and liberals as "big predators"... Interesting way to look at it. The masses certainly do react to them like sheep (ie. prey animals).

      Tho it never occurred to me to count liberals as "predators"; in my biology text, they're covered in the chapter on "parasites" ;)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
  139. dune by GEEK13 · · Score: 1

    Well, fear is the mind killer.

  140. Huh. by StarKruzr · · Score: 3, Funny

    There really IS a club for everything, isn't there?

    --

    +++ATH0
    1. Re:Huh. by ichigo+2.0 · · Score: 2, Funny

      Hey, I'm a member of the Pet Flesh-eating Bacteria Club, you insensitive clod!

  141. Fearless or dumb? by Carnage+Pants · · Score: 1
    Stathmin-lacking mice barely reacted to the sound at all.

    That's some fearless Mighty Mouse you've got there. Sounds more like it just deadens their responses in general rather than makes them fearless.

  142. Next step.... Daleks by VojakSvejk · · Score: 1

    exterminate! extermiNATE! EXTERMINATE!

    and pass the cheese

  143. Enter 'Meta-Fear' by delire · · Score: 1



    .. or the "Fear of being Fearless". I for one wouldn't like to have my principal warning system (imbalanced cognitive patterning (phobias) included) suddenly removed. Fear is an important agent of awareness when used with wisdom. When abused, it is destructive.

  144. Horror by Anonymous Coward · · Score: 0

    This has horror story written all over it, imagine unleashing fearless rats in New York :). I know their intentions are good but it seems a little scary to me

  145. Natural Selection by no_pets · · Score: 0

    There is a reason why mice carry the fear gene - it keeps them out of danger. There were probably "fearless" mice thousands of years ago but while they were being "fearless" and getting killed the other mice lived to breed.

    --
    "A government is a body of people, usually notably ungoverned." - Shepard Book Quoting Malcolm Reynolds
  146. I for one... by InterestingX · · Score: 2, Funny

    welcome our cheese-eating overlords

  147. Re: Fearless mouse - powered by beer by Anonymous Coward · · Score: 0


    Well, the cat came out
    and they had a little spat
    and the cat ate up on the mouse.
    And the moral of the story is...
    "You can't drink Guiness on the house!"

  148. Who Moved My Cheese? by quibbs0 · · Score: 1

    Does this mean that a new breed of mice will not be concerned with Who Moved Their Cheese?

  149. Pervitin by keosak · · Score: 1

    In fact, Nazis were so disappointed with effects of amphetamines that they developed a whole new drug called Pervitin. Wehrmacht soldiers were issued with Pervitin and its intended use was to inhibit pain. But it also made the soldiers nearly mad. They thought they were invulnerable and they thinking was not straight. Harry Thuerk described this in his book "Die Stunde der toten Augen" (Hour of The Dead Eyes in english, probably). Metamphetamines were used by RAF and USAF pilots on long flights over Germany to keep them awake. The flights took about 8--12 hours so it was quite necessary.

    1. Re:Pervitin by Frangible · · Score: 1
      Pervitin was simply a name for methamphetamine, which has an identical method of action to amphetamine (displacing catecholamines from the chromaffin, inhibiting their reuptake). The difference is the methyl group allows the drug to move through fatty brain tissue much easier, making it about 50% more potent by weight. Given the suspected method of production, the motivations were probably more economical in nature.

      Though amphetamines can produce psychosis and abherrant behavior in some cases, the actual dose of pervitin given out to the wehrmacht soldiers was only 5mg, a rather low amount. Those effects sound extremely exaggerated for that dosage and probably only happened in rare cases.

      Amphetamines aren't terrible effective at suppressing pain, which is why later in the war a mix of methamphetamine, cocaine, and opium was proposed. However, this was at too late an hour for Germany and it never saw production.

      Pervitin was chiefly used to suppress fatigue and hunger and improve morale (as it is a euphoric stimulant). It was also used on the Eastern Front in Russia to raise core body temperatures of German soldiers and prevent hypothermia.

