Slashdot Mirror
Mutation Creates SuperKid
Tzarius writes "It's not exactly regular Slashdot fare, but the NYTimes has a story about a kid in Berlin (now 4 years old) who was born with naturally massive muscles. It's not a new condition, but it apparently hasn't been recorded in humans before. It also looks like the cause is a suppression of the myostatin protein, which could be reproducible." Reader Spazmasta adds "A gene that blocks production of a muscle-limiting protein (called myostatin) has been found in a abnormally muscular German baby. This news comes apparently 7 years after researchers at Johns Hopkins created 'mighty mice' through a related approach, turning off the gene that produces the muscle-limiting protein. I, for one, welcome our new myostatin-free overlords."
he was born to become the governor of California!
Can you get him to give me my car back?
The Governator has been playing away from home
Do not try to read the dupe, thats impossible. Instead, only try to realize the truth
What truth?
There is no dupe
i expect it to be a sitcom-esque situation, where the baby lifts the family car when it gets stuck in the mud.
Reason, free market capitalism, and individualism
I'm not kidding!
Creationists are a lot like zombies. Slow, but powerful and numerous. And they all want to eat our brains.
they's us.
An Indian-American Hindu committed to non-violent thought/speech/action alarmed by the global explosion of radical Islam
Big muscleed freaks won't take over the world. on the other hand, tell me when we isolate the IQ genes...it's quite an advantage to be born smart and rich.
Someone told me he's weak to kryptonite...
and believe me later.
...as there seems to be little evolutionary pressure to supress myostatin in the normal population.
A product of late 20th century genetic engineering!
My rights don't need management.
KHAAAAAN!!!!!
R: That voice. Where have I heard that voice before? B: In about 365 other episodes. But I don't know who it is either.
Ok, two things about this story are amazing.
Firstly, that a 4 year old toddler can hold 3 kilo individual handheld weights, straight out.
Secondly, that 'many adults' can't hold that much weight. My leatherbound volume of the Lord of the Rings Trilogy has to weigh AT LEAST that much. What the hell is wrong with people?
Well, lets just hope Xavier gets to him first.
-Peter
Let me guess.......Bam-Bam?
Courtesy of Yahoo here.
Bush Lies On the Record.
What do you think the long term effects of this such a proposed treatment on humans might be by limiting this natural growth limiter?
I'm not necessarily speaking religiously, but isn't some of this stuff supposed to be here for a reason?
I wonder if steroids would make this kid even more huge when he gets about high school age and is lifting 500 lbs.
~S
I think it goes a bit far to claim that this mutation has NEVER been found in humans. Sure, there may not be any popular hospitals with records of this mutation, but I wouldn't be surprised if it turns out that this mutation happens about every 5-10 years in small areas all around the world.
For an example, there was a kid in my teeny little high school who had a muscular growth mutation. His muscles grew so much so fast that he had regular surgery to remove the excess lumps and knots of muscle. He didn't resemble a body builder. He looked like a mutation with lumps all over his body and scars where they had done surgery. I read this article and wondered if he has the same mutation.
The previous comment is purposely vague and generalized, but all of the facts are completely true.
Wait a sec, I'm not a biological specialist, but aren't some vital organs composed of muscles, like the heart? I mean, if there is no limit to muscle growth, eventually the kid's ribcage would cease expendaning when he's full grown and the only way the heart can grow then ( because it's no longer limited ) is to the inside...
Then again, I might be a fool and the heart might be excluded from this or not be made out of muscles at all...
Hate me!
It's a good thing this kid wasn't born in Germany in the mid-to-late thirties.
What I want to know is:
A. How soon will myostatin inhibiting pills become available and:
B. How soon before jock dads start feeding them to their toddlers.
3D Printing Tips and Tricks at Zheng3.com
If in most humans there is a process that actively limits muscle growth, then there must be a downside to being muscular... I wonder what it is.
THIS STORY IS USELESS WITHOUT PICS! :)
Jeremy (typing some non-caps here to pass the lame lameness filter)
Looking for a Python IRC bot?
Muscle doubling in cattle with the same gene was publishedin 1997, with extraordinary photos of a Belgian Blue bull: HERE
Products that claim to regulate myostatin are already used by many athletes and bodybuilders.These guys are always ahead of the game.
Think like a man of action, act like a man of thought.
Didn't I just watch this story on DVD last night? I guess we know where this kid is going to school.
--- Tolerance is the axiomatic "virtue" of those without convictions ---
The cover story in the July Scientific American is about genetic enhancements of muscle. (They havent put the article online free yet.) The thrust is finding an inhibitor for the muscle-growth inhibitor called myostatin. In the article is a picture of a bovine lacking the myostatin gene. It is so bulked up, that it looks like a cylinder of meat with a nose and four hooves sticking out.
In addition, myostatin blockers could be used as performance enhancers.
aaaand...whee!
Wouldn't it just be TOO funny if he ended up at Xavier University in Ohio?
I like the fact that they're already touting this as an advance for athletics. That is, until people find out that (for example) it increases ALL muscles, including the heart, which'll then overgrow and collapses at the age of 35. There's a reason why mutations don't happen all the time.
Does he turn green when he's having a tantrum?
Look at Gene Doping. Look at the bull on page 2.
I bet the long muscles in the limbs might see a benefit, but the heart gets so big it can't pump effectively.
I am adding this to my spam filter now.
boycott slashdot February 10th - 17th check out: altSlashdot.org
Though it's hard to see the definition inside those school uniforms: http://www.agh2o.org/badlarp/badlarp_files/musclem en.jpg
"Waste not one watt!" - CZ
we've had heroine babies, crack babies, and now we have 'roid babies??
It's already used for bodybuilders...
Hmmm.
From the article
There was no information on the baby's father
Second Coming of Christ! This time, he's kicking your ass!!
Rapid Nirvana
Will this be considered doping in sports?
NO, I DID NOT KNOW THAT WAS COMING! I have to disagree with all my might. Really, what does that mean?! And what are you going to do to save the day? Save whose day? You have just ruined my day, now I have to be angry all day long. Saved the day? More like here you came to ruin my day. So shut up, will you?
Someones gotta show the superbaby how to use his power correctly, right?
mmmmm, tasty buff boys . . . .
-ninjaneer
The story link already contained the GOOGLE referrer link already. There was no need to register you insensitive karma whoring clod.
A few years ago I managed a retail health/nutrition shop. Shortly before I left there was lots of commotion over new research involving certain myostatin inhibitors. Once such product was made from a special marine algae. You can read a review about it here.
Unfortunately, I left the position before I had a chance to discuss with any first-hand users of these things, but it looks like they're still being sold at various web sites, so somebody must think they're working.
the child's parents have decided on the name 'Clark Kent'
A picture of a belgian blue cattle.
they think he could very well use up his 'sattelite cells' (whatever those are) and his muscles would start to deflate at 30yrs...