  150. Ignorance, as usual... by Anonymous Coward · · Score: 0

    Wow, yet another statement made by the clueless about the military. I'm shocked. SHOCKED I say.

    Of the >200 soldiers I know, a solid 80% of which have seen combat duty in various places; Somalia, Croatia, Kuwait, Iraq, etc. not a single one has ever been exposed to any "illicit" drug besides morphine and its synthetic derivatives in the course of treating physical trauma (it's called anaethesia).

    I will never stop being in awe over the stupid things people come up with and believe about something as transparent as the US Army.

    1. Re:Ignorance, as usual... by Marc2k · · Score: 1

      All of those conflicts have occured since the early-90's, I'm assuming he was talking closer to the World Wars; both sides absolutely did heavy experimenting with personnel as well as weaponry during that time, obviously Germany did much more human testing during WW2 than either side previously.

      --
      --- What
  151. What is a phobia... by oliverthered · · Score: 1

    The question remains what is a phobia and why would you want to cure it. From casual observation it would appear that most phobias (spiders, open spaces, closed spaces, heights) and associated conditions such as vertigo are left behind evolutionary traits.

    We don't live in holes because people are claustrophobic, we don't fall off cliffs because people get vertigo, we don't wonder off into the desert because of agoraphobia etc....

    Anyhow, except in extram cases (where oversion therapy already works) why would you want to cure a phobia?

    --
    thank God the internet isn't a human right.
  152. He's the greatest! He's fantastic! Wherever ... by DirtyFly · · Score: 1

    He's the greatest! He's fantastic! Wherever there is danger, he'll be there! He's the ace! He's amazing! He's the strongest, he's the quickest, he's the best! Dangermouse! He's terrific! He's magnifique! He's the greatest secret agent in the world! Dangermouse - powerhouse! He's the fastest, he's the bravest, he's the best! Back to the top Dangermouse! (Amazing!) Dangermouse! (Astounding!!) Dangermouse!

  153. Now all we need to do is... by http101 · · Score: 1

    ...employ these new super-mice in the Army and have the Army show up on Bin Laden's doorstep, dump a crate of these wall-infesting; head-mounted, laser-cannon-sporting mice to crawl through the caves of the middle east. If equipped with small beacons, would be able to radio back to "home base" (your laptop or other system) and show you where they're going topographically, thus rendering a 3-D model of what a cave might look like on the inside. I love ADHD...

    --
    -- Game Developers: Stop porting badly-textured games from crappy console systems!
  154. Fearless or Fanatic by Anonymous Coward · · Score: 0

    Fearless soldiers are useless. Fear is healthy and important to survival. If you aren't afraid you do stupid things...like blow yourself up in a market to attack the "enemy".

  155. Fear, Evolution, and Intelligence by Anonymous Coward · · Score: 0

    Fearless mice in the wild would all be killed immediately because they'd walk into trouble and, jokes aside, they'd still be tiny helpless mice.

    Fear is not a negative accident of evolution: it serves a specific purpose. Just enough Fear is one of the things evolution selects *for*.

    It's actually a rule of thumb among animal breeders that fear is usually correlated with intelligence. If you want to breed a smarter dog or horse, for example, you have to be aware that your animals are also going to become more panicky and "high-strung".

  156. Fear and discipline by phorm · · Score: 1

    Indeed, part of discipline would be a very of consequences should you ever step out of line. In the military, discipline is an important thing. Won't help much when you fearless soldier shoots his CO in the head because of an arguement over whether his shoes were dressy enough...

  157. Fearless mice wreaking havoc and destruction...... by Anonymous Coward · · Score: 0

    Naw, no way....it's impossible. When you consider it as simple matter of weight ratios........

    Now should you considered doing this with white rabbits....now you got a real problem on your hands.........

  158. What is that Slow Motion Awareness Called? by Anonymous Coward · · Score: 0

    this unnamed state is a kind of emotional state -- one in which reactions are automatic and information is extensively filtered down to that which is paradigmatically most useful for survival...

    If you've ever been in a dangerous situation, like a car accident,
    or just taking a tumble off a mountain bike,
    and your awareness gets so hightened that everything seems to be moving in slow motion,
    what is that called?

    The Slow-Motion effect seems to make the world move slowly while you are think as quickly as possible - 'How the hell do I get out of this!?!'

    Now, if they had a drug that boosted awareness like that for four to six hours,
    without leaving the person Drain Bramaged for life,
    that would be a useful drug for Combat, Flight, Sports, Recreation (the co-ed type), even for medical operations and people studying for final exams.

    I imagine that 'SloMo' drug users would need some training to get the most benefit out of their hyper-awareness, instead of just zoning out for hours that would feel like weeks of time to them...

    1. Re:What is that Slow Motion Awareness Called? by mikefe · · Score: 1

      I don't know about you, but every time that slow-motion effect has happened to me, I have not been able to use it to help my situation.

      It is more like watching your own movie, where you get to see the bullet heading toward you, but can't do anything about it.

      --
      There: Something at a specific location.
      Their: Owned by someone.
      Please make sure your english compiles.
  159. Useful to study biological element of phobias by Wormholio · · Score: 1

    Rather than simply changing somebody's genes to cure a phobia, being able to study what this gene does (which protiens does it enable or inhibit?) could lead to a better understanding of the physiological (rather than psychological) component of phobias.

    --
    "Education is not the filling of a pail, but the lighting of a fire." -- William Butler Yeats
  160. I recall. . . by Fantastic+Lad · · Score: 1
    Does anybody else remember reading a few years back about an anti-fear pill produced by the U.S. military? It could turn off fear in a soldier for a few hours but had otherwise zero effect on one's judgement.

    In any case, I'd be pretty surprised if this science hasn't already been examined up the wazooo and applied somewhere. --One interesting thing about the big fast world today is that the same science keeps getting re-done by different departments and re-announced as new.

    Imagine if researchers spent less time patenting, copyrighting and otherwise working under the veil of secrecy and spent more energy making research openly and easily available for anybody who wanted to access it?

    Knowledge in this world might accelerate exponentially!

    Couldn't have that, now, could we? Such a paradigm would prevent people from being so easily manipulated for fun and profit.


    -FL

  161. Re:Something similar with a vaccination side effec by Reziac · · Score: 1

    I have to wonder if in fact it normalized his fear reaction, rather than removing it... or if maybe it was just a turning point in the kid's development that was attributed to a "vaccine reaction" but in fact was no such thing. ("Vaccine reaction" has become blamed for every sort of problem, but in my observation is at most a trigger for an existing problem, but not itself the cause.)

    See my post above where I mutter about how normal predators (that's us humans) have rational caution based on experience, rather than the unreasoning "panic over every little thing" of prey animals.

    --
    ~REZ~ #43301. Who'd fake being me anyway?
  162. Re:Maybe, maybe not, but nothing in it for the Arm by HTH+NE1 · · Score: 2, Insightful

    Because how do you maintain order in an Army if the soldier has totally no fear of the consequences of not obeying ?

    Start a eugenics war? Control them with drugs?

    --
    Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?
  163. Fat Cats by ClayDowling · · Score: 1

    Releasing fearless mice into the wild, at least around my house, is going to result mostly in fat cats. None of my cats seem to rely on their prey being afraid of them. Mostly they rely on their prey being slower than them, or at least less attentive. Could we leave this drug around for the local rabbits? If they stop fearing my cats, I'm pretty sure that there will be a lot fewer rabbits around to eat my garden.

  164. Fearless TV series by /cypher · · Score: 1

    Ohhh, maybe they'll bring back the Rachael Leigh Cook series Fearless. As far as I know, only a pilot was produced, and the show was not picked up.

    --
    :-| have a day
  165. Cue the.... by rolandog · · Score: 1
  166. Obligatory Simpson's reference by Matarick · · Score: 0

    Nah that was Itchy and Scratchy.
    Honestly, that cat dashes when he sees Itchy.