When you cut his hair?
This signiture copied from somewhere.
This month's Scientific American discusses gene doping. The basic premise is that the same gene therapies that can help individuals with genetic diseases can be twisted to give athletes an unfair advantage. More massive muscles, more oxygen carrying blood cells, taller, etc. Although it's years away, given the state of drug doping in athletics today, it only seems the next stage.
Well, there's spam egg sausage and spam, that's not got much spam in it.
Muscles spend energy when resting too. Good if you want to lose fat, bad if you are low on food.
In vino vici
Photo Here.
Life is the leading cause of death in America.
I wonder if the same thing happened to Hercules. It would explain a lot wouldn't it?
He killed snakes bare handed when he was a toddler. ref
Still no cure for cancer.
"You might as well get your son a ticket to hell as give him a five string banjo." -unknown minister
posting the article text for karma is gay...
Please don't read my sig.
I don't think it's a mutation. All the articles say that they have no information about the baby's father. It's obvious to me, at least, that the father is none other than Jor-El, famous Kryptonian scientist. The whole "myostatin" thing is just a red herring to cover up his unfaithfulness to Lara.
here is a picture of the child. Quite amazing! check out those quads!
-eric
They already sell sports supplements that claim to supress myosatin.
The claim to use a marine vegetable extract called Cystoseira canariensis that "has been shown to help safely and effectively scavenge myostatin in the body". I imagine a Ms. Pacman game at the cellular level but I'm sure it's not that interesting and I hear that it doesn't work so well.
I'm tired of bombing the universe
If anyone bother to RTFA (but hey this is /. so that's too much to ask) it would tell you the hypothesized downside.
Muscle cells are surrounded by immature satellite cells that lie dormant until the muscle is injured. Then they migrate into the muscle, replacing injured or dead cells. A recent paper indicated that myostatin might normally function to keep satellite cells quiescent. Without myostatin, he said, the satellite cells might be so active building muscle that they become depleted early in life.
So they worry that the muscle growth will stop, and eventually reverse without the cells to repair.
"Myostatin blockade," Dr. McNally wrote, "will probably work its way into professional and amateur athletics, as well as into the ever-growing business of physical enhancement."
/rower
No, it won't work its way into amateur athletics because by definition people who do amateur athletics do it for the LOVE of the sport, not money, respect, or fame. No one who wakes up at 5am to get down to the boathouse to go for a row or who goes for a jog before work is going to risk mucking up their heart and body in a sport no one else cares about.
Who saw this one comming?
I would rather be ashes than dust!
Bye bye V|1|A|G|RA| and iiiiinstant eeeeeeerection-pills, it's the gene we have to go after. Ladies, here I come!
"Honey, I feel a certain distance between us..." "Really? A 31ms ping ain't that bad..."
After 65 years worth of failed attempts, the german ubermensch experiment is a success!
Technically your heart is a muscle (okay so not technically but follow me), if your heart becomes too strong wouldn't it in theory screw up your blood flow? Also penis problems come to mind as well as many other things, but they seem to be the two major problems with having overly active muscles.
I like muppets.
For this to happen, it had to happen in Deutschland. If there is any justice in the world, he'll have a two inch penis, and be impotent as well. OK, lame, but I couldn't resist.
My fiance's little brother has MD, a disease where the muscles degrade over time. Eventually, his heart or diaphram will be affected and he will die. Would a myostatin treatment help him by increasing muscle production? I'm not that familiar with his condition, so maybe some doctors or future doctors could help.
I'm in the hole of the broadband donut.
GET THIS KID SOME PROTECTION!! Mr. Glass has been waiting for him!! (He's still vulnerable to water if u recall)
Cwm, fjord-bank glyphs vext quiz
And the resultant effect of being a chick magnet?
Is that good enough of an advantage for ya?
"I, for one, welcome our new myostatin-free overlords."
I think that you only welcome them because they could beat you up.
"If you have done 6 impossible things this morning, why not round it off with breakfast at Milliways" -- hhgg
OK lets connect some dots here:
1. This is a rare mutation.
2. The mother has one mutated gene and was unusually strong.
3. The mother had several close male relatives who were unusually strong as well. None of them would agree to genetic testing.
4. The boy has two copies of the gene - one of them had to come from the father.
Draw your own conclusions...
using gay for an insult is gay.
From spiegel.de:
spiegel.de
The picture shows the baby's legs at the age of nine months.
From this MSNBC article:
The boy has two copies. He could (absent an extremely unlikely second identical mutation on the other copy of the same gene) only get one from his mother. The other had to come from his father. The mutation is very rare. The mother has four male relatives with one copy of the mutation. The identity of the father has not been disclosed.
Anyone care to connect the dots?
I'm not pointing this out to be cruel or catty; I'm pointing it put because it's a good example of what's called the "founder's effect", a mechanism by which mutations -- by definition unique or nearly unique events -- became part of a general population.
Since this child has two copies of the mutation, not only are phenotypic effects greater -- he's even more muscular than his mother who has a single copy -- but all of his children will have at least a single copy, like his mother.
Were the conditions for founder's effect stronger -- that is, if he were a member of a smaller and more isolated population than modern Germany -- one can easily see how inbreeding could result in the mutation becoming common throughout that population.
When two persons with a single copy of the mutation breed, one-quarter of their offspring (on average) will have, like the child being studied, two copies of the mutated form (or allele) of the gene (and no copies of the gene's normal allele), one-quarter will have two copies of the normal allele, and one-half of the offspring will have, like the mother, one mutated allele and one "normal" allele.
But when a person with two copies breeds with a person with a single copy, one-half the offspring (on average) will have two copies of the mutation, and one-half will have one copy of it.
So if there's any preferential benefit to having the mutation -- if those with the mutation do better and so have more offspring -- and if there's the in-breeding of founder's effect, the mutation should become common in the founder population.
Indeed, it's likely that founder's effect, along with environmental conditions, explains why Germans and other Europeans, despite being descended from Africans 40,000 years ago, are white rather than black: being white is bad under the Africa sun, as, unprotected, it will lead to skin cancer and death by about age twelve. But being black in the weaker sunlight of Europe prevents the metabolization of vitamin D, leading to the weakened bones of rickets. In Africa, mutations that lead to less melanin production and whiteness also lead to death -- but in Europe it allowed a longer, better life.
But how did lessened melanin production and "whiteness" spread in Europe? Likely through founder's effect in small and isolated inbreeding populations -- but certainly not because of any "Aryan" superiority.
Opinions on the Twiddler2 hand-held keyboard?