  167. hang on a minute.. by TheJOsh!(tm) · · Score: 1
    why does everyone here seem to equate fearlessness with stupidity? A guy on PCP doesn't jump out the window because he's not afraid, he jumps because he's dosed and thinks he can fly.

    I don't get all the +5 posts saying we'd have soldiers shooting themselves in the face and flying planes into the ground for kicks, the only people I can see doing this are the ones whom are predisposed to suicide and have now lost their fear of death. that doesn't mean every tom-dick-and-harry is going to start signing up for suicide missions.

    I'm sure there are many situations where comrades are killed because someone choked when they should be firing, or firing randomly because they're so afraid they can't aim properly. as long as this "enhancement" didn't affect the logical thinking of the person, I'm sure this would be beneficial to soldiers: help them keep their heads clear when in high stress situations..

    --
    Rise up in the cafeteria and STAB them with your plastic forks!
  168. New species control? by GooberToo · · Score: 1

    I'm not sure if anyone else has considered this but, if you allow a genetically modified specimen to breed with ones in the wild and this gene is passed on to their offspring, you have instant population control. Think of it. How many rodents hide when a hawk flies over. Not this offspring. How many animals run for cover it sees a car coming? Not this offspring. The effects this could have on a species' population is incredible.

    Now, imagine the effects it could have on preditory animals! Suddenly lion, tiger and bear attacks are through the roof! Covert operations could suddenly drop on engineered animals into areas where they are free to breed with pack animals which reside close to humans. Imagine the effect this could have on countries which have large monkey populations and engineered monkies were introduced! They could seriously effect every aspect of human life and culture there. Imagine the amount of food that would be stolen! Imagine the human/primate conflicts! Remember, many primates are pack/heard animals with strict social structures. Imagine a pack of monkies attacking people for their food and living space!

    Seriously, this has the potential to become a VERY subvertive technology!

  169. Toxoplasmodium already does this by Jim+McCoy · · Score: 1

    The toxoplasmodium parasite already does this to rodents. As a part of its lifecycle it needs to get from a mouse into a cat. It manages to perform this by modifying the mouse's brain to no longer be afraid of the scent of a cat and to perform certain actions (e.g. don't worry about staying in the dark parts of the grain silo...) that increase the probability that a cat will end up eating the rodent. This allows the parasite to move on to its next host.

    The neurological effects of this parasite are also why pregnant women should not scoop the litter box, the parasite leaves the cat via its dung and if it gets inhaled by a pregnant woman it can cause neurological problems for the fetus (the woman's immune system can handle the parasite, but the fetus does not have a strong enough immune system to kill the parasite.)

    Annyone want to bet that what these researches have discovered is the chemical pathway that allows toxoplasmodium gondii to accomplish this neat neurological trick?

  170. Partisan? by ichigo+2.0 · · Score: 1

    "A partisan is a member of a irregular military force formed to oppose control of an area by a foreign power or by an army of occupation."

    http://en.wikipedia.org/wiki/Partisan_(military)

  171. Fear can be a good thing by Hoi+Polloi · · Score: 1

    I don't know if having fearless soldiers is a good thing in the age of machine guns. Just look at WWI to see what the results would be.

    "Why, my man, I am ashamed of you, dodging that way. They couldn't hit an elephant at this distance."

        - General John Sedgwick
            (Killed by a sharpshooter at that distance, near Spotsylvania, 1864)

    --
    It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
  172. Re:Interestingly however, rats are parttime predat by cloudmaster · · Score: 1

    You have an odd sense of what makes things "cute" and "excellent pets". Primary carrier of the plaugue = not cute / not excellent pet, for example. :) (yeah, I know it waas the fleas. So what?)

  173. that's just what we need by chrisnewbie · · Score: 0

    "it does not mention obvious military applications for the discovery"

    that's just what we need, crazy soldier who dont know when to duck when they are fired upon.....that's one sure way to deplete an army.

  174. OR better, people who are afraid;at birth & be by Anonymous Coward · · Score: 0

    heh

  175. Re:Maybe, maybe not, but nothing in it for the Arm by Chosen+Reject · · Score: 1
    If I were a soldier, I think I would be more afraid of obeying than not obeying. If I obey, I get to face a lot of people with a lot of weapons that do a lot of nasty things to a human body. If I disobey I am discharged dishonorably.

    Tell us, is it the fear of what the enemy will do to you, or the fear of what the general will do to you that keeps you out of the military?

    --
    Stop Global Warming!
    Just say no to irreversible processes!
  176. Opposite applications? by ichigo+2.0 · · Score: 1

    I wonder if this could be used to induce fear? Maybe spray some fear in gas form in a movie theater or something to make it more scary. I think being fearless isn't something to wish for, why would people go to horror movies unless they enjoyed being scared?

  177. Re:Maybe, maybe not, but nothing in it for the Arm by Pierric · · Score: 1

    Right... but let's go further: if you're fearless, you might just say "f... you" to the general and don't to battle, because you don't feel like it, and you're not affraid of the consequences of your act: not only punishment, but also your country being dishonored by losing the war, its being invaded, your family being killed by the invaders... just because you can't feel any fear. If you're fearless, actually, you have no reason to go to war ever !

  178. Horray!!! by andrelix · · Score: 1

    Ok, when can we get this for our politicians and leaders???

  179. Where are the Dune references? by scpotter · · Score: 1

    Mouse (aka muad'dib): I must not fear. Fear is the mind-killer. Fear is the little-death that brings total obliteration. I will face my fear. I will permit it to pass over me and through me. And when it has gone past I will turn the inner eye to see its path. Where the fear has gone there will be nothing. Only I will remain.
    Cat: [burp]

    Fearless mice are nothing, call me when they start mutating the worms.

  180. The world trembles! by ThePuceGuardian · · Score: 1
    You know, between the hyper-muscular mice (good news! The mutation's also appeared in humans!), the mice who can regenerate limbs, the mice who howl at the moon, and the mice with giant human brains, I was already a little on edge. Now this happens.

    Also - what do you suppose Blobmouse thinks of all this? Some mice get all the good mutations..

  181. This is a first! by rentedflowers · · Score: 1

    It's a /. discussion, of a scientific topic, where the vast majority of respondants get it! Seriously, it's nice to see how many of the posters actually understand that removing fear is severely maladaptive.

  182. I'm still trying to figure out by multiplexo · · Score: 1
    the military applications.

    It does not mention obvious military applications for the discovery.

    Hordes of fearless mice attacking our enemies? With lasers on their heads perhaps?

    --
    cheap labor conservatives - they want to keep you hungry enough to be thankful for minimum wage.
  183. They are his space mice by EC7 · · Score: 1

    and they shall know no fear....

  184. But... by ajlitt · · Score: 1

    do they still get cancer?

  185. Mockingbirds: cat terrorists by sean.peters · · Score: 1

    At my house, the cats are afraid to even go outside when little mockingbirds are getting ready to leave the nest. The parents dive bomb them (the cats) over and over again, until the cats are reduced to cowering under bushes. Once, though, my younger cat reared up and grabbed one of the mockingbirds (I forced her to let it go, though).

    Sean

  186. Re:If the fearless-gene was beneficial for the mic by HD+Webdev · · Score: 1

    this mutation would have dominated the species milions of years ago.

    And, mice wouldn't have eyes placed so far back on their faces.

    Just looking at the placement of eyes on an animal tells quite a lot about whether or not that animal spends much of it's time fearfully watching for something that wants to eat it.

    --
    This is not a dream, not a dream...we are transmitting from the year 1-9-9-9.
  187. 1 mouse takes on the Internet by dantheman82 · · Score: 1

    My little Microsoft Intellimouse fearlessly clicks where few other mice dare to click. But now my mouse is undergoing a serious identity crisis thanks to these silly scientists...

    --
    This sig donated to Pater. Long live /.
  188. Check Your Assumptions by Chunes · · Score: 1

    The article cites two examples as evidence of fearless mice. The first example is the affected mice venturing to the center of their cage, presumably with no regard for their safety. The second example is the lack of Pavlovian conditioning in the affected mice (basically, they don't learn). Why make the assumption that bravado is, in fact, the result of the experiment? One could instead assume even more plausible effects, such as disorentation, nerve damage (numbness), and mental retardation.