Before you all get carried away with the superhero wisecracks, lets hope that this is not a serious birthdefect, and that the kid will develop normally. I wouldn't be to excited about what these Dr. Frankenstein wannabe biologists are accomplishing with their superrats. My guess is they live shorter lives than plain ones.
an ill wind that blows no good
I'm assuming this is basically the same mutation that is present in Belgian Blue cattle. The mutation suppresses myostatin production, and thus muscle growth goes nearly unchecked. Google for a picture of one... they look like some sort of cross between cattle and a tank.
i wasn't posting it for karma. cry about it.
We have secretly replaced these Slashdot mods' sense of humor with a rusty nail. Let's see if they notice!!
We're here to pump you up!
This kid was designed to beat up Slashdotters, in high school.
-Patrick
"They never stop thinking about new ways to harm our country and our people, and neither do we."
So, one day those penis-enhancing emails will actually be touting something that works?
Hurculese Hurculese Hurculese Hurculese.
A super baby born in Berlin, Germany? And it only took them about 60 years...
Doesn't mentioning 'aryan' pretty much instantiate Godwin's Law?
So, move along folks, this thread is dead.
Larry Csonka was seen leaving ABC studios this morning, where he was rumored to be pitching a new show idea revolving around kids, a giant wall, and a gauntlet.
But it might be a cure for muscular dystrophy.
I'm in the hole of the broadband donut.
There's normally a reason for having a tight regulation of muscle growth in animals, as there's a reason for regulating cell divisions and changes that lead to growth and proliferation overall in all sorts of multicellular organisms (otherwise you'd be just a big blob of tumour).
So, taking out that regulatory protein myostatin will not perhaps be the healthies thing to do if you want to increase muscle size, as you'll just probably end up getting a heart-attack and all sorts of other nasty muscular problems with the most essential muscle tissues you have (heart and intestine at least). This sort of issues occur in GM-modified cattle with the similar myostatin mutation very regularly, and human as another not-too-distant mammal will probably not be any more safe from these problems.
Great! At last someone who can dump off Mr. Swarzenegger's muscle monopoly.
As someone who has muscular dystrophy and has a mother who is severely disabled by the same disease, this makes me very hopeful. Although the article specifically warns that they don't know what the long term effects of this disease are I think you would find that most people suffering from muscular dystrophy would gladly take 30 years of a somewhat "normal" life compared to being doomed to watch my body waste away for lack of a viable treatment. That said, I'm still very skeptical of this discovery. There are over 40 types of muscular dystrophy, not to be confused with multiple schlerosis, which may be affected to varying degrees by myostatin. One thing that the article didn't mention was that even with myostatin it's not possible to regrow muscle with our current technology. So what is already lost may be permanently lost, yet even a 25% improvement or even arrested development of the disease would be welcomed by many of us in the MD community.
For anyone who's wondering about the uses of treatments for blocking myostatin, here is an article you might want to read.
Myostatin and Myostatin Inhibitors: The Next Big Supplement Scam
Old papers of a Nazi Eugenics experiment were found...
Ribulose-1,5-bisphosphate carboxylase
When he grows up, will be look like Dan Ackroyd, Christopher Reeve, Dean Cain, or Tom Welling?
Mod Karma -1: I sed bad wurds. If I cep my mouf shut, I wud be at riyses.
Luckily, it will be too late for Völler to benefit from this.
Be wary of any facts that confirm your opinion.
I don't know if this is the first human w/o muscle-inhibiting protein.
I once saw a program on Discovery about the guy whos muscles grew indefinitelly, even w/o any physical activity. He had to have them removed surgically from time to time.
I'm not sure if that was the same condition, but I don't think I'd like to have it.
Robert
Bastard Operator From 193.219.28.162
They happen 'all the time' -- often enough -- but they mostly just don't result in an advantage that'll make you more successful, natural selection wise.
You'd have to think, though, that dying at 35 might not stop some people. Tonight's the NBA draft. There's a 7 foot-5 inch European center who'll get taken mid-lottery or so. The kid has a growth hormone problem, diagnosed, that he's being treated for; teams regard it as an advantage, pretty clearly. Andre the Giant didn't live to old age, but he sure could pull down a paycheck in the meantime. If you take a look at steroid use, you'll see a bunch of people who might think this'd be worth it...
...making them less likely to reproduce and have their children reproduce, probably, unless the gruopie factor outweighs the difference. Selected against, on balance.
(I love the popular idea that natural selection and evolution are constantly "improving the product." Super muscles! Rabbits get faster and faster, snakes get more and more poisonous! -- that idea. Sometimes the faster rabbits run out and get eaten by hawks before their more cautious friends. Sometimes a big brain means you're more likely to kill your mother during childbirth, reducing your chances of thriving and reproducing yourself. "Better" in that 6 Million Dollar Man sense isn't necessarily an evolutionary advantage at all.)
"Fundamentalism" isn't about divine morality. It's about human authority.
Comment removed based on user account deletion
I for one, re-welcome our German overlords.
I'm a signature virus. Please copy me to your signature so I can replicate.
A recent paper indicated that myostatin might normally function to keep satellite cells quiescent. Without myostatin, he said, the satellite cells might be so active building muscle that they become depleted early in life. ... will his satellite cells be used up so that his muscles start to deflate when he is 30 or so?
I'm wondering if that could be it. But then getting weak after age 30 doesn't sound like a big deal to me because humans' reproductive peak occurs well below that age. Any bio people have a clue about any other possibilities?
In general, I'm with the parent poster on this one - more is not always better, and there is likely a down side to this. However, as humans really can't say one way or the other. Perhaps you need this mutation AND another one, two, or 12 to really be "better". Even a "bad" mutation may be good when taken with another set of modifications we don't know about. Embrace genetic diversity.
OhGodOhGodOhGodOhGod
Human Growth Hormone
Ingest a Tapeworm
The human growth hormone was reall an idea to speed up your metabolism to what it was like when your body released lots of it into your blood. (Think 17 year old). You eat cake for breakfast and don't gain weight no matter what you do. Unfortunetly it doesn't really work, and their are nasty side effects. - Go figure.
As for the Tapeworm diet -I know what you're thinking, "He's Brilliant!". I could bottle tapeworms in a little jar and sell them for $19.95 each. It's the only diet where you can eat whatever you want, and still loose wait. - Again pretty ugly side effects.
This however seems to be spot on. Super muscles for nothing. This is so marketable to Americans it's not funny. Hell I'd love this sh!t. I'm always complaining that I need to go to the Gym. With some gene therapy I could continue to be lazy, yet still have the benefit of walking around saying "Yo, I'm jacked!!!"
I boycott signatures
I wonder if the baby will have an austrian accent.
'The Cincinnati Bengals have selected, as its first-round draft choice, from the BerlinKids-International Kindergarten e.V....'
Mod Karma -1: I sed bad wurds. If I cep my mouf shut, I wud be at riyses.
doesn't anyone remember Bam-Bam!!!?