  189. MIGHTY MOUSE.... by doctorjay · · Score: 0

    AWAAAAAAAY

  190. Already succesfully implemented in humans by doctorjay · · Score: 0

    Scientists have already able to remove fear from humans, ever see the crocodlie hunter? How do you think he got that way? Just another crazy Austrailian? I think not!

  191. In Other News by Anonymous Coward · · Score: 0

    Mice Apply To Green Lantern Corps

    Laboratory Mice (Whose Genes Have Been Spliced) Try (And Fail) To Take Over World

  192. So what are you going to damm next? Birds? by gd23ka · · Score: 1

    Did I groce you out there? Good. So you have chosen to hate little
    (cute!) furry mammals of the species Rattus Norvegicus and Rattus Rattus
    just because a parasite common to both man and rat spread a deadly
    disease to its hosts. (BTW... Millions of innocent, cute and cuddly
    little rats died too because of Yestinia Pestis).

    Enter the bird flu and it's potential to kill hundreds of millions
    of people on this planet. If and when the bird flu knocks one or
    two magnitudes off our population count on this planet... are you
    going vilify birds just as viciously?

    Here... let me groce you out a little more...

    Did you know that rats have the same kind of rough tounge like cats have??
    I got a bunch of them for pets and one of
    them regularily licks my lips and I lick him back. Me and my little
    pal both have good immune systems and exercise them regularily.

    1. Re:So what are you going to damm next? Birds? by fLameDogg · · Score: 1
      Did you know that rats have the same kind of rough tounge like cats have?? I got a bunch of them for pets and one of them regularily licks my lips and I lick him back. Me and my little pal both have good immune systems and exercise them regularily.

      I once had a Japanese Hooded Rat I got from a pet store when she was just weaned. She was a great pet. She would snuffle my lips, work her snout between them, and lick my tongue. I wonder why she did it. It sort of weirded me out the first time, but I thought it was kind of cute.

      She liked to chase my fingers, running in circles, almost in a cat-like way, although she didn't seem to have a cat's attention span.

      --
      fD
    2. Re:So what are you going to damm next? Birds? by cloudmaster · · Score: 1

      No, I'm not grossed out, nor did I particularly villify rodents - visciously or not. However, most any wild animal whose apparent primary purpose in life is to infiltrate and destroy my darned grain reserves, well, I don't particularly find them to be cute. And "cutest"? Well, that's in the eye of the beholder, but I think most anyone can agree that chickens aren't cute either. Were I looking for a pet, I'd choose a rat over a chicken any day - chickens are about the most filthy animals around... You're welcome to keep them as pets if you're all excited about the shock value of the animals in the house. Get some snakes, too - people get scared of them as well.

      My immune system gets exercised adequately without rubbing random animals on my face. Though, I don't see why a domestic rat would be any worse than those screwy pet owners who let their dogs or cats lick their faces (that toungue was on an ass just moments ago, darn it). But hey, I speed almost every day, and since I haven't been in a wreck yet I can say that speeding is prefectly good idea for anyone!

      BTW, if you really want a "viscious" rat story with some shock value, just picture me in a bad mood because rats have been eating the (fairly expensive) hog food and tearing up the paper feed bags, generally making a mess. Now picture me coming in to the feed shed and finding a bunch of those nasty little angry, hissing bastards somehow trapped in the bottom of a large barrel. Throw in a big hammer, or maybe it was an old ball bat. I forget, though I suppose it doesn't much matter. End the story with a barrel full of dead rats. "Did I gross you out? Good."

    3. Re:So what are you going to damm next? Birds? by gd23ka · · Score: 1

      I don't go around and shock people with rats and even though I try hard
      to get people to see how harmless and cute they really are, I do enjoy the
      occasional kneejerk reaction. I thought I saw your knee jerk and I thought
      I could get it to dance.