...Elijah Price has announced that his search can end. Of this tremendous discovery he said, "Now that we know who he is, I know who I am. I'm not a mistake. They called me Mr. Glass."
I give men fish.
X-men is becomming reality!
GAAH! MY PRINTER IS ON FIRE!!! PUT IT OUT! PUT IT OUT!
...the fatherland has plans to raise another army by the year 2024.
I see a strange, fragile comic book dealer in this kid's future.
--- Ban humanity.
The German people are a super race. This is only the beginning! Now that you have found out our secret we will accelerate our program of eugenics and create an entire nation of super people and once and for all have our thousand year reich.
We now return you to your regularly schedule programming.
Look out Pebbles Flintstone! You're dream man has arrived!
It was in a story called "Oryx and Crake". I thought it was fiction... but now...
supposidly has a rare mutation in this gene. google search first link
We're safe, I don't think Godwin reads slashdot any more.
Now I'm afraid that freakishly muscular bull will come to my house and beat the living crap out of me if I so much as look at another hamburger again!
Tofu and sprouts, it's what's for dinner...or else!
the simpsons reference? =P
I initially read that as "...naturally massive testicles..."
He's not taking any performance-enhancing substances. If he goes into weightlifting, and gets good at it, can he go to the Olympics?
I wonder what effect the blockers would have on the human body in zero gravity.
*It's not what you can do for the Dark Side but what the Dark Side can do for you!*
I hate to sound the banjo alarm, but I suspect the easiest way for these genes to double up in the bairn would be in a case of incest.
Eep. Wonder if they are recessive?...raise him to be good, not evil!
Imagine the money he'll earn supplying sperm banks and renting out his studly services..
Unfortunately he'll have to avoid red kryptonite for the rest of his life.
It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
Ok folks, while genetic mutations happen, sometimes they are bad. In the horse world there is a halter horse known as 'Impressive'. He was what the particular comunity was looking for, massivly muscled, very high definition etc. Well since he won just about everything that he was entered in, he was bread to many, many horses. The gene that causes this is a dominate so it is passed along with about a 50% chance. The problem comes when a horse has this on both sides, he developes etc then he will die, quite a painful death. It was called 'Impressive Syndrome' for the longest time. They re-labled to be HYperkalemic Periodic Paralysis. This link is older but gives a decent background in it. The key point I am making here is that it's the gene is responsible for myostatin production. I truly hope it doesn't affect humans in the same way. It has gotten to be so bad they require testing of all of the known decendants of Impressive to be tested for HYPP, and if either side has the defect, they are not allowed to be bread (AQHA and APHA in particular). If they are, then they cannot enter the events (no $$,$$$,$$$.$$). They are intentionally trying to kill off this gene. Since the liniage of most registerd horses can be traced back several hundred years, it gave a powerful way to research this one in particular.
User not found: Please check the world and try again.
I am kind of surprised no other /.'er mentioned this possibility, so I will. Wasn't a limiting factor to space travel always considered the shriveling of muscles?
In Zero-gravity, muscles atrophy rather quickly. Perhaps mystatin inhibition is part of an answer? If there was less Myostatin present in a given astronaut, perhaps muscles would rebuild themselves at a given rate. The rate would certainly vary with dose and individual, but I think there may be a possibility here for removing a serious limiting factor for long, manned space voyages.
Research must be done, but what does everyone here think?
http://www.chicagotribune.com/features/health/chi- 040624baby-photo,1,7431047.photo has a photo of the kid's legs. You might have to register. Hulk smash.
the major advances in civilization are processes which all but wreck the societies in which they occur - A.N. White
Faster rabbit -- sometimes runs out and gets nabbed by a hawk when the more cautious ones are holding back.
Higher metabolism and endothermism -- requires more energy to keep going. (Similar cost for huge muscles.)
There's a popular idea that things are getting "better" through natural selection and evolution. The things is, our ideas of what "better" would be are usually kind of silly and superficial. "Better adapted" is probably the way to think about it.
Imagine a genetic trend toward, say, bolder, more aggressive personalities, as Nazi eugenicists would have wanted things to go. People who aren't afraid of life, who'll go out and seize it and try to change things for the better! Great, right? Except maybe a more cautious social nature is a heck of a good thing, given how complex human society is. Maybe personalities like that would be a disaster: wars, instability in our societies, and so on.
"Fundamentalism" isn't about divine morality. It's about human authority.
The more testosterone, etc, you have, the greater muscle mass your body can sustain. Hence bodybuilders and steriods. Only by using the roids and HGH can bodybuilders sustain such massive bodies, which, in itself, is unhealthy. (5'4" at 260 lbs is unhealthy no matter what its composed of.) Take em off the roids, and they deflate like a balloon. So, this kid may or may not be limited to the amount of muscle he can sustain over time; it depends on his hormones.
That's right. All your base.
I guess that clicking the link and noting that you don't have to register is also gay?
A picture from a Danish newspaper. He is 7 months old at this picture.
Wasn't there (I suppose there still is) a Marvel character called Juggeernaut where this was his mutation?
Will this guy be allowed to compete in the Olympics when he grows up?
Are we going to accept this guy or make him an outcast like the X-Men series predicts?
So many unrelated questions so little time.
I tried for 5 years to come up with a clever sig...only to realize that I am not clever.
Does anyone know if this affects smooth muscle too? You may not want, say, your bowel muscles to be twice as strong... GRRRR! PLOP!
I can just see his parents putting green makeup on him for Halloween some year after he sees The Hulk for the first time...
If you can read this sig, congratulations, you have your glasses on!
After googling for myostatin, it looks like there have been other cases of this. It sounds like different specific mutations of this gene produce varying levels of inhibition; this kid is just an extreme case.
:)
;)
Also, although the scientists are moving cautiously on this, the bodybuilding-supplement industry has already jumped on the bandwagon (as usual). There's already a "natural" product (their quotes) on the market that claims to block myostatin. As always, I take their claims with several pounds of salt
Obviously I'll wait for the real scientists' findings, but a drug for this could be a real lifesaver for the modern geek^H^H^H^H white collar worker. Basically it causes your body to spend all its extra resources building & fueling muscle, instead of growing fat cells and dealing with hyperglycemia. We'd all be in great shape; that is, until the inevitable post-apocalyptic famine hit
Biology over ideology. Maybe now they can actually win a war.
- http://pakman.sytes.net/
...when I mod my body with gene therapy that I won't be allowed in my neighborhood WholeFoods because I'll be a GMO?
or does it mean that the market will pursue these changes (without federal funding in some cases) and all the luddites warnings be damned because people can make a choice to improve their lives?
Or does this mean that I can sit in front of my computer all day, alternating from coding robots to playing robots in UT2004, and stay in shape?