      Not for "shock value", just something to keep in mind:

      If I catch you trying to kill one of those "angry hissing bastards" or any
      other helpless trapped animal (why do you think the rat is angry and
      hissing?)... I would prevent you from doing that either now or ever again in
      the future.

      Yes. The little fur balls eat a lot of our grain. They've been doing that for
      thousands of years but they wont ever extinct us as a species.

    4. Re:So what are you going to damm next? Birds? by cloudmaster · · Score: 1

      I presume you're a vegiterian, too, 'cause those "raised for food" animals are usually trapped and killed, and are pretty helpless before they're put down, too. Yeah, even fish. People have been putting out rat traps, mouse traps, raising cats, and doing various other less humane things to rats for centuries. Rats don't seem to be nearing extinction either...

      Not that I should really care one way or another what you think, but I suppose I'll tell you that, as I've grown, I've developed a bit more respect for animal life in general, and wouldn't intentionally hurt a rat should I encounter one. For example, the last time we had a mouse in our home, I got it away from the house cats (which were playing with it at the time, and hadn't apparently hurt it), put it in a container, and drove out to the nearby national park where the mouse was released. Sure, some other animal probably ate it within minutes of my leaving it in the tall grass, but I suppose that's "nature" and better than me harming it. I still don't think rats are generaly cute, though the mouse was kinda cute.

      However, "current nature lover" cloudmaster wouldn't have been as appropriate as "past farmer" cloudmaster in response to the person who felt compelled to try to provoke a reaction, now would it? :)

    5. Re:So what are you going to damm next? Birds? by cloudmaster · · Score: 1

      Man, I don't need those damned lunatic vandals anywhere near me. Friggin' PETA. There's one group that causes me to actually support the anti-terrorism laws... :)

  193. Makes them what? by cyberbob2010 · · Score: 1

    "The research found that mice lacking an active gene for the protein stathmin are not only more courageous, but are also slower to learn fear responses to pain-associated stimuli, says geneticist Gleb Shumyatsky, at Rutgers University in New Jersey, US."


    Makes them more "courageous"? Sounds to me like it just makes them stupid.

    --
    We seldom regret saying too little but often regret saying too much.
  194. BOO! by butterwise · · Score: 0

    Eek. I am sooo afraid.

    --
    If a baby duck is a "duckling," why would anyone want to eat "dumplings?"
  195. Re: Fearless mouse - powered by beer by Getzen · · Score: 1

    LOL!

  196. Re:Interestingly however, rats are parttime predat by DonVictor · · Score: 1

    'The rat,' said O'Brien, still addressing his invisible audience, 'although a rodent, is carnivorous. You are aware of that. You will have heard of the things that happen in the poor quarters of this town. In some streets a woman dare not leave her baby alone in the house, even for five minutes. The rats are certain to attack it. Within quite a small time they will strip it to the bones. They also attack sick or dying people. They show astonishing intelligence in knowing when a human being is helpless.'

    - "1984", by George Orwell

  197. Dude... by inode_buddha · · Score: 1
    Dude...

    Do you have *any* idea how badly you can fsck yourself up with stuff like that??

    (And besides, wine is cheaper I bet.)

    --
    C|N>K
  198. Re:If the fearless-gene was beneficial for the mic by incom · · Score: 1
    Not necessarily. Darwinian evolution doesn't necessarily dictate that the best mutation wins out. It generally suggests that the mutation best adapted to the species' circumstances will survive, but really, anything that works well enough to allow further breeding will still continue to exist.
    C'mon, this is really just arguing about the semantics of what the "best mutation" is, for if it doesn't confer enough advantage to noticeably increase the rate at which it is passed down, it's really not the best, more like marginal or neutral. And if it does, it is passed down more often than the inferior gene variant, then it will get a higher frequency in the population, and over time it will supplant the inferior, or reduce it to insignificance. It's not that the inferior carriers can't survive, they just won't produce as many offspring, and over time through breeding with the superior carriers who exist in much higher numbers they will fade inexorably. And if they can exploit something in a way that the superior gene carriers can't, probably specialization and speciation occur. And most of those "absurd creatures" are quite well adapted in unobvious ways, or they don't have much competition, or live in some type of mediated environment.
    --
    True genius is grasping a situation like a peice of fruit, and peircing it just right so that it drains dry.
  199. Re:Interestingly however, rats are parttime predat by Dread_ed · · Score: 1

    "but they are actually some of the cutest mammals in existance and they
    make excellent pets."