Is it exercise if it only happens when I choose it to? wu-wu-walk...WALK in the park? What is that?
all hail the beauty and wealth of a world bettered by technology!
Robo-Blogs of the world: UNITE!
"But how did lessened melanin production and "whiteness" spread in Europe? Likely through founder's effect in small and isolated inbreeding populations -- but certainly not because of any "Aryan" superiority."
I disagree - your example of melanin doesn't really apply, because of environmental factors. Europeans are predominantly white due to the European lifestyle and climate, whereby considerable amounts of time are spent indoors, and (certianly in Britain), it isn't that sunny for most of the year. To quote Wikipedia: "As with peoples that migrated northward, those with light skin that migrated southward had to acclimate to the much stronger solar radiation."
Melanin production has very little, if anything, to do with the founder's effect, and more to do with adaption to changing environments...it's just a really bad example to use for your case.
It's the first I hear about this, and just googling it reveals a wasteland of affiliate spam for myostatin inhibitors.
It would be kind of neat if for a little while you could just do a search and find out what foods might inhibit the thing... but no, the affiliates have it already bottled and shrinkwrapped. f*ck!
Information: "I want to be anthropomorphized"
Let's all hope the doctors and scientists have good luck. They are trying to figure out how to save this child's life. If left the way he is, his heart will become too thick to stay functional.
This condition has been documented in animals, which have all died at a fairly young age.
This is just this child's misfortune to be the first documented human case.
Get a free ipod.
The downside may be that he needs to consume more calories to function. Since for most of our evolutionary history we've lived on the verge of starvation, being super strong but needing to eat more would have been a disadvantage...
Jesus used to be my co-pilot, but we crashed in the mountains and I had to eat him.
Notice how the mutation "adds" super strength not by adding something new but by blocking a protein that was already there
Barney and Betty's kid? How about a reality check. Consider the following from one of the articles:
They probably couldn't get ahold of the father because he was doing the laundry, taking out the trash or washing dishes, if he knows what's good for him!
A feeling of having made the same mistake before: Deja Foobar
When asked why he was destroying the town, the boy replied "Stan bad! Bechomp bechomp, bechewie chomp, bechewie chomp."
I'm trying to teach myself to set people on fire with my mind... Is it hot in here?
If drugs come out to block this protein, of course it's going to be abused by people.
I forget what it's called now, but there is a condition where your heart can grow too big inside your chest, and your ribcage and organs press on it and cause all sorts of problems. People who take steroids are susceptible to this condition.
I'm fairly active, and I used to take creatine before workouts. I started having chest pain and went to the doctor, and he was telling me that could be the problem, especially since I was using creatine. An X-ray showed I was fine, but it does happen to people, and I would think the abscence of this protein would surely make one more likely to have the problem.
Need Free Juniper/NetScreen Support? JuniperForum
> evolution was not a beauty contest. ("Chicks dig muscular guys! I want to be muscular too!") It was about tuning an animal to be able to at least survive its environment
Hence the dazzling fan of the peacock, which the peacock uses to beat it's prey to death in a frightening, yet fashionable, display of evolutionary fitness.
There are many examples of evolution in weird directions for better sexual selection. For example song birds, fireflies, and Bill Clinton's exaggerated male chin.
- For the complete works of Shakespeare: cat
Starvation is one thing, but there is more. Your bones and joints can't take arbitrarily large forces. Muscles need to regenerate, and that takes resources. If you get more muscles very early, it is possible that more of your cortex gets devoted to controling them (less available for other stuff, silly as that may sound). Having lots of muscle mass may increase the risks for some kinds of diseases. There are just lots of possibilities. Time will tell.
...I lived in Belgium for 18 years and must say that
:o)
a) The meat you get over there tends to be VERY lean, hardly any fat at all (which poses a problem for roast meals). However, their filet steaks are probably some of the best in the world, very tasty despite their being little fat.
and b) They have the best beer(s) in the world
Mmmm, what I wouldn't give for a Steak avec Sauce Bernaise, Frites et un distanguer de Bier from my favourite restaurant over there (if anyone ever goes to Waterloo, Belgium - eat out at l'Amusoir to see what I mean)
I am NaN
Latest Issue of Scientific American has an article on gene doping which talks about this.
Photo would be nice :)
A blog I run for the wealth
He grows up to have damaged skelatal structure, heart problems and will probobly die before he's forty and all the while biotech companies have patented his DNA, reaped massive benifit and he hasen't seen a cent, let alone a euro.
You doubt me. Call me back in 2050 and we'll see.
May the Maths Be with you!
Hans...or is it Franz?
Hmmmmmmmmmmmmm..........
Drugmaker Wyeth, based in Madison, N.J., already has begun human tests of a genetically engineered drug designed to bind to and neutralize myostatin, said spokeswoman Natalie de Vane.
Wow, can Steve Rogers' SuperSoldier formula be far behind?
+4 funny, Please. :)
--- Grow a pair, liberals... stop letting the Republicans bully you!
...I can say that they have some of the tastiest steak on the face of the planet...really lean, but yet still very, very flavoursome.
I am NaN
God bless my wife. Her sense of smell is much less defined than mine. Which helps me avoid diaper duty more often than not.
In only 14 more years, that 4 year old superkid will begin saving the planet!
--- Hindsight is 20/20, but walking backwards is not the answer.
From another link in this thread (about some bodybuilder, look for BALCO), it looks like there are multiple mutations that affect the genes in question (or multiple genes that affect muscular development). If the woman in question is a bodybuilder or any of those male relatives are, it's not at all unlikely that she's involved with another bodybuilder that she either met herself or met through a relative.
I could be wrong, but I suspect that folks with mutations that cause them to develop extra muscular tissue tend to gravitate to the social environments where that sort of thing is valued. In other words, while 0.1% of the bodybuilder population out there might have this mutation, I'd be surprised if more than 0.001% of the slashdot-reading population does. Welcome to the joy of choice in who you socialize with.
fencepost
just a little off
KOMPRESSOR in effect!
like siss? Ah dunno....
The Krauts are at it again. Colonel Hogan already knows and has formed a plan to blow up the secret superbaby factory.
nazi supermen are our superiors
Mutant woman who see in four primary colors!
3 ,4 128183,00.html
http://www.guardian.co.uk/Archive/Article/0,427
It's already been asked
Personally, I'm waiting for a mutation that keeps people from posting comments that say the same stuff over and over on Slashdot.
who is intensely jealous?
I am actually experimenting now on myself with a myostatin blocker. It is commercially available from
/day (good to rent an office with Gym use included ;) )
:>
....
& hl=en&lr=&ie=UTF-8&sa=N&tab=wi/ /images.google.com/images?hl=en&lr=&ie=UTF-8 &q=myostatin+&btnG=Search
:)
Cytodyne Technologies (same company who sells Xenadrine an Ephedra based (lately in the US ephedra free fat burner))
Anyway, the product is called Myo-Blast CSP^3.