    He is exactly right on this point, however let me relate and anecdote.

    My wife and I bought a rat as a pet. We named it Fuzzmeister. We adored our little rat, but we did not know whether or not is was a boy or a girl ratling.

    UNTIL ONE DAY... Fuzzmeister grew testicles the size of large grapes overnight! I kid you not.

    You have no idea how embarrasing it is to have your pet rat come bounding out of the bedroom, his gigantic nutsack bouncing off the hardwood floors with a muffled thwacking noise, right in front of friends, family, and guests. There is really no way to put it into words.

    The moral of this story is, if you are going to buy one of these exceedingly cute and adorable furry woodland creatures for a pet, GET A GIRL!

    --
    When the only tool you have is a claw hammer every problem starts to look like the back of someone's skull.
  200. this is fnord impossible by YesIAmAScript · · Score: 1

    There is fnord no way to fnord accomplish what you say. And fnord if there is such fnord a thing, it's years fnord away. It definitely fnord has not been around and fnord in public use for fnord quite some time now.

    --
    http://lkml.org/lkml/2005/8/20/95
  201. Re:Maybe, maybe not, but nothing in it for the Arm by HiThere · · Score: 1

    O, anger might work. I'm not at all certain that fearlessness would make one a pacifist. But a warrior isn't a soldier, and would be more likely to attack his sergeant before he ever got to the front than to be effective. Specialist groups that acted alone might want to self-medicate with this occasionally...but even then I'm not all that sure it would be a good (effective) idea.

    --

    I think we've pushed this "anyone can grow up to be president" thing too far.
  202. You said everything I was going to say by UpnAtom · · Score: 1

    You might have to take my word for it, but I am one of the most successful clinical therapists in the UK and have worked for a decade eliminating (as opposed to repressing) clients' fears as well as my own.

    Your assertions match my experience. The AC makes a partially relevant point in that a genetic alteration might knock out other more useful functions. However, fear is not necessary for protection. An obvious analogy is that a robot could be programmed to protect itself without fear.

    A transition to being fearless might lead to unforseen responses from others as this story from my own life should illustrate. I decided to eliminate as much of my anxiety around people (especially strangers) as possible.

    That weekend I got into 3 fights! Whereas my anxiety had previously compelled me to avoid situations where I'd push others' aggression buttons (usually around women), I then had to learn how to first communicate to those aggressive males that there was no point trying to intimidate me.

  203. Big Deal! by Anonymous Coward · · Score: 0

    I'll be impressed when they develop fearless gerbils.

  204. Fearless mice by tenquid · · Score: 1

    The criteria used to define and test for behavioral signs of "fearfulness" need to be reexamined in this case. One of the most common physiological deficits found in genetically altered mice is deafness. Even normal wild type mice cannot hear the human voice.

  205. Fuzzmeister != Rudolf Hess by gd23ka · · Score: 1

    Is Fuzzmeister your only rat...? If so, he needs at least one other rat for company, badly. You and your s.o. are not company enough, he needs someone he can really "squeak to" and that is another rat. I am not trying to be a wise-ass, it's just that I have worked with rats for half of my life. I would suggest (especially if fuzz is younger than 1.5 years) you get him castrated. him. That way... he wont exhibit dominant behavior once his hormones start hitting him. Don't take it out on him or get rid of him just because he bit you. Get him castrated and he will after four to six weeks get back to normal. Get him company, either a neutered female (not neutered if you also keep a snake) or another castrated male. He needs it.

  206. Pinky and the Brain by Thecarpe · · Score: 1

    Maybe they will actually rule the world!