Anyone interested might consider Juiced Protein from Pinnacle (pretty OK taste compared to other protein shakes)
Why ? Why not. I am not a Gym freak, but I do st 45-60 minutes weight training +
40-60 minutes cardio
While I am against steroids I happily take an algae based product or bioengineered protein
as a little experiment - at the end probably they makes less harm than a bigmac
ahm + I am a vegetarian who does lotsa sports so extra protein is welcome
for those who might wonder: myostatin is responsible for skeletal muscle! Your tongue, and your heart muscle won't grow bigger than it is if you block that enzyme (I hope it really)
I recommed these searches "myostatin cow" : http://images.google.com/images?q=myostatin%20cow
myostatin:
http:
cheers
My 8 year old can kick my ass as it is. Good thing he's not a mega-muscled freak.
No, that's not how evolution works in situations where food is amply available (such as this one). Evolution favors the individual most likely to breed.
So, if big muscles mean more sex, then evolution favors individuals with bigger muscles as long as there is no other downside that reduces survivability or likelyhood of breeding (since food is amply available the greater nutritional requirement to support the increased muscle mass is not a downside).
Putting moderation advice in your
A genetically superior Arian!
Legend has it when he was a baby he killed two snakes one in each hand.
Babies already have quite a decent grip strength, and often if you put something in their hand, they'll grip it almost automatically. I wonder whether what this kid's grip strength was like when he was born.
Enough to kill a small snake? I doubt it takes much to kill a small snake, and looking at his muscles, could just be enough.
Of course, I had the same thought about the "miraculous virgin birth" when I learned about parthenogenesis.
"A witty saying proves nothing." ~Voltaire
"d'Oh!" ~Homer
Evolution IS exactly a beauty contest. The only way to propogate genes is to reproduce. The only way to reproduce is to attract a mate. The only way to attract mate is to exhibit traits the opposite sex favors.
In sharp contrast to your "how the geeks won at evolution" just-so story is the fact that women DO prefer lean, muscular men. Why? This was evolutionarily selected for, and clearly ought to have some advantage. You can argue that it's "cultural" but even then you have to ask "why?"...Why would culture value fit, muscular men? First, it's unlikely to be contemporary culture, as muscular men have been revered for all human civilization (look at Roman art, renaissance art, Michaelangelo's David, etc.). And if the answer is aesthetics rather than survival fitness, then why are we a species that values the aesthetics of physique?
I think overproduction of musculature has the evolutionary disadvantage you describe. It consumes an excess amount of calories. And, indeed, if you ask the average woman, most prefer lean, athletically muscular men as opposed to hulking body-building giants. Many find muscular overdevelopment unattractive and intimidating. HOWEVER, muscular fitness in moderation is attractive for a very obvious reason: Protection and defense. Fit men, from a evolutionary perspective, are more likely to defend the family against intruders and predators, and also likely to pass on those traits to offspring. It's that simple.
True, even the fittest man isn't likely to take down a tiger, but I think a stronger selection pressure is to be able take down other MEN. All men are smart enough to know to stay the hell from the tigers of the world.
I think the disadvantages of pronounced musculature are only true in the extreme.
And, one can argue all this evolutionary heritage is moot at this point. The ladies like the athletic guys (in terms of sexual appeal). But it's true that women's assessment of mate fitness is more complicated that men's, and other factors (fidelity, ability to provide, fathering style) come to play. It being buff doesn't hurt. Today.
Sure, packing on a few (15-20) pounds of healthy muscle isn't a bad thing, but you don't need myostatin inhibitors to do the job. Proper training, proper diet, 6 months, and hard work are all anyone really needs. Continuously adding muscle is a quick way to heart trouble. Even if you could safely add "a lot" of muscle, you would have to jack your hormones (steriods, HGH) to maintain it. Not worth it in the long run.
That's right. All your base.
obligatory
"A witty saying proves nothing." ~Voltaire
"d'Oh!" ~Homer
> "Myostatin blockade," Dr. McNally wrote, "will probably work its
> way into professional and amateur athletics, as well as into the
> ever-growing business of physical enhancement."
Lookout! Another round of SPAM is on its way.
While this is (for the most part) true, until very recently it was exceedingly rare for an average human individual to have sufficient food for this sort of mutation to be preferable. Even then, this is only in Western society; most of the world's population still don't get very much protein in their diets.
WWD4D?
Our bigger brains allowed us to figure out that we could bang rocks on the femurs of large prey carcasses and crack them open to get at the bone marrow that the tiger couldn't.
The reason small groups of humans were cut off from each other was a supervolcano that caused a nuclear winter effect for many years, killing off most humans and keeping the rest separate long enough for superficial traits to become geographically dominant. This article on the Toba supervolcano talks about this theory:
Oh, and Yellowstone is a supervolcano that is overdue in its pattern of going off every 600,000 years:Seven years ago, they create myostatin-free mice. Three years later, a child is born with the same "mutation". Also, there is no record of the father to verify parentage or that he contributed the other gene.
...
If I were a researcher who had solved the various difficulties (heart problems, etc.) with the process, and I wanted a secret human trial, I'd find a mother which already had one gene as a cover and make sure there was no information available on the father to give away the fact he did not contain the other gene, or falsify it if there were. Then, I'd act real surprised when the baby was born.
It could be legit, but the rarity of the mutation makes the whole thing sound suspicious to me
If he did he would be turning into a giant monkey every full moon and no one would want that!
Tsukasa: All I really want, is to be left alone...
Translation: "Hi. I'm Hans, and I am here to 'Pump you Up!'"
"He who would learn astronomy, and other recondite arts, let him go elsewhere. " -- John Calvin, commenting on Genesis 1
... that he knows I'm a bull!
"Who controls the past controls the future. Who controls the present controls the past." -- George Orwell
Hey There,
...
... ... ... ...
Okay
You can't just throw out phrases like
Massive muscles
Overlords
Super Kid
And not provide any pictures!?!
I want pictures!
Inquireing minds want to know,
-- The Dude
It's been posted before but I'm one of those geeks who actually bookmarked it:
Khaaan!
Not to be confused with Belgian Red Bull, which is something entirely different...
All hail the ubermensch!
Kisses,
Nietzsche
Maybe, it's the Neanderthal gene !!
If medication was developed to reproduce the effect, wouldnt the drug also be usefull for long space missions where muscle degradation is a severe problem?
simultaneously, in another part of the world, another child is born with another mutation that causes his bones to be unusually brittle. kids nickname him Mr. Glass. he looks eerily like a moodily-lit Samuel Jackson.
Just raise the taxes on crack.
I wonder what the effect is of SUPER-steroids on a fellow's member?
Don't think that a small group of dedicated individuals can't change the world. It's the only thing that ever has.
not being a mutant?
Damn! I wondered whatever had happened to that lady after she had escaped out of my testing laboratory located deep underground in a remote location.
Luckily, I just sent my best agents to "collect" this child and do more genetic testing on him, as he obviously has far surpassed his mother.
Muhahahaha! Soon I will rule the world with my mutant armies of 4 1/2 year olds!
In the mother, one copy of the gene is mutated and the other is normal; the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people.
If this mutation is so rare in people then it is very likely that the boys father is also his uncle or grandfather. Just another side effect of inbreeding.
Sign outside office door of a ubernerd gazillionaire biotech CEO:
MY OSTAT is IN
Sign outside office door of his personal bodygaurd:
MY OSTAT is OUT
There is in fact a major disadvantage that you may not be aware of.
There is a finite number of times each cell in your body can replicate itself. Excessive muscle growth WILL limit the maximum lifespan of a life form, and it limits the lifespan of humans as well.
This is part of how limiting caloric intake increases lifespan, it literally reduces the overall cellular growth of a lifeform.
I don't read or respond to AC posts
And he's going to...pump...you up!
Mr. T pitied this fool on 27 July 1992.
15-20 pounds in six months?
For most people, I don't believe that's possible unless you play with anabolic supplements. I've been lifting off and on for years, and at my best I doubt I gained ten pounds in six months.
j lo's ass that is...a genetic muscular mutation
"Look Lois, the two symbols of the Republican Party: an elephant, and a fat white guy who is threatened by change."
She was working for Jabba the hut... He will bring balance to the force.
That was so cute! I'm printing that one out and hanging it on my wall in an English-Oak wood frame, next to the pussy (frollicking kitten) and the weiner (weiner-dog puppy in a bun).
... it is really a movie: http://www.imdb.com/title/tt0311361/
http://videodetective.com/home.asp?PublishedID=839 764
note it is a .wmv file
What will the kid become?
*If it is more than likely that someone with this condition would live only to a normal middle age, then wouldn't it be best for these people to be placed into jobs that require great strength and endurance, but with limited life expectancy? Firefighters, police enforcement, farmers, factory workers, and the army, all staffed with these "supermen".
/fear
/sarcasm
* Taking it a little further, wouldn't it be best to selectively breed this trait into a controlled population to produce an expendable workforce? Have this boy, at the age of sixteen, breed with, say, female prison inmates? Use him in cloning research? Produce large lots of him, creating a whole new subclass of humanity. Modify his genes to limit his intellect, and condition his childhood to instill loyalty, and this new class of people will never revolt, and we, the normals of humanity, will guide their actions to better our lives.
* Add to this scenario just a little more: After experiencing the reign of George Bush, a normal/below average intelligence man trying to run the country, it might be best to breed a class of humanity best suited to rule over others: highly intelligent, long lives, and pleasant to look upon. They too will be conditioned, to make them loyal to America, to humanity, to social stability.
* And we, the normals, are left in the middle. A permanent, middle class, unable to amount to anything grand, but also unable to fall through the cracks of society. Those that cannot produce will be "removed" from the world, into breeding programs, or worse. Everyone will have their place, and society would be perfect.
Damn, I love this brave new world.
3 degrees of separation from Vladimir Putin
THE EVERLASTING MAN
.
G.K. Chesterton
[ TABLE OF CONTENTS ]
PREFATORY NOTE
This book needs a preliminary note that its scope be not misunderstood The view suggested is historical rather than theological, and does not deal directly with a religious change which has been the chief event of my own life; and about which I am already writing a more purely controversial volume. It is impossible, I hope, for any Catholic to write any book on any subject, above all this subject, without showing that he is a Catholic; but this study is not specially concerned with the differences between a Catholic and a Protestant. Much of it is devoted to many sorts of Pagans rather than any sort of Christians; and its thesis is that those who say that Christ stands side by side with similar myths, and his religion side by side with similar religions, are only repeating a very stale formula contradicted by a very striking fact. To suggest this I have not needed to go much beyond matters known to us all; I make no claim to learning; and have to depend for some things, as has rather become the fashion, on those who are more learned. As I have more than once differed from Mr. H. G. Wells in his view of history, it is the more right that I should here congratulate him on the courage and constructive imagination which carried through his vast and varied and intensely interesting work; but still more on having asserted the reasonable right of the amateur to do what he can with the facts which the specialists provide.
* * *
INTRODUCTION
THE PLAN OF THIS BOOK
There are two ways of getting home; and one of them is to stay there. The other is to walk round the whole world till we come back to the same place; and I tried to trace such a journey in a story I once wrote. It is, however, a relief to turn from that topic to another story that I never wrote. Like every book I never wrote, it is by far the best book I have ever written. It is only too probable that I shall never write it, so I will use it symbolically here; for it was a symbol of the same truth. I conceived it as a romance of those vast valleys with sloping sides, like those along which the ancient White Horses of Wessex are scrawled along the flanks of the hills. It concerned some boy whose farm or cottage stood on such a slope, and who went on his travels to find something, such as the effigy and grave of some giant; and when he was far enough from home he looked back and saw that his own farm and kitchen-garden, shining flat on the hill-side like the colours and quarterings of a shield, were but parts of some such gigantic figure, on which he had always lived, but which was too large and too close to be seen. That, I think, is a true picture of the progress of any really independent intelligence today; and that is the point of this book . .
[ . . . ]
* * *
PART I. ON THE CREATURE CALLED MAN
* * *
I. THE MAN IN THE CAVE
Far away in some strange constellation in skies infinitely remote, there is a small star, which astronomers may some day discover. At least I could never observe in the faces or demeanour of most astronomers or men of science any evidence that they have discovered it; though as a matter of fact they were walking about on it all the time. It is a star that brings forth out of itself very strange plants and very strange animals; and none stranger than the men of science. That at least is the way in which I should begin a history of the world, if I had to follow the scientific custom of beginning with an account of the astronomical universe. I should try to see even this earth from the outside, not by the hackneyed insistence of its relative position to the sun, but by some imaginative effort to conceive its remote position for the dehumanised spectator. Only I do not believe in being dehumanised in order to study humanity. I do not believe in dwelling upon the distances that are supposed to dwarf the world; I think there is even someth
IC XC NIKA
Yeah, or he is the first of the real x-men!
As your Subject: line says, evolution IS a beauty contest -- at least, in large part. Vast numbers of the traits of organisms are a direct result of sexual competition, or of sexual competition in combination with some other, more necessary, survival trait.
You don't think female humans have breasts that large because mammary glands take up a lot of space, do you? Even the flattest-chested woman can breastfeed her children handily. The breasts of apes are all pancake-like, yet they work perfectly well. No, large human breasts are mostly fat -- and they're that way because human men like them that way.
As for why men like them that way in the first place, check out some of Desmond Morris's work sometime.
"A great democracy must be progressive or it will soon cease to be a great democracy." --Theodore Roosevelt
Ok, I made an error, I should have said a year. But 6 months is pretty much the time most people need for really noticeable changes.
That's right. All your base.
You know that chimpanzees hunt?
http://www-rcf.usc.edu/~stanford/chimphunt.html
We may not have been hunting the bigger animals, but I am sure we were hunting the small things because we did not need claws etc to get them.
Service guarantees Citizenship! Questions Guarantee GITMO.... Amerika Uber Alles!
You misspelled "Kalifohniya".
Barry Bonds has a new excuse, now.
It's a very dark ride.
I would say this "mutant" gene has probably been around since the hunter gatherer stage. I would also think that it has been deselected by the advent of agriculture.
According to many studies, so called "primitive" man was actually better fed, and had more lesiure time etc than those at the beginning of agriculture.
The driving force making agriculture a more viable option was probably the rise in population. With a relatively small amount of people on the planet, an HG lifestye is viable as there is plenty of game. However as the # of humans increase the pressure on foodstocks would increase almost geometrically. This would drive human activity towards a method of making food supply predictable (even if the overall diet became less nutritious). If we were like other predators, we would have gone through the feast famine cycle, and probably stayed roughly the same in terms of population (roughly 8 million or so). Because of our brain and tool making abilites, we found a another way out, to manipulate the enviornment to suit our needs.
Service guarantees Citizenship! Questions Guarantee GITMO.... Amerika Uber Alles!
You know the germans are nothing if not meticulous, methodical, and maniacal....
...because in Nazi Germany, baby spanks you!
testing out my trending skills
Let me take a wild guess at what might make someone say something that abysmally stupid.
You're sitting there in your faded blue pajamas because you're too damn fat for anything else. There are orangish stains up the tops of both thighs where you keep wiping your Doritos greased hands. There's a huge stain on the chest where you spilled your 60oz cherry cola from the Super Stop last night.
As your wandering along through Slashdot, you come upon my post stating my 150 pound weight. You reflect, for a moment, on those bygone days as a grade schooler when last you weighed so little, and then, in a fit of frustrated rage over your own self-inflicted morbid obesity, angrily ramble off the first thing that comes to your head.
Unfortunately, poor nutrition affects your ability to think and reason just as it does your body, and you, my friend, wound up rambling off some nonsense that suggests that mass is the determining factor in overall fitness.
Either that or you've been on the Atkins diet and developed a chronic brain disease. One or the other.
Alito: A vote for Alito is a punch in the eye to put that bitch back in her place!
Actually, white people have less melanin, because melanin absorbs sunlight radiation and blocks the synthesis of Vitamin D.
The sun does not cast down Vitamin D.
Ka me ha me ha
(followed by the obliteration of some small German village)
The best phot of the superkid so far:0 40624x superkid.jpg
http://www.mounteverest.net/story/images/20
Actually read above and beyond the article. In horses this condition is called Impressive Syndrome.
Get a free ipod.
The current issue of Scientific American talks about it. The cover mentions gene doping in atheletes. The article itself talks about scientists working on myostatin blocking therapies that might be useful for the elderly and people with MD.
Democracy Now! - your daily, uncensored, corporate-free
Natural selection? sure, he may have some advantages that help him to survive and procreate, but there's nothing new here.
09F91102 no, 455FE104 nope, F190A1E8 uh-uh, 7A5F8A09 that's not it, C87294CE no. Ah! 452F6E403CDF10714E41DFAA257D313F.
A Beowulf cluster of these!
What? Oh, sorry.
Cogito, ergo sig.
Kahn?
KAAAAaaaaaaaAAAHN!!!!!
KAAaaaaAAAAAHN!!!!
I only mod up parents of "mod parent up" posts...
No-carb Borden's milk
That photo looks like someone has crossed a cow and a Rhino!
For all of us lifting guys who read M.D., Flex. or other Bodybuilding Mags, this article should surely raise an eyebrow since Myostatin has always been a rival for common occurance of those "plateus". I see maybe the next possible Ronnie Coleman, or Jay Cutler, especially when you take into career that this child has special genetic characteristics that could easily allow him to surpass other competitors of the sport.
-- [H]itman_forhire
Guess which one.
Downside - normally born by C-section (caeserian)
The damn things are too big to be born naturally.
Thats a major evolutionary downside!
Comment removed based on user account deletion
If you like Microsoft Products, You have not read the EULA.
If you are reading this, You have not read the EULA.
Not just that, the muscles themselves will degenerate if growing unchecked. Highly dense muscle
becomes harder to supply with blood as the capiliaries are made smaller and fewer. Lactic acid builds up and destroys the muscles, rather like having permanent cramp. This is where the term 'muscle bound' comes from. He will probably have to take medication and do very careful exercise to keep 'healthy' with this condition.
This is stuff out out of a sophmore year biology class. The limiting factor is a part of the DNA strand known as a telomere.
it is generally theorized that the purpose of limiting cellular replication is it limits cancer, ie a single mutated cell shouldn't replicate forever.
Here are several medical journal articles you can look up on The National Library of Medicine regarding limiting caloric intake, and several microcellular observations regarding the DNA replication process.
Miller RA, Extending life: scientific prospects and political obstacles. Milbank Q 2002 ;80(1)
Sreekumar R, et al, Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am J Physiol Endocrinol Metab 2002 Jul ; 283 (1) / E38-43
Jolly CA, et al, Life span is prolonged in food-restricted autoimmune-prone (NZB x NZW)F(1) mice fed a diet enriched with (n-3) fatty acids. J Nutr 2001 Oct;131(10):2753-60.
Hansen BC, et al, Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality. Toxicol Sci 1999 Dec / 52 (2 Suppl) / 56-60.
I don't read or respond to AC posts
Hitler sentenced non-aryans, cripples, etc., to death with the ideal of breeding a superior race. If you think about it, his legacy lives on today. The people of Germany might be quite a bit more likely to produce such a mutant, as their gene pool has already been concentrated.
I just googled for Impressive Syndrome, and it was described as having a potassium-related side effect. Horses with IS can have spells of temporary paralysis. This is (according to the article I just read) controllable with a low-potassium diet.
So there may be some correlation. It may be that Der Uber-Squirt will have potassium issues. Or it may be that they are two seperate conditions.
Not enough information to tell.
Fooz Meister
Are you absolutely sure that the only muscles that will grow bigger after taking myostatin blocker are skeletal muscles? Are you saying that those spammers lied to me again? Damn you, email!
Sincerely,
Pan Tarhei Hosé, PhD.
"Homo sum et cogito ergo odi profanum vulgus et libido."